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Journal Articles

Pozelimab, a Human Monoclonal Antibody Against Complement Factor C5, Provided Inhibition of Intravascular Hemolysis in Patients with Paroxysmal Nocturnal Hemoglobinuria

Jun-Ho Jang, Jonathan Weyne, Umesh Chaudhari, Olivier Harari, Jutta Miller, Bradley Dain, Karoline A Meagher, Merideth L Rodgers, Lorah Perlee, Lori Morton, David M Weinreich, George D. Yancopoulos, Morag Griffin

Blood (2021) 138 (Supplement 1): 1128.

https://doi.org/10.1182/blood-2021-146178

Published: 2021

Journal Articles

Interim Analysis of an Open-Label, Ascending-Dose, Phase 1 Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Doses of the Subcutaneously Administered Human Monoclonal Antibody Pozelimab in Combination with Single Doses of the Subcutaneously Administered siRNA Cemdisiran in Healthy Volunteers

Tavé van Zyl, Jonathan Weyne, Umesh Chaudhari, Olivier Harari, Oren Levy, Jutta Miller, Yiziying Chen, Karoline A Meagher, Merideth L Rodgers, Lorah Perlee, Lori Morton, David M Weinreich, George D. Yancopoulos

Blood (2021) 138 (Supplement 1): 1998.

https://doi.org/10.1182/blood-2021-146205

Published: 2021

Journal Articles

Baseline Biomarkers of T-Cell Function Correlate with Clinical Responses to Odronextamab (REGN1979), and Loss of CD20 Target Antigen Expression Identified As a Mechanism of Treatment Resistance

Blood (2020) 136 (Supplement 1): 10–11.

https://doi.org/10.1182/blood-2020-137499

Published: 2020

Journal Articles

Odronextamab (REGN1979), a Human CD20 x CD3 Bispecific Antibody, Induces Durable, Complete Responses in Patients with Highly Refractory B-Cell Non-Hodgkin Lymphoma, Including Patients Refractory to CAR T Therapy

Rajat Bannerji, MDPhD, John N. Allan, MD, Jon E. Arnason, MD, Jennifer R. Brown, MD PhD, Ranjana Advani, MD, Stephen M. Ansell, MD PhD, Susan M. O'Brien, MD, Johannes Duell, MD, Peter Martin, FRCPC, MD MS, Robin M. Joyce, MD, Jingjin Li, PhD, Dina M. Flink, PhD, Min Zhu, PhD, David M. Weinreich, MD, George D. Yancopoulos, MD PhD, Andres Sirulnik, MD PhD, Aafia Chaudhry, MD MBA, MS, Srikanth R. Ambati, MBBS, MD, Max S. Topp, MD

Blood (2020) 136 (Supplement 1): 42–43.

https://doi.org/10.1182/blood-2020-136659

Published: 2020

Journal Articles

REGN5458, a BCMA x CD3 Bispecific Monoclonal Antibody, Induces Deep and Durable Responses in Patients with Relapsed/Refractory Multiple Myeloma (RRMM)

Blood (2020) 136 (Supplement 1): 41–42.

https://doi.org/10.1182/blood-2020-139192

Published: 2020

Journal Articles

Clinical Activity of REGN1979, a Bispecific Human, Anti-CD20 x Anti-CD3 Antibody, in Patients with Relapsed/Refractory (R/R) B-Cell Non-Hodgkin Lymphoma (B-NHL)

Blood (2019) 134 (Supplement_1): 762.

https://doi.org/10.1182/blood-2019-122451

Published: 2019

Journal Articles

Safety and Preliminary Clinical Activity of REGN5458, an Anti-Bcma x Anti-CD3 Bispecific Antibody, in Patients with Relapsed/Refractory Multiple Myeloma

Dennis Cooper, MD, Deepu Madduri, MD, Suzanne Lentzsch, MD PhD, Sundar Jagannath, Jingjin Li, PhD, Anita Boyapati, PhD, Lieve Adriaens, PharmD, Dhruti Chokshi, BS, Min Zhu, PhD, Israel Lowy, MD PhD, David M. Weinreich, MD, George D. Yancopoulos, MD PhD, Manish Sharma, MD, Maria Karasarides, PhD, David Sternberg, MD PhD

Blood (2019) 134 (Supplement_1): 3176.

https://doi.org/10.1182/blood-2019-126818

Published: 2019

Journal Articles

A novel humanized mouse model with significant improvement of class-switched, antigen-specific antibody production

Hua Yu, Chiara Borsotti, Jean-Nicolas Schickel, Shu Zhu, Till Strowig, Elizabeth E. Eynon, Davor Frleta, Cagan Gurer, Andrew J. Murphy, George D. Yancopoulos, Eric Meffre, Markus G. Manz, Richard A. Flavell

Blood (2017) 129 (8): 959–969.

https://doi.org/10.1182/blood-2016-04-709584

Published: 2017

Includes: Supplemental data

Journal Articles

Efficient differentiation and function of human macrophages in humanized CSF-1 mice

Chozhavendan Rathinam, William T. Poueymirou, Jose Rojas, Andrew J. Murphy, David M. Valenzuela, George D. Yancopoulos, Anthony Rongvaux, Elizabeth E. Eynon, Markus G. Manz, Richard A. Flavell

Blood (2011) 118 (11): 3119–3128.

https://doi.org/10.1182/blood-2010-12-326926

Published: 2011

Includes: Supplemental data

Journal Articles

The Dll4/Notch pathway controls postangiogenic blood vessel remodeling and regression by modulating vasoconstriction and blood flow

Ivan B. Lobov, Eunice Cheung, Rajeev Wudali, Jingtai Cao, Gabor Halasz, Yi Wei, Aris Economides, Hsin C. Lin, Nicholas Papadopoulos, George D. Yancopoulos, Stanley J. Wiegand

Blood (2011) 117 (24): 6728–6737.

https://doi.org/10.1182/blood-2010-08-302067

Published: 2011

Includes: Supplemental data

Journal Articles

Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis

Yu-Ping Xia, Baosheng Li, Donna Hylton, Michael Detmar, George D. Yancopoulos, John S. Rudge

Blood (2003) 102 (1): 161–168.

https://doi.org/10.1182/blood-2002-12-3793

Published: 2003

Journal Articles

Stromal cells expressing ephrin-B2 promote the growth and sprouting of ephrin-B2 + endothelial cells

Xiu-Qin Zhang, Nobuyuki Takakura, Yuichi Oike, Tomohisa Inada, Nicholas W. Gale, George D. Yancopoulos, Toshio Suda

Blood (2001) 98 (4): 1028–1037.

https://doi.org/10.1182/blood.V98.4.1028

Published: 2001

NARROW

Pozelimab, a Human Monoclonal Antibody Against Complement Factor C5, Provided Inhibition of Intravascular Hemolysis in Patients with Paroxysmal Nocturnal Hemoglobinuria

Baseline Biomarkers of T-Cell Function Correlate with Clinical Responses to Odronextamab (REGN1979), and Loss of CD20 Target Antigen Expression Identified As a Mechanism of Treatment Resistance

Odronextamab (REGN1979), a Human CD20 x CD3 Bispecific Antibody, Induces Durable, Complete Responses in Patients with Highly Refractory B-Cell Non-Hodgkin Lymphoma, Including Patients Refractory to CAR T Therapy

REGN5458, a BCMA x CD3 Bispecific Monoclonal Antibody, Induces Deep and Durable Responses in Patients with Relapsed/Refractory Multiple Myeloma (RRMM)

Clinical Activity of REGN1979, a Bispecific Human, Anti-CD20 x Anti-CD3 Antibody, in Patients with Relapsed/Refractory (R/R) B-Cell Non-Hodgkin Lymphoma (B-NHL)

Safety and Preliminary Clinical Activity of REGN5458, an Anti-Bcma x Anti-CD3 Bispecific Antibody, in Patients with Relapsed/Refractory Multiple Myeloma

A novel humanized mouse model with significant improvement of class-switched, antigen-specific antibody production

Efficient differentiation and function of human macrophages in humanized CSF-1 mice

The Dll4/Notch pathway controls postangiogenic blood vessel remodeling and regression by modulating vasoconstriction and blood flow

Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis

Stromal cells expressing ephrin-B2 promote the growth and sprouting of ephrin-B2 + endothelial cells

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American Society of Hematology

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ASH Publications

American Society of Hematology

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