Luca Agnelli,on behalf of the European T-Cell Lymphoma Study Group,Elisabetta Mereu,on behalf of the European T-Cell Lymphoma Study Group,Elisa Pellegrino,on behalf of the European T-Cell Lymphoma Study Group,Tania Limongi,on behalf of the European T-Cell Lymphoma Study Group,Ivo Kwee,on behalf of the European T-Cell Lymphoma Study Group,Elisa Bergaggio,on behalf of the European T-Cell Lymphoma Study Group,Maurilio Ponzoni,on behalf of the European T-Cell Lymphoma Study Group,Alberto Zamò,on behalf of the European T-Cell Lymphoma Study Group,Javeed Iqbal,on behalf of the European T-Cell Lymphoma Study Group,Pier Paolo Piccaluga,on behalf of the European T-Cell Lymphoma Study Group,Antonino Neri,on behalf of the European T-Cell Lymphoma Study Group,Wing C. Chan,on behalf of the European T-Cell Lymphoma Study Group,Stefano Pileri,on behalf of the European T-Cell Lymphoma Study Group,Francesco Bertoni,on behalf of the European T-Cell Lymphoma Study Group,Giorgio Inghirami,on behalf of the European T-Cell Lymphoma Study Group,Roberto Piva,on behalf of the European T-Cell Lymphoma Study Group

View Articletitled, Identification of a 3-gene model as a powerful diagnostic tool for the recognition of ALK-negative anaplastic large-cell lymphoma

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Myeloid Neoplasia

Mutated regions of nucleophosmin 1 elicit both CD4⁺ and CD8⁺ T-cell responses in patients with acute myeloid leukemia

Jochen Greiner,Yoko Ono,Susanne Hofmann,Anita Schmitt,Elmar Mehring,Marlies Götz,Philippe Guillaume,Konstanze Döhner,Joannis Mytilineos,Hartmut Döhner,Michael Schmitt

View Articletitled, Mutated regions of nucleophosmin 1 elicit both CD4+ and CD8+ T-cell responses in patients with acute myeloid leukemia

Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS

Laura Barreyro,Britta Will,Boris Bartholdy,Li Zhou,Tihomira I. Todorova,Robert F. Stanley,Susana Ben-Neriah,Cristina Montagna,Samir Parekh,Andrea Pellagatti,Jacqueline Boultwood,Elisabeth Paietta,Rhett P. Ketterling,Larry Cripe,Hugo F. Fernandez,Peter L. Greenberg,Martin S. Tallman,Christian Steidl,Constantine S. Mitsiades,Amit Verma,Ulrich Steidl

View Articletitled, Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS

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Phagocytes, Granulocytes, and Myelopoiesis

Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery

Takayuki Tanaka,Kazutoshi Takahashi,Mayu Yamane,Shota Tomida,Saori Nakamura,Koichi Oshima,Akira Niwa,Ryuta Nishikomori,Naotomo Kambe,Hideki Hara,Masao Mitsuyama,Nobuhiro Morone,John E. Heuser,Takuya Yamamoto,Akira Watanabe,Aiko Sato-Otsubo,Seishi Ogawa,Isao Asaka,Toshio Heike,Shinya Yamanaka,Tatsutoshi Nakahata,Megumu K. Saito

View Articletitled, Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery

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Platelets and Thrombopoiesis

Polymorphisms of protein tyrosine phosphatase CD148 influence FcγRIIA-dependent platelet activation and the risk of heparin-induced thrombocytopenia

Jérôme Rollin,Claire Pouplard,Marie-Pierre Gratacap,Dorothée Leroux,Marc-Antoine May,Michel Aupart,Valérie Gouilleux-Gruart,Bernard Payrastre,Yves Gruel

View Articletitled, Polymorphisms of protein tyrosine phosphatase CD148 influence FcγRIIA-dependent platelet activation and the risk of heparin-induced thrombocytopenia

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Intracellular cyclophilin A is an important Ca²⁺ regulator in platelets and critically involved in arterial thrombus formation

Margitta Elvers,Annika Herrmann,Peter Seizer,Patrick Münzer,Sandra Beck,Tanja Schönberger,Oliver Borst,Francisco Javier Martin-Romero,Florian Lang,Andreas E. May,Meinrad Gawaz

View Articletitled, Intracellular cyclophilin A is an important Ca2+ regulator in platelets and critically involved in arterial thrombus formation

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Transplantation

Validation of the Hematopoietic Cell Transplantation-Specific Comorbidity Index: a prospective, multicenter GITMO study
Clinical Trials & Observations

Roberto Raimondi,Alberto Tosetto,Rosi Oneto,Riccardo Cavazzina,Francesco Rodeghiero,Andrea Bacigalupo,Renato Fanin,Alessandro Rambaldi,Alberto Bosi

View Articletitled, Validation of the Hematopoietic Cell Transplantation-Specific Comorbidity Index: a prospective, multicenter GITMO study

Vascular Biology

Platelets can enhance vascular permeability

Nathalie Cloutier,Alexandre Paré,Richard W. Farndale,H. Ralph Schumacher,Peter A. Nigrovic,Steve Lacroix,Eric Boilard

View Articletitled, Platelets can enhance vascular permeability

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Cover Image

Cover Image

The cover shows efflux of 0.45-μm red microspheres from the vascular circulation (labeled in green) toward collagen matrix (in blue) within an inflamed joint of a mouse. These observations document the presence of gaps between endothelial cells in the vasculature during inflammation, consistent with increased tissue edema and likely similar to human inflammatory conditions such as arthritis. Although platelets are conventionally assigned the role of preserving vascular integrity, they are capable of triggering the formation of gaps during inflammation via serotonin release, a process inhibited by serotonin-specific reuptake inhibitor antidepressant drugs. This demonstration that platelets are capable of amplifying and maintaining vascular permeability adds to the rapidly growing list of unexpected functions for platelets. See the article by Cloutier et al on page 1334.
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Inside Blood

Blood Work

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Perspectives

Review Article

How I Treat

Clinical Trials and Observations

A prognostic model to predict survival in 867 World Health Organization–defined essential thrombocythemia at diagnosis: a study by the International Working Group on Myelofibrosis Research and Treatment Clinical Trials & Observations

Long-term outcomes of 107 patients with myelofibrosis receiving JAK1/JAK2 inhibitor ruxolitinib: survival advantage in comparison to matched historical controls Clinical Trials & Observations

Hematopoiesis and Stem Cells

Development of a vascular niche platform for expansion of repopulating human cord blood stem and progenitor cells Brief Report

Immunobiology

Lymphoid Neoplasia

Myeloid Neoplasia

Phagocytes, Granulocytes, and Myelopoiesis

Platelets and Thrombopoiesis

Transplantation

Validation of the Hematopoietic Cell Transplantation-Specific Comorbidity Index: a prospective, multicenter GITMO study Clinical Trials & Observations

Vascular Biology

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A prognostic model to predict survival in 867 World Health Organization–defined essential thrombocythemia at diagnosis: a study by the International Working Group on Myelofibrosis Research and Treatment
Clinical Trials & Observations

Long-term outcomes of 107 patients with myelofibrosis receiving JAK1/JAK2 inhibitor ruxolitinib: survival advantage in comparison to matched historical controls
Clinical Trials & Observations

Development of a vascular niche platform for expansion of repopulating human cord blood stem and progenitor cells
Brief Report

Validation of the Hematopoietic Cell Transplantation-Specific Comorbidity Index: a prospective, multicenter GITMO study
Clinical Trials & Observations