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Ruslana Tytarenko
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Journal Articles

The presence of large focal lesions is a strong independent prognostic factor in multiple myeloma

Clinical Trials & Observations
Leo Rasche, Edgardo J. Angtuaco, Terri L. Alpe, Grant H. Gershner, James E. McDonald, Rohan S. Samant, Manoj Kumar, Rudy Van Hemert, Joshua Epstein, Shayu Deshpande, Ruslana Tytarenko, Shmuel Yaccoby, Jens Hillengass, Sharmilan Thanendrarajan, Carolina Schinke, Frits van Rhee, Maurizio Zangari, Brian A. Walker, Bart Barlogie, Gareth J. Morgan, Faith E. Davies, Niels Weinhold
Journal: Blood
Blood (2018) 132 (1): 59–66.
https://doi.org/10.1182/blood-2018-04-842880
Published: 2018
Includes: Supplemental data
Journal Articles

A Survey of Fusion Genes in Myeloma Identifies Kinase Domain Activation Which Could be Targeted with Available Treatments

Brian A Walker, PhD, Shweta S. Chavan, PhD, Jie He, PhD, Ruslana Tytarenko, Shan Zhong, PhD, Shayu Deshpande, PhD, Purvi Patel, Caleb K. Stein, MS, Owen W Stephens, Niels Weinhold, PhD, Nathan Petty, MS, Doug Steward, Carolina Schinke, MD, Leo Rasche, MD, Mark Bailey, MSc, Siraj Ali, Jo-Anne Vergillo, MD, Jeff Ross, MD, Vincent A. Miller, MD, Phillip J Stephens, PhD, Sharmilan Thanendrarajan, MD, Maurizio Zangari, MD, Frits van Rhee, MD PhD, Tariq I Mughal, MD, Faith E Davies, MD, Gareth J Morgan, MDPhD
Journal: Blood
Blood (2016) 128 (22): 117.
https://doi.org/10.1182/blood.V128.22.117.117
Published: 2016
Journal Articles

Translocations and Jumping Rearrangements at 8q24 Result in over-Expression of MYC and are Key Drivers of Disease Progression

Erming Tian, PhD, Jeffery Sawyer, Owen W Stephens, Ruslana Tytarenko, Sharmilan Thanendrarajan, MD, Carolina Schinke, MD, Maurizio Zangari, MD, Frits van Rhee, MD PhD, Faith E Davies, MD, Brian A Walker, PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2016) 128 (22): 115.
https://doi.org/10.1182/blood.V128.22.115.115
Published: 2016
Journal Articles

Next Generation Sequencing (NGS) Based Minimal Residual Disease (MRD) Testing Is Highly Predictive of Overall and Progression Free Survival in the Total Therapy Trials and Shows Different Prognostic Implications in High Vs Standard Risk Multiple Myeloma

Carolina Schinke, MD, Shayu Deshpande, PhD, Hongwei Wang, Victoria Carlton, PhD, Katherine A. Kong, PhD, Martin Moorhead, PhD, Tom Willis, Purvi Patel, Sharmilan Thanendrarajan, MD, Meera Mohan, MD, Pankaj Mathur, MD, Sandra Susanibar, MD, Shadiqul Hoque, MD, Muthukumar Radhakrishnan, MD, Ruslana Tytarenko, Owen W Stephens, Leo Rasche, MD, Frits van Rhee, MD PhD, Maurizio Zangari, MD, Nathan Petty, MS, Daisy V. Alapat, MD, Sarah K. Johnson, PhD, Joshua Epstein, DSc, Bart Barlogie, MD PhD, Faith E Davies, MD, Antje Hoering, PhD, Niels Weinhold, PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2064.
https://doi.org/10.1182/blood.V128.22.2064.2064
Published: 2016
Journal Articles

Extensive Regional Intra-Clonal Heterogeneity in Multiple Myeloma - Implications for Diagnostics, Risk Stratification and Targeted Treatment

Niels Weinhold, PhD, Shweta S. Chavan, PhD, Leo Rasche, MD, Owen W Stephens, Purvi Patel, Ruslana Tytarenko, Cody Ashby, PhD, Caleb K. Stein, MS, Michael A Bauer, PhD, Christopher P Wardell, PhD, Shayu Deshpande, PhD, Timea Buzder, Gabor Molnar, Frits van Rhee, MD PhD, Maurizio Zangari, MD, Sharmilan Thanendrarajan, MD, Brian A Walker, PhD, Shmuel Yaccoby, PhD, Sarah K. Johnson, PhD, Joshua Epstein, DSc, Bart Barlogie, MD PhD, Christoph Heuck, MD, Faith E Davies, MD, Tobias Meissner, PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3278.
https://doi.org/10.1182/blood.V128.22.3278.3278
Published: 2016
Journal Articles

Clonal selection and double-hit events involving tumor suppressor genes underlie relapse in myeloma

Clinical Trials & Observations
Niels Weinhold, Cody Ashby, Leo Rasche, Shweta S. Chavan, Caleb Stein, Owen W. Stephens, Ruslana Tytarenko, Michael A. Bauer, Tobias Meissner, Shayu Deshpande, Purvi H. Patel, Timea Buzder, Gabor Molnar, Erich A. Peterson, Frits van Rhee, Maurizio Zangari, Sharmilan Thanendrarajan, Carolina Schinke, Erming Tian, Joshua Epstein, Bart Barlogie, Faith E. Davies, Christoph J. Heuck, Brian A Walker, Gareth J. Morgan
Journal: Blood
Blood (2016) 128 (13): 1735–1744.
https://doi.org/10.1182/blood-2016-06-723007
Published: 2016
Includes: Supplemental data
Journal Articles

High Risk Multiple Myeloma Demonstrates Marked Spatial Genomic Heterogeneity Between Focal Lesions and Random Bone Marrow; Implications for Targeted Therapy and Treatment Resistance

Niels Weinhold, PhD, Shweta S. Chavan, PhD, Christoph Heuck, MD, Owen W Stephens, PhD, Ruslana Tytarenko, Michael Bauer, Erich Allen Peterson, PhD BS, MS, Timothy C. Ashby, Tobias Meissner, Caleb K. Stein, MS, Donald Johann, MD MS, Sarah K. Johnson, PhD, Shmuel Yaccoby, PhD, Joshua Epstein, DSc, Frits van Rhee, MD PhD, Maurizio Zangari, MD, Carolina Schinke, MD, Sharmilan Thanendrarajan, MD, Faith E Davies, MD, Bart Barlogie, MD PhD, Gareth J Morgan, MDPhD
Journal: Blood
Blood (2015) 126 (23): 20.
https://doi.org/10.1182/blood.V126.23.20.20
Published: 2015
Journal Articles

Impact of Minimal Residual Disease in High and Standard Risk Multiple Myeloma

Carolina Schinke, MD, Shayu Deshpande, PhD, Alan Mitchell, Malek Faham, Purvi Patel, Sharmilan Thanendrarajan, MD, Meera Mohan, Pankaj Mathur, Aasiya Matin, Muthukumar Radhakrishnan, Ruslana Tytarenko, Owen W Stephens, PhD, Frits van Rhee, MD PhD, Maurizio Zangari, MD, Yogesh Jethava, MD, Nathan Petty, MS, Daisy V. Alapat, MD, Sarah K. Johnson, PhD, Joshua Epstein, DSc, Bart Barlogie, MD PhD, Faith E Davies, MD, Christoph Heuck, MD, Antje Hoering, Niels Weinhold, PhD, Gareth J Morgan, MDPhD
Journal: Blood
Blood (2015) 126 (23): 2979.
https://doi.org/10.1182/blood.V126.23.2979.2979
Published: 2015
Journal Articles

47 Genes Define Myeloma Cell Acquired Resistance to Bortezomib and Have Profound Prognostic Implications in Multiple Myeloma

Xenofon Papanikolaou, MD, Caleb K. Stein, MS, Ricky D Edmondson, PhD, Veronica Macleod, Ruslana Tytarenko, Bart Barlogie, MD PhD, Joshua Epstein, DSc, Christoph Heuck, MD
Journal: Blood
Blood (2015) 126 (23): 499.
https://doi.org/10.1182/blood.V126.23.499.499
Published: 2015
Journal Articles

The Impact of Combination Chemotherapy and Tandem Stem Cell Transplant on Clonal Substructure and Mutational Pattern at Relapse of MM

Christoph Heuck, MD, Niels Weinhold, PhD, Erich Allen Peterson, PhD BS, MS, Michael Bauer, Caleb K. Stein, MS, Timothy Ashby, Shweta S. Chavan, PhD, Ruslana Tytarenko, Owen W Stephens, PhD, Tobias Meissner, Donald Johann, MD MS, Frits van Rhee, MD PhD, Sarah Waheed, MD, Sarah K. Johnson, PhD, Maurizio Zangari, MD, Aasiya Matin, Nathan Petty, MS, Shmuel Yaccoby, PhD, Faith E Davies, MD, Joshua Epstein, DSc, Bart Barlogie, MD PhD, Gareth J Morgan, MDPhD
Journal: Blood
Blood (2015) 126 (23): 372.
https://doi.org/10.1182/blood.V126.23.372.372
Published: 2015
Journal Articles

Comprehensive Genomic Profiling of Multiple Myeloma in the Course of Clinical Care Identifies Targetable and Prognostically Significant Genomic Alterations

Christoph Heuck, MD, Shweta S. Chavan, PhD, Caleb K. Stein, MS, Ruslana Tytarenko, Niels Weinhold, PhD, Siraj Ali, MD PhD, Vincent A. Miller, MD, Sharmilan Thanendrarajan, MD, Carolina Schinke, MD, Meera Mohan, Jeffery Sawyer, Erich Allen Peterson, PhD BS, MS, Michael Bauer, Timothy C. Ashby, Donald Johann, MD MS, Frits van Rhee, MD PhD, Sarah Waheed, MD, Maurizio Zangari, MD, Faith E Davies, MD, Bart Barlogie, MD PhD, Gareth J Morgan, MDPhD
Journal: Blood
Blood (2015) 126 (23): 369.
https://doi.org/10.1182/blood.V126.23.369.369
Published: 2015
Journal Articles

Characterization of the Mutational Landscape of Multiple Myeloma Using Comprehensive Genomic Profiling

Christoph Heuck, MD, Donald Johann, MD MS, Brian A Walker, PhD, Caleb K Stein, MS, Yogesh Jethava, MB, MRCP, MD FRCPath, Rashid Z Khan, MD, Scott Miller, Frits van Rhee, MD PhD, Maurizio Zangari, MD, Ruslana Tytarenko, Phillip Farmer, Ryan Williams, Siraj Ali, MDPhD, Phil J Stephens, PhD, Vincent A. Miller, MD, Gareth J Morgan, MD PhD, Bart Barlogie, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3418.
https://doi.org/10.1182/blood.V124.21.3418.3418
Published: 2014
Journal Articles

The Antimalarial Agent Artesunate Exerts Its Antimyeloma Activity By Affecting The Mitochondria and The Reactive Oxygen Status Of The Myeloma Cells and Its Efficacy Depends On Intracellular Bivalent Iron Levels

Xenofon Papanikolaou, MD, Sarah K. Johnson, PhD, Tarun K. Garg, PhD, Erming Tian, PhD, Ruslana Tytarenko, Bart Barlogie, MD, PhD, Joshua Epstein, DSc, Christoph Heuck, MD
Journal: Blood
Blood (2013) 122 (21): 4444.
https://doi.org/10.1182/blood.V122.21.4444.4444
Published: 2013
Journal Articles

The Antimalarial Agent Artesunate Overcomes Bortezomib Resistance in Myeloma Cell Lines Through Non-Caspase Mediated Apoptosis

Xenofon Papanikolaou, MD, Ruslana Tytarenko, Tarun K. Garg, PhD, Sarah K. Johnson, PhD, Erming Tian, Senu Apewokin, MD, Bart Barlogie, MD, Joshua Epstein, DSc, Christoph Heuck, MD
Journal: Blood
Blood (2012) 120 (21): 4015.
https://doi.org/10.1182/blood.V120.21.4015.4015
Published: 2012