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Journal Articles

1‰ Regular Dose of Metabolically Armored CD19 CAR-T Cells Induces Robust in vivo Expansion and Complete Remission in Relapsed or Refractory Diffuse Large B-Cell Lymphoma Patients

Yongxian Hu, Mingming Zhang, Shan Fu, Ruimin Hong, Jiazhen Cui, Simao Huang, Min Gao, Daojun Bai, Jingjing Ren, Xingbing Wang, Yugang Guo, Li Tang, He Huang
Journal: Blood
Blood (2024) 144 (Supplement 1): 2074.
https://doi.org/10.1182/blood-2024-207694
Published: 2024
Journal Articles

Long-Term Follow-up of Sequential Allogeneic Hematopoietic Stem Cell Transplantation in Relapsed/Refractory Acute Lymphoblastic Leukemia Patients Achieving MRD-Negative CR after CAR-T Therapy

Tingting Yang, Yetian Dong, Jimin Shi, Mingming Zhang, Jingjing Feng, Shan Fu, Pingnan Xiao, Ruimin Hong, Huijun Xu, Yi Luo, Yanmin Zhao, Jian Yu, Xiaoyu Lai, Huarui Fu, Yishan Ye, Jiazhen Cui, Simao Huang, Guoqing Wei, Alex H. Chang, He Huang, Yongxian Hu
Journal: Blood
Blood (2024) 144 (Supplement 1): 7420.
https://doi.org/10.1182/blood-2024-209418
Published: 2024
Journal Articles

Sequential CD19 and CD22 CAR-T Therapy in Relapsed/Refractory Acute Lymphoblastic Leukemia

Tingting Yang, Yetian Dong, Mingming Zhang, Jingjing Feng, Shan Fu, Pingnan Xiao, Ruimin Hong, Huijun Xu, Jiazhen Cui, Simao Huang, Guoqing Wei, Alex H. Chang, He Huang, Yongxian Hu
Journal: Blood
Blood (2024) 144 (Supplement 1): 2818.
https://doi.org/10.1182/blood-2024-210124
Published: 2024
Journal Articles

Long Term Follow-up Results of Brl-201 Phase I Study, a Crispr-Based Non-Viral PD-1 Locus Specific Integrated Anti-CD19 CAR-T Cells in Treating Relapsed or Refractory Non-Hodgkin's Lymphoma

Biao Zheng, Yongxian Hu, Jiqin Zhang, Mingming Zhang, Wei Li, Wenjun Wu, Jiazhen Cui, Guoqing Wei, Bing Du, Mingyao Liu, He Huang
Journal: Blood
Blood (2023) 142 (Supplement 1): 2108.
https://doi.org/10.1182/blood-2023-185573
Published: 2023
Journal Articles

A Multi-Omic Single-Cell Landscape of Cytokine Release Syndrome in Multiple Myeloma Patients after Anti-BCMA CAR-T Cell Therapy

Yongxian HU, Xia Li, Penglei Jiang, Tingting Yang, Tianning Gu, Xiaohui Si, Yali Xie, Mingming Zhang, Guoqing Wei, Huijun Xu, Zenan Cen, Jiazhen Cui, Simao Huang, Fang Ni, Linqin Wang, Xiujian Wang, Xiangjun Zeng, Delin Kong, Houli Zhao, Alex H. Chang, Yanlei Zhang, Jin Zhang, Jinyan Huang, Pengxu Qian, He Huang
Journal: Blood
Blood (2023) 142 (Supplement 1): 101.
https://doi.org/10.1182/blood-2023-185236
Published: 2023
Journal Articles

Characteristics of Central Nervous System Relapse after CD19 CAR-T Cell Therapy in R/R NHL

Mengyu Zhao, Tingting Yang, Yetian Dong, Wenxiao Li, Tianning Gu, Linghui Zhou, Jiazhen Cui, Wenfa Huang, Mingming Zhang, Lei Wang, Lixin Wang, Delin Kong, He Huang, Yongxian HU
Journal: Blood
Blood (2023) 142 (Supplement 1): 6915.
https://doi.org/10.1182/blood-2023-187951
Published: 2023
Journal Articles

Neither Conditioning Chemotherapy Nor GvHD-Prophylaxis: CD7 CAR-T Treatment Bridging to Haplo-HSCT

Yongxian Hu, Mingming Zhang, Tingting Yang, Ruirui Jing, Houli Zhao, Rongrong Chen, Tianning Gu, Pingnan Xiao, Ruimin Hong, Jingjing Feng, Shan Fu, Delin Kong, Huijun Xu, Jiazhen Cui, Simao Huang, Bin Liang, Guoqing Wei, Xiaolin Yuan, Qu Cui, Jiangtao Ren, Alex H. Chang, Dongrui Wang, He Huang
Journal: Blood
Blood (2023) 142 (Supplement 1): 1039.
https://doi.org/10.1182/blood-2023-185697
Published: 2023
Journal Articles

Genomic and Transcriptomic Profiling Reveal the Mechanism and Risk Factors of CD19-Negative Relapse after CAR-T Cell Therapy

Ruimin Hong, Linghui Zhou, Ye Meng, Mingming Zhang, Houli Zhao, Jiazhen Cui, Simao Huang, Yongxian Hu, He Huang
Journal: Blood
Blood (2022) 140 (Supplement 1): 6354–6355.
https://doi.org/10.1182/blood-2022-164955
Published: 2022
Journal Articles

MEK Inhibition in CAR-T Cells Prevents Exhaustion and Terminal Differentiation Via Downregulating C-Fos and JunB

Xiujian Wang, Xiao Tao, Pengjie Chen, Penglei Jiang, Cong Wei, Wenxiao Li, Hao Zhang, Zuyu Liang, Hefeng Chang, Xinyi Lai, Yihan Pan, Lijuan Ding, Jiazhen Cui, Mi Shao, Xinyi Teng, Jieping Wei, Delin Kong, Xiaohui Si, Yingli Han, Huarui Fu, Yu Lin, Tianning Gu, Jian Yu, Yongxian Hu, Pengxu Qian, He Huang
Journal: Blood
Blood (2022) 140 (Supplement 1): 626–627.
https://doi.org/10.1182/blood-2022-158646
Published: 2022
Journal Articles

High Safety and Efficacy of CRISPR-Based Non-Viral PD-1 Locus Specific Integrated Anti-CD19 CAR-T Cells (BRL-201) in Treating Relapsed or Refractory Non-Hodgkin's Lymphoma: First-in-Human Phase I Study

Yongxian Hu, Jiqin Zhang, Mingming Zhang, Wei Li, Wenjun Wu, Jiazhen Cui, Guoqing Wei, Bing Du, Mingyao Liu, He Huang
Journal: Blood
Blood (2022) 140 (Supplement 1): 7491–7492.
https://doi.org/10.1182/blood-2022-156137
Published: 2022
Journal Articles

Safety and Efficacy of CD19 CAR-T Cells for Refractory Systemic Sclerosis: A Phase I Clinical Trial

Jingjing Feng, Yongxian Hu, Mingming Zhang, Heng Cao, Yini Ke, Huijun Xu, Jiazhen Cui, Yanlei Zhang, Alex Hongsheng Chang, Jin Lin, Guoqing Wei, He Huang
Journal: Blood
Blood (2022) 140 (Supplement 1): 10335–10336.
https://doi.org/10.1182/blood-2022-169265
Published: 2022
Journal Articles

Galectin-9 from Bone Marrow Mesenchymal Stromal Cells Mediates Immunosuppression on Chimeric Antigen Receptor T Cells

Xinyi Teng, BS, Hao Zhang, MD, Zuyu Liang, MD, Mi Shao, MD, Xiujian Wang, MD, Lijuan Ding, MD, Jiazhen Cui, msc, Yongxian Hu, MD, He Huang, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5609.
https://doi.org/10.1182/blood-2019-131680
Published: 2019
Journal Articles

Changes of T Lymphocyte Subsets after CAR-T Cell Therapy and Its Clinical Significance

Lijuan Ding, Jiazhen Cui, Yongxian Hu, MD PhD, Huijun Xu, Yanlei Zhang, Shaohui Liu, Kangyan Wang, Zhenxing Guo, AlexH Chang, MD, PhD, He Huang, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1423.
https://doi.org/10.1182/blood-2018-99-117885
Published: 2018