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Journal Articles

SNORD113-114 Cluster Maintains Hematopoietic Stem Cell Self-Renewal Via Orchestrating the Translation Machinery

Hui Wang, Zhaoru Zhang, Yingli Han, Weili Zhao, Penglei Jiang, Bing Liu, Jia Yu, Fang Wang, Pengxu Qian
Journal: Blood
Blood (2024) 144 (Supplement 1): 438.
https://doi.org/10.1182/blood-2024-199496
Published: 2024
Journal Articles

Transient Activation of PIEZO1 Mechanosensitive Channel Facilitates Ex Vivo expansion of Hematopoietic Stem Cells

Qiwei Wang, Weili Zhao, He Huang, Pengxu Qian
Journal: Blood
Blood (2024) 144 (Supplement 1): 2649.
https://doi.org/10.1182/blood-2024-193734
Published: 2024
Journal Articles

Lysosome Acidification Facilitates the Expansion of Circulating Hematopoietic Stem and Progenitor Cells

Xu Yulin, Meng Zhang, Jianghuan Lu, Dawei Huo, Penglei Jiang, Ruxiu Tie, Yijin Chen, Xiangjun Zeng, Pengxu Qian, He Huang
Journal: Blood
Blood (2024) 144 (Supplement 1): 5612.
https://doi.org/10.1182/blood-2024-206973
Published: 2024
Journal Articles

ULK1 Regulates the Proliferation and Differentiation of Erythroid Progenitors

Yijin Chen, Haiqiong Zheng, Qian Luo, Mengmeng Huang, Meng Zhang, Pengxu Qian, He Huang
Journal: Blood
Blood (2024) 144 (Supplement 1): 3843.
https://doi.org/10.1182/blood-2024-207275
Published: 2024
Journal Articles

A Single-Cell Transcriptomic Atlas of Cytokine Storm in CAR-T Therapy, COVID-19, and SLE

Xia Li, Haikun Lin, Boxiang Wu, Xinyi Lai, Yinnan Tong, Jinyan Huang, Pengxu Qian, Yongxian Hu, He Huang
Journal: Blood
Blood (2024) 144 (Supplement 1): 420.
https://doi.org/10.1182/blood-2024-201300
Published: 2024
Journal Articles

The ATF4-RPS19BP1 axis modulates ribosome biogenesis to promote erythropoiesis

Zhaofeng Zheng, Shangda Yang, Fanglin Gou, Chao Tang, Zhaoru Zhang, Quan Gu, Guohuan Sun, Penglei Jiang, Nini Wang, Xiangnan Zhao, Junnan Kang, Yifei Wang, Yicheng He, Meng Yang, Ting Lu, Shihong Lu, Pengxu Qian, Ping Zhu, Hui Cheng, Tao Cheng
Journal: Blood
Blood (2024) 144 (7): 742–756.
https://doi.org/10.1182/blood.2023021901
Published: 2024
Includes: Supplemental data
Journal Articles

Autophagy Inhibition Prevents CAR-T Exhaustion and Terminal Differentiation Via TCF7 Accumulation

Xinyi Teng, Mi Shao, Xin Guo, Tao Cheng, Pengxu Qian, He Huang
Journal: Blood
Blood (2023) 142 (Supplement 1): 4823.
https://doi.org/10.1182/blood-2023-189441
Published: 2023
Journal Articles

Deciphering the Impact of Donor Telomere Length on Allogeneic Transplantation Outcomes: Telomere Length Matters More Than Age

Hengwei Wu, Zhiyang Yuan, Xiang Xu, Jimin Shi, Yi Luo, Jian Yu, Xiaoyu Lai, Lizhen Liu, Yamin Tan, Huarui Fu, Pengxu Qian, Zhongzheng Zheng, He Huang, Yanmin Zhao
Journal: Blood
Blood (2023) 142 (Supplement 1): 366.
https://doi.org/10.1182/blood-2023-184465
Published: 2023
Journal Articles

Epigenetic Reprogramming By Histone Deacetylase Inhibitors Improves CAR-T Cell Functions

Tianning Gu, Meng Zhu, Yingli Han, Rui Wang, Pengxu Qian, He Huang
Journal: Blood
Blood (2023) 142 (Supplement 1): 2080.
https://doi.org/10.1182/blood-2023-186465
Published: 2023
Journal Articles

Nlrc3 Signaling Is Indispensable for Hematopoietic Stem Cell Emergence Via Notch Signaling in Vertebrates

Shuyang Cai, Honghu Li, Ruxiu Tie, Wei Shan, Qian Luo, Shufen Wang, Huiqiao Chen, Meng Zhang, Xu Yulin, Jiahui Lu, Pengxu Qian, He Huang
Journal: Blood
Blood (2023) 142 (Supplement 1): 2675.
https://doi.org/10.1182/blood-2023-186693
Published: 2023
Journal Articles

Constructing a Machine Learning-Based Rating Model to Predict the Outcome of GCSF Mobilization of Hematopoietic Stem Cells in Peripheral Blood

Xiangjun Zeng, Jimei Ge, Jimin Shi, Yi Luo, Jian Yu, Xiaoyu Lai, Lizhen Liu, Yamin Tan, Huarui Fu, Pengxu Qian, He Huang, Yanmin Zhao
Journal: Blood
Blood (2023) 142 (Supplement 1): 4890.
https://doi.org/10.1182/blood-2023-186179
Published: 2023
Journal Articles

Post-Transcriptional Features of CAR-T Cell Excessively Activated By Tonic Signaling

Xin Guo, Xinyi Teng, Mi Shao, Tao Cheng, Pengxu Qian, He Huang
Journal: Blood
Blood (2023) 142 (Supplement 1): 6832.
https://doi.org/10.1182/blood-2023-184844
Published: 2023
Journal Articles

A Multi-Omic Single-Cell Landscape of Cytokine Release Syndrome in Multiple Myeloma Patients after Anti-BCMA CAR-T Cell Therapy

Yongxian HU, Xia Li, Penglei Jiang, Tingting Yang, Tianning Gu, Xiaohui Si, Yali Xie, Mingming Zhang, Guoqing Wei, Huijun Xu, Zenan Cen, Jiazhen Cui, Simao Huang, Fang Ni, Linqin Wang, Xiujian Wang, Xiangjun Zeng, Delin Kong, Houli Zhao, Alex H. Chang, Yanlei Zhang, Jin Zhang, Jinyan Huang, Pengxu Qian, He Huang
Journal: Blood
Blood (2023) 142 (Supplement 1): 101.
https://doi.org/10.1182/blood-2023-185236
Published: 2023
Journal Articles

The ATF4-RPS19BP1 Axis Modulates Ribosome Biogenesis to Promote Erythropoiesis

Zhaofeng Zheng, Shangda Yang, Fanglin Gou, Chao Tang, Zhaoru Zhang, Penglei Jiang, Pengxu Qian, Ping Zhu, Hui Cheng, Tao Cheng
Journal: Blood
Blood (2023) 142 (Supplement 1): 142.
https://doi.org/10.1182/blood-2023-184592
Published: 2023
Journal Articles

Fecal microbiota transplantation from young mice rejuvenates aged hematopoietic stem cells by suppressing inflammation

Xiangjun Zeng, Xiaoqing Li, Xia Li, Cong Wei, Ce Shi, Kejia Hu, Delin Kong, Qian Luo, Yulin Xu, Wei Shan, Meng Zhang, Jimin Shi, Jingjing Feng, Yingli Han, He Huang, Pengxu Qian
Journal: Blood
Blood (2023) 141 (14): 1691–1707.
https://doi.org/10.1182/blood.2022017514
Published: 2023
Includes: Supplemental data
Journal Articles

MEK Inhibition in CAR-T Cells Prevents Exhaustion and Terminal Differentiation Via Downregulating C-Fos and JunB

Xiujian Wang, Xiao Tao, Pengjie Chen, Penglei Jiang, Cong Wei, Wenxiao Li, Hao Zhang, Zuyu Liang, Hefeng Chang, Xinyi Lai, Yihan Pan, Lijuan Ding, Jiazhen Cui, Mi Shao, Xinyi Teng, Jieping Wei, Delin Kong, Xiaohui Si, Yingli Han, Huarui Fu, Yu Lin, Tianning Gu, Jian Yu, Yongxian Hu, Pengxu Qian, He Huang
Journal: Blood
Blood (2022) 140 (Supplement 1): 626–627.
https://doi.org/10.1182/blood-2022-158646
Published: 2022
Journal Articles

Loss of sphingosine kinase 2 promotes the expansion of hematopoietic stem cells by improving their metabolic fitness

Changzheng Li, Binghuo Wu, Yishan Li, Yaxi Liu, Jin Wang, Jiayi Xie, Xi Xu, Xiaobin Tian, Zhitao Ye, Jingjing Guan, Jie Chen, Siyu Xie, Baolin Zhang, Boyong Cai, Qianhao Wang, Haopeng Yu, Tian Lan, Cheuk Him Man, Xunlei Kang, Pengxu Qian, John M. Perry, Aibin He, Linjia Jiang, Meng Zhao
Journal: Blood
Blood (2022) 140 (15): 1686–1701.
https://doi.org/10.1182/blood.2022016112
Published: 2022
Includes: Supplemental data
Journal Articles

The Methylation-Sensitive Enhancer Derare Maintains Hematopoietic Stem Cells through Regulation of Hoxb Cluster

Pengxu Qian, PhD, Bony De Kumar, PhD, Youngwook Ahn, PhD, Christof Nolte, PhD, Ariel Paulson, PhD, Xi C He, MD, Zhenrui Li, John M. Perry, PhD, Meng Zhao, PhD, Fang Tao, Robb Krumlauf, PhD, Linheng Li, PhD
Journal: Blood
Blood (2016) 128 (22): 725.
https://doi.org/10.1182/blood.V128.22.725.725
Published: 2016
Journal Articles

Amino Acid Transporter X Is Required for Hematopoietic Stem Cell Maintenance through Regulating Specific Amino Acids Level

Zhenrui Li, MS, Keiyo Takubo, MD PhD, Pengxu Qian, PhD, Toshio Suda, MD PhD, Linheng Li, PhD
Journal: Blood
Blood (2015) 126 (23): 1166.
https://doi.org/10.1182/blood.V126.23.1166.1166
Published: 2015
Journal Articles

Chemoresistant Leukemia-Initiating Cell Expansion Is Inhibited By Targeting Oncogenic Self-Renewal

John M. Perry, PhD, Anuradha Roy, Xiuling Lu, PhD, Xi C. He, MD, Fang Tao, Meng Zhao, PhD, Pengxu Qian, PhD, Linheng Li, PhD
Journal: Blood
Blood (2015) 126 (23): 1860.
https://doi.org/10.1182/blood.V126.23.1860.1860
Published: 2015