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Pomalidomide plus low-dose dexamethasone in myeloma refractory to both bortezomib and lenalidomide: comparison of 2 dosing strategies in dual-refractory disease
Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group
Prospective evaluation of a pharmacogenetics-guided warfarin loading and maintenance dose regimen for initiation of therapy
Acceptable HLA-mismatching in unrelated donor bone marrow transplantation for patients with acquired severe aplastic anemia
Issue Archive
September 15 2011
In this Issue
Table of Contents
Inside Blood
Blood Work
Plenary Paper
Perspectives
Review Article
Clinical Trials and Observations
Pomalidomide plus low-dose dexamethasone in myeloma refractory to both bortezomib and lenalidomide: comparison of 2 dosing strategies in dual-refractory disease
Clinical Trials & Observations
Martha Q. Lacy,Jacob B. Allred,Morie A. Gertz,Suzanne R. Hayman,Kristen Detweiler Short,Francis Buadi,Angela Dispenzieri,Shaji Kumar,Philip R. Greipp,John A. Lust,Stephen J. Russell,David Dingli,Steven Zeldenrust,Rafael Fonseca,P. Leif Bergsagel,Vivek Roy,A. Keith Stewart,Kristina Laumann,Sumithra J. Mandrekar,Craig Reeder,S. Vincent Rajkumar,Joseph R. Mikhael
Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group
Clinical Trials & Observations
Jinghui Zhang,Charles G. Mullighan,Richard C. Harvey,Gang Wu,Xiang Chen,Michael Edmonson,Kenneth H. Buetow,William L. Carroll,I-Ming Chen,Meenakshi Devidas,Daniela S. Gerhard,Mignon L. Loh,Gregory H. Reaman,Mary V. Relling,Bruce M. Camitta,W. Paul Bowman,Malcolm A. Smith,Cheryl L. Willman,James R. Downing,Stephen P. Hunger
Immunobiology
Monoclonal antibody blockade of IL-2 receptor α during lymphopenia selectively depletes regulatory T cells in mice and humans
Duane A. Mitchell,Xiuyu Cui,Robert J. Schmittling,Luis Sanchez-Perez,David J. Snyder,Kendra L. Congdon,Gary E. Archer,Annick Desjardins,Allan H. Friedman,Henry S. Friedman,James E. Herndon, II,Roger E. McLendon,David A. Reardon,James J. Vredenburgh,Darell D. Bigner,John H. Sampson
Lymphoid Neoplasia
Is there a role for antigen selection in mantle cell lymphoma? Immunogenetic support from a series of 807 cases
Anastasia Hadzidimitriou,Andreas Agathangelidis,Nikos Darzentas,Fiona Murray,Marie-Helene Delfau-Larue,Lone Bredo Pedersen,Alba Navarro Lopez,Antonis Dagklis,Paul Rombout,Kheira Beldjord,Arne Kolstad,Martin H. Dreyling,Achilles Anagnostopoulos,Athanasios Tsaftaris,Penelope Mavragani-Tsipidou,Andreas Rosenwald,Maurilio Ponzoni,Patricia Groenen,Paolo Ghia,Birgitta Sander,Theodora Papadaki,Elias Campo,Christian Geisler,Richard Rosenquist,Frederic Davi,Christiane Pott,Kostas Stamatopoulos
Myeloid Neoplasia
Targeting levels or oligomerization of nucleophosmin 1 induces differentiation and loss of survival of human AML cells with mutant NPM1
Ramesh Balusu,Warren Fiskus,Rekha Rao,Daniel G. Chong,Srilatha Nalluri,Uma Mudunuru,Hongwei Ma,Lei Chen,Sreedhar Venkannagari,Kyungsoo Ha,Sunil Abhyankar,Casey Williams,Joseph McGuirk,Hanna Jean Khoury,Celalettin Ustun,Kapil N. Bhalla
Phagocytes, Granulocytes, and Myelopoiesis
Platelets and Thrombopoiesis
Red Cells, Iron, and Erythropoiesis
Mutations in the second zinc finger of human EKLF reduce promoter affinity but give rise to benign and disease phenotypes
Belinda K. Singleton,Winnie Lau,Victoria S. S. Fairweather,Nicholas M. Burton,Marieangela C. Wilson,Steve F. Parsons,Ben M. Richardson,Kongtana Trakarnsanga,R. Leo Brady,David J. Anstee,Jan Frayne
Thrombosis and Hemostasis
Prospective evaluation of a pharmacogenetics-guided warfarin loading and maintenance dose regimen for initiation of therapy
Clinical Trials & Observations
Inna Y. Gong,Rommel G. Tirona,Ute I. Schwarz,Natalie Crown,George K. Dresser,Samantha LaRue,Nicole Langlois,Alejandro Lazo-Langner,Guangyong Zou,Dan M. Roden,C. Michael Stein,Marc Rodger,Marc Carrier,Melissa Forgie,Philip S. Wells,Richard B. Kim
Transplantation
Acceptable HLA-mismatching in unrelated donor bone marrow transplantation for patients with acquired severe aplastic anemia
Clinical Trials & Observations
Hiroshi Yagasaki,Seiji Kojima,Hiromasa Yabe,Koji Kato,Hisato Kigasawa,Hisashi Sakamaki,Masahiro Tsuchida,Shunichi Kato,Takakazu Kawase,Yasuo Morishima,Yoshihisa Kodera,for The Japan Marrow Donor Program
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Cover Image
Cover Image
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Human platelet spread on a fibrinogen surface and stained for S6K1 (green), Rac1 (blue), and actin (red). Immunofluorescence confocal microscopy reveals that S6K1 colocalizes with Rac1 and actin at the lamellipodial edge of spreading platelets. mTOR and its downstream effector S6K1 have long been known to orchestrate key cellular signaling systems. In this issue, Aslan et al show that platelet activation triggers S6K1 phosphorylation through mTOR in a signaling step before Rac1-mediated lamellipodial formation and demonstrate that mTOR and S6K1 have functional roles in platelet spreading, aggregation, and aggregate stability. See the article by Aslan et al on page 3129.
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