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Activated protein C (APC) has antithrombotic and cell signaling activities. Mutation of 3 Lys residues to Ala (3K3A-APC) reduces by >90% APC's anticoagulant activity without affecting cell signaling actions. Thus, 3K3A-APC is signaling-selective and is in clinical trials for ischemic stroke. See the review series on nontraditional roles for the hemostatic system in the vessel wall.
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Asciminib is a novel inhibitor of ABL1 and ABL2 gene fusions in ALL but requires the ABL SH3 domain for efficacy

NGS-based stratification refines the risk stratification in T-ALL and identifies a Very High-Risk subgroup of patients

Foxo1 is an iron-responsive transcriptional factor regulating systemic iron homeostasis

How I Treat Low-risk Polycythemia Vera Patients who Require Cytoreduction

How I manage major hemorrhage

Table of Contents

EDITORIAL

Introduction to a review series on nontraditional roles for the hemostatic system in the vessel wall

BLOOD COMMENTARIES

Roring ahead with DOCK2

FDG-PET in PMBCL: which heterogeneity?

Prognosis interfered with by clonal interference

Progress with pathogen-reduced blood

REVIEW SERIES

Extravascular coagulation in hematopoietic stem and progenitor cell regulation

von Willebrand factor regulation of blood vessel formation

Inflammation, von Willebrand factor, and ADAMTS13

Exploring traditional and nontraditional roles for thrombomodulin

Activated protein C, protease activated receptor 1, and neuroprotection

LYMPHOID NEOPLASIA

Wnt5a induces ROR1 to recruit DOCK2 to activate Rac1/2 in chronic lymphocytic leukemia

Metabolic heterogeneity on baseline 18FDG-PET/CT scan is a predictor of outcome in primary mediastinal B-cell lymphoma
Clinical Trials & Observations

MYELOID NEOPLASIA

Clonal interference of signaling mutations worsens prognosis in core-binding factor acute myeloid leukemia

PLATELETS AND THROMBOPOIESIS

Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion

IGF-1 facilitates thrombopoiesis primarily through Akt activation

TRANSFUSION MEDICINE

Hemostatic efficacy of pathogen-inactivated vs untreated platelets: a randomized controlled trial
Clinical Trials & Observations

LETTER TO BLOOD

Single-cell exomes in an index case of amp1q21 multiple myeloma reveal more diverse mutanomes than the whole population

BLOOD WORK

Internuclear bridging outside of primary myelodysplasia and congenital dyserythropoietic anemia

ERRATUM

Terness P, Navolan D, Opelz G, Roelcke D. Inverse association between IgG–anti-κ and antierythrocyte autoantibodies in patients with cold agglutination. Blood. 1999;94(12):4343-4346.

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Table of Contents

EDITORIAL

BLOOD COMMENTARIES

REVIEW SERIES

LYMPHOID NEOPLASIA

Metabolic heterogeneity on baseline 18FDG-PET/CT scan is a predictor of outcome in primary mediastinal B-cell lymphoma Clinical Trials & Observations

MYELOID NEOPLASIA

PLATELETS AND THROMBOPOIESIS

TRANSFUSION MEDICINE

Hemostatic efficacy of pathogen-inactivated vs untreated platelets: a randomized controlled trial Clinical Trials & Observations

LETTER TO BLOOD

BLOOD WORK

ERRATUM

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Metabolic heterogeneity on baseline 18FDG-PET/CT scan is a predictor of outcome in primary mediastinal B-cell lymphoma
Clinical Trials & Observations

Hemostatic efficacy of pathogen-inactivated vs untreated platelets: a randomized controlled trial
Clinical Trials & Observations