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Journal Articles

Lenalidomide Plus Bortezomib and Dexamethasone in the Treatment of Newly Diagnosed Multiple Myeloma: Results from a Canadian Cost-Effectiveness Analysis

Michael Sebag, MD PhD, Julie Stakiw, MD, Thomas J. Stephens, Amie Padhiar, Tony Kim, Jane Shum, Sujith Dhanasiri, Suzanne Trudel, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 70.
https://doi.org/10.1182/blood-2019-123636
Published: 2019
Journal Articles

Comprehensive Genomic Profiling Demonstrates Differences in Primary CNS Lymphoma and Systemic Diffuse Large B Cell Lymphoma and Reveals Biomarkers Indicating Potential Benefit from Immune Checkpoint Inhibitors

Eric A Severson, MD PhD MMSc, Jo-Anne Vergilio, MD, Laurie M Gay, PhD, Sugganth Daniel, MD, Julia A Elvin, MD PhD, James Suh, MD, Vincent A Miller, MD, Philip J Stephens, PhD, Jeffrey S Ross, MD, Shakti Ramkissoon, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3996.
https://doi.org/10.1182/blood.V130.Suppl_1.3996.3996
Published: 2017
Journal Articles

Unrecognized Clonal Hematopoiesis of Indeterminate Potential in Solid Tumors: Implications for Interpretation of Molecular Testing

Eric A Severson, MD PhD MMSc, Caitlin F Connelly, PhD, Shakti Ramkissoon, MD PhD, Garrett M Frampton, PhD, Laurie M Gay, PhD, Sugganth Daniel, MD, Julia A Elvin, MD PhD, James Suh, MD, Vincent A Miller, MD, Philip J Stephens, PhD, Siraj M Ali, MD PhD, Jeffrey S Ross, MD, Jo-Anne Vergilio, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 115.
https://doi.org/10.1182/blood.V130.Suppl_1.115.115
Published: 2017
Journal Articles

Comprehensive Genomic Profiling (CGP) Informs Molecular Diagnosis, Prognosis, and Therapeutic Decision-Making for Patients with Angioimmunoblastic T-Cell Lymphoma (AITL)

Samantha Morley, PhD, Jie He, PhD, Andrew M Intlekofer, MD PhD, Mark Bailey, MS, Michelle Nahas, PhD, Andreas Heilmann, PhD, Yakov Chudnovsky, PhD, David Fabrizio, PhD, Siraj M Ali, MD PhD, Doron Lipson, PhD, Philip J Stephens, PhD, Jeffrey S Ross, MD, Vincent A Miller, MD, Eric A Severson, MD PhD MMSc, Jo-Anne Vergilio, MD, Omar Abdel-Wahab, MD, Rachel Erlich, PhD, Tariq I Mughal, MD FRCP
Journal: Blood
Blood (2017) 130 (Supplement 1): 5134.
https://doi.org/10.1182/blood.V130.Suppl_1.5134.5134
Published: 2017
Journal Articles

Comprehensive Genomic Profiling (CGP) Identifies Novel BCL6 Rearrangements in Diverse Subtypes of Non-Hodgkin Lymphoma (NHL) As Well As Known Rearrangements Not Detected Using Standard of Care (SOC) Assays

Jo-Anne Vergilio, MD, Laurie M Gay, PhD, Lei Zhong, PhD, Mark Rosenzweig, PhD, Yakov Chudnovsky, PhD, Jie He, PhD, Michelle Nahas, PhD, Siraj M Ali, MD PhD, Sugganth Daniel, MD, Shakti Ramkissoon, MD PhD, James Suh, MD, Julia A Elvin, MD PhD, Tariq I Mughal, MD FRCP, Philip J Stephens, PhD, Vincent A Miller, MD, Rachel Erlich, PhD, Jeffrey S Ross, MD, Eric A Severson, MD PhD MMSc, Samantha Morley, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 417.
https://doi.org/10.1182/blood.V130.Suppl_1.417.417
Published: 2017
Journal Articles

Comprehensive Genomic Profiling Identifies Genomic Alterations That Define Philadelphia-like B-Acute Lymphoblastic Leukemia

Eric A Severson, MD PhD MMSc, Laurie M Gay, PhD, Sugganth Daniel, MD, Julia A Elvin, MD PhD, James Suh, MD, Michelle Nahas, PhD, Vincent A Miller, MD, Philip J Stephens, PhD, Jeffrey S Ross, MD, Shakti Ramkissoon, MD PhD, Jo-Anne Vergilio, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 476.
https://doi.org/10.1182/blood.V130.Suppl_1.476.476
Published: 2017
Journal Articles

High Risk Myeloma Is Characterized By the Bi-Allelic Inactivation of CDKN2C and RB1

Shweta S. Chavan, PhD, Christoph Heuck, MD, Jie He, PhD, Rusiana Tytarenko, Shayu Deshpande, PhD, Purvi Patel, Mark Bailey, MSc, Caleb K. Stein, MS, Owen W Stephens, Niels Weinhold, PhD, Nathan Petty, MS, Doug Steward, Leo Rasche, MD, Michael A Bauer, PhD, Cody Ashby, PhD, Erich Allen Peterson, PhD BS, MS, Shan Zhong, PhD, Michelle Nahas, PhD, Siraj M Ali, MD PhD, Jo-Anne Vergillo, MD, Jeff Ross, MD, Vincent A. Miller, MD, Phillip J Stephens, PhD, Carolina Schinke, MD, Maurizio Zangari, MD, Frits van Rhee, MD PhD, Bart Barlogie, MD PhD, Tariq I Mughal, MD, Faith E Davies, MD, Gareth J Morgan, MD PhD, Brian A Walker, PhD
Journal: Blood
Blood (2016) 128 (22): 4416.
https://doi.org/10.1182/blood.V128.22.4416.4416
Published: 2016
Journal Articles

A Survey of Fusion Genes in Myeloma Identifies Kinase Domain Activation Which Could be Targeted with Available Treatments

Brian A Walker, PhD, Shweta S. Chavan, PhD, Jie He, PhD, Ruslana Tytarenko, Shan Zhong, PhD, Shayu Deshpande, PhD, Purvi Patel, Caleb K. Stein, MS, Owen W Stephens, Niels Weinhold, PhD, Nathan Petty, MS, Doug Steward, Carolina Schinke, MD, Leo Rasche, MD, Mark Bailey, MSc, Siraj Ali, Jo-Anne Vergillo, MD, Jeff Ross, MD, Vincent A. Miller, MD, Phillip J Stephens, PhD, Sharmilan Thanendrarajan, MD, Maurizio Zangari, MD, Frits van Rhee, MD PhD, Tariq I Mughal, MD, Faith E Davies, MD, Gareth J Morgan, MDPhD
Journal: Blood
Blood (2016) 128 (22): 117.
https://doi.org/10.1182/blood.V128.22.117.117
Published: 2016
Journal Articles

Integrated genomic DNA/RNA profiling of hematologic malignancies in the clinical setting

Jie He, Omar Abdel-Wahab, Michelle K. Nahas, Kai Wang, Raajit K. Rampal, Andrew M. Intlekofer, Jay Patel, Andrei Krivstov, Garrett M. Frampton, Lauren E. Young, Shan Zhong, Mark Bailey, Jared R. White, Steven Roels, Jason Deffenbaugh, Alex Fichtenholtz, Timothy Brennan, Mark Rosenzweig, Kimberly Pelak, Kristina M. Knapp, Kristina W. Brennan, Amy L. Donahue, Geneva Young, Lazaro Garcia, Selmira T. Beckstrom, Mandy Zhao, Emily White, Vera Banning, Jamie Buell, Kiel Iwanik, Jeffrey S. Ross, Deborah Morosini, Anas Younes, Alan M. Hanash, Elisabeth Paietta, Kathryn Roberts, Charles Mullighan, Ahmet Dogan, Scott A. Armstrong, Tariq Mughal, Jo-Anne Vergilio, Elaine Labrecque, Rachel Erlich, Christine Vietz, Roman Yelensky, Philip J. Stephens, Vincent A. Miller, Marcel R. M. van den Brink, Geoff A. Otto, Doron Lipson, Ross L. Levine
Journal: Blood
Blood (2016) 127 (24): 3004–3014.
https://doi.org/10.1182/blood-2015-08-664649
Published: 2016
Includes: Supplemental data
Journal Articles

Genomic Profiling Combining DNA and RNA Analysis of 112 Formalin-Fixed Paraffin-Embedded Diffuse Large B Cell Lymphoma Specimens Identifies a High Frequency of Clinically Relevant Genomic Alterations

Andrew M. Intlekofer, MD PhD, Patrick Hilden, MS, Venkatraman E. Seshan, PhD, Amanda R. Copeland, MSN, Ross L. Levine, MD, Andrew D. Zelenetz, MD PhD, Julie Teruya-Feldstein, MD, Ahmet Dogan, MD PhD, Maria Lia Palomba, MD, Craig H. Moskowitz, MD, Marcel R. M. van den Brink, MD PhD, Kristina M. Knapp, BS, Janine D. Pichardo, BS, Kristina W. Brennan, BS, Geneva Young, BS, Jie He, PhD, Michelle K. Nahas, PhD, Roman Yelensky, PhD, Geoff A. Otto, PhD, Doron Lipson, PhD, Philip J. Stephens, PhD, Vincent A. Miller, MD, Anas Younes, MD
Journal: Blood
Blood (2014) 124 (21): 704.
https://doi.org/10.1182/blood.V124.21.704.704
Published: 2014
Journal Articles

Genomic Analysis of Serial Samples from CLL Patients Identifies Clonal Events Associated with Disease Progression

Jeffrey R Gardner, BS, MBA, Michelle Nahas, PhD, Jie He, PhD, Shlomzion Aumann, Mithat Gonen, Minal Patel, Kristina M. Knapp, BS, Maria Lia Palomba, MD, Roman Yelensky, PhD, Amy L Donahue, MS, Geoff Otto, PhD, Maria Arcila, MD, Nicole Lamanna, Mark G. Frattini, MD PhD, Ahmet Dogan, MD PhD, Jae H Park, MD, Doron Lipson, PhD, Martin S. Tallman, MD, Ross L. Levine, MD, Philip J. Stephens, PhD, Marcel R. M. van den Brink, MD PhD, Mark L Heaney, MD PhD, Vincent A. Miller, MD, Andrew D. Zelenetz, MD PhD, Omar Abdel-Wahab, MD
Journal: Blood
Blood (2014) 124 (21): 1954.
https://doi.org/10.1182/blood.V124.21.1954.1954
Published: 2014
Journal Articles

A Comprehensive Clinical Next Generation Sequencing-Based Assay Can Impact Hematopathologic Diagnosis in a Significant Subset of Patients with Hematologic Malignancies

Janine D. Pichardo, BS, Julie T Feldstein, MD, Maria Arcila, MD, Connie Batlevi, MD PhD, Andrew D. Zelenetz, MD PhD, Craig H. Moskowitz, MD, Steven M. Horwitz, MD, Martin S. Tallman, MD, Eytan M. Stein, Virginia M. Klimek, MD, Dan Douer, MD, Raajit K. Rampal, MD PhD, Jae H Park, MD, Sergio A Giralt, MD, Jie He, PhD, Philip J. Stephens, PhD, Vincent Miller, MD, Anas Younes, MD, Ross L. Levine, MD, Ahmet Dogan, MD PhD
Journal: Blood
Blood (2014) 124 (21): 2984.
https://doi.org/10.1182/blood.V124.21.2984.2984
Published: 2014
Journal Articles

Novel Chromatin Modifying Gene Alterations and Significant Survival Association of ATM and P53 in Mantle Cell Lymphoma

Kai Wang, MDPhD, Michelle K. Nahas, PhD, Roman Yelensky, PhD, Geoff A. Otto, PhD, Doron Lipson, PhD, Jie He, PhD, Jeff Ross, MD, Phil J Stephens, PhD, Kar Fai Chow, MD, Tania Zielonka, Pritish K Bhattacharyya, MD, Ewelina A Protomastro, MS, Tatyana Feldman, MD, Anthony R. Mato, MD MSCE, Alan P Skarbnik, MD, Coleen Bejot, APN, Gabriella Gadaleta, NP, Andrew L Pecora, MD FACP, Vincent A. Miller, MD, Andre Goy, MD MS
Journal: Blood
Blood (2014) 124 (21): 3033.
https://doi.org/10.1182/blood.V124.21.3033.3033
Published: 2014
Journal Articles

Patient Derived Xenograft (PDX) Models Recapitulate the Genomic-Driver Composition of Acute Leukemia Samples

Andrei V. Krivtsov, PhD, Xujun Wang, MD, Noushin Rahnamay Farnoud, PhD, Michael Hadler, MSc, Marta Sanchez Martin, Kristina M. Knapp, BS, Eytan M. Stein, Doron Lipson, PhD, Michelle K. Nahas, PhD, Philip J. Stephens, PhD, Eric M Sanford, BS, Kai Wang, MDPhD, Garrett M Frampton, PhD, Tim Brennan, PhD, Geoff A. Otto, PhD, Roman Yelensky, PhD, Vincent Miller, MD, Ross L. Levine, MD, Adolfo A. Ferrando, MD PhD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2014) 124 (21): 286.
https://doi.org/10.1182/blood.V124.21.286.286
Published: 2014
Journal Articles

Identification of Actionable Genomic Alterations Across Different Lymphoma Histologies Using a Comprehensive Next Generation Genomic Sequencing Clinical Assay

Connie Batlevi, MD PhD, Craig H. Moskowitz, MD, Andrew D. Zelenetz, MD PhD, Steven M. Horwitz, MD, Lia Palomba, MD, John F. Gerecitano, MD PhD, Amanda R. M. Copeland, MSN, Paul Hamlin, MD, Matthew J. Matasar, MD MS, Craig S. Sauter, MD, Alison J Moskowitz, MD, Ariela Noy, David J. Straus, MD, Carol S Portlock, MD, Colleen Mazzei, BS, Janine D. Pichardo, BS, Vincent Miller, MD, Phil J Stephens, PhD, Jie He, PhD, Julie T Feldstein, MD, Ross L. Levine, MD, Ahmet Dogan, MD PhD, Anas Younes, MD
Journal: Blood
Blood (2014) 124 (21): 3000.
https://doi.org/10.1182/blood.V124.21.3000.3000
Published: 2014
Journal Articles

Genomic Alterations of Histone Modification Genes Are Significantly Less Common in Non-Hodgkin Lymphomas of Adolescents and Young Adults Compared to Older Patients

Kai Wang, MDPhD, Deborah Morosini, MD, Roman Yelensky, PhD, Norma Palma, PhD, Adrienne Johnson, MS, Doron Lipson, PhD, Juliann Chmielecki, PhD, Siraj Ali, MDPhD, Jeffrey S Ross, MD, Philip J. Stephens, PhD, Vincent Miller, MD
Journal: Blood
Blood (2014) 124 (21): 1684.
https://doi.org/10.1182/blood.V124.21.1684.1684
Published: 2014
Journal Articles

Comprehensive Hybrid Capture-Based Genomic Profiling of T-Cell Leukemias and Lymphomas Reveals Targetable JAK1 and JAK3 Co-Existing Mutations

Utpal P. Dave, MD, Norma Palma, PhD, Kai Wang, MDPhD, Nishitha M Reddy, M.B.B.S., Siraj Ali, MDPhD, Rati Tripathi, PhD, Allison Greenplate, BS, Jonathan Michael Irish, PhD, Derya Unutmaz, MD, Phil J Stephens, PhD, Vincent A. Miller, MD
Journal: Blood
Blood (2014) 124 (21): 1672.
https://doi.org/10.1182/blood.V124.21.1672.1672
Published: 2014
Journal Articles

Characterization of the Mutational Landscape of Multiple Myeloma Using Comprehensive Genomic Profiling

Christoph Heuck, MD, Donald Johann, MD MS, Brian A Walker, PhD, Caleb K Stein, MS, Yogesh Jethava, MB, MRCP, MD FRCPath, Rashid Z Khan, MD, Scott Miller, Frits van Rhee, MD PhD, Maurizio Zangari, MD, Ruslana Tytarenko, Phillip Farmer, Ryan Williams, Siraj Ali, MDPhD, Phil J Stephens, PhD, Vincent A. Miller, MD, Gareth J Morgan, MD PhD, Bart Barlogie, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3418.
https://doi.org/10.1182/blood.V124.21.3418.3418
Published: 2014
Journal Articles

Clinical Utility of Comprehensive Profiling of Genomic Alterations in Hematologic Malignancies

Jie He, PhD, Jose A. Bufill, MD, Michelle K. Nahas, PhD, Kai Wang, MDPhD, Lauren E Young, MS, Kristina M. Knapp, Kristina W. Brennan, BS, Amy L Donahue, MS, Geneva Young, BS, Jeffrey S Ross, MD, Deborah Morosini, MD, Marcel R. M. van den Brink, MD PhD, Omar Abdel-Wahab, MD, Raajit K. Rampal, MD PhD, Andrew M. Intlekofer, MD PhD, Ahmet Dogan, MD PhD, Scott Armstrong, MD PhD, Roman Yelensky, PhD, Geoff Otto, PhD, Doron Lipson, PhD, Philip J. Stephens, PhD, Vincent A. Miller, MD, Ross L. Levine, MD
Journal: Blood
Blood (2014) 124 (21): 1072.
https://doi.org/10.1182/blood.V124.21.1072.1072
Published: 2014
Journal Articles

Utility of Combined DNA and RNA Next Generation Sequencing in Leukemias for Identification of Prognostic and Therapeutically Relevant Genomic Alterations in Clinical Practice

Catherine C. Coombs, MD, Aaron D. Viny, MD MS, Jie He, PhD, Rachel Kobos, MD, Doron Lipson, PhD, Neerav Shukla, MD, Kristina M. Knapp, BS, Geoff Otto, PhD, Omar Abdel-Wahab, MD, Eytan M. Stein, Raajit K. Rampal, MD PhD, Vincent A. Miller, MD, Ahmet Dogan, MD PhD, Marcel R.M. van den Brink, MD PhD, Scott A. Armstrong, MD PhD, Phil J Stephens, PhD, Martin S. Tallman, MD, Ross L. Levine, MD
Journal: Blood
Blood (2014) 124 (21): 1039.
https://doi.org/10.1182/blood.V124.21.1039.1039
Published: 2014