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Issue Archive

Volume 119, Issue 25
June 21 2012
Issue Cover

Table of Contents

Inside Blood

CLINICAL TRIALS
Baby, it's cold outside!
Morie A. Gertz
View Articletitled, Baby, it's cold outside!
CLINICAL TRIALS
Are all mutant SNARES equal?
Kenneth L. McClain
View Articletitled, Are all mutant SNARES equal?
IMMUNOBIOLOGY
Boosting antibody therapy with complement
Peter Boross,Jeanette H. W. Leusen
View Articletitled, Boosting antibody therapy with complement
MYELOID NEOPLASIA
BH3 mimetics and multi-kinase inhibition in AML
Elspeth M. Beauchamp,Leonidas C. Platanias
View Articletitled, BH3 mimetics and multi-kinase inhibition in AML
RED CELLS & IRON
Losing a “nucleus” to gain a cytoplasm
James Palis
View Articletitled, Losing a “nucleus” to gain a cytoplasm
THROMBOSIS & HEMOSTASIS
The platelet “sugar high” in diabetes
Heyu Ni
View Articletitled, The platelet “sugar high” in diabetes
VASCULAR BIOLOGY
“Inactivating” PF4: a new approach to HIT treatment?
Richard H. Aster
View Articletitled, “Inactivating” PF4: a new approach to HIT treatment?

Blood Work

CNS hyperleukocytosis
Javier Munoz,Vijayalakshmi Donthireddy
View Articletitled, CNS hyperleukocytosis

Plenary Paper

VASCULAR BIOLOGY
Rational design and characterization of platelet factor 4 antagonists for the study of heparin-induced thrombocytopenia
Bruce S. Sachais,Ann H. Rux,Douglas B. Cines,Serge V. Yarovoi,Lee I. Garner,Stephen P. Watson,Jillian L. Hinds,John J. Rux
View Articletitled, Rational design and characterization of platelet factor 4 antagonists for the study of heparin-induced thrombocytopenia

Perspectives

Definitions, methodological and statistical issues for phase 3 clinical trials in chronic myeloid leukemia: a proposal by the European LeukemiaNet
Joëlle Guilhot,Michele Baccarani,Richard E. Clark,Francisco Cervantes,François Guilhot,Andreas Hochhaus,Sergei Kulikov,Jiri Mayer,Andreas L. Petzer,Gianantonio Rosti,Philippe Rousselot,Giuseppe Saglio,Susanne Saussele,Bengt Simonsson,Juan-Luis Steegmann,Andrey Zaritskey,Rüdiger Hehlmann
View Articletitled, Definitions, methodological and statistical issues for phase 3 clinical trials in chronic myeloid leukemia: a proposal by the European LeukemiaNet

Review Article

Polyphosphate: an ancient molecule that links platelets, coagulation, and inflammation
James H. Morrissey,Sharon H. Choi,Stephanie A. Smith
View Articletitled, Polyphosphate: an ancient molecule that links platelets, coagulation, and inflammation

How I treat

How I treat pediatric acute myeloid leukemia
Jeffrey E. Rubnitz
View Articletitled, How I treat pediatric acute myeloid leukemia

Clinical Trials and Observations

Outcomes 5 years after response to rituximab therapy in children and adults with immune thrombocytopenia
Clinical Trials & Observations
Vivek L. Patel,Matthieu Mahévas,Soo Y. Lee,Roberto Stasi,Susanna Cunningham-Rundles,Bertrand Godeau,Julie Kanter,Ellis Neufeld,Tillmann Taube,Ugo Ramenghi,Shalini Shenoy,Mary J. Ward,Nino Mihatov,Vinay L. Patel,Philippe Bierling,Martin Lesser,Nichola Cooper,James B. Bussel
View Articletitled, Outcomes 5 years after response to rituximab therapy in children and adults with immune thrombocytopenia
Management of noninfectious mixed cryoglobulinemia vasculitis: data from 242 cases included in the CryoVas survey
Clinical Trials & Observations
Benjamin Terrier,Evguenia Krastinova,Isabelle Marie,David Launay,Adeline Lacraz,Pauline Belenotti,Luc de Saint-Martin,Thomas Quemeneur,Antoine Huart,Fabrice Bonnet,Guillaume Le Guenno,Jean-Emmanuel Kahn,Olivier Hinschberger,Patricia Rullier,Elisabeth Diot,Estibaliz Lazaro,Frank Bridoux,Thierry Zénone,Fabrice Carrat,Olivier Hermine,Jean-Marc Léger,Xavier Mariette,Patricia Senet,Emmanuelle Plaisier,Patrice Cacoub
View Articletitled, Management of noninfectious mixed cryoglobulinemia vasculitis: data from 242 cases included in the CryoVas survey
Supplemental data

Hematopoiesis and Stem Cells

Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice
Eleonora Ottina,Francesca Grespi,Denise Tischner,Claudia Soratroi,Stephan Geley,Andreas Ploner,Holger M. Reichardt,Andreas Villunger,Marco J. Herold
View Articletitled, Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice
Supplemental data

Immunobiology

A targeted complement-dependent strategy to improve the outcome of mAb therapy, and characterization in a murine model of metastatic cancer
Michelle Elvington,Yuxiang Huang,B. Paul Morgan,Fei Qiao,Nico van Rooijen,Carl Atkinson,Stephen Tomlinson
View Articletitled, A targeted complement-dependent strategy to improve the outcome of mAb therapy, and characterization in a murine model of metastatic cancer
Supplemental data
DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues
Lionel F. Poulin,Yasmin Reyal,Heli Uronen-Hansson,Barbara U. Schraml,David Sancho,Kenneth M. Murphy,Ulf K. Håkansson,Luis Ferreira Moita,William W. Agace,Dominique Bonnet,Caetano Reis e Sousa
View Articletitled, DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues
Supplemental data
Tissue-specific differentiation of a circulating CCR9− pDC-like common dendritic cell precursor
Andreas Schlitzer,Alexander F. Heiseke,Henrik Einwächter,Wolfgang Reindl,Matthias Schiemann,Calin-Petru Manta,Peter See,Jan-Hendrik Niess,Tobias Suter,Florent Ginhoux,Anne B. Krug
View Articletitled, Tissue-specific differentiation of a circulating CCR9<sup>−</sup> pDC-like common dendritic cell precursor
Supplemental data

Lymphoid Neoplasia

Evaluation of treatment outcome in 175 patients with Hodgkin lymphoma aged 60 years or over: the SHIELD study
Clinical Trials & Observations
Stephen J. Proctor,Jennifer Wilkinson,Gail Jones,Gillian C. Watson,Helen H. Lucraft,Tryfonia Mainou-Fowler,Dominic Culligan,Michael J. Galloway,Katrina M. Wood,Richard J. Q. McNally,Peter W. James,John R. Goodlad
View Articletitled, Evaluation of treatment outcome in 175 patients with Hodgkin lymphoma aged 60 years or over: the SHIELD study
Supplemental data
Expression of COX-2 on Reed-Sternberg cells is an independent unfavorable prognostic factor in Hodgkin lymphoma treated with ABVD
Francisco Mestre,Antonio Gutierrez,Rafael Ramos,Jordi Martinez-Serra,Lydia Sánchez,Gabriel Matheu,Teresa Ros,Juan Fernando Garcia,Jose Rodriguez
View Articletitled, Expression of COX-2 on Reed-Sternberg cells is an independent unfavorable prognostic factor in Hodgkin lymphoma treated with ABVD
Supplemental data
Inhibition of the mTORC2 and chaperone pathways to treat leukemia
Fan Zhang,Adam S. Lazorchak,Dou Liu,Fangping Chen,Bing Su
View Articletitled, Inhibition of the mTORC2 and chaperone pathways to treat leukemia

Myeloid Neoplasia

Clinical and pharmacodynamic activity of bortezomib and decitabine in acute myeloid leukemia
Clinical Trials & Observations
William Blum,Sebastian Schwind,Somayeh S. Tarighat,Susan Geyer,Ann-Kathrin Eisfeld,Susan Whitman,Alison Walker,Rebecca Klisovic,John C. Byrd,Ramasamy Santhanam,Hongyan Wang,John P. Curfman,Steven M. Devine,Samson Jacob,Celia Garr,Cheryl Kefauver,Danilo Perrotti,Kenneth K. Chan,Clara D. Bloomfield,Michael A. Caligiuri,Michael R. Grever,Ramiro Garzon,Guido Marcucci
View Articletitled, Clinical and pharmacodynamic activity of bortezomib and decitabine in acute myeloid leukemia
Supplemental data
Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process
Mohamed Rahmani,Mandy Mayo Aust,Elisa Attkisson,David C. Williams, Jr,Andrea Ferreira-Gonzalez,Steven Grant
View Articletitled, Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process
Supplemental data
Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10
Kevin Oakley,Yufen Han,Bandana A. Vishwakarma,Su Chu,Ravi Bhatia,Kristbjorn O. Gudmundsson,Jonathan Keller,Xiongfong Chen,Vasyl Vasko,Nancy A. Jenkins,Neal G. Copeland,Yang Du
View Articletitled, <em>Setbp1</em> promotes the self-renewal of murine myeloid progenitors via activation of <em>Hoxa9</em> and <em>Hoxa10</em>
Supplemental data
Loss of heterozygosity in 7q myeloid disorders: clinical associations and genomic pathogenesis
Andres Jerez,Yuka Sugimoto,Hideki Makishima,Amit Verma,Anna M. Jankowska,Bartlomiej Przychodzen,Valeria Visconte,Ramon V. Tiu,Christine L. O'Keefe,Azim M. Mohamedali,Austin G. Kulasekararaj,Andrea Pellagatti,Kathy McGraw,Hideki Muramatsu,Alison R. Moliterno,Mikkael A. Sekeres,Michael A. McDevitt,Seiji Kojima,Alan List,Jacqueline Boultwood,Ghulam J. Mufti,Jaroslaw P. Maciejewski
View Articletitled, Loss of heterozygosity in 7q myeloid disorders: clinical associations and genomic pathogenesis
Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

Distinct mutations in STXBP2 are associated with variable clinical presentations in patients with familial hemophagocytic lymphohistiocytosis type 5 (FHL5)
Clinical Trials & Observations
Julia Pagel,Karin Beutel,Kai Lehmberg,Florian Koch,Andrea Maul-Pavicic,Anna-Katharina Rohlfs,Abdullah Al-Jefri,Rita Beier,Lilian Bomme Ousager,Karoline Ehlert,Ute Gross-Wieltsch,Norbert Jorch,Bernhard Kremens,Arnulf Pekrun,Monika Sparber-Sauer,Ester Mejstrikova,Angela Wawer,Stephan Ehl,Udo zur Stadt,Gritta Janka
View Articletitled, Distinct mutations in <em>STXBP2</em> are associated with variable clinical presentations in patients with familial hemophagocytic lymphohistiocytosis type 5 (FHL5)
Supplemental data

Red Cells, Iron, and Erythropoiesis

Signaling and cytoskeletal requirements in erythroblast enucleation
Diamantis G. Konstantinidis,Suvarnamala Pushkaran,James F. Johnson,Jose A. Cancelas,Stefanos Manganaris,Chad E. Harris,David A. Williams,Yi Zheng,Theodosia A. Kalfa
View Articletitled, Signaling and cytoskeletal requirements in erythroblast enucleation

Thrombosis and Hemostasis

A new mouse model mimicking thrombotic thrombocytopenic purpura: correction of symptoms by recombinant human ADAMTS13
Alexandra Schiviz,Kuno Wuersch,Christina Piskernik,Barbara Dietrich,Werner Hoellriegl,Hanspeter Rottensteiner,Friedrich Scheiflinger,Hans Peter Schwarz,Eva-Maria Muchitsch
View Articletitled, A new mouse model mimicking thrombotic thrombocytopenic purpura: correction of symptoms by recombinant human ADAMTS13
Supplemental data
Advanced glycation end products induce a prothrombotic phenotype in mice via interaction with platelet CD36
Weifei Zhu,Wei Li,Roy L. Silverstein
View Articletitled, Advanced glycation end products induce a prothrombotic phenotype in mice via interaction with platelet CD36
Supplemental data

Transplantation

Prophylactic rituximab after allogeneic transplantation decreases B-cell alloimmunity with low chronic GVHD incidence
Clinical Trials & Observations
Sally Arai,Bita Sahaf,Balasubramanian Narasimhan,George L. Chen,Carol D. Jones,Robert Lowsky,Judith A. Shizuru,Laura J. Johnston,Ginna G. Laport,Wen-Kai Weng,Jonathan E. Benjamin,Joanna Schaenman,Janice Brown,Jessica Ramirez,James L. Zehnder,Robert S. Negrin,David B. Miklos
View Articletitled, Prophylactic rituximab after allogeneic transplantation decreases B-cell alloimmunity with low chronic GVHD incidence
Supplemental data
Impact of immune modulation with in vivo T-cell depletion and myleoablative total body irradiation conditioning on outcomes after unrelated donor transplantation for childhood acute lymphoblastic leukemia
Clinical Trials & Observations
Paul Veys,Robert F. Wynn,Kwang Woo Ahn,Sujith Samarasinghe,Wensheng He,Denise Bonney,John Craddock,Jacqueline Cornish,Stella M. Davies,Christopher C. Dvorak,Reggie E. Duerst,Thomas G. Gross,Neena Kapoor,Carrie Kitko,Robert A. Krance,Wing Leung,Victor A. Lewis,Colin Steward,John E. Wagner,Paul A. Carpenter,Mary Eapen
View Articletitled, Impact of immune modulation with in vivo T-cell depletion and myleoablative total body irradiation conditioning on outcomes after unrelated donor transplantation for childhood acute lymphoblastic leukemia

Vascular Biology

BMP9 and BMP10 are critical for postnatal retinal vascular remodeling
Nicolas Ricard,Delphine Ciais,Sandrine Levet,Mariela Subileau,Christine Mallet,Teresa A. Zimmers,Se-Jin Lee,Marie Bidart,Jean-Jacques Feige,Sabine Bailly
View Articletitled, BMP9 and BMP10 are critical for postnatal retinal vascular remodeling
Supplemental data

Correspondence

Long-term outcome of higher-risk MDS patients treated with azacitidine: an update of the GFM compassionate program cohort
Raphael Itzykson,Sylvain Thépot,Bruno Quesnel,Francois Dreyfus,Christian Recher,Eric Wattel,Claude Gardin,Lionel Adès,Pierre Fenaux
View Articletitled, Long-term outcome of higher-risk MDS patients treated with azacitidine: an update of the GFM compassionate program cohort
Development of myeloproliferative disease in 12/15-lipoxygenase deficiency
Philip R. Taylor,Dagmar Heydeck,Gareth W. Jones,Gerhard Krönke,Colin D. Funk,Steven Knapper,Deborah Adams,Hartmut Kühn,Valerie B. O'Donnell
View Articletitled, Development of myeloproliferative disease in 12/15-lipoxygenase deficiency
Supplemental data
Response: hematopoietic defects in 12/15-lipoxygenase–deficient mice
Ellen Puré,Michelle Kinder
View Articletitled, Response: hematopoietic defects in 12/15-lipoxygenase–deficient mice
Dasatinib enhances the expansion of CD56+CD3− NK cells from cord blood
Junji Tanaka,Junichi Sugita,Souichi Shiratori,Akio Shigematsu,Masahiro Imamura
View Articletitled, Dasatinib enhances the expansion of CD56<sup>+</sup>CD3<sup>−</sup> NK cells from cord blood
All Issues

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