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Issue Archive

Volume 126, Issue 26
December 24 2015
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Tailoring steroid-sensitive virus-specific T cells with TALEN
Austin J. Barrett
View Articletitled, Tailoring steroid-sensitive virus-specific T cells with TALEN
INSIDE BLOOD COMMENTARY
Treatment of Hodgkin lymphoma in older patients
Clinical Trials & Observations
John Radford
View Articletitled, Treatment of Hodgkin lymphoma in older patients
INSIDE BLOOD COMMENTARY
Enlightening light chain deposition disease
Clinical Trials & Observations
Giampaolo Merlini,Giovanni Palladini
View Articletitled, Enlightening light chain deposition disease
INSIDE BLOOD COMMENTARY
CD30-targeting drugs: cure for mastocytosis?
Irina Maric
View Articletitled, CD30-targeting drugs: cure for mastocytosis?
INSIDE BLOOD COMMENTARY
DNA damage signals inhibit neutrophil function
Jeffrey J. Bednarski
View Articletitled, DNA damage signals inhibit neutrophil function
INSIDE BLOOD COMMENTARY
Not dead yet
Shawn M. Jobe
View Articletitled, Not dead yet
INSIDE BLOOD COMMENTARY
Transporting down the road to dehydration
Patrick G. Gallagher
View Articletitled, Transporting down the road to dehydration
INSIDE BLOOD COMMENTARY
Platelet FcγRIIA signaling: new clues for HIT
Alice Assinger
View Articletitled, Platelet FcγRIIA signaling: new clues for HIT
INSIDE BLOOD COMMENTARY
Cord blood T cells are “completely different”
Juliet Barker,Alan Hanash
View Articletitled, Cord blood T cells are “completely different”

PLENARY PAPER

IMMUNOBIOLOGY
TALEN-mediated genetic inactivation of the glucocorticoid receptor in cytomegalovirus-specific T cells
Laurie Menger,Agnes Gouble,Maria A. V. Marzolini,Annette Pachnio,Katharina Bergerhoff,Jake Y. Henry,Julianne Smith,Martin Pule,Paul Moss,Stanley R. Riddell,Sergio A. Quezada,Karl S. Peggs
View Articletitled, TALEN-mediated genetic inactivation of the glucocorticoid receptor in cytomegalovirus-specific T cells
Supplemental data

EVIDENCE-BASED FOCUSED REVIEW

Primary antifungal prophylaxis during curative-intent therapy for acute myeloid leukemia
Clinical Trials & Observations
Anna B. Halpern,Gary H. Lyman,Thomas J. Walsh,Dimitrios P. Kontoyiannis,Roland B. Walter
View Articletitled, Primary antifungal prophylaxis during curative-intent therapy for acute myeloid leukemia
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Phase 2 study of frontline brentuximab vedotin monotherapy in Hodgkin lymphoma patients aged 60 years and older
Clinical Trials & Observations
Andres Forero-Torres,Beata Holkova,Jerome Goldschmidt,Robert Chen,Gregg Olsen,Ralph V. Boccia,Rodolfo E. Bordoni,Jonathan W. Friedberg,Jeff P. Sharman,Maria Corinna Palanca-Wessels,Yinghui Wang,Christopher A. Yasenchak
View Articletitled, Phase 2 study of frontline brentuximab vedotin monotherapy in Hodgkin lymphoma patients aged 60 years and older
Supplemental data
Natural history and outcome of light chain deposition disease
CME Clinical Trials & Observations
Rabya H. Sayed,Ashutosh D. Wechalekar,Janet A. Gilbertson,Paul Bass,Shameem Mahmood,Sajitha Sachchithanantham,Marianna Fontana,Ketna Patel,Carol J. Whelan,Helen J. Lachmann,Philip N. Hawkins,Julian D. Gillmore
View Articletitled, Natural history and outcome of light chain deposition disease
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression
Heidi Anderson,Taylor C. Patch,Pavankumar N. G. Reddy,Elliott J. Hagedorn,Peter G. Kim,Kathleen A. Soltis,Michael J. Chen,Owen J. Tamplin,Maike Frye,Glenn A. MacLean,Kathleen Hübner,Daniel E. Bauer,John P. Kanki,Guillaume Vogin,Nicholas C. Huston,Minh Nguyen,Yuko Fujiwara,Barry H. Paw,Dietmar Vestweber,Leonard I. Zon,Stuart H. Orkin,George Q. Daley,Dhvanit I. Shah
View Articletitled, Hematopoietic stem cells develop in the absence of endothelial <em>cadherin 5</em> expression
Supplemental data

LYMPHOID NEOPLASIA

Targeting HGF/c-MET induces cell cycle arrest, DNA damage, and apoptosis for primary effusion lymphoma
Lu Dai,Jimena Trillo-Tinoco,Yueyu Cao,Karlie Bonstaff,Lisa Doyle,Luis Del Valle,Denise Whitby,Chris Parsons,Krzysztof Reiss,Jovanny Zabaleta,Zhiqiang Qin
View Articletitled, Targeting HGF/c-MET induces cell cycle arrest, DNA damage, and apoptosis for primary effusion lymphoma
Supplemental data

MYELOID NEOPLASIA

Identification of the Ki-1 antigen (CD30) as a novel therapeutic target in systemic mastocytosis
Katharina Blatt,Sabine Cerny-Reiterer,Juliana Schwaab,Karl Sotlar,Gregor Eisenwort,Gabriele Stefanzl,Gregor Hoermann,Matthias Mayerhofer,Mathias Schneeweiss,Sylvia Knapp,Thomas Rülicke,Emir Hadzijusufovic,Karin Bauer,Dubravka Smiljkovic,Michael Willmann,Andreas Reiter,Hans-Peter Horny,Peter Valent
View Articletitled, Identification of the Ki-1 antigen (CD30) as a novel therapeutic target in systemic mastocytosis
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Neutrophil oxidative burst activates ATM to regulate cytokine production and apoptosis
C. J. Harbort,Paulo Vitor Soeiro-Pereira,Horst von Bernuth,Angela M. Kaindl,Beatriz Tavares Costa-Carvalho,Antonio Condino-Neto,Janine Reichenbach,Joachim Roesler,Arturo Zychlinsky,Borko Amulic
View Articletitled, Neutrophil oxidative burst activates ATM to regulate cytokine production and apoptosis
Supplemental data

PLATELETS AND THROMBOPOIESIS

Necrotic platelets provide a procoagulant surface during thrombosis
Vu Minh Hua,Latasha Abeynaike,Elias Glaros,Heather Campbell,Leonardo Pasalic,Philip J. Hogg,Vivien M. Y. Chen
View Articletitled, Necrotic platelets provide a procoagulant surface during thrombosis
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model
Fiona C. Brown,Ashlee J. Conway,Loretta Cerruti,Janelle E. Collinge,Catriona McLean,James S. Wiley,Ben T. Kile,Stephen M. Jane,David J. Curtis
View Articletitled, Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model
Supplemental data

THROMBOSIS AND HEMOSTASIS

Anti–miR-148a regulates platelet FcγRIIA signaling and decreases thrombosis in vivo in mice
Yuhang Zhou,Shaji Abraham,Pierrette Andre,Leonard C. Edelstein,Chad A. Shaw,Carol A. Dangelmaier,Alexander Y. Tsygankov,Satya P. Kunapuli,Paul F. Bray,Steven E. McKenzie
View Articletitled, Anti–miR-148a regulates platelet FcγRIIA signaling and decreases thrombosis in vivo in mice
Supplemental data

TRANSPLANTATION

Cord blood T cells mediate enhanced antitumor effects compared with adult peripheral blood T cells
Prashant Hiwarkar,Waseem Qasim,Ida Ricciardelli,Kimberly Gilmour,Sergio Quezada,Aurore Saudemont,Persis Amrolia,Paul Veys
View Articletitled, Cord blood T cells mediate enhanced antitumor effects compared with adult peripheral blood T cells
Supplemental data

BLOOD WORK

Hemophagocytic lymphohistiocytosis in a patient with granulomatosis with polyangiitis (Wegener's granulomatosis)
Aparna Harbhajanka,Brett Mahon
View Articletitled, Hemophagocytic lymphohistiocytosis in a patient with granulomatosis with polyangiitis (Wegener's granulomatosis)

CORRESPONDENCE

Bioluminescent reporters to monitor killer cell–mediated delivery of granzymes inside target cells
Stefanie A. H. de Poot,Elisabeth A. van Erp,Jan Meeldijk,Roel Broekhuizen,Roel Goldschmeding,Marjolein C. Olthof,Elisabeth M. P. Steeghs,Niels Bovenschen
View Articletitled, Bioluminescent reporters to monitor killer cell–mediated delivery of granzymes inside target cells
Supplemental data
Outcome of children with hypodiploid ALL treated with risk-directed therapy based on MRD levels
Clinical Trials & Observations
Charles G. Mullighan,Sima Jeha,Deqing Pei,Debbie Payne-Turner,Elaine Coustan-Smith,Kathryn G. Roberts,Esmé Waanders,John K. Choi,Xiaotu Ma,Susana C. Raimondi,Yiping Fan,Wenjian Yang,Guangchun Song,Jun J. Yang,Hiroto Inaba,James R. Downing,Wing H. Leung,W. Paul Bowman,Mary V. Relling,William E. Evans,Jinghui Zhang,Dario Campana,Ching-Hon Pui
View Articletitled, Outcome of children with hypodiploid ALL treated with risk-directed therapy based on MRD levels
Haploinsufficient loss of multiple 5q genes may fine-tune Wnt signaling in del(5q) therapy-related myeloid neoplasms
Angela Stoddart,Joy Nakitandwe,Shann-Ching Chen,James R. Downing,Michelle M. Le Beau
View Articletitled, Haploinsufficient loss of multiple 5q genes may fine-tune Wnt signaling in del(5q) therapy-related myeloid neoplasms

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

Light chain deposition disease
CME
View Articletitled, Light chain deposition disease
  • Cover Image

    Cover Image

    issue cover

    Two zebrafish embryos of different genetic backgrounds fused with each other using parabiotic surgery. The authors used parabiotic fusion of zebrafish embryos to investigate how hematopoietic stem cells emerge, migrate, engraft, and differentiate in the absence of endothelial cadherin 5. The image represents the power of parabiosis to investigate temporal, cell-intrinsic, and cell-extrinsic functions of a gene of interest. See the article by Anderson et al on page 2811.

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