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Volume 122, Issue 9
August 29 2013
Issue Cover

Table of Contents

INSIDE BLOOD

HEMATOPOIESIS & STEM CELLS
Interfering with histone demethylases in HSCs
Jonas Larsson
View Articletitled, Interfering with histone demethylases in HSCs
INSIDE BLOOD
Pinning down myeloma with Pim2 inhibitors!
Paola Neri,Nizar J. Bahlis
View Articletitled, Pinning down myeloma with Pim2 inhibitors!
MYELOID NEOPLASIA
The ne plus ultra for deep BCR-ABL sequencing?
Martin C. Müller
View Articletitled, The <em>ne plus ultra</em> for deep BCR-ABL sequencing?
PLATELETS & THROMBOPOIESIS
No more sugar-coating it: mucins and platelet biology
Yumiko Matsubara
View Articletitled, No more sugar-coating it: mucins and platelet biology
RED CELLS, IRON, & ERYTHROPOIESIS
A translational link between Fe and Epo
Mario Cazzola
View Articletitled, A translational link between Fe and Epo
TRANSPLANTATION
Ferritin and FerriScan in HCT recipients
Bipin N. Savani
View Articletitled, Ferritin and FerriScan in HCT recipients

BLOOD WORK

Plasma cell leukemia masquerading as carcinocythemia
Man Updesh Singh Sachdeva,Narender Kumar,Reena Das
View Articletitled, Plasma cell leukemia masquerading as carcinocythemia
Platelet phagocytosis by neutrophils
Lisa Senzel,Chunghun Chang
View Articletitled, Platelet phagocytosis by neutrophils

PLENARY PAPER

RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity
Sonia Cellot,Kristin J. Hope,Jalila Chagraoui,Martin Sauvageau,Éric Deneault,Tara MacRae,Nadine Mayotte,Brian T. Wilhelm,Josette R. Landry,Stephen B. Ting,Jana Krosl,Keith Humphries,Alexander Thompson,Guy Sauvageau
View Articletitled, RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity
Supplemental data

BLOOD SPOTLIGHT

Development of gene therapy for blood disorders: an update
Arthur W. Nienhuis
View Articletitled, Development of gene therapy for blood disorders: an update

REVIEW ARTICLE

Advanced drug delivery systems for antithrombotic agents
Colin F. Greineder,Melissa D. Howard,Ronald Carnemolla,Douglas B. Cines,Vladimir R. Muzykantov
View Articletitled, Advanced drug delivery systems for antithrombotic agents
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

The value of allogeneic and autologous hematopoietic stem cell transplantation in prognostically favorable acute myeloid leukemia with double mutant CEBPA
Clinical Trials & Observations
Richard F. Schlenk,Erdogan Taskesen,Yvette van Norden,Jürgen Krauter,Arnold Ganser,Lars Bullinger,Verena I. Gaidzik,Peter Paschka,Andrea Corbacioglu,Gudrun Göhring,Andrea Kündgen,Gerhard Held,Katharina Götze,Edo Vellenga,Juergen Kuball,Urs Schanz,Jakob Passweg,Thomas Pabst,Johan Maertens,Gert J. Ossenkoppele,Ruud Delwel,Hartmut Döhner,Jan J. Cornelissen,Konstanze Döhner,Bob Löwenberg
View Articletitled, The value of allogeneic and autologous hematopoietic stem cell transplantation in prognostically favorable acute myeloid leukemia with double mutant <em>CEBPA</em>
Supplemental data
Long-term remission of T-cell large granular lymphocyte leukemia associated with rheumatoid arthritis after rituximab therapy
Brief Report
Divi Cornec,Valérie Devauchelle-Pensec,Sandrine Jousse-Joulin,Thierry Marhadour,Valérie Ugo,Christian Berthou,Nathalie Douet-Guilbert,Alain Saraux
View Articletitled, Long-term remission of T-cell large granular lymphocyte leukemia associated with rheumatoid arthritis after rituximab therapy

LYMPHOID NEOPLASIA

Requirement for antiapoptotic MCL-1 in the survival of BCR-ABL B-lineage acute lymphoblastic leukemia
Brian Koss,Jeffrey Morrison,Rhonda M. Perciavalle,Harpreet Singh,Jerold E. Rehg,Richard T. Williams,Joseph T. Opferman
View Articletitled, Requirement for antiapoptotic MCL-1 in the survival of BCR-ABL B-lineage acute lymphoblastic leukemia
Supplemental data
Mer receptor tyrosine kinase is a therapeutic target in pre–B-cell acute lymphoblastic leukemia
Rachel M. A. Linger,Alisa B. Lee-Sherick,Deborah DeRyckere,Rebecca A. Cohen,Kristen M. Jacobsen,Amy McGranahan,Luis N. Brandão,Amanda Winges,Kelly K. Sawczyn,Xiayuan Liang,Amy K. Keating,Aik Choon Tan,H. Shelton Earp,Douglas K. Graham
View Articletitled, Mer receptor tyrosine kinase is a therapeutic target in pre–B-cell acute lymphoblastic leukemia
Supplemental data
Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation
Jing Lu,Tatiana Zavorotinskaya,Yumin Dai,Xiao-Hong Niu,Joseph Castillo,Janet Sim,Jianjun Yu,Yingyun Wang,John L. Langowski,Jocelyn Holash,Kevin Shannon,Pablo D. Garcia
View Articletitled, Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation
Supplemental data
Insulin-like growth factor-1 receptor (IGF1R) as a novel target in chronic lymphocytic leukemia
Niuscha Yaktapour,Rudolf Übelhart,Julia Schüler,Konrad Aumann,Christine Dierks,Meike Burger,Dietmar Pfeifer,Hassan Jumaa,Hendrik Veelken,Tilman Brummer,Katja Zirlik
View Articletitled, Insulin-like growth factor-1 receptor (IGF1R) as a novel target in chronic lymphocytic leukemia
Supplemental data

MYELOID NEOPLASIA

Unraveling the complexity of tyrosine kinase inhibitor–resistant populations by ultra-deep sequencing of the BCR-ABL kinase domain
Simona Soverini,Caterina De Benedittis,K. Machova Polakova,Adela Brouckova,David Horner,Michele Iacono,Fausto Castagnetti,Gabriele Gugliotta,Francesca Palandri,Cristina Papayannidis,Ilaria Iacobucci,Claudia Venturi,Maria Teresa Bochicchio,Hana Klamova,Federica Cattina,Domenico Russo,Paola Bresciani,Gianni Binotto,Barbara Giannini,Alexander Kohlmann,Torsten Haferlach,Andreas Roller,Gianantonio Rosti,Michele Cavo,Michele Baccarani,Giovanni Martinelli
View Articletitled, Unraveling the complexity of tyrosine kinase inhibitor–resistant populations by ultra-deep sequencing of the <em>BCR-ABL</em> kinase domain
Supplemental data

PLATELETS AND THROMBOPOIESIS

C1galt1-deficient mice exhibit thrombocytopenia due to abnormal terminal differentiation of megakaryocytes
Takashi Kudo,Takashi Sato,Kozue Hagiwara,Yukinori Kozuma,Takashi Yamaguchi,Yuzuru Ikehara,Michito Hamada,Ken Matsumoto,Masatsugu Ema,Soichiro Murata,Nobuhiro Ohkohchi,Hisashi Narimatsu,Satoru Takahashi
View Articletitled, C1galt1-deficient mice exhibit thrombocytopenia due to abnormal terminal differentiation of megakaryocytes

RED CELLS, IRON, AND ERYTHROPOIESIS

IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation
Nicole Wilkinson,Kostas Pantopoulos
View Articletitled, IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation
Supplemental data

TRANSPLANTATION

Targeting apoptosis to induce stable mixed hematopoietic chimerism and long-term allograft survival without myelosuppressive conditioning in mice
Pietro E. Cippà,Sarah S. Gabriel,Jin Chen,Philip D. Bardwell,Andrew Bushell,Annick Guimezanes,Anna K. Kraus,Thomas Wekerle,Rudolf P. Wüthrich,Thomas Fehr
View Articletitled, Targeting apoptosis to induce stable mixed hematopoietic chimerism and long-term allograft survival without myelosuppressive conditioning in mice
Supplemental data
Association of iron overload with allogeneic hematopoietic cell transplantation outcomes: a prospective cohort study using R2-MRI–measured liver iron content
Bryan J. Trottier,Linda J. Burns,Todd E. DeFor,Sarah Cooley,Navneet S. Majhail
View Articletitled, Association of iron overload with allogeneic hematopoietic cell transplantation outcomes: a prospective cohort study using R2-MRI–measured liver iron content

ERRATA

Tiacci E, Schiavoni G, Forconi F, et al. Simple genetic diagnosis of hairy cell leukemia by sensitive detection of the BRAF-V600E mutation. Blood. 2012;119(1):192-195.
View Articletitled, Tiacci E, Schiavoni G, Forconi F, et al. Simple genetic diagnosis of hairy cell leukemia by sensitive detection of the <em>BRAF</em>-V600E mutation. <em>Blood</em>. 2012;119(1):<span class="related-article">192-195</span>.
  • Cover Image

    Cover Image

    issue cover

    To determine whether thrombocytopenia in C1galt1-deficient mice was derived from defects in the terminal differentiation of megakaryotocytes, we performed a proplatelet forming assay using primary megakaryocytes from bone marrow. This image shows β-tubulin expression in megakaryocytes forming proplatelets from C1galt1-deficient mice. C1galt1-deficient proplatelets were shorter and exhibited less branching and budding. See the article by Kudo et al on page 1649.

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