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Issue Archive

Volume 5, Issue 20
October 26 2021
Issue Cover

Table of Contents

BLOOD ADVANCES TALK

Why is AAV FVIII gene therapy not approved by the US Food and Drug Administration yet?
Clinical Trials & Observations
Valder R. Arruda
View Articletitled, Why is AAV FVIII gene therapy not approved by the US Food and Drug Administration yet?
Supplemental data

CLINICAL GUIDELINES

American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: May 2021 update on the use of intermediate-intensity anticoagulation in critically ill patients
Adam Cuker,Eric K. Tseng,Robby Nieuwlaat,Pantep Angchaisuksiri,Clifton Blair,Kathryn Dane,Jennifer Davila,Maria T. DeSancho,David Diuguid,Daniel O. Griffin,Susan R. Kahn,Frederikus A. Klok,Alfred Ian Lee,Ignacio Neumann,Ashok Pai,Marc Righini,Kristen M. Sanfilippo,Deborah Siegal,Mike Skara,Deirdra R. Terrell,Kamshad Touri,Elie A. Akl,Imad Bou Akl,Antonio Bognanni,Mary Boulos,Romina Brignardello-Petersen,Rana Charide,Matthew Chan,Karin Dearness,Andrea J. Darzi,Philipp Kolb,Luis E. Colunga-Lozano,Razan Mansour,Gian Paolo Morgano,Rami Z. Morsi,Giovanna Muti-Schünemann,Atefeh Noori,Binu A. Philip,Thomas Piggott,Yuan Qiu,Yetiani Roldan,Finn Schünemann,Adrienne Stevens,Karla Solo,Wojtek Wiercioch,Reem A. Mustafa,Holger J. Schünemann
View Articletitled, American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: May 2021 update on the use of intermediate-intensity anticoagulation in critically ill patients
Supplemental data

EXCEPTIONAL CASE REPORTS

Anticoagulant therapy in patients with congenital FXI deficiency
Clinical Trials & Observations
Carlos Bravo-Pérez,María Jose Serna,Julio Esteban,Eugenia Fernandez-Mellid,Emilia Fontanes-Trabazo,Alvaro Lorenzo,Michael Calviño-Suárez,Antonia Miñano,José Padilla,Vanessa Roldán,Vicente Vicente,Javier Corral,María Eugenia de la Morena-Barrio
View Articletitled, Anticoagulant therapy in patients with congenital FXI deficiency

STIMULUS REPORTS

Long-term outcome of hyper-CVAD-R for Burkitt leukemia/lymphoma and high-grade B-cell lymphoma: focus on CNS relapse
Clinical Trials & Observations
Bachar Samra,Joseph D. Khoury,Kiyomi Morita,Farhad Ravandi,Guillaume Richard-Carpentier,Nicholas J. Short,Siba El Hussein,Philip Thompson,Nitin Jain,Hagop Kantarjian,Elias Jabbour
View Articletitled, Long-term outcome of hyper-CVAD-R for Burkitt leukemia/lymphoma and high-grade B-cell lymphoma: focus on CNS relapse
Supplemental data
Outcomes of patients with CLL sequentially resistant to both BCL2 and BTK inhibition
Clinical Trials & Observations
Thomas E. Lew,Victor S. Lin,Edward R. Cliff,Piers Blombery,Ella R. Thompson,Sasanka M. Handunnetti,David A. Westerman,Bryone J. Kuss,Constantine S. Tam,David C. S. Huang,John F. Seymour,Andrew W. Roberts,Mary Ann Anderson
View Articletitled, Outcomes of patients with CLL sequentially resistant to both BCL2 and BTK inhibition
Supplemental data
CD19-directed CAR T-cell therapy for treatment of primary CNS lymphoma
Clinical Trials & Observations
Tanya Siddiqi,Xiuli Wang,M. Suzette Blanchard,Jamie R. Wagner,Leslie L. Popplewell,L. Elizabeth Budde,Tracey L. Stiller,Mary C. Clark,Laura Lim,Vibhuti Vyas,Christine E. Brown,Stephen J. Forman
View Articletitled, CD19-directed CAR T-cell therapy for treatment of primary CNS lymphoma
Supplemental data
Blood transfusion trends in the United States: national inpatient sample, 2015 to 2018
Clinical Trials & Observations
Ruchika Goel,Xianming Zhu,Eshan U. Patel,Elizabeth P. Crowe,Paul M. Ness,Louis M. Katz,Evan M. Bloch,Aaron A.R. Tobian
View Articletitled, Blood transfusion trends in the United States: national inpatient sample, 2015 to 2018
Supplemental data
Gata2 haploinsufficiency promotes proliferation and functional decline of hematopoietic stem cells with myeloid bias during aging
Ali Abdelfattah,Antonia Hughes-Davies,Liam Clayfield,Juan Bautista Menendez-Gonzalez,Alhomidi Almotiri,Badi Alotaibi,Alex Tonks,Neil P. Rodrigues
View Articletitled, Gata2 haploinsufficiency promotes proliferation and functional decline of hematopoietic stem cells with myeloid bias during aging
Supplemental data

REVIEW ARTICLE

Adoptive T-cell therapy for Hodgkin lymphoma
Carrie Ho,Marco Ruella,Bruce L. Levine,Jakub Svoboda
View Articletitled, Adoptive T-cell therapy for Hodgkin lymphoma
Follicular lymphoma and macrophages: impact of approved and novel therapies
Sushanth Gouni,Mario L. Marques-Piubelli,Paolo Strati
View Articletitled, Follicular lymphoma and macrophages: impact of approved and novel therapies
Population pharmacokinetic modeling of factor concentrates in hemophilia: an overview and evaluation of best practice
Tine M. H. J. Goedhart,Laura H. Bukkems,C. Michel Zwaan,Ron A. A. Mathôt,Marjon H. Cnossen,for the OPTI-CLOT study group and SYMPHONY consortium
View Articletitled, Population pharmacokinetic modeling of factor concentrates in hemophilia: an overview and evaluation of best practice

SYSTEMATIC REVIEW

A systematic review of the association between anti-β-2 glycoprotein I antibodies and APS manifestations
Debbie Jiang,Wendy Lim,Mark Crowther,David Garcia
View Articletitled, A systematic review of the association between anti-β-2 glycoprotein I antibodies and APS manifestations

CLINICAL TRIALS AND OBSERVATIONS

A phase 1/2 study of thiotepa-based immunochemotherapy in relapsed/refractory primary CNS lymphoma: the TIER trial
Clinical Trials & Observations
Christopher P. Fox,Ayesha S. Ali,Graham McIlroy,Steffi Thust,Nicolás Martinez-Calle,Aimee E. Jackson,Louise M. Hopkins,Catherine M. Thomas,Shireen Kassam,Josh Wright,Sridhar Chaganti,Jeffery Smith,Ian Chau,Dominic Culligan,Kim M. Linton,Graham P. Collins,Andrés J. M. Ferreri,David Lewis,Andrew J. Davies,Rod Johnson,Dorothee P. Auer,Kate Cwynarski
View Articletitled, A phase 1/2 study of thiotepa-based immunochemotherapy in relapsed/refractory primary CNS lymphoma: the TIER trial
Supplemental data
Therapy-related myeloid neoplasms in 109 patients after radiation monotherapy
Clinical Trials & Observations
Anand Ashwin Patel,Alexandra E. Rojek,Michael W. Drazer,Howard Weiner,Lucy A. Godley,Michelle M. Le Beau,Richard A. Larson
View Articletitled, Therapy-related myeloid neoplasms in 109 patients after radiation monotherapy
Supplemental data
Improved survival of patients with aggressive ATL by increased use of allo-HCT: a prospective observational study
Clinical Trials & Observations
Ayumu Ito,Nobuaki Nakano,Takashi Tanaka,Shigeo Fuji,Junya Makiyama,Yoshitaka Inoue,Ilseung Choi,Hirohisa Nakamae,Koji Nagafuji,Ken Takase,Shinichiro Machida,Tsutomu Takahashi,Yasushi Sawayama,Tomohiko Kamimura,Koji Kato,Toshiro Kawakita,Masao Ogata,Rika Sakai,Souichi Shiratori,Kaoru Uchimaru,Yoshihiro Inamoto,Atae Utsunomiya,Takahiro Fukuda
View Articletitled, Improved survival of patients with aggressive ATL by increased use of allo-HCT: a prospective observational study
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Abnormal B-cell development in TIMP-deficient bone marrow
Ashley Weiss,Sanjay Saw,Alison Aiken,Kazeera Aliar,Yang W. Shao,Hui Fang,Swami Narala,Ronak Shetty,Paul D. Waterhouse,Rama Khokha
View Articletitled, Abnormal B-cell development in TIMP-deficient bone marrow
Supplemental data
TLR7 ligation augments hematopoiesis in Rps14 (uS11) deficiency via paradoxical suppression of inflammatory signaling
Oscar A. Peña,Alexandra Lubin,Catherine Hockings,Jasmine Rowell,Youngrock Jung,Yvette Hoade,Phoebe Dace,Leonardo E. Valdivia,Karin Tuschl,Charlotta Böiers,Maria C. Virgilio,Simon Richardson,Elspeth M. Payne
View Articletitled, TLR7 ligation augments hematopoiesis in Rps14 (uS11) deficiency via paradoxical suppression of inflammatory signaling
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Altered microbiota-host metabolic cross talk preceding neutropenic fever in patients with acute leukemia
Clinical Trials & Observations
Armin Rashidi,Maryam Ebadi,Tauseef Ur Rehman,Heba Elhusseini,Harika Nalluri,Thomas Kaiser,Sivapriya Ramamoorthy,Shernan G. Holtan,Alexander Khoruts,Daniel J. Weisdorf,Christopher Staley
View Articletitled, Altered microbiota-host metabolic cross talk preceding neutropenic fever in patients with acute leukemia
Supplemental data
Antagonism of inhibitors of apoptosis proteins reveals a novel, immune response-based therapeutic approach for T-cell lymphoma
Nicola Ferrari,George Ward,Christina Gewinner,Matthew P. Davis,Simone Jueliger,Harpreet Saini,Joanne Munck,Tomoko Smyth,Roberta Ferraldeschi,Harold Keer,John Lyons,Martin J. Sims
View Articletitled, Antagonism of inhibitors of apoptosis proteins reveals a novel, immune response-based therapeutic approach for T-cell lymphoma
Supplemental data

LYMPHOID NEOPLASIA

Genetic profiles of subcutaneous panniculitis-like T-cell lymphoma and clinicopathological impact of HAVCR2 mutations
Clinical Trials & Observations
Jiwon Koh,Insoon Jang,Seungchan Mun,Cheol Lee,Hee Jeong Cha,Young Ha Oh,Jin-Man Kim,Jae Ho Han,Jin Ho Paik,Junhun Cho,Young Hyeh Ko,Chan-Sik Park,Heounjeong Go,Jooryung Huh,Kwangsoo Kim,Yoon Kyung Jeon
View Articletitled, Genetic profiles of subcutaneous panniculitis-like T-cell lymphoma and clinicopathological impact of <em>HAVCR2</em> mutations
Supplemental data
Heterogeneous modulation of Bcl-2 family members and drug efflux mediate MCL-1 inhibitor resistance in multiple myeloma
Arnold Bolomsky,Juho J. Miettinen,Alina Malyutina,Andrej Besse,Julia Huber,Stefanie Fellinger,Helene Breid,Alun Parsons,Kristaps Klavins,J. Thomas Hannich,Stefan Kubicek,Jo Caers,Wolfgang Hübl,Martin Schreder,Niklas Zojer,Christoph Driessen,Jing Tang,Lenka Besse,Caroline A. Heckman,Heinz Ludwig
View Articletitled, Heterogeneous modulation of Bcl-2 family members and drug efflux mediate MCL-1 inhibitor resistance in multiple myeloma
Supplemental data
Comparison of 2-year outcomes with CAR T cells (ZUMA-1) vs salvage chemotherapy in refractory large B-cell lymphoma
Clinical Trials & Observations
Sattva S. Neelapu,Frederick L. Locke,Nancy L. Bartlett,Lazaros J. Lekakis,Patrick M. Reagan,David B. Miklos,Caron A. Jacobson,Ira Braunschweig,Olalekan O. Oluwole,Tanya Siddiqi,Yi Lin,Michael Crump,John Kuruvilla,Eric Van Den Neste,Umar Farooq,Lynn Navale,Venita DePuy,Jenny J. Kim,Christian Gisselbrecht
View Articletitled, Comparison of 2-year outcomes with CAR T cells (ZUMA-1) vs salvage chemotherapy in refractory large B-cell lymphoma
Supplemental data
Excellent response to very-low-dose radiation (4 Gy) for indolent B-cell lymphomas: is 4 Gy suitable for curable patients?
Clinical Trials & Observations
Brandon S. Imber,Karen W. Chau,Jasme Lee,Jisun Lee,Dana L. Casey,Joanna C. Yang,N. Ari Wijentunga,Annemarie Shepherd,Carla Hajj,Shunan Qi,Monica R. Chelius,Paul A. Hamlin,M. Lia Palomba,Erel Joffe,Zhigang Zhang,Andrew D. Zelenetz,Gilles A. Salles,Joachim Yahalom
View Articletitled, Excellent response to very-low-dose radiation (4 Gy) for indolent B-cell lymphomas: is 4 Gy suitable for curable patients?
Supplemental data
Next-generation sequencing–based monitoring of circulating tumor DNA reveals clonotypic heterogeneity in untreated PTCL
Clinical Trials & Observations
Milos D. Miljkovic,Christopher Melani,Stefania Pittaluga,Rahul Lakhotia,Nicole Lucas,Allison Jacob,Erik Yusko,Elaine S. Jaffe,Wyndham H. Wilson,Mark Roschewski
View Articletitled, Next-generation sequencing–based monitoring of circulating tumor DNA reveals clonotypic heterogeneity in untreated PTCL
Supplemental data

MYELOID NEOPLASIA

Exogenous mitochondrial transfer and endogenous mitochondrial fission facilitate AML resistance to OxPhos inhibition
Kaori Saito,Qi Zhang,Haeun Yang,Kotoko Yamatani,Tomohiko Ai,Vivian Ruvolo,Natalia Baran,Tianyu Cai,Helen Ma,Rodrigo Jacamo,Vinitha Kuruvilla,Junichi Imoto,Sonoko Kinjo,Kazuho Ikeo,Kaori Moriya,Koya Suzuki,Takashi Miida,Yong-Mi Kim,Christopher P. Vellano,Michael Andreeff,Joseph R. Marszalek,Yoko Tabe,Marina Konopleva
View Articletitled, Exogenous mitochondrial transfer and endogenous mitochondrial fission facilitate AML resistance to OxPhos inhibition
Supplemental data

PLATELETS AND THROMBOPOIESIS

Multiparameter phenotyping of platelet reactivity for stratification of human cohorts
Joanne L. Dunster,Alexander P. Bye,Neline Kriek,Tanya Sage,Joanne L. Mitchell,Carly Kempster,Joana Batista,Harriet McKinney,Patrick Thomas,Chris I. Jones,Kate Downes,Amanda J. Unsworth,Jonathan M. Gibbins
View Articletitled, Multiparameter phenotyping of platelet reactivity for stratification of human cohorts
Supplemental data
Abnormalities of bone marrow B cells and plasma cells in primary immune thrombocytopenia
Tian-shu Yu,Hao-yi Wang,Ya-jing Zhao,Ya-fei Yu,Yu Hou,Shuang Liu,Pan-pan Han,Xiao-fei Ni,Xue-bin Ji,Jun Peng,Xin-guang Liu,Ming Hou
View Articletitled, Abnormalities of bone marrow B cells and plasma cells in primary immune thrombocytopenia
Supplemental data
Blood–brain barrier permeability in survivors of immune-mediated thrombotic thrombocytopenic purpura: a pilot study
Clinical Trials & Observations
Shih-Han Susan Huang,Katerina Pavenski,Ting-Yim Lee,Michael T. Jurkiewicz,Aditya Bharatha,Jonathan Dale Thiessen,Keith St. Lawrence,Jean Théberge,Jennifer Mandzia,David Barth,Christoph Licht,Christopher Jordan Patriquin
View Articletitled, Blood–brain barrier permeability in survivors of immune-mediated thrombotic thrombocytopenic purpura: a pilot study
Supplemental data
Platelet variability index: a measure of platelet count fluctuations in patients with immune thrombocytopenia
Clinical Trials & Observations
Na Li,Nancy M. Heddle,Ishac Nazy,John G. Kelton,Donald M. Arnold
View Articletitled, Platelet variability index: a measure of platelet count fluctuations in patients with immune thrombocytopenia
Supplemental data
A novel mechanism of thrombocytopenia by PS exposure through TMEM16F in sphingomyelin synthase 1 deficiency
Yoritaka Fujii,Makoto Taniguchi,Shingo Nagaya,Yoshibumi Ueda,Chieko Hashizume,Ken Watanabe,Hiroyuki Takeya,Takeo Kosaka,Toshiro Okazaki
View Articletitled, A novel mechanism of thrombocytopenia by PS exposure through TMEM16F in sphingomyelin synthase 1 deficiency
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

A new murine Rpl5 (uL18) mutation provides a unique model of variably penetrant Diamond-Blackfan anemia
Lei Yu,Philippe Lemay,Alexander Ludlow,Marie-Claude Guyot,Morgan Jones,Fatma F. Mohamed,Ghazi-Abdullah Saroya,Christopher Panaretos,Emily Schneider,Yu Wang,Greggory Myers,Rami Khoriaty,Qing Li,Renny Franceschi,James Douglas Engel,Vesa Kaartinen,Thomas L. Rothstein,Monica J. Justice,Zoha Kibar,Sharon A. Singh
View Articletitled, A new murine <em>Rpl5</em> (<em>uL18</em>) mutation provides a unique model of variably penetrant Diamond-Blackfan anemia
Supplemental data

THROMBOSIS AND HEMOSTASIS

Platelet binding to polymerizing fibrin is avidity driven and requires activated αIIbβ3 but not fibrin cross-linking
Lorena Buitrago,Samuel Lefkowitz,Ohad Bentur,Julio Padovan,Barry Coller
View Articletitled, Platelet binding to polymerizing fibrin is avidity driven and requires activated αIIbβ3 but not fibrin cross-linking
Supplemental data
Pregnancy in women with an inferior vena cava filter: a tertiary center experience and overview of the literature
Clinical Trials & Observations
Ingrid M. Bistervels,Abby E. Geerlings,Peter I. Bonta,Wessel Ganzevoort,IJsbrand A.J. Zijlstra,Saskia Middeldorp
View Articletitled, Pregnancy in women with an inferior vena cava filter: a tertiary center experience and overview of the literature
Supplemental data
Late-occurring venous thromboembolism in allogeneic blood or marrow transplant survivors: a BMTSS-HiGHS2 risk model
Clinical Trials & Observations
Radhika Gangaraju,Yanjun Chen,Lindsey Hageman,Jessica Wu,Liton Francisco,Michelle Kung,Daniel J. Weisdorf,Stephen J. Forman,Mukta Arora,Saro H. Armenian,Smita Bhatia
View Articletitled, Late-occurring venous thromboembolism in allogeneic blood or marrow transplant survivors: a BMTSS-HiGHS2 risk model

TRANSFUSION MEDICINE

Transfusion of target antigens to preimmunized recipients: a new mechanism in transfusion-related acute lung injury
Behnaz Bayat,Kaspar René Nielsen,Gregor Bein,Annalena Traum,Monika Burg-Roderfeld,Ulrich J. Sachs
View Articletitled, Transfusion of target antigens to preimmunized recipients: a new mechanism in transfusion-related acute lung injury
Supplemental data

TRANSPLANTATION

Treatment of allosensitized patients receiving allogeneic transplantation
Clinical Trials & Observations
Stefan O. Ciurea,Monzr M. Al Malki,Piyanuch Kongtim,Jun Zou,Fleur M. Aung,Gabriela Rondon,Julianne Chen,Michiko Taniguchi,Salman Otoukesh,Auayporn Nademanee,Stephen J. Forman,Richard Champlin,Ketevan Gendzekhadze,Kai Cao
View Articletitled, Treatment of allosensitized patients receiving allogeneic transplantation
Comparison of haploidentical and umbilical cord blood transplantation after myeloablative conditioning
Clinical Trials & Observations
John E. Wagner, Jr,Karen K. Ballen,Mei-Jie Zhang,Mariam Allbee-Johnson,Chatchada Karanes,Filippo Milano,Michael R. Verneris,Mary Eapen,Claudio G. Brunstein
View Articletitled, Comparison of haploidentical and umbilical cord blood transplantation after myeloablative conditioning
Supplemental data
Activation status dictates the function of unlicensed natural killer cells in mice and humans
Ethan G. Aguilar,Cordelia Dunai,Sean J. Judge,Anthony E. Zamora,Lam T. Khuat,Logan V. Vick,Craig P. Collins,Kevin M. Stoffel,Maite Alvarez,Isabel Barao,Jeffrey S. Miller,Bruce R. Blazar,Patrice Chevallier,Christelle Retiere,Robert J. Canter,William J. Murphy
View Articletitled, Activation status dictates the function of unlicensed natural killer cells in mice and humans
Supplemental data
Nonrelapse mortality among patients diagnosed with chronic GVHD: an updated analysis from the Chronic GVHD Consortium
Clinical Trials & Observations
Zachariah DeFilipp,Amin M. Alousi,Joseph A. Pidala,Paul A. Carpenter,Lynn E. Onstad,Sally Arai,Mukta Arora,Corey S. Cutler,Mary E. D. Flowers,Carrie L. Kitko,George L. Chen,Stephanie J. Lee,Betty K. Hamilton
View Articletitled, Nonrelapse mortality among patients diagnosed with chronic GVHD: an updated analysis from the Chronic GVHD Consortium
Supplemental data
  • Cover Image

    Cover Image

    issue cover

    Platelets and fibrin during clot retraction. Thrombin (0.2 U/ml) and CaCl2 (2 mM) were added to washed platelets, and the sample was fixed after 15 minutes and analyzed by scanning electron microscopy. Original magnification ×44,600. See the article by Buitrago et al.

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