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Volume 126, Issue 19
November 5 2015
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
First prospective clinical trial in adult HLH
Clinical Trials & Observations
Paul La Rosée
View Articletitled, First prospective clinical trial in adult HLH
INSIDE BLOOD COMMENTARY
Cell-specific PD-L1 expression in DLBCL
Vassiliki A. Boussiotis
View Articletitled, Cell-specific PD-L1 expression in DLBCL
INSIDE BLOOD COMMENTARY
Ibrutinib in CLL: 2 sides of the same coin
Francesc Bosch,Pau Abrisqueta
View Articletitled, Ibrutinib in CLL: 2 sides of the same coin
INSIDE BLOOD COMMENTARY
Platelets promote pulmonary pull of polys
Timothy J. McMahon
View Articletitled, Platelets promote pulmonary pull of polys
INSIDE BLOOD COMMENTARY
Inflammation is key to hemophilic arthropathy
Alok Srivastava
View Articletitled, Inflammation is key to hemophilic arthropathy
INSIDE BLOOD COMMENTARY
Animal models of VT: to change or not to change?
Jose Antonio Diaz
View Articletitled, Animal models of VT: to change or not to change?

HOW I TREAT

How I treat fragile myeloma patients
Alessandra Larocca,Antonio Palumbo
View Articletitled, How I treat fragile myeloma patients

CLINICAL TRIALS AND OBSERVATIONS

Multicenter study of combination DEP regimen as a salvage therapy for adult refractory hemophagocytic lymphohistiocytosis
Clinical Trials & Observations
Yini Wang,Wenqiu Huang,Liangding Hu,Xinan Cen,Lihong Li,Jijun Wang,Jianliang Shen,Na Wei,Zhao Wang
View Articletitled, Multicenter study of combination DEP regimen as a salvage therapy for adult refractory hemophagocytic lymphohistiocytosis

LYMPHOID NEOPLASIA

Expression of programmed cell death ligand 1 is associated with poor overall survival in patients with diffuse large B-cell lymphoma
Clinical Trials & Observations
Junichi Kiyasu,Hiroaki Miyoshi,Akie Hirata,Fumiko Arakawa,Ayako Ichikawa,Daisuke Niino,Yasuo Sugita,Yuji Yufu,Ilseung Choi,Yasunobu Abe,Naokuni Uike,Koji Nagafuji,Takashi Okamura,Koichi Akashi,Ryoichi Takayanagi,Motoaki Shiratsuchi,Koichi Ohshima
View Articletitled, Expression of programmed cell death ligand 1 is associated with poor overall survival in patients with diffuse large B-cell lymphoma
Supplemental data
MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia
Courtney L. Jones,Christy M. Gearheart,Susan Fosmire,Cristina Delgado-Martin,Nikki A. Evensen,Karen Bride,Angela J. Waanders,Faye Pais,Jinhua Wang,Teena Bhatla,Danielle S. Bitterman,Simone R. de Rijk,Wallace Bourgeois,Smita Dandekar,Eugene Park,Tamara M. Burleson,Pillai Pallavi Madhusoodhan,David T. Teachey,Elizabeth A. Raetz,Michelle L. Hermiston,Markus Müschen,Mignon L. Loh,Stephen P. Hunger,Jinghui Zhang,Michael J. Garabedian,Christopher C. Porter,William L. Carroll
View Articletitled, MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia
Supplemental data
Partial reconstitution of humoral immunity and fewer infections in patients with chronic lymphocytic leukemia treated with ibrutinib
Clinical Trials & Observations
Clare Sun,Xin Tian,Yuh Shan Lee,Sreenivasulu Gunti,Andrew Lipsky,Sarah E. M. Herman,Dalia Salem,Maryalice Stetler-Stevenson,Constance Yuan,Lela Kardava,Susan Moir,Irina Maric,Janet Valdez,Susan Soto,Gerald E. Marti,Mohammed Z. Farooqui,Abner L. Notkins,Adrian Wiestner,Georg Aue
View Articletitled, Partial reconstitution of humoral immunity and fewer infections in patients with chronic lymphocytic leukemia treated with ibrutinib
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Platelet-derived Wnt antagonist Dickkopf-1 is implicated in ICAM-1/VCAM-1–mediated neutrophilic acute lung inflammation
Yujie Guo,Amarjit Mishra,Emily Howland,Chunling Zhao,Dhananjay Shukla,Tingting Weng,Lin Liu
View Articletitled, Platelet-derived Wnt antagonist Dickkopf-1 is implicated in ICAM-1/VCAM-1–mediated neutrophilic acute lung inflammation
Supplemental data

PLATELETS AND THROMBOPOIESIS

CD32a antibodies induce thrombocytopenia and type II hypersensitivity reactions in FCGR2A mice
Todd Meyer,Liza Robles-Carrillo,Monica Davila,Meghan Brodie,Hina Desai,Mildred Rivera-Amaya,John L. Francis,Ali Amirkhosravi
View Articletitled, CD32a antibodies induce thrombocytopenia and type II hypersensitivity reactions in FCGR2A mice
Supplemental data

THROMBOSIS AND HEMOSTASIS

IL-1β, in contrast to TNFα, is pivotal in blood-induced cartilage damage and is a potential target for therapy
Lize F. D. van Vulpen,Roger E. G. Schutgens,Katja Coeleveld,Els C. Alsema,Goris Roosendaal,Simon C. Mastbergen,Floris P. J. G. Lafeber
View Articletitled, IL-1β, in contrast to TNFα, is pivotal in blood-induced cartilage damage and is a potential target for therapy
Exacerbated venous thromboembolism in mice carrying a protein S K196E mutation
Fumiaki Banno,Toshiyuki Kita,José A. Fernández,Hiroji Yanamoto,Yuko Tashima,Koichi Kokame,John H. Griffin,Toshiyuki Miyata
View Articletitled, Exacerbated venous thromboembolism in mice carrying a protein S K196E mutation
Supplemental data

BLOOD WORK

Immunoglobulin G4-positive plasma cell myeloma
Jianfeng Zhu,Boting Wu
View Articletitled, Immunoglobulin G4-positive plasma cell myeloma
Vitamin B12 deficiency presenting as pancytopenia with ring sideroblasts
Vighnesh Bharath,Cyrus C. Hsia
View Articletitled, Vitamin B<sub>12</sub> deficiency presenting as pancytopenia with ring sideroblasts

ERRATA

Brunstein CG, Wagner JE, Weisdorf DJ, et al. Negative effect of KIR alloreactivity in recipients of umbilical cord blood transplant depends on transplantation conditioning intensity. Blood. 2009;113(22):5628-5634.
View Articletitled, Brunstein CG, Wagner JE, Weisdorf DJ, et al. Negative effect of KIR alloreactivity in recipients of umbilical cord blood transplant depends on transplantation conditioning intensity. <em>Blood</em>. 2009;113(22):5628-5634.
Lorenz V, Stegner D, Stritt S, et al. Targeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization. Blood. 2015;125(26):4069-4077.
View Articletitled, Lorenz V, Stegner D, Stritt S, et al. Targeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization. <em>Blood</em>. 2015;125(26):4069-4077.
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