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Kunihiro Hattori
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A Novel Clot Waveform Analysis to Measure the Plasma Coagulation Potency in the Presence of Anti-Fixa/Fx Bispecific Antibody, Emicizumab

Keiji Nogami, MD PhD, Tomoko Matsumoto, PhD, Yuka Tabuchi, Tetsuhiro Soeda, PhD, Nobuo Arai, Takehisa Kitazawa, Hidenari Takaoka, Kunihiro Hattori, PhD, Midori Shima, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1388.
https://doi.org/10.1182/blood.V128.22.1388.1388
Published: 2016
Journal Articles

Activated FVIII Released from FVIII/VWF Complex Facilitates Thrombus Development Under High Shear Flow Condition

Hiroaki Yaoi, MD, Yasuaki Shida, MD PhD, Takehisa Kitazawa, Kunihiro Hattori, PhD, Midori Shima, MD PhD, Keiji Nogami, MD PhD
Journal: Blood
Blood (2016) 128 (22): 83.
https://doi.org/10.1182/blood.V128.22.83.83
Published: 2016
Journal Articles

ACE910 Facilitates Its Hemostatic Effect with the Lower Concentration of Factor X Than That Required for Factor VIIa-Driven Coagulation

Koji Yada, MD PhD, Keiji Nogami, MD PhD, Takehisa Kitazawa, DVM, Kunihiro Hattori, PhD, Midori Shima, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1077.
https://doi.org/10.1182/blood.V126.23.1077.1077
Published: 2015
Journal Articles

Anti-Factor IXa/Factor X Antibody (ACE910) Improves the Coagulation Function in Acquired Hemophilia A ex vivo

Masahiro Takeyama, MD PhD, Keiji Nogami, MD PhD, Tomoko Matsumoto, PhD, Takehisa Kitazawa, DVM, Kunihiro Hattori, PhD, Midori Shima, MD PhD
Journal: Blood
Blood (2015) 126 (23): 3565.
https://doi.org/10.1182/blood.V126.23.3565.3565
Published: 2015
Journal Articles

Activated Protein C-Catalyzed Factor Va Inactivation Predominantly Contributes to the Downregulation of Coagulation Rather Than Factor VIIIa Inactivation

Koji Yada, MD PhD, Keiji Nogami, MD PhD, Tomoko Matsumoto, PhD, Takehisa Kitazawa, DVM, Kunihiro Hattori, PhD, Midori Shima, MD PhD
Journal: Blood
Blood (2014) 124 (21): 4222.
https://doi.org/10.1182/blood.V124.21.4222.4222
Published: 2014
Journal Articles

FVIII Heavy Chain Enhances Tenase Activity Induced By FVIIIa Mimicking Bispesific Antibody, ACE910

Hiroaki Minami, MD, Keiji Nogami, MD PhD, Takehisa Kitazawa, DVM, Kunihiro Hattori, PhD, Midori Shima, MD PhD
Journal: Blood
Blood (2014) 124 (21): 1481.
https://doi.org/10.1182/blood.V124.21.1481.1481
Published: 2014
Journal Articles

Distinct Localization of Coagulation Factor VIII, Von Willebrand Factor and Factor VIIIa-Mimetic Bispecific Antibody Contributing to Thrombus Formation Under Whole Blood Flow Conditions

Yasuaki Shida, MD PhD, Keiji Nogami, MD PhD, Hiroaki Minami, MD, Hiroaki Yaoi, MD, Tomoko Matsumoto, PhD, Takehisa Kitazawa, DVM, Kunihiro Hattori, PhD, Midori Shima, MD PhD
Journal: Blood
Blood (2014) 124 (21): 1483.
https://doi.org/10.1182/blood.V124.21.1483.1483
Published: 2014
Journal Articles

Anti-factor IXa/X bispecific antibody ACE910 prevents joint bleeds in a long-term primate model of acquired hemophilia A

Atsushi Muto, Kazutaka Yoshihashi, Minako Takeda, Takehisa Kitazawa, Tetsuhiro Soeda, Tomoyuki Igawa, Zenjiro Sampei, Taichi Kuramochi, Akihisa Sakamoto, Kenta Haraya, Kenji Adachi, Yoshiki Kawabe, Keiji Nogami, Midori Shima, Kunihiro Hattori
Journal: Blood
Blood (2014) 124 (20): 3165–3171.
https://doi.org/10.1182/blood-2014-07-585737
Published: 2014
Includes: Supplemental data
Journal Articles

Hemostatic Effect of a Novel Bispecific Antibody (ACE910) Against Activated Factor IX and Factor X in an Acquired Hemophilia A Model

Atsushi Muto, Takehisa Kitazawa, DVM, Kazutaka Yoshihasi, DVM, PhD, Minako Takeda, DVM, Tetsuhiro Soeda, PhD, Tomoyuki Igawa, PhD, Zenjiro Sampei, Yuichiro Sakamoto, Yukiko Okuyama-Nishida, PhD, Hiroyuki Saito, Yoshiki Kawabe, PhD, Midori Shima, MD, PhD, Akira Yoshioka, MD, PhD, Kunihiro Hattori, PhD
Journal: Blood
Blood (2012) 120 (21): 42.
https://doi.org/10.1182/blood.V120.21.42.42
Published: 2012
Journal Articles

Generation of a Novel Bispecific Antibody (ACE910) Against Activated Factor IX and Factor X Mimicking the Function of Factor VIII Cofactor Activity

Tomoyuki Igawa, PhD, Zenjiro Sampei, Tetsuhiro Soeda, PhD, Yukiko Okuyama-Nishida, PhD, Chifumi Moriyama, Tetsuya Wakabayashi, Eriko Tanaka, Atsushi Muto, Tetsuo Kojima, PhD, Takehisa Kitazawa, DVM, Kazutaka Yoshihashi, DVM, PhD, Aya Harada, Miho Funaki, Kenta Haraya, Tachibana Tatsuhiko, PhD, Sachiyo Suzuki, Keiko Esaki, Yoshiaki Nabuchi, PhD, Kunihiro Hattori, PhD
Journal: Blood
Blood (2012) 120 (21): 1126.
https://doi.org/10.1182/blood.V120.21.1126.1126
Published: 2012
Journal Articles

Humanized Sc(Fv)2 Minibody against C-Mpl Successfully Increased Platelet Number in Monkey and Increased Engraftment of Human Umbilical Cord Blood Cells in NOD/SCID Mouse.

Takashi Yoshikubo, Yoshihiro Matsumoto, Masahiko Nanami, Takayuki Sakurai, Hiroyuki Tsunoda, Akihisa Kaneko, Yukiko Inagaki, Masashi Shiina, Mizuho Noguchi, Makoto Monnai, Souhei Ohyama, Yukihito Miura, Tetsuro Orita, Yasufumi Kikuchi, Tomoyuki Igawa, Kunihiro Hattori, Hisafumi Okabe
Journal: Blood
Blood (2008) 112 (11): 2322.
https://doi.org/10.1182/blood.V112.11.2322.2322
Published: 2008
Journal Articles

Characterization of an Anti-Factor VIII Monoclonal Antibody with A1 and A3 Epitopes Which Increases Factor VIII Activity.

Masahiro Takeyama, MD, Keiji Nogami, MD,PhD, Tetsuhiro Soeda, phD, Tsukasa Suzuki, phD, Kunihiro Hattori, phD, Kohei Tatsumi, MD, Yuri Fujita, MD, Ichiro Tanaka, MD.PhD, Akira Yoshioka, MD,PhD, Midori Shima, MD,PhD
Journal: Blood
Blood (2006) 108 (11): 1702.
https://doi.org/10.1182/blood.V108.11.1702.1702
Published: 2006