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Volume 113, Issue 11

March 12 2009

In this Issue

INSIDE BLOOD
PLENARY PAPERS
PERSPECTIVE
REVIEW ARTICLES
CLINICAL TRIALS AND OBSERVATIONS
IMMUNOBIOLOGY
LYMPHOID NEOPLASIA
MYELOID NEOPLASIA
PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS
PLATELETS AND THROMBOPOIESIS
RED CELLS, IRON, AND ERYTHROPOIESIS
THROMBOSIS AND HEMOSTASIS
TRANSPLANTATION
VASCULAR BIOLOGY

New insights into the biology and origin of mature aggressive B-cell lymphomas by combined epigenomic, genomic, and transcriptional profiling

José I. Martín-Subero,Markus Kreuz,Marina Bibikova,Stefan Bentink,Ole Ammerpohl,Eliza Wickham-Garcia,Maciej Rosolowski,Julia Richter,Lidia Lopez-Serra,Esteban Ballestar,Hilmar Berger,Xabier Agirre,Heinz-Wolfram Bernd,Vincenzo Calvanese,Sergio B. Cogliatti,Hans G. Drexler,Jian-Bing Fan,Mario F. Fraga,Martin L. Hansmann,Michael Hummel,Wolfram Klapper,Bernhard Korn,Ralf Küppers,Roderick A. F. MacLeod,Peter Möller,German Ott,Christiane Pott,Felipe Prosper,Andreas Rosenwald,Carsten Schwaenen,Dirk Schübeler,Marc Seifert,Benjamin Stürzenhofecker,Michael Weber,Swen Wessendorf,Markus Loeffler,Lorenz Trümper,Harald Stein,Rainer Spang,Manel Esteller,David Barker,Dirk Hasenclever,for the Molecular Mechanisms in Malignant Lymphomas Network Project of the Deutsche Krebshilfe,Reiner Siebert

View Articletitled, New insights into the biology and origin of mature aggressive B-cell lymphomas by combined epigenomic, genomic, and transcriptional profiling

Supplemental data

INSIDE BLOOD

Syk to death

P. Leif Bergsagel

Using elegant mouse models of B-cell lymphoma, Young and colleagues validate targeting syk-mediated B-cell receptor signaling as an effective antitumor strategy for the treatment of non-Hodgkin lymphoma.

View Articletitled, Syk to death

MYELOID NEOPLASIA

Might as well face it: MLL's addicted to HOX

Jacquelyn J. Roth,Richard C. Crist,Arthur M. Buchberg

Overexpression of HOXA9 is a hallmark of MLL-rearranged leukemias. In this issue of Blood, Faber and colleagues show that HOXA9 is critical for proliferation and survival of leukemic cells.

View Articletitled, Might as well face it: MLL's addicted to HOX

PLATELETS & THROMBOPOIESIS

Platelet antigen-induced regulation in ITP

John W. Semple

Tregs maintain self-tolerance and, although they are significantly deficient in patients with ITP,^1,,,,–6 it now seems that their antigen-specific counterparts can be generated de novo from the patient's other nonregulatory T cells. This may set the future stage for platelet-induced cellular therapy as a treatment for ITP.

View Articletitled, Platelet antigen-induced regulation in ITP

PLENARY PAPERS

HOXA9 is required for survival in human MLL-rearranged acute leukemias

Joerg Faber,Andrei V. Krivtsov,Matthew C. Stubbs,Renee Wright,Tina N. Davis,Marry van den Heuvel-Eibrink,Christian M. Zwaan,Andrew L. Kung,Scott A. Armstrong

View Articletitled, HOXA9 is required for survival in human MLL-rearranged acute leukemias

Supplemental data

PERSPECTIVE

Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group

Francesco Rodeghiero,Roberto Stasi,Terry Gernsheimer,Marc Michel,Drew Provan,Donald M. Arnold,James B. Bussel,Douglas B. Cines,Beng H. Chong,Nichola Cooper,Bertrand Godeau,Klaus Lechner,Maria Gabriella Mazzucconi,Robert McMillan,Miguel A. Sanz,Paul Imbach,Victor Blanchette,Thomas Kühne,Marco Ruggeri,James N. George

View Articletitled, Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group

REVIEW ARTICLES

The role of indoleamine 2,3-dioxygenase in the induction of immune tolerance: focus on hematology

Antonio Curti,Sara Trabanelli,Valentina Salvestrini,Michele Baccarani,Roberto M. Lemoli

View Articletitled, The role of indoleamine 2,3-dioxygenase in the induction of immune tolerance: focus on hematology

CLINICAL TRIALS AND OBSERVATIONS

Dosing lepirudin in patients with heparin-induced thrombocytopenia and normal or impaired renal function: a single-center experience with 68 patients
Clinical Trials & Observations

Martina Tschudi,Bernhard Lämmle,Lorenzo Alberio

View Articletitled, Dosing lepirudin in patients with heparin-induced thrombocytopenia and normal or impaired renal function: a single-center experience with 68 patients

Acute graft-versus-host disease after unrelated donor umbilical cord blood transplantation: analysis of risk factors
Clinical Trials & Observations

Margaret L. MacMillan,Daniel J. Weisdorf,Claudio G. Brunstein,Qing Cao,Todd E. DeFor,Michael R. Verneris,Bruce R. Blazar,John E. Wagner

View Articletitled, Acute graft-versus-host disease after unrelated donor umbilical cord blood transplantation: analysis of risk factors

IMMUNOBIOLOGY

PARP-14, a member of the B aggressive lymphoma family, transduces survival signals in primary B cells

Sung Hoon Cho,Shreevrat Goenka,Tiina Henttinen,Prathyusha Gudapati,Arja Reinikainen,Christine M. Eischen,Riitta Lahesmaa,Mark Boothby

View Articletitled, PARP-14, a member of the B aggressive lymphoma family, transduces survival signals in primary B cells

Supplemental data

Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities

Fouad Eddahri,Sébastien Denanglaire,Fabrice Bureau,Rosanne Spolski,Warren J. Leonard,Oberdan Leo,Fabienne Andris

View Articletitled, Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities

Supplemental data

The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells

Petter Brodin,Tadepally Lakshmikanth,Sofia Johansson,Klas Kärre,Petter Höglund

View Articletitled, The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells

Supplemental data

Enhancing the in vivo expansion of adoptively transferred EBV-specific CTL with lymphodepleting CD45 monoclonal antibodies in NPC patients

Chrystal U. Louis,Karin Straathof,Catherine M. Bollard,Claudia Gerken,M. Helen Huls,M. Victoria Gresik,Meng-Fen Wu,Heidi L. Weiss,Adrian P. Gee,Malcolm K. Brenner,Cliona M. Rooney,Helen E. Heslop,Stephen Gottschalk

View Articletitled, Enhancing the in vivo expansion of adoptively transferred EBV-specific CTL with lymphodepleting CD45 monoclonal antibodies in NPC patients

Supplemental data

Prostaglandin E₂ enhances T-cell proliferation by inducing the costimulatory molecules OX40L, CD70, and 4-1BBL on dendritic cells

Petra Krause,Markus Bruckner,Christina Uermösi,Eva Singer,Marcus Groettrup,Daniel F. Legler

View Articletitled, Prostaglandin E2 enhances T-cell proliferation by inducing the costimulatory molecules OX40L, CD70, and 4-1BBL on dendritic cells

Blood-borne human plasma cells in steady state are derived from mucosal immune responses

Henrik E. Mei,Taketoshi Yoshida,Wondossen Sime,Falk Hiepe,Kathi Thiele,Rudolf A. Manz,Andreas Radbruch,Thomas Dörner

View Articletitled, Blood-borne human plasma cells in steady state are derived from mucosal immune responses

Supplemental data

The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development

Il-Kyoo Park,Chiara Giovenzana,Tiffany L. Hughes,Jianhua Yu,Rossana Trotta,Michael A. Caligiuri

View Articletitled, The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development

LYMPHOID NEOPLASIA

Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas

Matthew J. Frank,David W. Dawson,Steven J. Bensinger,Jason S. Hong,Wendy M. Knosp,Lizhong Xu,Cynthia E. Balatoni,Eric L. Allen,Rhine R. Shen,Dafna Bar-Sagi,Gail R. Martin,Michael A. Teitell

View Articletitled, Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas

Supplemental data

Regulation of multiple myeloma survival and progression by CD1d

Emmanouil Spanoudakis,Ming Hu,Kikkeri Naresh,Evangelos Terpos,Valeria Melo,Alistair Reid,Ioannis Kotsianidis,Saad Abdalla,Amin Rahemtulla,Anastasios Karadimitris

View Articletitled, Regulation of multiple myeloma survival and progression by CD1d

Mouse models of non-Hodgkin lymphoma reveal Syk as an important therapeutic target

Ryan M. Young,Ian R. Hardy,Raedun L. Clarke,Nicolai Lundy,Polly Pine,Brian C. Turner,Terry A. Potter,Yosef Refaeli

View Articletitled, Mouse models of non-Hodgkin lymphoma reveal Syk as an important therapeutic target

Supplemental data

MYELOID NEOPLASIA

Genetic variants in the candidate genes of the apoptosis pathway and susceptibility to chronic myeloid leukemia

Dong Hwan (Dennis) Kim,Wei Xu,Clement Ma,Xiangdong Liu,Katherine Siminovitch,Hans A. Messner,Jeffrey H. Lipton

View Articletitled, Genetic variants in the candidate genes of the apoptosis pathway and susceptibility to chronic myeloid leukemia

Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster

Xueqing Zhang,Zheng Lian,Carolyn Padden,Mark B. Gerstein,Joel Rozowsky,Michael Snyder,Thomas R. Gingeras,Philipp Kapranov,Sherman M. Weissman,Peter E. Newburger

View Articletitled, A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster

Supplemental data

Zebrafish granulocyte colony-stimulating factor receptor signaling promotes myelopoiesis and myeloid cell migration

Clifford Liongue,Chris J. Hall,Bree A. O'Connell,Phil Crosier,Alister C. Ward

View Articletitled, Zebrafish granulocyte colony-stimulating factor receptor signaling promotes myelopoiesis and myeloid cell migration

Supplemental data

Granulocyte/macrophage–colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy subjects

Kanji Uchida,Koh Nakata,Takuji Suzuki,Maurizio Luisetti,Masato Watanabe,Diana E. Koch,Carrie A. Stevens,David C. Beck,Lee A. Denson,Brenna C. Carey,Naoto Keicho,Jeffrey P. Krischer,Yoshitsugu Yamada,Bruce C. Trapnell

View Articletitled, Granulocyte/macrophage–colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy subjects

Supplemental data

PLATELETS AND THROMBOPOIESIS

Impaired activation of platelets lacking protein kinase C-θ isoform

Bela Nagy, Jr,Kamala Bhavaraju,Todd Getz,Yamini S. Bynagari,Soochong Kim,Satya P. Kunapuli

View Articletitled, Impaired activation of platelets lacking protein kinase C-θ isoform

De novo induction of platelet-specific CD4⁺CD25⁺ regulatory T cells from CD4⁺CD25⁻ cells in patients with idiopathic thrombocytopenic purpura

Xiao-Lin Zhang,Jun Peng,Jian-Zhi Sun,Jia-Jun Liu,Cheng-Shan Guo,Zhen-Guang Wang,Yuan Yu,Yan Shi,Ping Qin,Shu-Guang Li,Li-Ning Zhang,Ming Hou

View Articletitled, De novo induction of platelet-specific CD4+CD25+ regulatory T cells from CD4+CD25− cells in patients with idiopathic thrombocytopenic purpura

Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification

Paul W. Buehler,Bindu Abraham,Florence Vallelian,Charlotte Linnemayr,Claudia P. Pereira,John F. Cipollo,Yiping Jia,Malgorzata Mikolajczyk,Felicitas S. Boretti,Gabriele Schoedon,Abdu I. Alayash,Dominik J. Schaer

View Articletitled, Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification

Supplemental data

THROMBOSIS AND HEMOSTASIS

Quantitation of anti–factor VIII antibodies in human plasma

Jolanta Krudysz-Amblo,Behnaz Parhami-Seren,Saulius Butenas,Kathleen E. Brummel-Ziedins,Edward D. Gomperts,Georges E. Rivard,Kenneth G. Mann

View Articletitled, Quantitation of anti–factor VIII antibodies in human plasma

TRANSPLANTATION

Mesenchymal stem cell–mediated ectopic hematopoiesis alleviates aging-related phenotype in immunocompromised mice

Takayoshi Yamaza,Yasuo Miura,Kentaro Akiyama,Yanming Bi,Wataru Sonoyama,Stan Gronthos,WanJun Chen,Anh Le,Songtao Shi

View Articletitled, Mesenchymal stem cell–mediated ectopic hematopoiesis alleviates aging-related phenotype in immunocompromised mice

Supplemental data

VASCULAR BIOLOGY

Toll-like receptor 4 in lymphatic endothelial cells contributes to LPS-induced lymphangiogenesis by chemotactic recruitment of macrophages

Shinae Kang,Seung-Pyo Lee,Kyung Eun Kim,Hak-Zoo Kim,Sylvie Mémet,Gou Young Koh

View Articletitled, Toll-like receptor 4 in lymphatic endothelial cells contributes to LPS-induced lymphangiogenesis by chemotactic recruitment of macrophages

Supplemental data

Cover Image

Cover Image

Under severe peroxidative conditions, haptoglobin preserves hemoglobin structural integrity and maintains clearance of the Hb-Hp complex by the macrophage scavenger receptor CD163. As a result, oxidative stress-exposed Hb (red) is sequestered within lysosomes (green) as illustrated in the 3-dimensional reconstruction of confocal laser scanning microscopy data (yellow indicates colocalization). See the article by Buehler et al on page 2578.
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