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Owen W. Stephens
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Journal Articles

Spatial Genomic Heterogeneity in Multiple Myeloma: Surrogate Markers and Its Significance for Understanding the Evolutionary Processes Leading to Relapse

Free
Leo Rasche, MD, Tobias Meissner, PhD, Grant Gershner, Cody Cody Ashby, PhD, Ruslana G. Tytarenko, MS, Owen W. Stephens, Michael Bauer, PhD, Sharmilan Thanendrarajan, MD, Carolina D. Schinke, MD, Joshua Epstein, DSc, Frits van Rhee, MD PhD, Maurizio Zangari, MD, Bart Barlogie, MD PhD, Brian A Walker, PhD, Faith E Davies, MD, Gareth J. Morgan, MD PhD, Niels Weinhold, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4372.
https://doi.org/10.1182/blood.V130.Suppl_1.4372.4372
Published: 2017
Journal Articles

MYC Rearrangements in Multiple Myeloma Are Complex, Can Involve More Than Five Different Chromosomes, and Correlate with Increased Expression of MYC and a Distinct Downstream Gene Expression Pattern

Free
Aneta Mikulasova, PhD, Cody Cody Ashby, PhD, Ruslana G. Tytarenko, MS, Michael Bauer, PhD, Konstantimos Mavrommatis, PhD, Christopher P. Wardell, PhD, Matthew Trotter, PhD, Shayu Deshpande, Owen W. Stephens, Erming Tian, PhD MBA, Graham Jackson, Faith E. Davies, MD, Anjan Thakurta, PhD, Nikhil Munshi, MD, Gareth J. Morgan, MD PhD, Brian A Walker, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 65.
https://doi.org/10.1182/blood.V130.Suppl_1.65.65
Published: 2017
Journal Articles

Whole Genome Sequencing Reveals the Extent of Structural Variants in Multiple Myeloma and Identifies Recurrent Mutational Hotspots within the Non-Coding Regions

Free
Cody Cody Ashby, PhD, Michael Bauer, PhD, Owen W. Stephens, Christopher P. Wardell, PhD, Ruslana G. Tytarenko, MS, Aneta Mikulasova, PhD, Purvi Patel, Shayu Deshpande, Frits van Rhee, MD PhD, Maurizio Zangari, MD, Sharmilan Thanendrarajan, MD, Carolina D. Schinke, MD, Niels Weinhold, PhD, Leo Rasche, MD, Faith E Davies, MD, Gareth J. Morgan, MD PhD, Brian A Walker, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3032.
https://doi.org/10.1182/blood.V130.Suppl_1.3032.3032
Published: 2017
Journal Articles

Next Generation Sequencing (NGS) Based Minimal Residual Disease (MRD) Testing Is Highly Predictive of Overall and Progression Free Survival in the Total Therapy Trials and Shows Different Prognostic Implications in High Vs Standard Risk Multiple Myeloma

Free
Carolina Schinke, MD, Shayu Deshpande, PhD, Hongwei Wang, Victoria Carlton, PhD, Katherine A. Kong, PhD, Martin Moorhead, PhD, Tom Willis, Purvi Patel, Sharmilan Thanendrarajan, MD, Meera Mohan, MD, Pankaj Mathur, MD, Sandra Susanibar, MD, Shadiqul Hoque, MD, Muthukumar Radhakrishnan, MD, Ruslana Tytarenko, Owen W Stephens, Leo Rasche, MD, Frits van Rhee, MD PhD, Maurizio Zangari, MD, Nathan Petty, MS, Daisy V. Alapat, MD, Sarah K. Johnson, PhD, Joshua Epstein, DSc, Bart Barlogie, MD PhD, Faith E Davies, MD, Antje Hoering, PhD, Niels Weinhold, PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2064.
https://doi.org/10.1182/blood.V128.22.2064.2064
Published: 2016
Journal Articles

High Risk Myeloma Is Characterized By the Bi-Allelic Inactivation of CDKN2C and RB1

Free
Shweta S. Chavan, PhD, Christoph Heuck, MD, Jie He, PhD, Rusiana Tytarenko, Shayu Deshpande, PhD, Purvi Patel, Mark Bailey, MSc, Caleb K. Stein, MS, Owen W Stephens, Niels Weinhold, PhD, Nathan Petty, MS, Doug Steward, Leo Rasche, MD, Michael A Bauer, PhD, Cody Ashby, PhD, Erich Allen Peterson, PhD BS, MS, Shan Zhong, PhD, Michelle Nahas, PhD, Siraj M Ali, MD PhD, Jo-Anne Vergillo, MD, Jeff Ross, MD, Vincent A. Miller, MD, Phillip J Stephens, PhD, Carolina Schinke, MD, Maurizio Zangari, MD, Frits van Rhee, MD PhD, Bart Barlogie, MD PhD, Tariq I Mughal, MD, Faith E Davies, MD, Gareth J Morgan, MD PhD, Brian A Walker, PhD
Journal: Blood
Blood (2016) 128 (22): 4416.
https://doi.org/10.1182/blood.V128.22.4416.4416
Published: 2016
Journal Articles

Extensive Regional Intra-Clonal Heterogeneity in Multiple Myeloma - Implications for Diagnostics, Risk Stratification and Targeted Treatment

Free
Niels Weinhold, PhD, Shweta S. Chavan, PhD, Leo Rasche, MD, Owen W Stephens, Purvi Patel, Ruslana Tytarenko, Cody Ashby, PhD, Caleb K. Stein, MS, Michael A Bauer, PhD, Christopher P Wardell, PhD, Shayu Deshpande, PhD, Timea Buzder, Gabor Molnar, Frits van Rhee, MD PhD, Maurizio Zangari, MD, Sharmilan Thanendrarajan, MD, Brian A Walker, PhD, Shmuel Yaccoby, PhD, Sarah K. Johnson, PhD, Joshua Epstein, DSc, Bart Barlogie, MD PhD, Christoph Heuck, MD, Faith E Davies, MD, Tobias Meissner, PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3278.
https://doi.org/10.1182/blood.V128.22.3278.3278
Published: 2016
Journal Articles

A Survey of Fusion Genes in Myeloma Identifies Kinase Domain Activation Which Could be Targeted with Available Treatments

Free
Brian A Walker, PhD, Shweta S. Chavan, PhD, Jie He, PhD, Ruslana Tytarenko, Shan Zhong, PhD, Shayu Deshpande, PhD, Purvi Patel, Caleb K. Stein, MS, Owen W Stephens, Niels Weinhold, PhD, Nathan Petty, MS, Doug Steward, Carolina Schinke, MD, Leo Rasche, MD, Mark Bailey, MSc, Siraj Ali, Jo-Anne Vergillo, MD, Jeff Ross, MD, Vincent A. Miller, MD, Phillip J Stephens, PhD, Sharmilan Thanendrarajan, MD, Maurizio Zangari, MD, Frits van Rhee, MD PhD, Tariq I Mughal, MD, Faith E Davies, MD, Gareth J Morgan, MDPhD
Journal: Blood
Blood (2016) 128 (22): 117.
https://doi.org/10.1182/blood.V128.22.117.117
Published: 2016
Journal Articles

Translocations and Jumping Rearrangements at 8q24 Result in over-Expression of MYC and are Key Drivers of Disease Progression

Free
Erming Tian, PhD, Jeffery Sawyer, Owen W Stephens, Ruslana Tytarenko, Sharmilan Thanendrarajan, MD, Carolina Schinke, MD, Maurizio Zangari, MD, Frits van Rhee, MD PhD, Faith E Davies, MD, Brian A Walker, PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2016) 128 (22): 115.
https://doi.org/10.1182/blood.V128.22.115.115
Published: 2016
Journal Articles

Clonal selection and double-hit events involving tumor suppressor genes underlie relapse in myeloma

Free
Clinical Trials & Observations
Niels Weinhold, Cody Ashby, Leo Rasche, Shweta S. Chavan, Caleb Stein, Owen W. Stephens, Ruslana Tytarenko, Michael A. Bauer, Tobias Meissner, Shayu Deshpande, Purvi H. Patel, Timea Buzder, Gabor Molnar, Erich A. Peterson, Frits van Rhee, Maurizio Zangari, Sharmilan Thanendrarajan, Carolina Schinke, Erming Tian, Joshua Epstein, Bart Barlogie, Faith E. Davies, Christoph J. Heuck, Brian A Walker, Gareth J. Morgan
Journal: Blood
Blood (2016) 128 (13): 1735–1744.
https://doi.org/10.1182/blood-2016-06-723007
Published: 2016
Includes: Supplemental data
Journal Articles

The Impact of Combination Chemotherapy and Tandem Stem Cell Transplant on Clonal Substructure and Mutational Pattern at Relapse of MM

Free
Christoph Heuck, MD, Niels Weinhold, PhD, Erich Allen Peterson, PhD BS, MS, Michael Bauer, Caleb K. Stein, MS, Timothy Ashby, Shweta S. Chavan, PhD, Ruslana Tytarenko, Owen W Stephens, PhD, Tobias Meissner, Donald Johann, MD MS, Frits van Rhee, MD PhD, Sarah Waheed, MD, Sarah K. Johnson, PhD, Maurizio Zangari, MD, Aasiya Matin, Nathan Petty, MS, Shmuel Yaccoby, PhD, Faith E Davies, MD, Joshua Epstein, DSc, Bart Barlogie, MD PhD, Gareth J Morgan, MDPhD
Journal: Blood
Blood (2015) 126 (23): 372.
https://doi.org/10.1182/blood.V126.23.372.372
Published: 2015
Journal Articles

High Risk Multiple Myeloma Demonstrates Marked Spatial Genomic Heterogeneity Between Focal Lesions and Random Bone Marrow; Implications for Targeted Therapy and Treatment Resistance

Free
Niels Weinhold, PhD, Shweta S. Chavan, PhD, Christoph Heuck, MD, Owen W Stephens, PhD, Ruslana Tytarenko, Michael Bauer, Erich Allen Peterson, PhD BS, MS, Timothy C. Ashby, Tobias Meissner, Caleb K. Stein, MS, Donald Johann, MD MS, Sarah K. Johnson, PhD, Shmuel Yaccoby, PhD, Joshua Epstein, DSc, Frits van Rhee, MD PhD, Maurizio Zangari, MD, Carolina Schinke, MD, Sharmilan Thanendrarajan, MD, Faith E Davies, MD, Bart Barlogie, MD PhD, Gareth J Morgan, MDPhD
Journal: Blood
Blood (2015) 126 (23): 20.
https://doi.org/10.1182/blood.V126.23.20.20
Published: 2015
Journal Articles

Impact of Minimal Residual Disease in High and Standard Risk Multiple Myeloma

Free
Carolina Schinke, MD, Shayu Deshpande, PhD, Alan Mitchell, Malek Faham, Purvi Patel, Sharmilan Thanendrarajan, MD, Meera Mohan, Pankaj Mathur, Aasiya Matin, Muthukumar Radhakrishnan, Ruslana Tytarenko, Owen W Stephens, PhD, Frits van Rhee, MD PhD, Maurizio Zangari, MD, Yogesh Jethava, MD, Nathan Petty, MS, Daisy V. Alapat, MD, Sarah K. Johnson, PhD, Joshua Epstein, DSc, Bart Barlogie, MD PhD, Faith E Davies, MD, Christoph Heuck, MD, Antje Hoering, Niels Weinhold, PhD, Gareth J Morgan, MDPhD
Journal: Blood
Blood (2015) 126 (23): 2979.
https://doi.org/10.1182/blood.V126.23.2979.2979
Published: 2015
Journal Articles

Genome-wide scan identifies variant in 2q12.3 associated with risk for multiple myeloma

Free
Stephen W. Erickson, Vinay R. Raj, Owen W. Stephens, Ishwori Dhakal, Shweta S. Chavan, Naveen Sanathkumar, Elizabeth Ann Coleman, Jeannette Y. Lee, Julia A. Goodwin, Senu Apewokin, Daohong Zhou, Joshua Epstein, Christoph J. Heuck, Annette J. Vangsted
Journal: Blood
Blood (2014) 124 (12): 2001–2003.
https://doi.org/10.1182/blood-2014-07-586701
Published: 2014
Includes: Supplemental data
Journal Articles

An intermediate-risk multiple myeloma subgroup is defined by sIL-6r: levels synergistically increase with incidence of SNP rs2228145 and 1q21 amplification

Free
Owen W. Stephens, Qing Zhang, Pingping Qu, Yiming Zhou, Shweta Chavan, Erming Tian, David R. Williams, Joshua Epstein, Bart Barlogie, John D. Shaughnessy, Jr
Journal: Blood
Blood (2012) 119 (2): 503–512.
https://doi.org/10.1182/blood-2011-07-367052
Published: 2012
Includes: Supplemental data