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Confocal fluorescence micrograph of an in vitro–derived CD103⁺ dendritic cell depicting CD103 antibody staining (yellow), phalloidin for F-actin (magenta), and nucleus counterstain with DAPI (cyan) of a cytospin preparation. The newly described protocol, termed iCD103, efficiently generates CD103⁺ dendritic cells from murine bone marrow. See the article by Mayer et al on page 3081.
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Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of Diffuse Large B-cell Lymphoma

High-throughput drug screening identifies SMAC mimetics as enhancers of NK cell cytotoxicity in chronic myeloid leukemia

Donor Regulatory T-Cell Therapy to Prevent Graft-Versus-Host Disease

Epcoritamab plus GemOx in transplant-ineligible relapsed/refractory DLBCL: results from the EPCORE NHL-2 trial

Doubling down on GPRC5D in multiple myeloma

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Table of Contents

INSIDE BLOOD COMMENTARIES

Engraftment’s Holy Grail: is one signal enough?

How to generate large numbers of CD103⁺ dendritic cells

HiJAKing T-ALL

Stress equips CLL cells to survive

Cautious enthusiasm about GWAS findings

PERSPECTIVES

Curing myeloma at last: defining criteria and providing the evidence
Clinical Trials & Observations

HOW I TREAT

How I treat patients with massive hemorrhage
Clinical Trials & Observations

CLINICAL TRIALS AND OBSERVATIONS

Long-term results of first salvage treatment in CLL patients treated initially with FCR (fludarabine, cyclophosphamide, rituximab)
Clinical Trials & Observations

HEMATOPOIESIS AND STEM CELLS

HOXA9 promotes hematopoietic commitment of human embryonic stem cells

Growth hormone receptor signaling is dispensable for HSC function and aging
Brief Report

Antioxidant N-acetyl-l-cysteine increases engraftment of human hematopoietic stem cells in immune-deficient mice
e-blood

IMMUNOBIOLOGY

Selective and efficient generation of functional Batf3-dependent CD103⁺ dendritic cells from mouse bone marrow

LYMPHOID NEOPLASIA

JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model

Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded protein response dependent on BTK and SYK

Differential and limited expression of mutant alleles in multiple myeloma

FOXO1 repression contributes to block of plasma cell differentiation in classical Hodgkin lymphoma

MYELOID NEOPLASIA

The TAK1-NF-κB axis as therapeutic target for AML

PLATELETS AND THROMBOPOIESIS

Interaction of platelet-derived autotaxin with tumor integrin α_Vβ₃ controls metastasis of breast cancer cells to bone

RED CELLS, IRON, AND ERYTHROPOIESIS

Cell-type–specific transcriptional regulation of PIGM underpins the divergent hematologic phenotype in inherited GPl deficiency
Brief Report

THROMBOSIS AND HEMOSTASIS

Genetic variants in PLG, LPA, and SIGLEC 14 as well as smoking contribute to plasma plasminogen levels

Anti-factor IXa/X bispecific antibody ACE910 prevents joint bleeds in a long-term primate model of acquired hemophilia A

In vitro evidence of a tissue factor-independent mode of action of recombinant factor VIIa in hemophilia
Brief Report

BLOOD WORK

Small-cell variant of ALK⁺ anaplastic large-cell lymphoma with a leukemic phase

Granular lymphoid cells are not always part of T-cell lineage: an atypical case of mantle cell lymphoma

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Table of Contents

INSIDE BLOOD COMMENTARIES

PERSPECTIVES

Curing myeloma at last: defining criteria and providing the evidence Clinical Trials & Observations

HOW I TREAT

How I treat patients with massive hemorrhage Clinical Trials & Observations

CLINICAL TRIALS AND OBSERVATIONS

Long-term results of first salvage treatment in CLL patients treated initially with FCR (fludarabine, cyclophosphamide, rituximab) Clinical Trials & Observations

HEMATOPOIESIS AND STEM CELLS

Growth hormone receptor signaling is dispensable for HSC function and aging Brief Report

Antioxidant N-acetyl-l-cysteine increases engraftment of human hematopoietic stem cells in immune-deficient mice e-blood

IMMUNOBIOLOGY

LYMPHOID NEOPLASIA

MYELOID NEOPLASIA

PLATELETS AND THROMBOPOIESIS

RED CELLS, IRON, AND ERYTHROPOIESIS

Cell-type–specific transcriptional regulation of PIGM underpins the divergent hematologic phenotype in inherited GPl deficiency Brief Report

THROMBOSIS AND HEMOSTASIS

In vitro evidence of a tissue factor-independent mode of action of recombinant factor VIIa in hemophilia Brief Report

BLOOD WORK

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ASH Publications

American Society of Hematology

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Curing myeloma at last: defining criteria and providing the evidence
Clinical Trials & Observations

How I treat patients with massive hemorrhage
Clinical Trials & Observations

Long-term results of first salvage treatment in CLL patients treated initially with FCR (fludarabine, cyclophosphamide, rituximab)
Clinical Trials & Observations

Growth hormone receptor signaling is dispensable for HSC function and aging
Brief Report

Antioxidant N-acetyl-l-cysteine increases engraftment of human hematopoietic stem cells in immune-deficient mice
e-blood

Cell-type–specific transcriptional regulation of PIGM underpins the divergent hematologic phenotype in inherited GPl deficiency
Brief Report

In vitro evidence of a tissue factor-independent mode of action of recombinant factor VIIa in hemophilia
Brief Report