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Journal Articles

A CEBPB/IL-1β/TNF-α feedback loop drives drug resistance to venetoclax and MDM2 inhibitors in monocytic leukemia

Available to Purchase
Basil Allen, Daniel Bottomly, Thomas Köhnke, Anthony Wang, Hsin-Yun Lin, Kara Johnson, Isabel Kenna, Anastatia Streltsova, Emma Martin, Reid Chen, Lindsey Savoy, Nicola Long, Peter Ryabinin, Stephen E. Kurtz, Christopher A. Eide, Amy Carlos, Andy Kaempf, Tingting Liu, Cristina Tognon, Robert Searles, Paul D. Piehowski, Sara J. C. Gosline, Anupriya Agarwal, Bill H. Chang, Michelle Barton, Brian J. Druker, Shannon K. McWeeney, Ravindra Majeti, Jeffrey W. Tyner, Haijiao Zhang
Journal: Blood
Blood (2025) 145 (21): 2488–2506.
https://doi.org/10.1182/blood.2024028239
Published: 2025
Includes: Supplemental data
Journal Articles

Project EVOLVE: An international analysis of postimmunotherapy lineage switch, an emergent form of relapse in leukemia

Open Access
Sara K Silbert, Alexander W Rankin, Chloe N Hoang, Alexandra Semchenkova, Regina M Myers, Elena Zerkalenkova, PhD, Hao-Wei Wang, Alexandra E Kovach, Constance M Yuan, Dana Delgado Colon, Loic Vasseur, Alex Bataller, Samuel John, Kaylyn Utley Lyons, Barbara D. Friedes, Anna Alonso-Saladrigues, Hisham Abdel-Azim, Estelle Balducci, Ahmed Aljudi, Marie Balsat, D. Nathan Biery, Aghiad Chamdin, Bill H Chang, Raymund S Cuevo, MD, Barbara De Moerloose, David S. Dickens, Ulrich A Duffner, Nicolas Duployez, Firas El Chaer, Michelle Ann Elliott, Gabriele Escherich, Sneha Fernandes, Mandi R Fitzjohn, Zhubin J Gahvari, Stephan A. Grupp, Rui Rochelle He, M.D., Cynthia Harrison, Christopher Bruce Hergott, Emily M. Hsieh, Annette S Kim, Dennis John Kuo, Daniel P Larson, Benjamin J Lee, Thibaut TL Leguay, R. Coleman Lindsley, Abhishek A. Mangaonkar, Kerstin Mezger, Holly L Pacenta, Jing Pan, Marlie R. M. Provost, Latika Puri, Sunil Sudhir Raikar, Armando Jose Martinez, Isabella Quijada Bristol, Kyle Daniel Murphy, Lauren Reiman, Michele S Redell, Kelly Reed, Gabrielle Roth Guepin, Jeremy D Rubinstein, Süreyya Savaşan, Kristian T Schafernak, Alexandra McLean Stevens, Aimee C Talleur, Naomi Torres Carapia, Jacques Vargaftig, Anant Vatsayan, Matthias Wölfl, Lipng Zhao, Susana Rives, Vanessa A. Fabrizio, Koji Sasaki, Ibrahim Aldoss, Nicolas Boissel, Susan R Rheingold, Kara L Davis, Sara Ghorashian, Elad Jacoby, Alexander Popov, Adam Joseph Lamble, Nirali N Shah
Journal: Blood
Blood blood.2024026655.
https://doi.org/10.1182/blood.2024026655
Published: 2025
Includes: Supplemental data
Journal Articles

Rituximab, Lenalidomide, and Zanubrutinib (ZR 2 ) with Sequential CAR-T Cell As First-Line Therapy for High-Risk Large B Cell Lymphoma

Free
Mingming Zhang, Yongxian Hu, Guoqing Wei, Shan Fu, Jingjing Feng, Ruimin Hong, Alex H. Chang, He Huang
Journal: Blood
Blood (2024) 144 (Supplement 1): 91.
https://doi.org/10.1182/blood-2024-210462
Published: 2024
Journal Articles

A Single-Center, Single-Arm, Phase I Clinical Trial of Anti-BCMA/GPRC5D Bispecific CAR T-Cells in Patients with Refractory and Relapsed Multiple Myeloma with Extramedullary Disease

Free
Ling Qiu, Shihui Ren, Ying He, Dan Chen, Sihan Lai, Baitao Dou, Mengjiao Li, Rou Shu, Alex H. Chang, Yi Su, Hao Yao, Fangyi Fan
Journal: Blood
Blood (2024) 144 (Supplement 1): 1028.
https://doi.org/10.1182/blood-2024-210226
Published: 2024
Journal Articles

Combination with Palbociclib Overcomes Venetoclax Resistance Mechanisms and Outperforms Single Agent Efficacy in Acute Myeloid Leukemia

Free
Melissa L Stewart, Jessica Gibbs, Daniel Bottomly, Andy Kaempf, Stephen E. Kurtz, Christopher A. Eide, Ariane Huang, Luca Sax, Nicola Long, Shannon K McWeeney, Bill H Chang, Jeffrey W. Tyner
Journal: Blood
Blood (2024) 144 (Supplement 1): 1566.
https://doi.org/10.1182/blood-2024-198516
Published: 2024
Journal Articles

Donor-Derived CD7 Chimeric Antigen Receptor T Cells for T-Cell Prolymphocytic Leukemia: Two Case Reports

Free
Sihan Lai, Yisong Xiong, Yanrong Shuai, Xupai Zhang, Guangcui He, Hao Yao, Hui Yang, Ling Zhang, Rong Huang, Yi Su, Alex H. Chang, Hai Yi
Journal: Blood
Blood (2024) 144 (Supplement 1): 7204.
https://doi.org/10.1182/blood-2024-202015
Published: 2024
Journal Articles

Different T-Cell Activation Approaches Impact the Resulting CART-Cell Products and Possible Clinical Outcomes

Free
Biping Deng, Zhaoli Liu, Xiaoming Qu, Yu'e Zhang, Zhongxin Zhang, Rong Luan, Lingli Zhang, Ming Ma, Xiai Wu, Rui Liu, Alex H. Chang, Kai Hu, Chunrong Tong
Journal: Blood
Blood (2024) 144 (Supplement 1): 4856.
https://doi.org/10.1182/blood-2024-203423
Published: 2024
Journal Articles

Retrospective Cohort Analysis of Response and Survival of Children, Adolescents, and Young Adults (CAYA) with Relapsed and/or Refractory (R/R) T-Cell Acute Lymphoblastic Leukemia (T-ALL) and Lymphoma (T-LL) Treated with Curative Intent: A TACL Consortium Study

Free
Melinda G Pauly, Yueh-Yun Chi, Jemily Malvar, Roy Leong, Susan Colace, Nathan Gossai, Nobuko Hijiya, Chintan Parekh, Susan R Rheingold, Anupam Verma, Bill H Chang, Todd M Cooper, Andrew Doan, Yamilet Huerta, Kelly Elizabeth Faulk, Diane Hanna, Kenneth Matthew Heym, Mallorie M. Heneghan, Joel Kaplan, Luciano Dalla-Pozza, Seth E. Karol, Andrew E. Place, Jenna Rossoff, Eric S. Schafer, Tamra Slone, Michelle L. Hermiston, Maria Luisa Sulis
Journal: Blood
Blood (2024) 144 (Supplement 1): 4187.
https://doi.org/10.1182/blood-2024-209138
Published: 2024
Journal Articles

Prior ASCT Has a Negative Impact on Outcomes in Relapsed/Refractory Multiple Myeloma Patients after BCMA CAR-T Therapy

Free
Chunxiang Jin, Rongrong Chen, Shan Fu, Alex H. Chang, He Huang, Yongxian Hu
Journal: Blood
Blood (2024) 144 (Supplement 1): 7082.
https://doi.org/10.1182/blood-2024-201470
Published: 2024
Journal Articles

Long-Term Follow-up of Sequential Allogeneic Hematopoietic Stem Cell Transplantation in Relapsed/Refractory Acute Lymphoblastic Leukemia Patients Achieving MRD-Negative CR after CAR-T Therapy

Free
Tingting Yang, Yetian Dong, Jimin Shi, Mingming Zhang, Jingjing Feng, Shan Fu, Pingnan Xiao, Ruimin Hong, Huijun Xu, Yi Luo, Yanmin Zhao, Jian Yu, Xiaoyu Lai, Huarui Fu, Yishan Ye, Jiazhen Cui, Simao Huang, Guoqing Wei, Alex H. Chang, He Huang, Yongxian Hu
Journal: Blood
Blood (2024) 144 (Supplement 1): 7420.
https://doi.org/10.1182/blood-2024-209418
Published: 2024
Journal Articles

Survey on Institutional Practices of Calaspargase Administration

Free
Lori E Morgan, Jennifer L Raybin, Bill H Chang, Linda C Stork
Journal: Blood
Blood (2024) 144 (Supplement 1): 5875.
https://doi.org/10.1182/blood-2024-206723
Published: 2024
Journal Articles

APRIL CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma: A Phase I Clinical Trial

Free
Wenxiao Li, Yongxian Hu, Mingming Zhang, Xinyi Lai, Mengyu Zhao, Shan Fu, Ruimin Hong, Alex H. Chang, He Huang
Journal: Blood
Blood (2024) 144 (Supplement 1): 7229.
https://doi.org/10.1182/blood-2024-209660
Published: 2024
Journal Articles

Sequential CD19 and CD22 CAR-T Therapy in Relapsed/Refractory Acute Lymphoblastic Leukemia

Free
Tingting Yang, Yetian Dong, Mingming Zhang, Jingjing Feng, Shan Fu, Pingnan Xiao, Ruimin Hong, Huijun Xu, Jiazhen Cui, Simao Huang, Guoqing Wei, Alex H. Chang, He Huang, Yongxian Hu
Journal: Blood
Blood (2024) 144 (Supplement 1): 2818.
https://doi.org/10.1182/blood-2024-210124
Published: 2024
Journal Articles

Outcome of Infants Treated on Total Therapy for Infants with Acute Lymphoblastic Leukemia I: Results from a Non-Randomized Multi-Center Study

Free
Tanja A. Gruber, Minxuan Huang, Sima Jeha, Rebecca J. Deyell, Victor A. Lewis, Bill H. Chang, Eric J. Lowe, Jamie Frediani, Catherine Vezina, Bruno Michon, Nathan Gossai, Erin H. Breese, Thai Hoa Tran, Norman J. Lacayo, Christine Bolen, Sunil J. Desai, Jennifer L. Pauley, Emily Ashcraft, Cheng Cheng, Kirk R. Schultz, Krysta Schils, Linda C. Stork, Van Thu Huynh, Michael Richards, Yoav H. Messinger, Henrique Bittencourt, Terzah M. Horton, Uma Athale, Duncan Stearns, Deborah E. Schiff, Paul S. Gaynon
Journal: Blood
Blood (2023) 142 (Supplement 1): 823.
https://doi.org/10.1182/blood-2023-177798
Published: 2023
Journal Articles

A Multi-Omic Single-Cell Landscape of Cytokine Release Syndrome in Multiple Myeloma Patients after Anti-BCMA CAR-T Cell Therapy

Free
Yongxian HU, Xia Li, Penglei Jiang, Tingting Yang, Tianning Gu, Xiaohui Si, Yali Xie, Mingming Zhang, Guoqing Wei, Huijun Xu, Zenan Cen, Jiazhen Cui, Simao Huang, Fang Ni, Linqin Wang, Xiujian Wang, Xiangjun Zeng, Delin Kong, Houli Zhao, Alex H. Chang, Yanlei Zhang, Jin Zhang, Jinyan Huang, Pengxu Qian, He Huang
Journal: Blood
Blood (2023) 142 (Supplement 1): 101.
https://doi.org/10.1182/blood-2023-185236
Published: 2023
Journal Articles

Risk Stratified Treatment for Patients with Newly Diagnosed Juvenile Myelomonocytic Leukemia: A Phase 1/2 Non-Randomized Study of Trametinib and Azacitidine with or without Chemotherapy

Free
Elliot Stieglitz, Yueh-Yun Chi, Bill H. Chang, Sarah K. Tasian, Marielle Yohe, Christopher C Dvorak, Erica Southworth, Janel R. Long-Boyle, Jessica Van Ziffle, Zied Abdullaev, Roy Leong, Alan S. Wayne, Deepa Bhojwani, Mignon L. Loh
Journal: Blood
Blood (2023) 142 (Supplement 1): 3210.
https://doi.org/10.1182/blood-2023-177838
Published: 2023
Journal Articles

Dasatinib and CAR-T Cell Therapy for Newly Diagnosed Ph-Positive Acute Lymphoblastic Leukemia in Adults

Free
Mingming Zhang, Yongxian Hu, Guoqing Wei, Shan Fu, Jingjing Feng, Ruimin Hong, Alex H. Chang, He Huang
Journal: Blood
Blood (2023) 142 (Supplement 1): 891.
https://doi.org/10.1182/blood-2023-186225
Published: 2023
Journal Articles

Absence of Neutropenia in Patient with an Exon 2 Nonsense Mutation in ELANE : Clinical Evidence to Support Gene Therapy Efforts for Severe Congenital Neutropenia

Free
Margret Joos, Akiko Shimamura, Timothy H. Chang, Peter E. Newburger
Journal: Blood
Blood (2023) 142 (Supplement 1): 5661.
https://doi.org/10.1182/blood-2023-190110
Published: 2023
Journal Articles

Project Evolve, Evaluation of Lineage Switch (LS), an International Initiative: Preliminary Results Reveal Dismal Outcomes in Patients with LS

Free
Sara K. Silbert, Cynthia Harrison, D. Nathan Biery, Alexandra Semchenkova, Elena Zerkalenkova, Anna Alonso-Saladrigues, Kaylyn Utley, Ibrahim Aldoss, Liping Zhao, Sneha Fernandes, Jeremy D. Rubinstein, Naomi Torres Carapia, Bill H. Chang, Anant Vatsayan, Barbara De Moerloose, Holly L. Pacenta, Dennis John Kuo, Gabriele Escherich, Benjamin J. Lee, Michele S. Redell, Mandi R. Fitzjohn, Daniel P. Larson, Nicolas Duployez, Raymund S. Cuevo, Rui Rochelle He, David Dickens, Firas El Chaer, Kelly Reed, Matthias Wolfl, Sunil S. Raikar, Süreyya Savaşan, Latika Puri, Zhubin J. Gahvari, Aimee C. Talleur, Hisham Abdel-Azim, Aghiad Chamdin, Marlie R.M. Provost, Vanessa A. Fabrizio, Kerstin Mezger, Alexandra McLean Stevens, Emily M. Hsieh, Hao-Wei Wang, Constance M. Yuan, Ulrich A. Duffner, Jing Pan, Sara Ghorashian, Susana Rives, Chloe Hoang, Kara L. Davis, Elad Jacoby, Alexander Popov, Adam Lamble, Nirali N. Shah
Journal: Blood
Blood (2023) 142 (Supplement 1): 4202.
https://doi.org/10.1182/blood-2023-182293
Published: 2023
Journal Articles

CD19/BCMA CAR-T Cell Therapy for Refractory Systemic Lupus Erythematosus - Safety and Preliminary Efficacy Data from a Phase I Clinical Study

Free
Jingjing Feng, Yongxian HU, Alex H. Chang, He Huang
Journal: Blood
Blood (2023) 142 (Supplement 1): 4835.
https://doi.org/10.1182/blood-2023-186669
Published: 2023