Issue Archive

Antiphospholipid antibody syndrome is caused by antiphospholipid antibodies (aPLs) that cause thrombosis and pregnancy loss. In a Plenary Paper, Müller-Calleja et al dissect the complex and multifaceted mechanism by which aPLs induce thrombosis through priming of monocytes and disruption of the balance of tissue factor activation and inhibition.

In a Special Report, the T-PLL International Study group presents consensus criteria for the diagnosis, staging, and treatment response assessment of patients with T-cell prolymphocytic leukemia.

Chen and colleagues report excellent durability of response at 2 years for patients responding to pembrolizumab for relapsed Hodgkin lymphoma.

KDM4 and JMJD2 are histone demethylases that are considered promising targets for treatment of MLL translocation–bearing acute myeloid leukemia. Agger and colleagues demonstrate an important role of KDM4 activity in long-term normal hematopoiesis that should be considered when contemplating the clinical use of long-term inhibition of KDM4 demethylase activity.

Polycomb repressive complex 2 (PRC2) dysregulation is associated with proliferation of hematological malignancies. Ren et al elucidate the mechanisms of PRC2 in multiple myeloma (MM), demonstrating that malignant progression of MM is associated with overexpression of PHF19, a PRC2-associated factor that enhances its gene-regulatory function.

Using sickle cell disease as a model, Cutts et al describe a highly sensitive method for prenatal diagnosis of known single-gene defects using next-generation sequencing of maternal plasma cell-free DNA.