Issue Archive
Table of Contents
INSIDE BLOOD COMMENTARIES
Setting the table for macrophages
In this issue of Blood, Das et al assign a very novel and unanticipated function to plasminogen by showing that it is an enhancer of the phagocytic function of macrophages.1
MDSCs: the final frontier of the microenvironment in CLL?
In this issue of Blood, Jitschin et al identify increased numbers of myeloid-derived suppressor cells (MDSCs) in untreated patients with chronic lymphocytic leukemia (CLL) suppressing T cells and inducing regulatory T cells (Tregs), resulting in impaired immune responses.1
p53 at the crossroads of MPN treatment
In this issue of Blood, Lu et al describe the cooperation between an orally bioavailable mouse double minute 2 (MDM2) antagonist (RG7112) and the pegylated interferon α (Peg-IFNα 2a) to target JAK2V617F hematopoietic progenitors and stem cells. Their work provides a rationale for the treatment of patients suffering from myeloproliferative neoplasms (MPNs).1
Errant innate immune signaling in del(5q) MDS
In this issue of Blood, Keerthivasan et al have identified that the deletion of mDia1, a chromosome 5q gene, contributes to myelodysplastic syndromes (MDSs) by increasing innate immune signaling in granulocytes.1
Platelets: crossroads of immunity and hemostasis
In this issue of Blood, Koupenova and colleagues report that platelets express functional TOLL-like receptor 7 (TLR7) and contribute to host survival during viral infection.1 Through a series of experiments utilizing mice deficient for TLR7 together with adoptive transfer of wild-type platelets, Koupenova et al1 demonstrate that platelets specifically respond to viral analogs and intact virus, leading to platelet activation and binding to various leukocyte subsets. Perhaps most importantly, this platelet activation appears absolutely essential for host survival during infection with some viral pathogens such as encephalomyocarditis virus (EMCV).
KLF1: when less is more
In this issue of Blood, Liu et al gain an understanding of phenotypic variability in hemoglobinopathies.1 They find that mutations in Krüppel-like factor-1 (KLF1) are significantly more prevalent in patients with β-thalassemia than previously recognized and correlate with a milder phenotype. This supports the emerging concept that monoallelic KLF1 mutations can play a modulatory role in hemoglobinopathies.
Innate protection from graft-versus-host disease
In this issue of Blood, Hazenberg and Spits provide a detailed overview of human innate lymphoid cell (ILC) subsets and their development and distribution throughout the human body, discussing these cells in the context of human disease. In the same issue, Munneke et al for the first time link ILCs to human hematopoietic malignancies by identifying a clear correlation between the presence of activated ILCs after induction chemotherapy and the absence of acute graft-versus-host disease (GVHD) development following subsequent hematopoietic stem cell transplantation (HSCT).1,2
Haplo is the new black
In this edition of Blood, Bertaina et al report 3-year survival exceeding 90% by using haploidentical αβ+CD3+/CD19+-depleted allogeneic transplantation for children with nonmalignant disorders.1
BLOOD WORK
PLENARY PAPER
PERSPECTIVES
REVIEW ARTICLE
CLINICAL TRIALS AND OBSERVATIONS
The role of radiotherapy and intrathecal CNS prophylaxis in extralymphatic craniofacial aggressive B-cell lymphomas
Clinical Trials & Observations
Deep molecular responses achieved in patients with CML-CP who are switched to nilotinib after long-term imatinib
Clinical Trials & Observations
IMMUNOBIOLOGY
LYMPHOID NEOPLASIA
CLL-cells induce IDOhi CD14+HLA-DRlo myeloid-derived suppressor cells that inhibit T-cell responses and promote TRegs
MYELOID NEOPLASIA
Aberrant overexpression of CD14 on granulocytes sensitizes the innate immune response in mDia1 heterozygous del(5q) MDS
PLATELETS AND THROMBOPOIESIS
RED CELLS, IRON, AND ERYTHROPOIESIS
THROMBOSIS AND HEMOSTASIS
TRANSPLANTATION
Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease
HLA-haploidentical stem cell transplantation after removal of αβ+ T and B cells in children with nonmalignant disorders
Brief Report
-
Cover Image
Cover Image
Scanning electron micrograph of human platelets interacting with a leukocyte in the presence of a single stranded RNA virus. Viral particles are located at the tip of the pseudopodia of the platelet positioned on the leukocyte. The image was taken at ×10 000 with FEI Quanta 200 FEG MKII scanning electron microscope. See the article by Koupenova et al on page 791.
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkBack Matter
- PDF Icon PDF LinkAdvertising
- PDF Icon PDF LinkEditorial Board
Advertisement intended for health care professionals
Email alerts
Advertisement intended for health care professionals