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Issue Archive

Volume 114, Issue 16
October 15 2009
Issue Cover

Table of Contents

INSIDE BLOOD

CLINICAL TRIALS
One step back but 2 steps forward
John G. Gribben
View Articletitled, One step back but 2 steps forward
IMMUNOBIOLOGY
Accumulations of KIR+ T cells in the elderly
Graham Pawelec
View Articletitled, Accumulations of KIR<sup>+</sup> T cells in the elderly
INSIDE BLOOD
The doctor's dilemma: stimulating T cells
Mark Vickers
View Articletitled, The doctor's dilemma: stimulating T cells
MYELOID NEOPLASIA
Through the looking glass
Joshi J. Alumkal
View Articletitled, Through the looking glass
PLATELETS & THROMBOPOIESIS
CLEC … too!
Thomas J. Kunicki
View Articletitled, CLEC … too!

REVIEW ARTICLES

The microenvironment in mature B-cell malignancies: a target for new treatment strategies
Jan A. Burger,Paolo Ghia,Andreas Rosenwald,Federico Caligaris-Cappio
View Articletitled, The microenvironment in mature B-cell malignancies: a target for new treatment strategies

HOW I TREAT

How I monitor residual disease in chronic myeloid leukemia
Jerald P. Radich
View Articletitled, How I monitor residual disease in chronic myeloid leukemia

CLINICAL TRIALS AND OBSERVATIONS

First-line therapy with fludarabine compared with chlorambucil does not result in a major benefit for elderly patients with advanced chronic lymphocytic leukemia
Clinical Trials & Observations
Barbara F. Eichhorst,Raymonde Busch,Stephan Stilgenbauer,Martina Stauch,Manuela A. Bergmann,Matthias Ritgen,Nicole Kranzhöfer,Robert Rohrberg,Ulrike Söling,Oswald Burkhard,Anne Westermann,Valentin Goede,Carmen D. Schweighofer,Kirsten Fischer,Anna-Maria Fink,Clemens M. Wendtner,Günter Brittinger,Hartmut Döhner,Bertold Emmerich,Michael Hallek,the German CLL Study Group (GCLLSG)
View Articletitled, First-line therapy with fludarabine compared with chlorambucil does not result in a major benefit for elderly patients with advanced chronic lymphocytic leukemia
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Overexpression of Rheb2 enhances mouse hematopoietic progenitor cell growth while impairing stem cell repopulation
Timothy B. Campbell,Sunanda Basu,Giao Hangoc,Wen Tao,Hal E. Broxmeyer
View Articletitled, Overexpression of Rheb2 enhances mouse hematopoietic progenitor cell growth while impairing stem cell repopulation
Supplemental data
Tight control of MEK-ERK activation is essential in regulating proliferation, survival, and cytokine production of CD34+-derived neutrophil progenitors
Christian R. Geest,Miranda Buitenhuis,Marian J. A. Groot Koerkamp,Frank C. P. Holstege,Edo Vellenga,Paul J. Coffer
View Articletitled, Tight control of MEK-ERK activation is essential in regulating proliferation, survival, and cytokine production of CD34<sup>+</sup>-derived neutrophil progenitors
Supplemental data

IMMUNOBIOLOGY

Dominant role of CD47–thrombospondin-1 interactions in myeloma-induced fusion of human dendritic cells: implications for bone disease
Anjli Kukreja,Soroosh Radfar,Ben-Hua Sun,Karl Insogna,Madhav V. Dhodapkar
View Articletitled, Dominant role of CD47–thrombospondin-1 interactions in myeloma-induced fusion of human dendritic cells: implications for bone disease
Supplemental data
Epigenetic regulation of killer immunoglobulin–like receptor expression in T cells
Guangjin Li,Mingcan Yu,Cornelia M. Weyand,Jörg J. Goronzy
View Articletitled, Epigenetic regulation of killer immunoglobulin–like receptor expression in T cells

LYMPHOID NEOPLASIA

Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion
Roch Houot,Matthew J. Goldstein,Holbrook E. Kohrt,June H. Myklebust,Ash A. Alizadeh,Jack T. Lin,Jonathan M. Irish,James A. Torchia,Arne Kolstad,Lieping Chen,Ronald Levy
View Articletitled, Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by T<sub>reg</sub> depletion
Supplemental data

MYELOID NEOPLASIA

Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome
Francesco Parlati,Susan J. Lee,Monette Aujay,Erika Suzuki,Konstantin Levitsky,James B. Lorens,David R. Micklem,Paulina Ruurs,Catherine Sylvain,Yan Lu,Kevin D. Shenk,Mark K. Bennett
View Articletitled, Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome
Supplemental data
MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation
Maria E. Figueroa,Lucy Skrabanek,Yushan Li,Anchalee Jiemjit,Tamer E. Fandy,Elisabeth Paietta,Hugo Fernandez,Martin S. Tallman,John M. Greally,Hetty Carraway,Jonathan D. Licht,Steven D. Gore,Ari Melnick
View Articletitled, MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation
Supplemental data
Acute dasatinib exposure commits Bcr-Abl–dependent cells to apoptosis
Jennifer L. Snead,Thomas O'Hare,Lauren T. Adrian,Christopher A. Eide,Thoralf Lange,Brian J. Druker,Michael W. Deininger
View Articletitled, Acute dasatinib exposure commits Bcr-Abl–dependent cells to apoptosis
Supplemental data

PLATELETS AND THROMBOPOIESIS

CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis
Frauke May,Ina Hagedorn,Irina Pleines,Markus Bender,Timo Vögtle,Johannes Eble,Margitta Elvers,Bernhard Nieswandt
View Articletitled, CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Cerebrovascular reserve capacity is impaired in patients with sickle cell disease
Erfan Nur,Yu-Sok Kim,Jasper Truijen,Eduard J. van Beers,Shyrin C. A. T. Davis,Dees P. Brandjes,Bart J. Biemond,Johannes J. van Lieshout
View Articletitled, Cerebrovascular reserve capacity is impaired in patients with sickle cell disease
Supplemental data
Histone hyperacetylation within the β-globin locus is context-dependent and precedes high-level gene expression
George Fromm,Christina de Vries,Rachel Byron,Jennifer Fields,Steven Fiering,Mark Groudine,M. A. Bender,James Palis,Michael Bulger
View Articletitled, Histone hyperacetylation within the β-globin locus is context-dependent and precedes high-level gene expression
Supplemental data

THROMBOSIS AND HEMOSTASIS

Characterization of W1745C and S1783A: 2 novel mutations causing defective collagen binding in the A3 domain of von Willebrand factor
Anne F. Riddell,Keith Gomez,Carolyn M. Millar,Gillian Mellars,Saher Gill,Simon A. Brown,Megan Sutherland,Mike A. Laffan,Thomas A. J. McKinnon
View Articletitled, Characterization of W1745C and S1783A: 2 novel mutations causing defective collagen binding in the A3 domain of von Willebrand factor

CORRESPONDENCE

Reconstitution of protection against Aspergillus infection in chronic granulomatous disease (CGD)
Quinten Remijsen,Peter Vandenabeele,Jean Willems,Taco W. Kuijpers
View Articletitled, Reconstitution of protection against <em>Aspergillus</em> infection in chronic granulomatous disease (CGD)
Response: Protecting against Aspergillus infection in CGD
Abdul Hakkim,Robert Hurwitz,Matteo Bianchi,Volker Brinkmann,Ulrich Siler,Reinhard A. Seger,Arturo Zychlinsky,Janine Reichenbach
View Articletitled, Response: Protecting against <em>Aspergillus</em> infection in CGD
Bugs and marginal zone lymphoma of the ocular adnexae: is the future already here?
Maurilio Ponzoni,Riccardo Dolcetti,Claudio Doglioni,Andrés J. M. Ferreri
View Articletitled, Bugs and marginal zone lymphoma of the ocular adnexae: is the future already here?
Response: Variability in the prevalence of Chlamydophila psittaci infection in patients with OAML
Alexandra Stefanovic,Izidore S. Lossos
View Articletitled, Response: Variability in the prevalence of <em>Chlamydophila psittaci</em> infection in patients with OAML
Chronic natural killer–cell lymphocytosis successfully treated with alemtuzumab
Cheng E. Chee,Kenneth J. Warrington,Ayalew Tefferi
View Articletitled, Chronic natural killer–cell lymphocytosis successfully treated with alemtuzumab
Chronic myeloid leukemia with p190BCR-ABL: prevalence, morphology, tyrosine kinase inhibitor response, and kinase domain mutation analysis
Animesh Pardanani,Ayalew Tefferi,Mark R. Litzow,Clive Zent,William J. Hogan,Rebecca F. McClure,David Viswanatha
View Articletitled, Chronic myeloid leukemia with p190<sup>BCR-ABL</sup>: prevalence, morphology, tyrosine kinase inhibitor response, and kinase domain mutation analysis
RAS and CSF3R mutations in severe congenital neutropenia
Manuela Germeshausen,Christian P. Kratz,Matthias Ballmaier,Karl Welte
View Articletitled, <em>RAS</em> and <em>CSF3R</em> mutations in severe congenital neutropenia

ERRATA

Lapalombella et al. Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells. Blood. 2008;112(13):5180–5189.
View Articletitled, Lapalombella et al. Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells. <em>Blood</em>. 2008;112(13):5180–5189.
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