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Issue Archive

Volume 120, Issue 1
July 5 2012
Issue Cover

Table of Contents

Inside Blood

IMMUNOBIOLOGY
Soluble IL-15/IL-15Rα complexes in human serum
David J. Cole,Mark P. Rubinstein
View Articletitled, Soluble IL-15/IL-15Rα complexes in human serum
CLINICAL TRIALS
Consolidation therapy in myeloma: a consolidated approach?
Jesús F. San-Miguel
View Articletitled, Consolidation therapy in myeloma: a consolidated approach?
PLATELETS & THROMBOPOIESIS
The computing platelet: integrating environmental cues
Sriram Neelamegham
View Articletitled, The computing platelet: integrating environmental cues
THROMBOSIS & HEMOSTASIS
Coagulopathy in APL: a step forward?
Giuseppe Avvisati
View Articletitled, Coagulopathy in APL: a step forward?
TRANSPLANTATION
Bacterial sepsis and GI tract GVHD: more commensal than you think
Jonathan Serody
View Articletitled, Bacterial sepsis and GI tract GVHD: more commensal than you think

Blood Work

Bone marrow oxalosis
Nasir A. Bakshi,Hazzaa Al-Zahrani
View Articletitled, Bone marrow oxalosis

Plenary Paper

PLENARY PAPER
Bortezomib-thalidomide-dexamethasone is superior to thalidomide-dexamethasone as consolidation therapy after autologous hematopoietic stem cell transplantation in patients with newly diagnosed multiple myeloma
Clinical Trials & Observations
Michele Cavo,Lucia Pantani,Maria Teresa Petrucci,Francesca Patriarca,Elena Zamagni,Daniela Donnarumma,Claudia Crippa,Mario Boccadoro,Giulia Perrone,Antonietta Falcone,Chiara Nozzoli,Renato Zambello,Luciano Masini,Anna Furlan,Annamaria Brioli,Daniele Derudas,Stelvio Ballanti,Maria Laura Dessanti,Valerio De Stefano,Angelo Michele Carella,Magda Marcatti,Andrea Nozza,Felicetto Ferrara,Vincenzo Callea,Catello Califano,Annalisa Pezzi,Anna Baraldi,Mariella Grasso,Pellegrino Musto,Antonio Palumbo,for the GIMEMA (Gruppo Italiano Malattie Ematologiche dell'Adulto) Italian Myeloma Network
View Articletitled, Bortezomib-thalidomide-dexamethasone is superior to thalidomide-dexamethasone as consolidation therapy after autologous hematopoietic stem cell transplantation in patients with newly diagnosed multiple myeloma
Supplemental data

Perspectives

Myeloma as a model for the process of metastasis: implications for therapy
Irene M. Ghobrial
View Articletitled, Myeloma as a model for the process of metastasis: implications for therapy

Review Article

The COPII pathway and hematologic disease
Rami Khoriaty,Matthew P. Vasievich,David Ginsburg
View Articletitled, The COPII pathway and hematologic disease

Hematopoiesis and Stem Cells

Emergence of NK-cell progenitors and functionally competent NK-cell lineage subsets in the early mouse embryo
Yanjuan Tang,Claudia Peitzsch,Hojjatollah Nozad Charoudeh,Min Cheng,Patricia Chaves,Sten Eirik W. Jacobsen,Ewa Sitnicka
View Articletitled, Emergence of NK-cell progenitors and functionally competent NK-cell lineage subsets in the early mouse embryo
Supplemental data
On the role of FAN1 in Fanconi anemia
Brief Report
Juan P. Trujillo,Leonardo B. Mina,Roser Pujol,Massimo Bogliolo,Joris Andrieux,Muriel Holder,Beatrice Schuster,Detlev Schindler,Jordi Surrallés
View Articletitled, On the role of FAN1 in Fanconi anemia
Supplemental data

Immunobiology

Pivotal role of plasmacytoid dendritic cells in inflammation and NK-cell responses after TLR9 triggering in mice
Camille Guillerey,Juliette Mouriès,Giulia Polo,Noelle Doyen,Helen K. W. Law,Susan Chan,Philippe Kastner,Claude Leclerc,Gilles Dadaglio
View Articletitled, Pivotal role of plasmacytoid dendritic cells in inflammation and NK-cell responses after TLR9 triggering in mice
Supplemental data
Epitope targeting and viral inoculum are determinants of Nef-mediated immune evasion of HIV-1 from cytotoxic T lymphocytes
Diana Y. Chen,Arumugam Balamurugan,Hwee L. Ng,William G. Cumberland,Otto O. Yang
View Articletitled, Epitope targeting and viral inoculum are determinants of Nef-mediated immune evasion of HIV-1 from cytotoxic T lymphocytes
IgG opsonization of bacteria promotes Th17 responses via synergy between TLRs and FcγRIIa in human dendritic cells
Jeroen den Dunnen,Lisa T. C. Vogelpoel,Tomasz Wypych,Femke J. M. Muller,Leonie de Boer,Taco W. Kuijpers,Sebastiaan A. J. Zaat,Martien L. Kapsenberg,Esther C. de Jong
View Articletitled, IgG opsonization of bacteria promotes Th17 responses via synergy between TLRs and FcγRIIa in human dendritic cells
Supplemental data
SAP expression in invariant NKT cells is required for cognate help to support B-cell responses
Cynthia Detre,Marton Keszei,Natividad Garrido-Mesa,Katalin Kis-Toth,Wilson Castro,Amma F. Agyemang,Natacha Veerapen,Gurdyal S. Besra,Michael C. Carroll,George C. Tsokos,Ninghai Wang,Elizabeth A. Leadbetter,Cox Terhorst
View Articletitled, SAP expression in invariant NKT cells is required for cognate help to support B-cell responses
Supplemental data
Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function
Molly F. Thomas,Sarah Abdul-Wajid,Marisella Panduro,Joshua E. Babiarz,Misha Rajaram,Prescott Woodruff,Lewis L. Lanier,Vigo Heissmeyer,K. Mark Ansel
View Articletitled, Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function
Supplemental data
Circulating IL-15 exists as heterodimeric complex with soluble IL-15Rα in human and mouse serum
e-blood
Cristina Bergamaschi,Jenifer Bear,Margherita Rosati,Rachel Kelly Beach,Candido Alicea,Raymond Sowder,Elena Chertova,Steven A. Rosenberg,Barbara K. Felber,George N. Pavlakis
View Articletitled, Circulating IL-15 exists as heterodimeric complex with soluble IL-15Rα in human and mouse serum

Lymphoid Neoplasia

Inducible expression and pathophysiologic functions of T-plastin in cutaneous T-cell lymphoma
Elodie Bégué,Francette Jean-Louis,Martine Bagot,Sébastien Jauliac,Jean-Michel Cayuela,Liliane Laroche,Nathalie Parquet,Hervé Bachelez,Armand Bensussan,Gilles Courtois,Laurence Michel
View Articletitled, Inducible expression and pathophysiologic functions of T-plastin in cutaneous T-cell lymphoma
Supplemental data

Myeloid Neoplasia

Sox4 cooperates with CREB in myeloid transformation
Salemiz Sandoval,Christina Kraus,Er-Chieh Cho,Michelle Cho,Juraj Bies,Elena Manara,Benedetta Accordi,Elliot M. Landaw,Linda Wolff,Martina Pigazzi,Kathleen M. Sakamoto
View Articletitled, Sox4 cooperates with CREB in myeloid transformation
Supplemental data
Distinct roles for long-term hematopoietic stem cells and erythroid precursor cells in a murine model of Jak2V617F-mediated polycythemia vera
Ann Mullally,Luke Poveromo,Rebekka K. Schneider,Fatima Al-Shahrour,Steven W. Lane,Benjamin L. Ebert
View Articletitled, Distinct roles for long-term hematopoietic stem cells and erythroid precursor cells in a murine model of Jak2V617F-mediated polycythemia vera
Supplemental data
Survivin is highly expressed in CD34+38− leukemic stem/progenitor cells and predicts poor clinical outcomes in AML
Bing Z. Carter,Yihua Qiu,Xuelin Huang,Lixia Diao,Nianxiang Zhang,Kevin R. Coombes,Duncan H. Mak,Marina Konopleva,Jorge Cortes,Hagop M. Kantarjian,Gordon B. Mills,Michael Andreeff,Steven M. Kornblau
View Articletitled, Survivin is highly expressed in CD34<sup>+</sup>38<sup>−</sup> leukemic stem/progenitor cells and predicts poor clinical outcomes in AML
Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

Critical role of P1-Runx1 in mouse basophil development
Kaori Mukai,Maya J. BenBarak,Masashi Tachibana,Keigo Nishida,Hajime Karasuyama,Ichiro Taniuchi,Stephen J. Galli
View Articletitled, Critical role of P1-Runx1 in mouse basophil development
Supplemental data
WHIM syndrome caused by a single amino acid substitution in the carboxy-tail of chemokine receptor CXCR4
Qian Liu,Haoqian Chen,Teresa Ojode,Xiangxi Gao,Sandra Anaya-O'Brien,Nicholas A. Turner,Jean Ulrick,Rosamma DeCastro,Corin Kelly,Adela R. Cardones,Stuart H. Gold,Eugene I. Hwang,Daniel S. Wechsler,Harry L. Malech,Philip M. Murphy,David H. McDermott
View Articletitled, WHIM syndrome caused by a single amino acid substitution in the carboxy-tail of chemokine receptor CXCR4
Supplemental data

Platelets and Thrombopoiesis

Multiscale prediction of patient-specific platelet function under flow
Matthew H. Flamm,Thomas V. Colace,Manash S. Chatterjee,Huiyan Jing,Songtao Zhou,Daniel Jaeger,Lawrence F. Brass,Talid Sinno,Scott L. Diamond
View Articletitled, Multiscale prediction of patient-specific platelet function under flow
Supplemental data
Granule exocytosis is required for platelet spreading: differential sorting of α-granules expressing VAMP-7
Christian G. Peters,Alan D. Michelson,Robert Flaumenhaft
View Articletitled, Granule exocytosis is required for platelet spreading: differential sorting of α-granules expressing VAMP-7
Supplemental data

Thrombosis and Hemostasis

Management of bleeding in acquired hemophilia A: results from the European Acquired Haemophilia (EACH2) Registry
Clinical Trials & Observations
Francesco Baudo,Peter Collins,Angela Huth-Kühne,Hervé Lévesque,Pascual Marco,László Nemes,Fabio Pellegrini,Lilian Tengborn,Paul Knoebl,on behalf of the EACH2 registry contributors
View Articletitled, Management of bleeding in acquired hemophilia A: results from the European Acquired Haemophilia (EACH2) Registry
Supplemental data
Immunosuppression for acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2)
Clinical Trials & Observations
Peter Collins,Francesco Baudo,Paul Knoebl,Hervé Lévesque,László Nemes,Fabio Pellegrini,Pascual Marco,Lilian Tengborn,Angela Huth-Kühne,on behalf of the EACH2 registry collaborators
View Articletitled, Immunosuppression for acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2)
Supplemental data
Methionine-induced hyperhomocysteinemia reverts fibrinolytic pathway activation in a murine model of acute promyelocytic leukemia
Rafael H. Jácomo,Barbara A. Santana-Lemos,Ana Silvia G. Lima,Patricia A. Assis,Ana Paula A. Lange,Lorena L. Figueiredo-Pontes,Luciana O. Oliveira,Sarah C. Bassi,Mariana T. L. Benício,Márcia S. Baggio,Aglair B. Garcia,Roberto P. Falcão,Eduardo M. Rego
View Articletitled, Methionine-induced hyperhomocysteinemia reverts fibrinolytic pathway activation in a murine model of acute promyelocytic leukemia
O-linked glycosylation of von Willebrand factor modulates the interaction with platelet receptor glycoprotein Ib under static and shear stress conditions
Agata A. Nowak,Kevin Canis,Anne Riddell,Michael A. Laffan,Thomas A. J. McKinnon
View Articletitled, <em>O</em>-linked glycosylation of von Willebrand factor modulates the interaction with platelet receptor glycoprotein Ib under static and shear stress conditions
Supplemental data

Transplantation

Long-term outcomes after autologous stem cell transplantation for patients with POEMS syndrome (osteosclerotic myeloma): a single-center experience
Clinical Trials & Observations
Anita D'Souza,Martha Lacy,Morie Gertz,Shaji Kumar,Francis Buadi,Suzanne Hayman,David Dingli,Steven Zeldenrust,Robert Kyle,Stephen Ansell,David Inwards,Patrick Johnston,Ivana Micallef,Luis Porrata,Mark Litzow,Dennis Gastineau,William Hogan,Angela Dispenzieri
View Articletitled, Long-term outcomes after autologous stem cell transplantation for patients with POEMS syndrome (osteosclerotic myeloma): a single-center experience
Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of α-defensins
Yoshihiro Eriguchi,Shuichiro Takashima,Hideyo Oka,Sonoko Shimoji,Kiminori Nakamura,Hidetaka Uryu,Shinji Shimoda,Hiromi Iwasaki,Nobuyuki Shimono,Tokiyoshi Ayabe,Koichi Akashi,Takanori Teshima
View Articletitled, Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of α-defensins

Vascular Biology

PV-1 is recognized by the PAL-E antibody and forms complexes with NRP-1
Brief Report
Johannes Keuschnigg,Denis Tvorogov,Kati Elima,Marko Salmi,Kari Alitalo,Tiina Salminen,Sirpa Jalkanen
View Articletitled, PV-1 is recognized by the PAL-E antibody and forms complexes with NRP-1
Supplemental data
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