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Shayu Deshpande
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Journal Articles

Analysis of the Sub-Clonal Structure of Smoldering Myeloma over Time Provides a New Means of Disease Monitoring and Highlights Evolutionary Trajectories Leading to Myeloma

Free
Eileen M Boyle, MD MSc, Faith E. Davies, MD, Shayu Deshpande, Ruslana G. Tytarenko, MS, Cody Ashby, PhD, Yan Wang, Christopher P. Wardell, PhD MSc, BSc, Michael A Bauer, PhD, Sarah K Johnson, PhD, Carolina D. Schinke, MD, Sharmilan Thanendrarajan, MD, Frits van Rhee, MD PhD, Maurizio Zangari, MD, Louis Williams, MD MBA, Thierry Facon, MD, Charles Dumontet, Bart Barlogie, MD PhD, Gareth Morgan, MDPhDFRCP, Brian A Walker, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4333.
https://doi.org/10.1182/blood-2019-126679
Published: 2019
Journal Articles

Long-Term Follow-up Identifies Double Hit and Key Mutations As Impacting Progression Free and Overall Survival in Multiple Myeloma

Free
Cody Ashby, PhD, Eileen Boyle, Ruslana G. Tytarenko, MS, Hongwei Wang, MS, Adam Rosenthal, MS, Purvi Patel, Yan Wang, Shayu Deshpande, Maria Ortiz, Erin Flynt, Antje Hoering, PhD, Sharmilan Thanendrarajan, MD, Carolina D. Schinke, MD, Maurizio Zangari, MD, Frits van Rhee, MD PhD, Bart Barlogie, MD PhD, Anjan Thakurta, PhD, Gareth Morgan, MD, Brian A Walker, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 110.
https://doi.org/10.1182/blood-2018-99-113045
Published: 2018
Journal Articles

Mutations and Copy Number Changes Predict Progression from Smoldering Myeloma to Symptomatic Myeloma in the Era of Novel IMWG Criteria

Free
Eileen M Boyle, MD MSc, Cody Ashby, PhD, Ruslana G. Tytarenko, MS, Yan Wang, Michael A Bauer, PhD, Shayu Deshpande, Sarah K Johnson, PhD, Carolina D. Schinke, MD, Sharmilan Thanendrarajan, MD, Frits van Rhee, MD PhD, Christopher Wardell, PhD, Niels Weinhold, PhD, Thierry Facon, Charles Dumontet, Gareth Morgan, MD, Faith E. Davies, MD, Brian A Walker, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4456.
https://doi.org/10.1182/blood-2018-99-117193
Published: 2018
Journal Articles

The presence of large focal lesions is a strong independent prognostic factor in multiple myeloma

Free
Clinical Trials & Observations
Leo Rasche, Edgardo J. Angtuaco, Terri L. Alpe, Grant H. Gershner, James E. McDonald, Rohan S. Samant, Manoj Kumar, Rudy Van Hemert, Joshua Epstein, Shayu Deshpande, Ruslana Tytarenko, Shmuel Yaccoby, Jens Hillengass, Sharmilan Thanendrarajan, Carolina Schinke, Frits van Rhee, Maurizio Zangari, Brian A. Walker, Bart Barlogie, Gareth J. Morgan, Faith E. Davies, Niels Weinhold
Journal: Blood
Blood (2018) 132 (1): 59–66.
https://doi.org/10.1182/blood-2018-04-842880
Published: 2018
Includes: Supplemental data
Journal Articles

MYC Rearrangements in Multiple Myeloma Are Complex, Can Involve More Than Five Different Chromosomes, and Correlate with Increased Expression of MYC and a Distinct Downstream Gene Expression Pattern

Free
Aneta Mikulasova, PhD, Cody Cody Ashby, PhD, Ruslana G. Tytarenko, MS, Michael Bauer, PhD, Konstantimos Mavrommatis, PhD, Christopher P. Wardell, PhD, Matthew Trotter, PhD, Shayu Deshpande, Owen W. Stephens, Erming Tian, PhD MBA, Graham Jackson, Faith E. Davies, MD, Anjan Thakurta, PhD, Nikhil Munshi, MD, Gareth J. Morgan, MD PhD, Brian A Walker, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 65.
https://doi.org/10.1182/blood.V130.Suppl_1.65.65
Published: 2017
Journal Articles

Whole Genome Sequencing Reveals the Extent of Structural Variants in Multiple Myeloma and Identifies Recurrent Mutational Hotspots within the Non-Coding Regions

Free
Cody Cody Ashby, PhD, Michael Bauer, PhD, Owen W. Stephens, Christopher P. Wardell, PhD, Ruslana G. Tytarenko, MS, Aneta Mikulasova, PhD, Purvi Patel, Shayu Deshpande, Frits van Rhee, MD PhD, Maurizio Zangari, MD, Sharmilan Thanendrarajan, MD, Carolina D. Schinke, MD, Niels Weinhold, PhD, Leo Rasche, MD, Faith E Davies, MD, Gareth J. Morgan, MD PhD, Brian A Walker, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3032.
https://doi.org/10.1182/blood.V130.Suppl_1.3032.3032
Published: 2017
Journal Articles

Next Generation Sequencing (NGS) Based Minimal Residual Disease (MRD) Testing Is Highly Predictive of Overall and Progression Free Survival in the Total Therapy Trials and Shows Different Prognostic Implications in High Vs Standard Risk Multiple Myeloma

Free
Carolina Schinke, MD, Shayu Deshpande, PhD, Hongwei Wang, Victoria Carlton, PhD, Katherine A. Kong, PhD, Martin Moorhead, PhD, Tom Willis, Purvi Patel, Sharmilan Thanendrarajan, MD, Meera Mohan, MD, Pankaj Mathur, MD, Sandra Susanibar, MD, Shadiqul Hoque, MD, Muthukumar Radhakrishnan, MD, Ruslana Tytarenko, Owen W Stephens, Leo Rasche, MD, Frits van Rhee, MD PhD, Maurizio Zangari, MD, Nathan Petty, MS, Daisy V. Alapat, MD, Sarah K. Johnson, PhD, Joshua Epstein, DSc, Bart Barlogie, MD PhD, Faith E Davies, MD, Antje Hoering, PhD, Niels Weinhold, PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2064.
https://doi.org/10.1182/blood.V128.22.2064.2064
Published: 2016
Journal Articles

High Risk Myeloma Is Characterized By the Bi-Allelic Inactivation of CDKN2C and RB1

Free
Shweta S. Chavan, PhD, Christoph Heuck, MD, Jie He, PhD, Rusiana Tytarenko, Shayu Deshpande, PhD, Purvi Patel, Mark Bailey, MSc, Caleb K. Stein, MS, Owen W Stephens, Niels Weinhold, PhD, Nathan Petty, MS, Doug Steward, Leo Rasche, MD, Michael A Bauer, PhD, Cody Ashby, PhD, Erich Allen Peterson, PhD BS, MS, Shan Zhong, PhD, Michelle Nahas, PhD, Siraj M Ali, MD PhD, Jo-Anne Vergillo, MD, Jeff Ross, MD, Vincent A. Miller, MD, Phillip J Stephens, PhD, Carolina Schinke, MD, Maurizio Zangari, MD, Frits van Rhee, MD PhD, Bart Barlogie, MD PhD, Tariq I Mughal, MD, Faith E Davies, MD, Gareth J Morgan, MD PhD, Brian A Walker, PhD
Journal: Blood
Blood (2016) 128 (22): 4416.
https://doi.org/10.1182/blood.V128.22.4416.4416
Published: 2016
Journal Articles

Extensive Regional Intra-Clonal Heterogeneity in Multiple Myeloma - Implications for Diagnostics, Risk Stratification and Targeted Treatment

Free
Niels Weinhold, PhD, Shweta S. Chavan, PhD, Leo Rasche, MD, Owen W Stephens, Purvi Patel, Ruslana Tytarenko, Cody Ashby, PhD, Caleb K. Stein, MS, Michael A Bauer, PhD, Christopher P Wardell, PhD, Shayu Deshpande, PhD, Timea Buzder, Gabor Molnar, Frits van Rhee, MD PhD, Maurizio Zangari, MD, Sharmilan Thanendrarajan, MD, Brian A Walker, PhD, Shmuel Yaccoby, PhD, Sarah K. Johnson, PhD, Joshua Epstein, DSc, Bart Barlogie, MD PhD, Christoph Heuck, MD, Faith E Davies, MD, Tobias Meissner, PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3278.
https://doi.org/10.1182/blood.V128.22.3278.3278
Published: 2016
Journal Articles

A Survey of Fusion Genes in Myeloma Identifies Kinase Domain Activation Which Could be Targeted with Available Treatments

Free
Brian A Walker, PhD, Shweta S. Chavan, PhD, Jie He, PhD, Ruslana Tytarenko, Shan Zhong, PhD, Shayu Deshpande, PhD, Purvi Patel, Caleb K. Stein, MS, Owen W Stephens, Niels Weinhold, PhD, Nathan Petty, MS, Doug Steward, Carolina Schinke, MD, Leo Rasche, MD, Mark Bailey, MSc, Siraj Ali, Jo-Anne Vergillo, MD, Jeff Ross, MD, Vincent A. Miller, MD, Phillip J Stephens, PhD, Sharmilan Thanendrarajan, MD, Maurizio Zangari, MD, Frits van Rhee, MD PhD, Tariq I Mughal, MD, Faith E Davies, MD, Gareth J Morgan, MDPhD
Journal: Blood
Blood (2016) 128 (22): 117.
https://doi.org/10.1182/blood.V128.22.117.117
Published: 2016
Journal Articles

Clonal selection and double-hit events involving tumor suppressor genes underlie relapse in myeloma

Free
Clinical Trials & Observations
Niels Weinhold, Cody Ashby, Leo Rasche, Shweta S. Chavan, Caleb Stein, Owen W. Stephens, Ruslana Tytarenko, Michael A. Bauer, Tobias Meissner, Shayu Deshpande, Purvi H. Patel, Timea Buzder, Gabor Molnar, Erich A. Peterson, Frits van Rhee, Maurizio Zangari, Sharmilan Thanendrarajan, Carolina Schinke, Erming Tian, Joshua Epstein, Bart Barlogie, Faith E. Davies, Christoph J. Heuck, Brian A Walker, Gareth J. Morgan
Journal: Blood
Blood (2016) 128 (13): 1735–1744.
https://doi.org/10.1182/blood-2016-06-723007
Published: 2016
Includes: Supplemental data
Journal Articles

Impact of Minimal Residual Disease in High and Standard Risk Multiple Myeloma

Free
Carolina Schinke, MD, Shayu Deshpande, PhD, Alan Mitchell, Malek Faham, Purvi Patel, Sharmilan Thanendrarajan, MD, Meera Mohan, Pankaj Mathur, Aasiya Matin, Muthukumar Radhakrishnan, Ruslana Tytarenko, Owen W Stephens, PhD, Frits van Rhee, MD PhD, Maurizio Zangari, MD, Yogesh Jethava, MD, Nathan Petty, MS, Daisy V. Alapat, MD, Sarah K. Johnson, PhD, Joshua Epstein, DSc, Bart Barlogie, MD PhD, Faith E Davies, MD, Christoph Heuck, MD, Antje Hoering, Niels Weinhold, PhD, Gareth J Morgan, MDPhD
Journal: Blood
Blood (2015) 126 (23): 2979.
https://doi.org/10.1182/blood.V126.23.2979.2979
Published: 2015