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Issue Archive

Volume 115, Issue 7
February 18 2010
Issue Cover

Table of Contents

INSIDE BLOOD

THROMBOSIS & HEMOSTASIS
A new plasminogen receptor
Dudley K. Strickland
View Articletitled, A new plasminogen receptor
IMMUNOBIOLOGY
Targeting telomerase: T-cell friendly fire
Rodrigo T. Calado
View Articletitled, Targeting telomerase: T-cell friendly fire
VASCULAR BIOLOGY
Malignant malaria and microangiopathies: merging mechanisms
José A. López
View Articletitled, Malignant malaria and microangiopathies: merging mechanisms

PLENARY PAPERS

Proteomics-based discovery of a novel, structurally unique, and developmentally regulated plasminogen receptor, Plg-RKT, a major regulator of cell surface plasminogen activation
Nicholas M. Andronicos,Emily I. Chen,Nagyung Baik,Hongdong Bai,Caitlin M. Parmer,William B. Kiosses,Mark P. Kamps,John R. Yates, III,Robert J. Parmer,Lindsey A. Miles
View Articletitled, Proteomics-based discovery of a novel, structurally unique, and developmentally regulated plasminogen receptor, Plg-R<sub>KT</sub>, a major regulator of cell surface plasminogen activation
Supplemental data

HOW I TREAT

How I treat influenza in patients with hematologic malignancies
Corey Casper,Janet Englund,Michael Boeckh
View Articletitled, How I treat influenza in patients with hematologic malignancies

CLINICAL TRIALS AND OBSERVATIONS

Lenalidomide plus dexamethasone versus thalidomide plus dexamethasone in newly diagnosed multiple myeloma: a comparative analysis of 411 patients
Clinical Trials & Observations
Francesca Gay,Suzanne R. Hayman,Martha Q. Lacy,Francis Buadi,Morie A. Gertz,Shaji Kumar,Angela Dispenzieri,Joseph R. Mikhael,P. Leif Bergsagel,David Dingli,Craig B. Reeder,John A. Lust,Stephen J. Russell,Vivek Roy,Steven R. Zeldenrust,Thomas E. Witzig,Rafael Fonseca,Robert A. Kyle,Philip R. Greipp,A. Keith Stewart,S. Vincent Rajkumar
View Articletitled, Lenalidomide plus dexamethasone versus thalidomide plus dexamethasone in newly diagnosed multiple myeloma: a comparative analysis of 411 patients
Supplemental data
Intravenous PEG-asparaginase during remission induction in children and adolescents with newly diagnosed acute lymphoblastic leukemia
Brief Report
Lewis B. Silverman,Jeffrey G. Supko,Kristen E. Stevenson,Christina Woodward,Lynda M. Vrooman,Donna S. Neuberg,Barbara L. Asselin,Uma H. Athale,Luis Clavell,Peter D. Cole,Kara M. Kelly,Caroline Laverdière,Bruno Michon,Marshall Schorin,Cindy L. Schwartz,Jane E. O'Brien,Harvey J. Cohen,Stephen E. Sallan
View Articletitled, Intravenous PEG-asparaginase during remission induction in children and adolescents with newly diagnosed acute lymphoblastic leukemia

IMMUNOBIOLOGY

HIV-1 Vpr up-regulates expression of ligands for the activating NKG2D receptor and promotes NK cell–mediated killing
Jonathan Richard,Sardar Sindhu,Tram N. Q. Pham,Jean-Philippe Belzile,Éric A. Cohen
View Articletitled, HIV-1 Vpr up-regulates expression of ligands for the activating NKG2D receptor and promotes NK cell–mediated killing
Supplemental data
Crystal structure and collagen-binding site of immune inhibitory receptor LAIR-1: unexpected implications for collagen binding by platelet receptor GPVI
T. Harma C. Brondijk,Talitha de Ruiter,Joost Ballering,Hans Wienk,Robert Jan Lebbink,Hugo van Ingen,Rolf Boelens,Richard W. Farndale,Linde Meyaard,Eric G. Huizinga
View Articletitled, Crystal structure and collagen-binding site of immune inhibitory receptor LAIR-1: unexpected implications for collagen binding by platelet receptor GPVI
Supplemental data
Autoimmune B-cell lymphopenia after successful adoptive therapy with telomerase-specific T lymphocytes
Stefano Ugel,Elisa Scarselli,Manuela Iezzi,Carmela Mennuni,Tania Pannellini,Francesco Calvaruso,Barbara Cipriani,Raffaele De Palma,Lucia Ricci-Vitiani,Elisa Peranzoni,Piero Musiani,Paola Zanovello,Vincenzo Bronte
View Articletitled, Autoimmune B-cell lymphopenia after successful adoptive therapy with telomerase-specific T lymphocytes
Supplemental data

LYMPHOID NEOPLASIA

Malignant transformation of Slp65-deficient pre-B cells involves disruption of the Arf-Mdm2-p53 tumor suppressor pathway
Van B. T. Ta,Marjolein J. W. de Bruijn,Petra J. ter Brugge,Jan Piet van Hamburg,Hans J. A. Diepstraten,Pieter Fokko van Loo,Rogier Kersseboom,Rudi W. Hendriks
View Articletitled, Malignant transformation of Slp65-deficient pre-B cells involves disruption of the Arf-Mdm2-p53 tumor suppressor pathway
Supplemental data
Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia
Huining Kang,I.-Ming Chen,Carla S. Wilson,Edward J. Bedrick,Richard C. Harvey,Susan R. Atlas,Meenakshi Devidas,Charles G. Mullighan,Xuefei Wang,Maurice Murphy,Kerem Ar,Walker Wharton,Michael J. Borowitz,W. Paul Bowman,Deepa Bhojwani,William L. Carroll,Bruce M. Camitta,Gregory H. Reaman,Malcolm A. Smith,James R. Downing,Stephen P. Hunger,Cheryl L. Willman
View Articletitled, Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia
Supplemental data

MYELOID NEOPLASIA

Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice
Michael G. Kharas,Rachel Okabe,Jared J. Ganis,Maricel Gozo,Tulasi Khandan,Mahnaz Paktinat,D. Gary Gilliland,Kira Gritsman
View Articletitled, Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice
Supplemental data
STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease
Geqiang Li,Kristy L. Miskimen,Zhengqi Wang,Xiu Yan Xie,Jennifer Brenzovich,John J. Ryan,William Tse,Richard Moriggl,Kevin D. Bunting
View Articletitled, STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease
Supplemental data
FLT3-mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AML
Keith W. Pratz,Takashi Sato,Kathleen M. Murphy,Adam Stine,Trivikram Rajkhowa,Mark Levis
View Articletitled, FLT3-mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AML
Cbfb/Runx1 repression–independent blockage of differentiation and accumulation of Csf2rb-expressing cells by Cbfb-MYH11
R. Katherine Hyde,Yasuhiko Kamikubo,Stacie Anderson,Martha Kirby,Lemlem Alemu,Ling Zhao,P. Paul Liu
View Articletitled, <em>Cbfb/Runx1</em> repression–independent blockage of differentiation and accumulation of Csf2rb-expressing cells by <em>Cbfb-MYH11</em>
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Three-dimensional migration of macrophages requires Hck for podosome organization and extracellular matrix proteolysis
Céline Cougoule,Véronique Le Cabec,Renaud Poincloux,Talal Al Saati,Jean-Louis Mège,Guillaume Tabouret,Clifford A. Lowell,Nathalie Laviolette-Malirat,Isabelle Maridonneau-Parini
View Articletitled, Three-dimensional migration of macrophages requires Hck for podosome organization and extracellular matrix proteolysis
Supplemental data

VASCULAR BIOLOGY

Erythropoietin accelerates smooth muscle cell–rich vascular lesion formation in mice through endothelial cell activation involving enhanced PDGF-BB release
Maarten L. Janmaat,Jasper L. T. Heerkens,Alexander M. de Bruin,Anita Klous,Vivian de Waard,Carlie J. M. de Vries
View Articletitled, Erythropoietin accelerates smooth muscle cell–rich vascular lesion formation in mice through endothelial cell activation involving enhanced PDGF-BB release
Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy
Saul J. Priceman,James L. Sung,Zory Shaposhnik,Jeremy B. Burton,Antoni X. Torres-Collado,Diana L. Moughon,Mai Johnson,Aldons J. Lusis,Donald A. Cohen,M. Luisa Iruela-Arispe,Lily Wu
View Articletitled, Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy
Supplemental data
Rapid activation of endothelial cells enables Plasmodium falciparum adhesion to platelet-decorated von Willebrand factor strings
Brief Report
Daniel J. Bridges,James Bunn,Jan A. van Mourik,Georges Grau,Roger J.S. Preston,Malcolm Molyneux,Valery Combes,James S. O'Donnell,Bas de Laat,Alister Craig
View Articletitled, Rapid activation of endothelial cells enables <em>Plasmodium falciparum</em> adhesion to platelet-decorated von Willebrand factor strings
Supplemental data
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