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Kylee H. Maclachlan
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Journal Articles

High WEE1 Expression Correlates with Poor Survival in Multiple Myeloma, Independent of Standard Prognostic Factors

Anish Kumar Simhal, Ross S Firestone, Jung Hun Oh, Larry Norton, Malin Hultcrantz, Saad Z. Usmani, Kylee H Maclachlan, Joseph O. Deasy
Journal: Blood
Blood (2024) 144 (Supplement 1): 6827.
https://doi.org/10.1182/blood-2024-205838
Published: 2024
Journal Articles

Genomic Complexity Correlates with the Degree of Marrow Independence of Malignant Plasma Cells in the Context of Extramedullary Disease

Kylee H Maclachlan, Juan-Jose Garces, Tala Shekarkhand, Sridevi Rajeeve, Hamza Hashmi, Hani Hassoun, Malin Hultcrantz, Neha Korde, Carlyn Rose Tan, Sham Mailankody, Anish Simhal, David J. Chung, Gunjan L. Shah, Michael Scordo, Sergio Giralt, Alexandra Maria Poos, Lukas John, Yanming Zhang, Robert Cimera, Maria E. Arcila, Juan E Arango Ossa, Umesh Bhanot, Mala Jain, Tala Merghoub, Heather J. Landau, Alexander M. Lesokhin, Saad Z. Usmani, Niels Weinhold, Francesco Maura, Urvi A. Shah
Journal: Blood
Blood (2024) 144 (Supplement 1): 248.
https://doi.org/10.1182/blood-2024-204341
Published: 2024
Journal Articles

Genomic Determinants of Resistance to Anti-BCMA Chimeric Antigen Receptor T-Cell (CART) Therapies in Patients with Relapsed/Refractory Multiple Myeloma

Francesco Maura, Ciara Louise Freeman, Holly Lee, Kylee H Maclachlan, Michael Durante, Bachisio Ziccheddu, Meghan Menges, Benjamin Diamond, Marios Papadimitriou, Ariosto Siqueira Silva, Praneeth Reddy Sudalagunta, Noemie Leblay, Sungwoo Ahn, Ethan Fuller, Edward Briercheck, Phaedra Agius, Doris K. Hansen, Xiaofei Song, Xiaohong Zhao, Mark B. Meads, Jamie Teer, Ross S Firestone, Juan-Jose Garces, Tomas Jelinek, Rachid Baz, Melissa Alsina, Anusuyam Ramasubramanian, Eric Smith, Sergio Giralt, Sham Mailankody, Paola Neri, Saad Z. Usmani, Frederick Locke, Nizar J. Bahlis, Ola Landgren, Kenneth H. Shain
Journal: Blood
Blood (2024) 144 (Supplement 1): 247.
https://doi.org/10.1182/blood-2024-201288
Published: 2024
Journal Articles

Whole Genome Sequencing Reveals Lower Apobec-Mutational Activity in Multiple Myeloma Patients with African Ancestry Compared with Those Having European Ancestry

Kylee H Maclachlan, Marios Papadimitriou, Patrick Blaney, Tala Shekarkhand, Timothy R. Chu, Alexandra Maria Poos, Elizabeth Brown, Antje Hoering, Benjamin Diamond, Bachisio Ziccheddu, Marc S. Raab, Niels Weinhold, Ola Landgren, Faith E Davies, Alexander M. Lesokhin, Saad Z. Usmani, Francesco Maura, Gareth Morgan
Journal: Blood
Blood (2024) 144 (Supplement 1): 766.
https://doi.org/10.1182/blood-2024-203675
Published: 2024
Journal Articles

Immune-MRD Status Informs Tumor-MRD Outcome Prognostication in Multiple Myeloma Patients on Lenalidomide Maintenance

Ross S Firestone, Anish Kumar Simhal, Devin McAvoy, Eric M Jurgens, Juan-José Garcés, David Nemirovsky, Andriy Derkach, Kylee H Maclachlan, Malin Hultcrantz, Sham Mailankody, Urvi A. Shah, Carlyn Rose Tan, Neha Korde, Hani Hassoun, Sridevi Rajeeve, Hamza Hashmi, Heather J. Landau, Michael Scordo, Gunjan L. Shah, Sergio Giralt, Benjamin Diamond, Francesco Maura, Kinga K. Hosszu, David J. Chung, Ola Landgren, Saad Z. Usmani, Alexander M. Lesokhin
Journal: Blood
Blood (2024) 144 (Supplement 1): 672.
https://doi.org/10.1182/blood-2024-206646
Published: 2024
Journal Articles

A High-Fiber Dietary Intervention (NUTRIVENTION) in Precursor Plasma Cell Disorders Improves Biomarkers of Disease and May Delay Progression to Myeloma

Urvi A. Shah, Laura Lucia Cogrossi, Andriy Derkach, Francesca Castro, Teng Fei, Susan DeWolf, Juan-Jose Garces, Anna Policastro, Matteo Grioni, Sofia Sisti, Blaslov Jenna, Peter Adintori, Kinga K. Hosszu, Devin McAvoy, Mirae Baichoo, Justin Cross, Aishwarya Anuraj, Charlotte Pohl, Ruben Ramos, Jenny Paredes Sanchez, Brianna Gipson, Kylee H Maclachlan, Ana Gradissimo, Leonardo Boiocchi, Richard Koche, Ronan Chaligne, Torin Block, Neha Korde, Carlyn Rose Tan, Malin Hultcrantz, Hani Hassoun, Gunjan L. Shah, Michael Scordo, Oscar B Lahoud, David J. Chung, Heather J. Landau, Jonathan U. Peled, Nicola Clementi, Marta Chesi, P. Leif Bergsagel, Sham Mailankody, Michael Pollak, Anita D'Souza, Ola Landgren, Susan Chimonas, Sergio Giralt, Saad Z. Usmani, Neil M. Iyengar, Alexander M. Lesokhin, Matteo Bellone, Marcel R.M. van den Brink
Journal: Blood
Blood (2024) 144 (Supplement 1): 671.
https://doi.org/10.1182/blood-2024-202224
Published: 2024
Journal Articles

Impact of Daratumumab Refractoriness on Clinical Outcomes Following CAR T-Cell Therapy for Relapsed/Refractory Multiple Myeloma

Sridevi Rajeeve, Bruno Almeida Costa, Eric M Jurgens, Noriko Nishimura, Tasmin Farzana, Ross S Firestone, Kevin Miller, Alexander M. Lesokhin, Gunjan L. Shah, Neha Korde, Carlyn Rose Tan, David J. Chung, Heather J. Landau, Michael Scordo, Hani Hassoun, Kylee H Maclachlan, Urvi A. Shah, Malin Hultcrantz, Issam S. Hamadeh, Sergio Giralt, Sham Mailankody, Saad Z. Usmani, Hamza Hashmi
Journal: Blood
Blood (2024) 144 (Supplement 1): 7090.
https://doi.org/10.1182/blood-2024-206511
Published: 2024
Journal Articles

Belantamab Mafodotin , nirogacestat and Pomalidomide for Patients with Relapsed/Refractory Multiple Myeloma

Malin Hultcrantz, Hani Hassoun, Carlyn Rose Tan, Neha Korde, Alexander M. Lesokhin, Hamza Hashmi, Kylee H Maclachlan, Sridevi Rajeeve, Urvi A. Shah, Dhwani Patel, Andriy Derkach, Selena Hamid, Tala Shekarkhand, Linh Tran, Julia Caple, Kelly Barnett, Tara Sood, Blaslov Jenna, Amanda Konsky, Kazunori Murata, Mikhail Roshal, Sergio A. Giralt, Saad Z. Usmani, Sham Mailankody
Journal: Blood
Blood (2024) 144 (Supplement 1): 7077.
https://doi.org/10.1182/blood-2024-211857
Published: 2024
Journal Articles

Infectious Complications during Treatment with Commercial CAR T-Cell Therapy and Bispecific Antibodies for Relapsed/Refractory Multiple Myeloma

Eric M Jurgens, Tala Shekarkhand, Tasmin Farzana, Colin Rueda, David Nemirovsky, Andriy Derkach, Ross S Firestone, Noriko Nishimura, Kevin Miller, Bruno Almeida Costa, Karthik Nath, Sridevi Rajeeve, Alexander M. Lesokhin, Neha Korde, Carlyn Rose Tan, Hamza Hashmi, Hani Hassoun, Kylee H Maclachlan, Urvi A. Shah, Malin Hultcrantz, Issam S. Hamadeh, Sergio A. Giralt, David J. Chung, Heather J. Landau, Michael Scordo, Gunjan L. Shah, Saad Z. Usmani, Sham Mailankody, Zainab Shahid
Journal: Blood
Blood (2024) 144 (Supplement 1): 6935.
https://doi.org/10.1182/blood-2024-207977
Published: 2024
Journal Articles

Real-World Safety and Early Efficacy of Talquetamab in Patients with Heavily-Pretreated Relapsed/Refractory Multiple Myeloma

Bruno Almeida Costa, Carlyn Rose Tan, Tala Shekarkhand, Ross S Firestone, Eric M Jurgens, Kevin Miller, Alexander M. Lesokhin, Gunjan L. Shah, Neha Korde, Sridevi Rajeeve, David J. Chung, Heather J. Landau, Michael Scordo, Hani Hassoun, Kylee H Maclachlan, Urvi A. Shah, Malin Hultcrantz, Issam S. Hamadeh, Sergio Giralt, Sham Mailankody, Saad Z. Usmani, Hamza Hashmi
Journal: Blood
Blood (2024) 144 (Supplement 1): 7026.
https://doi.org/10.1182/blood-2024-206413
Published: 2024
Journal Articles

Defining the Rates of Cytokine Release Syndrome Associated with Talquetamab Step-up Doses

Issam S. Hamadeh, Tala Shekarkhand, Colin Rueda, Ross S Firestone, Alice X Wang, Neha Korde, Malin Hultcrantz, Alexander M. Lesokhin, Sham Mailankody, Hani Hassoun, Urvi A. Shah, Kylee H Maclachlan, Sridevi Rajeeve, Hamza Hashmi, Gunjan L. Shah, Michael Scordo, David J. Chung, Heather J. Landau, Sergio A. Giralt, Saad Z. Usmani, Carlyn Rose Tan
Journal: Blood
Blood (2024) 144 (Supplement 1): 6990.
https://doi.org/10.1182/blood-2024-209891
Published: 2024
Journal Articles

Body Mass Index Trajectory during Triplet Induction Therapy: Clinical Implications in Newly Diagnosed Multiple Myeloma

Ram Prakash Thirugnanasambandam, Ross S Firestone, Andriy Derkach, Helena Furberg, Tala Shekarkhand, Colin Rueda, Kylee H Maclachlan, Malin Hultcrantz, Sham Mailankody, Dhwani Patel, Oscar Boutros Lahoud, Heather J. Landau, David J. Chung, Gunjan L. Shah, Michael Scordo, Hani Hassoun, Alexander M. Lesokhin, Sergio Giralt, Neha Korde, Saad Z. Usmani, Carlyn Rose Tan, Urvi A. Shah
Journal: Blood
Blood (2024) 144 (Supplement 1): 6948.
https://doi.org/10.1182/blood-2024-201845
Published: 2024
Journal Articles

Comparison of Acute Kidney Injury in Patients with Relapsed or Refractory Multiple Myeloma Following CAR T-Cell and Bispecific Antibody Therapies

Noriko Nishimura, Sham Mailankody, David Nemirovsky, Andriy Derkach, Bruno Almeida Costa, Tasmin Farzana, Aisha Shaikh, Sheron Latcha, Victoria Gutgarts, Eric M Jurgens, Ross S Firestone, Karthik Nath, David J. Chung, Heather J. Landau, Michael Scordo, Gunjan L. Shah, Roni Shouval, Hamza Hashmi, Hani Hassoun, Kylee H Maclachlan, Malin Hultcrantz, Neha Korde, Alexander M. Lesokhin, Urvi A. Shah, Carlyn Rose Tan, Sergio A. Giralt, Saad Z. Usmani, Sridevi Rajeeve
Journal: Blood
Blood (2024) 144 (Supplement 1): 6944.
https://doi.org/10.1182/blood-2024-212006
Published: 2024
Journal Articles

Daratumumab Versus Lenalidomide As Maintenance Therapy in Newly Diagnosed Multiple Myeloma - Interim Efficacy Results of a Randomized Clinical Trial

Sridevi Rajeeve, Andriy Derkach, Sean M. Devlin, Jeannen Santos, Anna Przemielewska, Tara Sood, Kylee H Maclachlan, Hamza Hashmi, Carlyn Rose Tan, Neha Korde, Malin Hultcrantz, Parastoo B Dahi, Alexander M. Lesokhin, Michael Scordo, David J. Chung, Heather J. Landau, Gunjan L. Shah, Ola Landgren, Sergio A. Giralt, Sham Mailankody, Saad Z. Usmani, Urvi A. Shah
Journal: Blood
Blood (2024) 144 (Supplement 1): 3362.
https://doi.org/10.1182/blood-2024-208094
Published: 2024
Journal Articles

Frailty and Outcomes after Bispecific T-Cell Engager Therapy for Patients with Relapsed/Refractory Multiple Myeloma

Benjamin O Adegbite, Carlyn Rose Tan, Tala Shekarkhand, Ross S Firestone, Eric M Jurgens, Kevin Miller, Alexander M. Lesokhin, Gunjan L. Shah, Neha Korde, Sridevi Rajeeve, David J. Chung, Heather J. Landau, Michael Scordo, Hani Hassoun, Kylee H Maclachlan, Urvi A. Shah, Malin Hultcrantz, Issam S. Hamadeh, Sergio Giralt, Sham Mailankody, Saad Z. Usmani, Hamza Hashmi
Journal: Blood
Blood (2024) 144 (Supplement 1): 4735.
https://doi.org/10.1182/blood-2024-201824
Published: 2024
Journal Articles

Replication Stress Induces Hyper-Apobec Mutagenesis in Multiple Myeloma

Marios Papadimitriou, Marilena Tauro, Afsaneh Panahi, Bachisio Ziccheddu, Alexandra Maria Poos, Abdessamad Youssfi Alaoui, Dario Magaletti, Mark B. Meads, Kylee H Maclachlan, Marc S. Raab, Gareth Morgan, Saad Z. Usmani, Niels Weinhold, Ola Landgren, Kenneth H. Shain, Florian Kuchenbauer, Francesco Maura
Journal: Blood
Blood (2024) 144 (Supplement 1): 3276.
https://doi.org/10.1182/blood-2024-211173
Published: 2024
Journal Articles

Mutationally Enriched Regions of the Non-Coding Genome Harbor Functionally Impactful Mutations That Dysregulate Key Genes Involved in Multiple Myeloma Pathogenesis

Patrick Blaney, Kylee H Maclachlan, Marios Papadimitriou, Aneta Mikulasova, Dylan C Gagler, Marc J Braunstein, Oscar B Lahoud, David Kaminetzky, Yubao Wang, Sanxiong Liu, Di Zhang, Anthony Cirrincione, Alexandra Maria Poos, Bachisio Ziccheddu, Marcella Kaddoura, Monika Chojnacka, Benjamin Diamond, Neha Korde, Alexander M. Lesokhin, Saad Z. Usmani, Leo Rasche, Elias K. Mai, Marc S. Raab, Niels Weinhold, Elizabeth E. Brown, Nicolas Robine, Leif Bergsagel, Brian A. Walker, Ola Landgren, Francesco Maura, Faith E Davies, Gareth Morgan
Journal: Blood
Blood (2024) 144 (Supplement 1): 4655.
https://doi.org/10.1182/blood-2024-211012
Published: 2024
Journal Articles

Clonal Evolution of Lymphoid Malignancies Following the Mutagenic Impact of Radiotherapy

Benjamin Diamond, Dhanvantri Chahar, Michael D. Jain, Alexandra Maria Poos, Michael Durante, Bachisio Ziccheddu, Marcella Kaddoura, Marios Papadimitriou, Kylee H Maclachlan, Tomas Jelinek, Faith E Davies, Nicholas B Figura, Gareth Morgan, Elias K. Mai, Hartmut Goldschmidt, Katja C. Weisel, Roland Fenk, Saad Z. Usmani, Ola Landgren, Frederick Locke, Marc S. Raab, Jonathan H. Schatz, Niels Weinhold, Francesco Maura
Journal: Blood
Blood (2024) 144 (Supplement 1): 1607.
https://doi.org/10.1182/blood-2024-200927
Published: 2024
Journal Articles

Impact of Absolute Lymphocyte Count at Pre-Apheresis and Pre-Lymphodepletion on Chimeric Antigen Receptor (CAR)-T Therapy Outcomes in Relapsed Refractory Multiple Myeloma (RRMM)

Noriko Nishimura, Sham Mailankody, Samantha Brown, Sean M. Devlin, Bruno Almeida Costa, Tasmin Farzana, Eric M Jurgens, Ross S Firestone, Karthik Nath, David J. Chung, Heather J. Landau, Michael Scordo, Gunjan L. Shah, Roni Shouval, Hamza Hashmi, Hani Hassoun, Kylee H Maclachlan, Malin Hultcrantz, Neha Korde, Alexander M. Lesokhin, Urvi A. Shah, Carlyn Rose Tan, Sergio A. Giralt, Saad Z. Usmani, Sridevi Rajeeve
Journal: Blood
Blood (2024) 144 (Supplement 1): 1944.
https://doi.org/10.1182/blood-2024-208490
Published: 2024
Journal Articles

Manufacture of Anti-BCMA CAR T Cell Is Feasible after Salvage Autologous or Allogeneic Hematopoietic Stem Cell Transplantation

Gunjan L. Shah, Karlo Perica, Katherine Nagel, Erica Payson, Kinga K. Hosszu, David J. Chung, Heather J. Landau, Michael Scordo, Malin Hultcrantz, Neha Korde, Kylee H Maclachlan, Urvi A. Shah, Carlyn Rose Tan, Hamza Hashmi, Alexander M. Lesokhin, Sridevi Rajeeve, Saad Z. Usmani, Sham Mailankody, Sergio A. Giralt
Journal: Blood
Blood (2024) 144 (Supplement 1): 4850.
https://doi.org/10.1182/blood-2024-212230
Published: 2024