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Issue Archive

Volume 140, Issue 16
October 20 2022
Issue Cover

Table of Contents

Blood Commentaries

Connecting the dots: lenalidomide and t-MNs
Sohini Chakraborty,Christopher Y. Park
View Articletitled, Connecting the dots: lenalidomide and <em>t</em>-MNs
The burden of heavy menstrual bleeding
Clinical Trials & Observations
Barbara A. Konkle
View Articletitled, The burden of heavy menstrual bleeding
Clonal hematopoiesis transcending species barriers
Philipp J. Rauch,Benjamin L. Ebert
View Articletitled, Clonal hematopoiesis transcending species barriers
Optimized CD19/CD22/CD3 antibody
Dafne Müller
View Articletitled, Optimized CD19/CD22/CD3 antibody
Tackling ALK-positive LBCL
Clinical Trials & Observations
Fabian Frontzek,Georg Lenz
View Articletitled, Tackling ALK-positive LBCL

Plenary Paper

Lenalidomide promotes the development of TP53-mutated therapy-related myeloid neoplasms
Clinical Trials & Observations
Adam S. Sperling,Veronica A. Guerra,James A. Kennedy,Yuanqing Yan,Joanne I. Hsu,Feng Wang,Andrew T. Nguyen,Peter G. Miller,Marie E. McConkey,Vanessa A. Quevedo Barrios,Ken Furudate,Linda Zhang,Rashmi Kanagal-Shamanna,Jianhua Zhang,Latasha Little,Curtis Gumbs,Naval Daver,Courtney D. DiNardo,Tapan Kadia,Farhad Ravandi,Hagop Kantarjian,Guillermo Garcia-Manero,P. Andrew Futreal,Benjamin L. Ebert,Koichi Takahashi
View Articletitled, Lenalidomide promotes the development of <em>TP53</em>-mutated therapy-related myeloid neoplasms
Supplemental data
Connecting the dots: lenalidomide and t-MNs
Sohini Chakraborty,Christopher Y. Park
View Articletitled, Connecting the dots: lenalidomide and <em>t</em>-MNs

Clinical Trials and Observations

Incidence and impact of anticoagulation-associated abnormal menstrual bleeding in women after venous thromboembolism
CME Clinical Trials & Observations
C. M. M. de Jong,M. Blondon,C. Ay,A. Buchmuller,J. Beyer-Westendorf,J. Biechele,L. Bertoletti,G. Colombo,M. P. Donadini,S. V. Hendriks,L. Jara-Palomares,S. Nopp,P. Ruiz-Artacho,P. Stephan,C. Tromeur,T. Vanassche,P. E. Westerweel,F. A. Klok,for the TEAM-VTE investigators
View Articletitled, Incidence and impact of anticoagulation-associated abnormal menstrual bleeding in women after venous thromboembolism
Supplemental data
The burden of heavy menstrual bleeding
Clinical Trials & Observations
Barbara A. Konkle
View Articletitled, The burden of heavy menstrual bleeding

Hematopoiesis and Stem Cells

A macaque clonal hematopoiesis model demonstrates expansion of TET2-disrupted clones and utility for testing interventions
Tae-Hoon Shin,Yifan Zhou,Shirley Chen,Stefan Cordes,Max Z. Grice,Xing Fan,Byung-Chul Lee,Aisha A. Aljanahi,So Gun Hong,Kelli L. Vaughan,Julie A. Mattison,Steven G. Kohama,Margarete A. Fabre,Naoya Uchida,Selami Demirci,Marcus A. F. Corat,Jean-Yves Métais,Katherine R. Calvo,Manuel Buscarlet,Hannah Natanson,Kathy L. McGraw,Alan F. List,Lambert Busque,John F. Tisdale,George S. Vassiliou,Kyung-Rok Yu,Cynthia E. Dunbar
View Articletitled, A macaque clonal hematopoiesis model demonstrates expansion of TET2-disrupted clones and utility for testing interventions
Supplemental data
Clonal hematopoiesis transcending species barriers
Philipp J. Rauch,Benjamin L. Ebert
View Articletitled, Clonal hematopoiesis transcending species barriers

Immunobiology and Immunotherapy

A novel CD19/CD22/CD3 trispecific antibody enhances therapeutic efficacy and overcomes immune escape against B-ALL
Lijun Zhao,Shuhong Li,Xiaoyi Wei,Xuexiu Qi,Dong Liu,Lei Liu,Feiqiu Wen,Ji-shuai Zhang,Feng Wang,Ze-lin Liu,Yu J. Cao
View Articletitled, A novel CD19/CD22/CD3 trispecific antibody enhances therapeutic efficacy and overcomes immune escape against B-ALL
Supplemental data
Optimized CD19/CD22/CD3 antibody
Dafne Müller
View Articletitled, Optimized CD19/CD22/CD3 antibody
Antigen-guided depletion of anti-HLA antibody–producing cells by HLA-Fc fusion proteins
Ashlee M. Webber,Tara R. Bradstreet,Xiaoli Wang,Hongjie Guo,Christopher A. Nelson,Daved H. Fremont,Brian T. Edelson,Chang Liu
View Articletitled, Antigen-guided depletion of anti-HLA antibody–producing cells by HLA-Fc fusion proteins
Supplemental data

Lymphoid Neoplasia

Loss of COP9 signalosome genes at 2q37 is associated with IMiD resistance in multiple myeloma
Brief Report
Sarah Gooding,Naser Ansari-Pour,Mohammad Kazeroun,Kubra Karagoz,Ann Polonskaia,Mirian Salazar,Evie Fitzsimons,Korsuk Sirinukunwattana,Selina Chavda,Maria Ortiz Estevez,Fadi Towfic,Erin Flynt,William Pierceall,Daniel Royston,Kwee Yong,Karthik Ramasamy,Paresh Vyas,Anjan Thakurta
View Articletitled, Loss of COP9 signalosome genes at 2q37 is associated with IMiD resistance in multiple myeloma
Supplemental data

Letters to Blood

Next-generation ALK inhibitors are highly active in ALK-positive large B-cell lymphoma
Clinical Trials & Observations
Jacob D. Soumerai,Allison Rosenthal,Shannon Harkins,Jessica Duffy,Carmen Mecca,Yingbing Wang,Ravinder K. Grewal,Areej R. El-Jawahri,Huiyun Liu,Cedric Menard,Ahmet Dogan,Lei Yang,Lisa M. Rimsza,Kurt Bantilan,Haley Martin,Matthew Lei,Sydney Mohr,Anna Kurilovich,Olga Kudryashova,Ekaterina Postovalova,Valentina Nardi,Jeremy S. Abramson,Roberto Chiarle,Andrew D. Zelenetz,Abner Louissaint, Jr.
View Articletitled, Next-generation ALK inhibitors are highly active in ALK-positive large B-cell lymphoma
Supplemental data
A model of painful vaso-occlusive crisis in mice with sickle cell disease
Iryna I. Khasabova,Joseph Juliette,Victoria M. Rogness,Sergey G. Khasabov,Mikhail Y. Golovko,Svetlana A. Golovko,Stacy Kiven,Kalpna Gupta,John D. Belcher,Gregory M. Vercellotti,Virginia S. Seybold,Donald A. Simone
View Articletitled, A model of painful vaso-occlusive crisis in mice with sickle cell disease

Blood Work

Multiple myeloma presenting with extracellular crystal deposition in the bone marrow
Lise Schoonen,Anja A. van Houten
View Articletitled, Multiple myeloma presenting with extracellular crystal deposition in the bone marrow

Continuing Medical Education (CME) Questions

Anticoagulation-associated AUB after VTE
CME
View Articletitled, Anticoagulation-associated AUB after VTE
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