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Journal Articles

Evaluation of Common Gamma Chain Cytokine Signaling Blockade with REGN7257, an Interleukin 2 Receptor Gamma (IL2RG) Monoclonal Antibody, on Immune Cell Populations in Monkey and Human

Audrey Le Floch-Ramondou, Kirsten Nagashima, Kaitlyn Gayvert, Hao Pan, Chandrashekhar Korgaonkar, Hassan Shakil, Erica Ullman, Thomas Norton, Lorah Perlee, Andrew J. Murphy, Matthew Sleeman, Jamie Orengo
Journal: Blood
Blood (2022) 140 (Supplement 1): 2924–2925.
https://doi.org/10.1182/blood-2022-159629
Published: 2022
Journal Articles

The Effect of Clonal Hematopoiesis of Indeterminate Potential (CHIP) and Aspirin on Clinical Outcomes in the Healthy Elderly: A Sub-Study of the Aspirin in Reducing Events in the Elderly (ASPREE) Randomized Controlled Trial

Zoe McQuilten, Nicholas C. Wong, Anna Leichter, Le T.P. Thao, James Phung, Andrew J Murphy, Moeen Riaz, Robert Sebra, Alexander G. Bick, John J. McNeil, Rory Wolfe, Robyn L. Woods, Paul Lacaze, Erica M. Wood, David J. Curtis
Journal: Blood
Blood (2022) 140 (Supplement 1): 2238–2239.
https://doi.org/10.1182/blood-2022-170761
Published: 2022
Journal Articles

Germline Missense Variants in SH2B3 Underpin Platelet Count Variation and Inherited MPN

Liesl Butler, Christine Lee, Graham William Magor, Rhiannon Morris, Michael Tallack, Charlene Lam, Adam Ivey, Jane Lin, Zihao Deng, Andrew Grigg, Jane Mason, Malaika Perchard, Helen Weston, Nik Cummings, Andrew Brooks, Jeffrey J Babon, Andrew J Murphy, Jessica M Salmon, Andrew Charles Perkins
Journal: Blood
Blood (2022) 140 (Supplement 1): 1093–1094.
https://doi.org/10.1182/blood-2022-159416
Published: 2022
Journal Articles

The Growth Kinetics of Clonal Hematopoiesis Inform Risk of Blood Cancer Progression

David J. Curtis, Nicholas C. Wong, Anna Leichter, Le T.P. Thao, James Phung, Andrew J Murphy, Moeen Riaz, Robert Sebra, Alexander G. Bick, John J. McNeil, Rory Wolfe, Robyn L. Woods, Paul Lacaze, Erica M. Wood, Zoe McQuilten
Journal: Blood
Blood (2022) 140 (Supplement 1): 8607–8608.
https://doi.org/10.1182/blood-2022-168526
Published: 2022
Journal Articles

Blockade of Common Gamma Chain Cytokine Signaling with REGN7257, an Interleukin 2 Receptor Gamma (IL2RG) Monoclonal Antibody, Protected Mice from Inflammatory and Autoimmune Diseases

Audrey Le Floch-Ramondou, Kirsten Nagashima, Pamela Farrales, Amanda Tay, Olivier Herbin, Dharani Ajithdoss, Thomas Norton, Lorah Perlee, Andrew J. Murphy, Matthew Sleeman, Jamie Orengo
Journal: Blood
Blood (2022) 140 (Supplement 1): 473–474.
https://doi.org/10.1182/blood-2022-159209
Published: 2022
Journal Articles

Manipulation of Fatty Acid Metabolism Impairs Megakaryocyte Differentiation and Platelet Production

Maria N. Barrachina, Gerard Pernes, Isabelle C Becker, Dafna Groeneveld, James P. Luyendyk, Peter J Meikle, Graeme I Lancaster, Andrew J Murphy, Kellie Machlus
Journal: Blood
Blood (2021) 138 (Supplement 1): 577.
https://doi.org/10.1182/blood-2021-151316
Published: 2021
Journal Articles

Baseline Biomarkers of T-Cell Function Correlate with Clinical Responses to Odronextamab (REGN1979), and Loss of CD20 Target Antigen Expression Identified As a Mechanism of Treatment Resistance

Jurriaan Brouwer-Visser, PhD, Nathalie Fiaschi, PhD, Raquel P. Deering, PhD, Ankur Dhanik, PhD, Kamil J. Cygan, PhD, Wen Zhang, PhD, Se Jeong, MPH, Stephane Pourpe, MS, Lauren Boucher, Sara Hamon, PhD, Max S. Topp, MD, Rajat Bannerji, MDPhD, Johannes Duell, MD, Ranjana Advani, MD, Dina M. Flink, PhD, Aafia Chaudhry, MD MBA, MS, Andres Sirulnik, MD PhD, Andrew J. Murphy, PhD, David M. Weinreich, MD, George D. Yancopoulos, MD PhD, Gavin Thurston, PhD, Srikanth R. Ambati, MBBS, MD, Vladimir Jankovic, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 10–11.
https://doi.org/10.1182/blood-2020-137499
Published: 2020
Journal Articles

Clinical Activity of REGN1979, a Bispecific Human, Anti-CD20 x Anti-CD3 Antibody, in Patients with Relapsed/Refractory (R/R) B-Cell Non-Hodgkin Lymphoma (B-NHL)

Rajat Bannerji, MD PhD, John N. Allan, MD, Jon E. Arnason, MD, Jennifer R. Brown, MD PhD, Ranjana H Advani, MD, Jeffrey A. Barnes, MD PhD, Stephen M Ansell, MD PhD, Susan M. O'Brien, MD, Julio Chavez, Johannes Duell, MD, Kevin A. David, MD, Peter Martin, FRCPC, MD MS, Robin M. Joyce, MD, Robert Charnas, PhD, Srikanth R. Ambati, MBBS, MD, Lieve Adriaens, PharmD, Melanie Ufkin, PhD, Min Zhu, PhD, Jingjin Li, PhD, Peter Gasparini, MS, Anfal Ibrahim, BS, Vladimir Jankovic, MD, Nathalie Fiaschi, PhD, Olulanu Aina, PhD, Wen Zhang, PhD, Raquel P. Deering, PhD, Sara Hamon, PhD, Gavin Thurston, PhD, Andrew J. Murphy, PhD, David M. Weinreich, MD, George D. Yancopoulos, MD PhD, Israel Lowy, MD PhD, David Sternberg, MD PhD, Max S. Topp, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 762.
https://doi.org/10.1182/blood-2019-122451
Published: 2019
Journal Articles

A novel humanized mouse model with significant improvement of class-switched, antigen-specific antibody production

Hua Yu, Chiara Borsotti, Jean-Nicolas Schickel, Shu Zhu, Till Strowig, Elizabeth E. Eynon, Davor Frleta, Cagan Gurer, Andrew J. Murphy, George D. Yancopoulos, Eric Meffre, Markus G. Manz, Richard A. Flavell
Journal: Blood
Blood (2017) 129 (8): 959–969.
https://doi.org/10.1182/blood-2016-04-709584
Published: 2017
Includes: Supplemental data
Journal Articles

Efficient differentiation and function of human macrophages in humanized CSF-1 mice

Chozhavendan Rathinam, William T. Poueymirou, Jose Rojas, Andrew J. Murphy, David M. Valenzuela, George D. Yancopoulos, Anthony Rongvaux, Elizabeth E. Eynon, Markus G. Manz, Richard A. Flavell
Journal: Blood
Blood (2011) 118 (11): 3119–3128.
https://doi.org/10.1182/blood-2010-12-326926
Published: 2011
Includes: Supplemental data
Journal Articles

Hematopoietic Stem Cell Expansion Leads to Monocytosis In Animal Models of Atherosclerosis

Mani Akhtari, Andrew J Murphy, Ph.D., Tamara A Pagler, Ph.D., Alan R Tall, M.D.
Journal: Blood
Blood (2010) 116 (21): 4797.
https://doi.org/10.1182/blood.V116.21.4797.4797
Published: 2010