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Issue Archive

Volume 7, Issue 20
October 24 2023
Issue Cover

Table of Contents

INSIDE BLOOD ADVANCES

ADP: the missing link between thrombosis and hemolysis
Gloria F. Gerber,Robert A. Brodsky
View Articletitled, ADP: the missing link between thrombosis and hemolysis

SYSTEMATIC REVIEW

Significance of E-lesions in Hodgkin lymphoma and the creation of a new consensus definition: a report from SEARCH
Clinical Trials & Observations
Eline A. M. Zijtregtop,Jamie Zeal,Monika L. Metzger,Kara M. Kelly,Christine Mauz-Koerholz,Stephan D. Voss,Kathleen McCarten,Jamie E. Flerlage,Auke Beishuizen
View Articletitled, Significance of E-lesions in Hodgkin lymphoma and the creation of a new consensus definition: a report from SEARCH

CLINICAL TRIALS AND OBSERVATIONS

Feasibility trial for the management of severe acute malnutrition in older children with sickle cell anemia in Nigeria
Clinical Trials & Observations Global Advances
Shehu U. Abdullahi,Safiya Gambo,Hassan Adam Murtala,Halima Kabir,Khadija A. Shamsu,Garba Gwarzo,Sari Acra,Virginia A. Stallings,Mark Rodeghier,Michael R. DeBaun,Lauren J. Klein
View Articletitled, Feasibility trial for the management of severe acute malnutrition in older children with sickle cell anemia in Nigeria
Supplemental data
A feasibility randomized controlled trial of an mHealth app vs booklets for patient-facing guidelines in adults with SCD
Clinical Trials & Observations
Robert M. Cronin,Nives Quaye,Xin Liu,Kristina Landes,Lori E. Crosby,Adetola A. Kassim,Emmanuel J. Volanakis,Patrick M. Schnell,Michael R. DeBaun
View Articletitled, A feasibility randomized controlled trial of an mHealth app vs booklets for patient-facing guidelines in adults with SCD
Supplemental data
Myeloablative fractionated busulfan for allogeneic stem cell transplant in older patients or patients with comorbidities
Clinical Trials & Observations
Uday R. Popat,Oren Pasvolsky,Roland Bassett Jr.,Rohtesh S. Mehta,Amanda Olson,Julianne Chen,Amin M. Alousi,Gheath Al-Atrash,Qaiser Bashir,Alison M. Gulbis,Chitra M. Hosing,Jin S. Im,Partow Kebriaei,Issa Khouri,David Marin,Yago Nieto,Betul Oran,Neeraj Saini,Terri Lynn Shigle,Samer A. Srour,Jeremy L. Ramdial,Katayoun Rezvani,Muzaffar H. Qazilbash,Borje S. Andersson,Richard E. Champlin,Elizabeth J. Shpall
View Articletitled, Myeloablative fractionated busulfan for allogeneic stem cell transplant in older patients or patients with comorbidities
Supplemental data
Nivolumab for relapsed/refractory classical Hodgkin lymphoma: 5-year survival from the pivotal phase 2 CheckMate 205 study
Clinical Trials & Observations
Stephen M. Ansell,Paul J. Bröckelmann,Gottfried von Keudell,Hun Ju Lee,Armando Santoro,Pier Luigi Zinzani,Graham P. Collins,Jonathon B. Cohen,Jan Paul de Boer,John Kuruvilla,Kerry J. Savage,Marek Trněný,Mariano Provencio,Ulrich Jäger,Wolfgang Willenbacher,Rachael Wen,Alev Akyol,Joanna Mikita-Geoffroy,Margaret A. Shipp,Andreas Engert,Philippe Armand
View Articletitled, Nivolumab for relapsed/refractory classical Hodgkin lymphoma: 5-year survival from the pivotal phase 2 CheckMate 205 study
Supplemental data
More intensive therapy has a better effect for frail parents with multiple myeloma
Clinical Trials & Observations
Clark DuMontier,Jennifer La,John Bihn,June Corrigan,Cenk Yildirim,Mayuri Dharne,Hamza Hassan,Sarvari Yellapragada,Gregory A. Abel,J Michael Gaziano,Nhan V. Do,Mary Brophy,Dae H. Kim,Nikhil C. Munshi,Nathanael R. Fillmore,Jane A. Driver
View Articletitled, More intensive therapy has a better effect for frail parents with multiple myeloma
Supplemental data
Targeted therapy with nanatinostat and valganciclovir in recurrent EBV-positive lymphoid malignancies: a phase 1b/2 study
Clinical Trials & Observations
Bradley Haverkos,Onder Alpdogan,Robert Baiocchi,Jonathan E. Brammer,Tatyana A. Feldman,Marcelo Capra,Elizabeth A. Brem,Santosh Nair,Phillip Scheinberg,Juliana Pereira,Leyla Shune,Erel Joffe,Patricia Young,Susan Spruill,Afton Katkov,Robert McRae,Ivor Royston,Douglas V. Faller,Lisa Rojkjaer,Pierluigi Porcu
View Articletitled, Targeted therapy with nanatinostat and valganciclovir in recurrent EBV-positive lymphoid malignancies: a phase 1b/2 study
Supplemental data

HEMATOPOIESIS AND STEM CELLS

An in vitro model of human hematopoiesis identifies a regulatory role for the aryl hydrocarbon receptor
D M Isha Olive Khan,Peer W. F. Karmaus,Anthony Bach,Robert B. Crawford,Norbert E. Kaminski
View Articletitled, An in vitro model of human hematopoiesis identifies a regulatory role for the aryl hydrocarbon receptor
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Anti-myeloma efficacy of CAR-iNKT is enhanced with a long-acting IL-7, rhIL-7-hyFc
Julie O’Neal,Matthew L. Cooper,Julie K. Ritchey,Susan Gladney,Jessica Niswonger,L. Sofía González,Emily Street,Gabriel J. Haas,Alun Carter,Parmeshwar N. Amayta,Feng Gao,Byung Ha Lee,Donghoon Choi,Melissa Berrien-Elliott,Alice Zhou,Todd A. Fehniger,Mike P. Rettig,John F. DiPersio
View Articletitled, Anti-myeloma efficacy of CAR-iNKT is enhanced with a long-acting IL-7, rhIL-7-hyFc
Supplemental data
Mosunetuzumab in combination with CHOP in previously untreated DLBCL: safety and efficacy results from a phase 2 study
Adam J. Olszewski,Tycel J. Phillips,Marc S. Hoffmann,Philippe Armand,Tae Min Kim,Dok Hyun Yoon,Amitkumar Mehta,Richard Greil,Jason Westin,Izidore S. Lossos,Javier L. Munoz,Jason Sit,Michael C. Wei,Annie Yang,Vivian Chen,Enkhtsetseg Purev,Donald L. Yee,Ulrich Jaeger
View Articletitled, Mosunetuzumab in combination with CHOP in previously untreated DLBCL: safety and efficacy results from a phase 2 study
Supplemental data
Off-the-shelf CAR–engineered natural killer cells targeting FLT3 enhance killing of acute myeloid leukemia
Anthony G. Mansour,Kun-Yu Teng,Zhiyao Li,Zheng Zhu,Hanyu Chen,Lei Tian,Aliya Ali,Jianying Zhang,Ting Lu,Shoubao Ma,Chih-Min Lin,Michael A. Caligiuri,Jianhua Yu
View Articletitled, Off-the-shelf CAR–engineered natural killer cells targeting FLT3 enhance killing of acute myeloid leukemia
Supplemental data
Complement and platelets: prothrombotic cell activation requires membrane attack complex–induced release of danger signals
Marco Mannes,Veronika Pechtl,Susanne Hafner,Arthur Dopler,Oskar Eriksson,Vivek Anand Manivel,Lisa Wohlgemuth,David Alexander Christian Messerer,Hubert Schrezenmeier,Kristina N. Ekdahl,Bo Nilsson,Eva-Maria Jacobsen,Manfred Hoenig,Markus Huber-Lang,Christian K. Braun,Christoph Q. Schmidt
View Articletitled, Complement and platelets: prothrombotic cell activation requires membrane attack complex–induced release of danger signals
Supplemental data
ADP: the missing link between thrombosis and hemolysis
Gloria F. Gerber,Robert A. Brodsky
View Articletitled, ADP: the missing link between thrombosis and hemolysis

LYMPHOID NEOPLASIA

Uptake of long-chain fatty acids from the bone marrow suppresses CD8+ T-cell metabolism and function in multiple myeloma
Nancy Gudgeon,Hannah Giles,Emma L. Bishop,Taylor Fulton-Ward,Cristina Escribano-Gonzalez,Haydn Munford,Anna James-Bott,Kane Foster,Farheen Karim,Dedunu Jayawardana,Ansar Mahmood,Adam P. Cribbs,Daniel A. Tennant,Supratik Basu,Guy Pratt,Sarah Dimeloe
View Articletitled, Uptake of long-chain fatty acids from the bone marrow suppresses CD8<sup>+</sup> T-cell metabolism and function in multiple myeloma
Supplemental data
Predictors of treatment response and survival outcomes in patients with advanced cardiac AL amyloidosis
Clinical Trials & Observations
Joshua N. Gustine,Andrew Staron,Lisa Mendelson,Tracy Joshi,Deepa M. Gopal,Omar K. Siddiqi,Frederick L. Ruberg,Vaishali Sanchorawala
View Articletitled, Predictors of treatment response and survival outcomes in patients with advanced cardiac AL amyloidosis
Supplemental data
PRMT5 inhibition drives therapeutic vulnerability to combination treatment with BCL-2 inhibition in mantle cell lymphoma
Clinical Trials & Observations
Fiona Brown-Burke,Inah Hwang,Shelby Sloan,Claire Hinterschied,JoBeth Helmig-Mason,Mackenzie Long,Wing Keung Chan,Alexander Prouty,Ji-Hyun Chung,Yang Zhang,Satishkumar Singh,Youssef Youssef,Neha Bhagwat,Zhengming Chen,Selina Chen-Kiang,Maurizio Di Liberto,Olivier Elemento,Lalit Sehgal,Lapo Alinari,Kris Vaddi,Peggy Scherle,Rosa Lapalombella,Jihye Paik,Robert A. Baiocchi
View Articletitled, PRMT5 inhibition drives therapeutic vulnerability to combination treatment with BCL-2 inhibition in mantle cell lymphoma
Supplemental data
Resistance mechanism to Notch inhibition and combination therapy in human T-cell acute lymphoblastic leukemia
Linlin Cao,Gustavo A. Ruiz Buendía,Nadine Fournier,Yuanlong Liu,Florence Armand,Romain Hamelin,Maria Pavlou,Freddy Radtke
View Articletitled, Resistance mechanism to Notch inhibition and combination therapy in human T-cell acute lymphoblastic leukemia
Supplemental data

MYELOID NEOPLASIA

Samples from patients with AML show high concordance in detection of mutations by NGS at local institutions vs central laboratories
Clinical Trials & Observations
Uma Borate,Fei Yang,Richard Press,Amy S. Ruppert,Dan Jones,Sean Caruthers,Weiqiang Zhao,Jo-Anne Vergilio,Dean C. Pavlick,Luke Juckett,Brianna Norris,Taylor Bucy,Amy Burd,Eytan M. Stein,Prapti Patel,Maria R. Baer,Wendy Stock,Gary Schiller,William Blum,Tibor Kovacsovics,Mark Litzow,James Foran,Nyla A. Heerema,Leonard Rosenberg,Sonja Marcus,Ashley Yocum,Mona Stefanos,Brian Druker,John C. Byrd,Ross L. Levine,Alice Mims
View Articletitled, Samples from patients with AML show high concordance in detection of mutations by NGS at local institutions vs central laboratories
Supplemental data
Somatic mutational landscape of hereditary hematopoietic malignancies caused by germline variants in RUNX1, GATA2, and DDX41
Claire C. Homan,Michael W. Drazer,Kai Yu,David M. Lawrence,Jinghua Feng,Luis Arriola-Martinez,Matthew J. Pozsgai,Kelsey E. McNeely,Thuong Ha,Parvathy Venugopal,Peer Arts,Sarah L. King-Smith,Jesse Cheah,Mark Armstrong,Paul Wang,Csaba Bödör,Alan B. Cantor,Mario Cazzola,Erin Degelman,Courtney D. DiNardo,Nicolas Duployez,Remi Favier,Stefan Fröhling,Ana Rio-Machin,Jeffery M. Klco,Alwin Krämer,Mineo Kurokawa,Joanne Lee,Luca Malcovati,Neil V. Morgan,Georges Natsoulis,Carolyn Owen,Keyur P. Patel,Claude Preudhomme,Hana Raslova,Hugh Rienhoff,Tim Ripperger,Rachael Schulte,Kiran Tawana,Elvira Velloso,Benedict Yan,Erika Kim,Raman Sood,Amy P. Hsu,Steven M. Holland,Kerry Phillips,Nicola K. Poplawski,Milena Babic,Andrew H. Wei,Cecily Forsyth,Helen Mar Fan,Ian D. Lewis,Julian Cooney,Rachel Susman,Lucy C. Fox,Piers Blombery,Deepak Singhal,Devendra Hiwase,Belinda Phipson,Andreas W. Schreiber,Christopher N. Hahn,Hamish S. Scott,Paul Liu,Lucy A. Godley,Anna L. Brown
View Articletitled, Somatic mutational landscape of hereditary hematopoietic malignancies caused by germline variants in <em>RUNX1</em>, <em>GATA2</em>, and <em>DDX41</em>
Supplemental data
Discordant pathologic diagnoses of myelodysplastic neoplasms and their implications for registries and therapies
Clinical Trials & Observations
Edward J. Gorak,Michael Otterstatter,Tareq Al Baghdadi,Nancy Gillis,James M. Foran,Jane Jijun Liu,Rafael Bejar,Steven D. Gore,Steven H. Kroft,Alexandra Harrington,Wael Saber,Daniel Starczynowski,Dana E. Rollison,Ling Zhang,Lynn Moscinski,Steffanie Wilson,Jason Thompson,Christine Borchert,Seth Sherman,Donnie Hebert,Mary Ellen Walker,Eric Padron,Amy E. DeZern,Mikkael A. Sekeres
View Articletitled, Discordant pathologic diagnoses of myelodysplastic neoplasms and their implications for registries and therapies
Supplemental data
A novel GATA2 distal enhancer mutation results in MonoMAC syndrome in 2 second cousins
Robert R. West,Thomas R. Bauer, Jr.,Laura M. Tuschong,Lisa J. Embree,Katherine R. Calvo,Desiree Tillo,Joie Davis,Steven M. Holland,Dennis D. Hickstein
View Articletitled, A novel <em>GATA2</em> distal enhancer mutation results in MonoMAC syndrome in 2 second cousins
Supplemental data

PLATELETS AND THROMBOPOIESIS

High-throughput microfluidic blood testing to phenotype genetically linked platelet disorders: an aid to diagnosis
Delia I. Fernandez,Isabella Provenzale,Matthias Canault,Salome Fels,Antonia Lenz,Felicia Andresen,Anne Krümpel,Arnaud Dupuis,Johan W. M. Heemskerk,Doris Boeckelmann,Barbara Zieger
View Articletitled, High-throughput microfluidic blood testing to phenotype genetically linked platelet disorders: an aid to diagnosis
Supplemental data
The fate of mitochondria during platelet activation
Alexei Grichine,Shancy Jacob,Anita Eckly,Joran Villaret,Clotilde Joubert,Florence Appaix,Mylène Pezet,Anne-Sophie Ribba,Eric Denarier,Jacques Mazzega,Jean-Yves Rinckel,Laurence Lafanechère,Bénédicte Elena-Herrmann,Jesse W. Rowley,Karin Sadoul
View Articletitled, The fate of mitochondria during platelet activation
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Defining a cohort of anemia-activated cis elements reveals a mechanism promoting erythroid precursor function
Yichao Zhou,Venkatasai Rahul Dogiparthi,Suhita Ray,Meg A. Schaefer,Hannah L. Harris,M. Jordan Rowley,Kyle J. Hewitt
View Articletitled, Defining a cohort of anemia-activated cis elements reveals a mechanism promoting erythroid precursor function
Supplemental data

THROMBOSIS AND HEMOSTASIS

Small interfering RNA–mediated allele-selective silencing of von Willebrand factor in vitro and in vivo
Yvonne K. Jongejan,Elisa Schrader Echeverri,Richard J. Dirven,Kalina Paunovska,Noa A. Linthorst,Annika de Jong,Johannes C. Wellershoff,Kim D. van der Gouw,Bart J. M. van Vlijmen,James E. Dahlman,Jeroen C. J. Eikenboom
View Articletitled, Small interfering RNA–mediated allele-selective silencing of von Willebrand factor in vitro and in vivo
Supplemental data
Comparison of thromboembolism outcomes in patients with sickle cell disease prescribed hormonal contraception
Natasha S. Bala,Joseph R. Stanek,Sara K. Vesely,Robert M. Cronin,Susan E. Creary,Andrea H. Roe,Wendy Xu,Sarah H. O’Brien
View Articletitled, Comparison of thromboembolism outcomes in patients with sickle cell disease prescribed hormonal contraception
Supplemental data

TRANSPLANTATION

Ultrasensitive chimerism enhances measurable residual disease testing after allogeneic hematopoietic cell transplantation
Clinical Trials & Observations
Sami B. Kanaan,Francesca Urselli,Jerald P. Radich,J. Lee Nelson
View Articletitled, Ultrasensitive chimerism enhances measurable residual disease testing after allogeneic hematopoietic cell transplantation
Supplemental data

RESEARCH LETTERS

Cardiac involvement resolution is frequent and associated with improved outcome in Erdheim-Chester disease
Clinical Trials & Observations
Lévi-Dan Azoulay,Marine Bravetti,Fleur Cohen-Aubart,Jean-Francois Emile,Frederic Charlotte,Zahir Amoura,Philippe Cluzel,Julien Haroche
View Articletitled, Cardiac involvement resolution is frequent and associated with improved outcome in Erdheim-Chester disease
Supplemental data
Free interleukin-18 is elevated in CD22 CAR T-cell–associated hemophagocytic lymphohistiocytosis–like toxicities
Clinical Trials & Observations
Joseph M. Rocco,Jon Inglefield,Bonnie Yates,Daniel A. Lichtenstein,Yanyu Wang,Laurence Goffin,Djordje Filipovic,Eduardo J. Schiffrin,Nirali N. Shah
View Articletitled, Free interleukin-18 is elevated in CD22 CAR T-cell–associated hemophagocytic lymphohistiocytosis–like toxicities
Supplemental data
Use of flow cytometric light scattering to recognize the characteristic vacuolated marrow cells in VEXAS syndrome
Yanna Ding,Alina E. Dulau-Florea,Emma M. Groarke,Bhavisha A. Patel,David B. Beck,Peter C. Grayson,Marcela A. Ferrada,Neal S. Young,Katherine R. Calvo,Raul C. Braylan
View Articletitled, Use of flow cytometric light scattering to recognize the characteristic vacuolated marrow cells in VEXAS syndrome
Supplemental data
Comparison of MHG and DZsig reveals shared biology and a core overlap group with inferior prognosis in DLBCL
John R. Davies,Laura K. Hilton,Aixiang Jiang,Sharon Barrans,Catherine Burton,Peter W. M. Johnson,Andrew J. Davies,Ming-Qing Du,Reuben Tooze,Francesco Cucco,Matthew A. Care,Ryan D. Morin,Christian Steidl,Chulin Sha,David R. Westhead,David W. Scott
View Articletitled, Comparison of MHG and DZsig reveals shared biology and a core overlap group with inferior prognosis in DLBCL
Supplemental data
Combining BCMA-targeting CAR T cells with TCR-engineered T-cell therapy to prevent immune escape of multiple myeloma
Tassilo L. A. Wachsmann,Miranda H. Meeuwsen,Dennis F. G. Remst,Karen Buchner,Anne K. Wouters,Renate S. Hagedoorn,J. H. Frederik Falkenburg,Mirjam H. M. Heemskerk
View Articletitled, Combining BCMA-targeting CAR T cells with TCR-engineered T-cell therapy to prevent immune escape of multiple myeloma
Supplemental data
Outcomes of axicabtagene ciloleucel in PMBCL compare favorably with those in DLBCL: a GLA/DRST registry study
Maria-Luisa Schubert,Wolfgang A. Bethge,Francis A. Ayuk,Malte von Bonin,Vladan Vucinic,Eva Marie Wagner-Drouet,Marion Subklewe,Claudia D. Baldus,Bertram Glass,Reinhard Marks,Dimitrios Mougiakakos,Roland Schroers,Matthias Stelljes,Max S. Topp,Gerald Wulf,Nicolaus Kröger,Peter Dreger,on behalf of the German Lymphoma Alliance and the German Registry for Stem Cell Transplantation
View Articletitled, Outcomes of axicabtagene ciloleucel in PMBCL compare favorably with those in DLBCL: a GLA/DRST registry study
Supplemental data
The overlap of skin and blood T-cell clones in early-stage mycosis fungoides
Clinical Trials & Observations
Daniel Joffe,Safiyyah Bhatti,Lauren Banner,Romsin Zaya,Laura Gleason,Anjali Mishra,Ilan Kirsch,Pierluigi Porcu,Neda Nikbakht
View Articletitled, The overlap of skin and blood T-cell clones in early-stage mycosis fungoides
Supplemental data
Digital pathology in pediatric nodular lymphocyte-predominant Hodgkin lymphoma: correlation with treatment response
Sergej Sereda,Ananth Shankar,Luise Weber,Alan D. Ramsay,Georgina W. Hall,Janis Hayward,William Hamish B. Wallace,Judith Landman-Parker,Andreas Braeuninger,Dirk Hasenclever,Astrid Schneider,Christine Mauz-Koerholz,Dieter Koerholz,Stefan Gattenloehner
View Articletitled, Digital pathology in pediatric nodular lymphocyte-predominant Hodgkin lymphoma: correlation with treatment response
Supplemental data
CD19 CAR T-cell therapy demonstrates activity against extramedullary disease in pediatric patients with B-ALL
Clinical Trials & Observations
Rebecca Epperly,Barry L. Shulkin,Asim K. Bag,Cheng Cheng,Hiroto Inaba,John T. Lucas, Jr.,Swati Naik,Brandon M. Triplett,Stephen Gottschalk,Aimee C. Talleur
View Articletitled, CD19 CAR T-cell therapy demonstrates activity against extramedullary disease in pediatric patients with B-ALL
Supplemental data

ERRATUM

Alquezar-Artieda N, Kuzilkova D, Roberts J, et al. Restored biosynthetic pathways induced by MSCs serve as rescue mechanism in leukemia cells after L-asparaginase therapy. Blood Adv. 2023;7(10):2228-2236.
View Articletitled, Alquezar-Artieda N, Kuzilkova D, Roberts J, et al. Restored biosynthetic pathways induced by MSCs serve as rescue mechanism in leukemia cells after L-asparaginase therapy. <em>Blood Adv</em>. 2023;7(10):2228-2236.
  • Cover Image

    Cover Image

    issue cover

    A platelet at the onset of collagen-induced activation. Most platelet mitochondria (light gray) are located within the encircled center, but some have escaped to peripheral locations. See the article by Grichine et al.

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