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Issue Archive

Volume 130, Issue 25
December 21 2017
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
ALCL: is it now a curable disease?
Clinical Trials & Observations
Pier Luigi Zinzani
View Articletitled, ALCL: is it now a curable disease?
INSIDE BLOOD COMMENTARY
Etoposide for HLH: the limits of efficacy
Clinical Trials & Observations
Stephan Ehl
View Articletitled, Etoposide for HLH: the limits of efficacy
INSIDE BLOOD COMMENTARY
Single-cell dissection of monosomy 7 syndromes
Irene Gutierrez-Perez,Yenan T. Bryceson
View Articletitled, Single-cell dissection of monosomy 7 syndromes
INSIDE BLOOD COMMENTARY
CK2: a key regulator of thrombopoiesis
William Vainchenker,Hana Raslova
View Articletitled, CK2: a key regulator of thrombopoiesis

REVIEW ARTICLE

Disorders of erythrocyte hydration
Patrick G. Gallagher
View Articletitled, Disorders of erythrocyte hydration

CLINICAL TRIALS AND OBSERVATIONS

Five-year results of brentuximab vedotin in patients with relapsed or refractory systemic anaplastic large cell lymphoma
Clinical Trials & Observations
Barbara Pro,Ranjana Advani,Pauline Brice,Nancy L. Bartlett,Joseph D. Rosenblatt,Tim Illidge,Jeffrey Matous,Radhakrishnan Ramchandren,Michelle Fanale,Joseph M. Connors,Keenan Fenton,Dirk Huebner,Juan M. Pinelli,Dana A. Kennedy,Andrei Shustov
View Articletitled, Five-year results of brentuximab vedotin in patients with relapsed or refractory systemic anaplastic large cell lymphoma
Supplemental data
Immune reconstitution and survival of 100 SCID patients post–hematopoietic cell transplant: a PIDTC natural history study
Clinical Trials & Observations
Jennifer Heimall,Brent R. Logan,Morton J. Cowan,Luigi D. Notarangelo,Linda M. Griffith,Jennifer M. Puck,Donald B. Kohn,Michael A. Pulsipher,Suhag Parikh,Caridad Martinez,Neena Kapoor,Richard O’Reilly,Michael Boyer,Sung-Yun Pai,Frederick Goldman,Lauri Burroughs,Sharat Chandra,Morris Kletzel,Monica Thakar,James Connelly,Geoff Cuvelier,Blachy J. Davila Saldana,Evan Shereck,Alan Knutsen,Kathleen E. Sullivan,Kenneth DeSantes,Alfred Gillio,Elie Haddad,Aleksandra Petrovic,Troy Quigg,Angela R. Smith,Elizabeth Stenger,Ziyan Yin,William T. Shearer,Thomas Fleisher,Rebecca H. Buckley,Christopher C. Dvorak
View Articletitled, Immune reconstitution and survival of 100 SCID patients post–hematopoietic cell transplant: a PIDTC natural history study
Supplemental data
Confirmed efficacy of etoposide and dexamethasone in HLH treatment: long-term results of the cooperative HLH-2004 study
CME Clinical Trials & Observations
Elisabet Bergsten,AnnaCarin Horne,Maurizio Aricó,Itziar Astigarraga,R. Maarten Egeler,Alexandra H. Filipovich,Eiichi Ishii,Gritta Janka,Stephan Ladisch,Kai Lehmberg,Kenneth L. McClain,Milen Minkov,Scott Montgomery,Vasanta Nanduri,Diego Rosso,Jan-Inge Henter
View Articletitled, Confirmed efficacy of etoposide and dexamethasone in HLH treatment: long-term results of the cooperative HLH-2004 study

IMMUNOBIOLOGY AND IMMUNOTHERAPY

c-MPL provides tumor-targeted T-cell receptor-transgenic T cells with costimulation and cytokine signals
Christopher D. Nishimura,Daniel A. Brenner,Malini Mukherjee,Rachel A. Hirsch,Leah Ott,Meng-Fen Wu,Hao Liu,Olga Dakhova,Jordan S. Orange,Malcolm K. Brenner,Charles Y. Lin,Caroline Arber
View Articletitled, c-MPL provides tumor-targeted T-cell receptor-transgenic T cells with costimulation and cytokine signals
Supplemental data

LYMPHOID NEOPLASIA

Glucocorticoid resistance is reverted by LCK inhibition in pediatric T-cell acute lymphoblastic leukemia
Valentina Serafin,Giorgia Capuzzo,Gloria Milani,Sonia Anna Minuzzo,Marica Pinazza,Roberta Bortolozzi,Silvia Bresolin,Elena Porcù,Chiara Frasson,Stefano Indraccolo,Giuseppe Basso,Benedetta Accordi
View Articletitled, Glucocorticoid resistance is reverted by LCK inhibition in pediatric T-cell acute lymphoblastic leukemia
Supplemental data

MYELOID NEOPLASIA

Single-cell RNA-seq reveals a distinct transcriptome signature of aneuploid hematopoietic cells
Xin Zhao,Shouguo Gao,Zhijie Wu,Sachiko Kajigaya,Xingmin Feng,Qingguo Liu,Danielle M. Townsley,James Cooper,Jinguo Chen,Keyvan Keyvanfar,Maria del Pilar Fernandez Ibanez,Xujing Wang,Neal S. Young
View Articletitled, Single-cell RNA-seq reveals a distinct transcriptome signature of aneuploid hematopoietic cells
Supplemental data

PLATELETS AND THROMBOPOIESIS

CK2β regulates thrombopoiesis and Ca2+-triggered platelet activation in arterial thrombosis
Patrick Münzer,Britta Walker-Allgaier,Sascha Geue,Friederike Langhauser,Eva Geuss,David Stegner,Katja Aurbach,Daniela Semeniak,Madhumita Chatterjee,Irene Gonzalez Menendez,Melanie Märklin,Leticia Quintanilla-Martinez,Helmut R. Salih,David W. Litchfield,Thierry Buchou,Christoph Kleinschnitz,Florian Lang,Bernhard Nieswandt,Irina Pleines,Harald Schulze,Meinrad Gawaz,Oliver Borst
View Articletitled, CK2β regulates thrombopoiesis and Ca<sup>2+</sup>-triggered platelet activation in arterial thrombosis
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Hepatocyte nuclear factor 1A deficiency causes hemolytic anemia in mice by altering erythrocyte sphingolipid homeostasis
Karin von Wnuck Lipinski,Sarah Weske,Petra Keul,Susann Peters,Hideo A. Baba,Gerd Heusch,Markus H. Gräler,Bodo Levkau
View Articletitled, Hepatocyte nuclear factor 1A deficiency causes hemolytic anemia in mice by altering erythrocyte sphingolipid homeostasis
Supplemental data

THROMBOSIS AND HEMOSTASIS

VLITL is a major cross-β-sheet signal for fibrinogen Aα-chain frameshift variants
Cyrille Garnier,Fatma Briki,Brigitte Nedelec,Patrick Le Pogamp,Ahmet Dogan,Nathalie Rioux-Leclercq,Renan Goude,Caroline Beugnet,Laurent Martin,Marc Delpech,Frank Bridoux,Gilles Grateau,Jean Doucet,Philippe Derreumaux,Sophie Valleix
View Articletitled, VLITL is a major cross-β-sheet signal for fibrinogen Aα-chain frameshift variants

BLOOD WORK

Acquired “pyro”-poikilocytosis
Benoît Thomas,Julien Perrin
View Articletitled, Acquired “pyro”-poikilocytosis

ERRATA

Wang X, Haylock D, Hu CS, et al. A thrombopoietin receptor antagonist is capable of depleting myelofibrosis hematopoietic stem and progenitor cells. Blood. 2016;127(26):3398-3409.
View Articletitled, Wang X, Haylock D, Hu CS, et al. A thrombopoietin receptor antagonist is capable of depleting myelofibrosis hematopoietic stem and progenitor cells. <em>Blood.</em> 2016;127(26):3398-3409.
Li H, Choesang T, Bao W, et al. Decreasing TfR1 expression reverses anemia and hepcidin suppression in β-thalassemic mice. Blood. 2017;129(11):1514-1526.
View Articletitled, Li H, Choesang T, Bao W, et al. Decreasing TfR1 expression reverses anemia and hepcidin suppression in β-thalassemic mice. <em>Blood</em>. 2017;129(11):1514-1526.
Konkle BA. Impacting inhibitor development in hemophilia A. Blood. 2017;130(15):1689-1690.
View Articletitled, Konkle BA. Impacting inhibitor development in hemophilia A. <em>Blood.</em> 2017;130(15):1689-1690.
Holtan SG, Weisdorf DJ. Vorinostat is victorious in GVHD prevention. Blood. 2017;130(15):1690-1691.
View Articletitled, Holtan SG, Weisdorf DJ. Vorinostat is victorious in GVHD prevention. <em>Blood.</em> 2017;130(15):1690-1691.

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

Results of the HLH-2004 study
CME
View Articletitled, Results of the HLH-2004 study
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