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A phase 1 study of the bispecific anti-CD30/CD16A antibody construct AFM13 in patients with relapsed or refractory Hodgkin lymphoma
Inducible caspase-9 suicide gene controls adverse effects from alloreplete T cells after haploidentical stem cell transplantation
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Table of Contents
EDITORIAL
INSIDE BLOOD COMMENTARIES
REVIEW SERIES
REVIEW SERIES
REVIEW SERIES
REVIEW SERIES
REVIEW SERIES
CLINICAL TRIALS AND OBSERVATIONS
A phase 1 study of the bispecific anti-CD30/CD16A antibody construct AFM13 in patients with relapsed or refractory Hodgkin lymphoma
Clinical Trials & Observations
Achim Rothe,Stephanie Sasse,Max S. Topp,Dennis A. Eichenauer,Horst Hummel,Katrin S. Reiners,Markus Dietlein,Georg Kuhnert,Joerg Kessler,Carolin Buerkle,Miroslav Ravic,Stefan Knackmuss,Jens-Peter Marschner,Elke Pogge von Strandmann,Peter Borchmann,Andreas Engert
LYMPHOID NEOPLASIA
The PI3K/mTOR inhibitor PF-04691502 induces apoptosis and inhibits microenvironmental signaling in CLL and the Eµ-TCL1 mouse model
Matthew D. Blunt,Matthew J. Carter,Marta Larrayoz,Lindsay D. Smith,Maria Aguilar-Hernandez,Kerry L. Cox,Thomas Tipton,Mark Reynolds,Sarah Murphy,Elizabeth Lemm,Samantha Dias,Andrew Duncombe,Jonathan C. Strefford,Peter W. M. Johnson,Francesco Forconi,Freda K. Stevenson,Graham Packham,Mark S. Cragg,Andrew J. Steele
Clinical and pharmacodynamic analysis of pomalidomide dosing strategies in myeloma: impact of immune activation and cereblon targets
Kartik Sehgal,Rituparna Das,Lin Zhang,Rakesh Verma,Yanhong Deng,Mehmet Kocoglu,Juan Vasquez,Srinivas Koduru,Yan Ren,Maria Wang,Suzana Couto,Mike Breider,Donna Hansel,Stuart Seropian,Dennis Cooper,Anjan Thakurta,Xiaopan Yao,Kavita M. Dhodapkar,Madhav V. Dhodapkar
Ebf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiency
Mahadesh A. J. Prasad,Jonas Ungerbäck,Josefine Åhsberg,Rajesh Somasundaram,Tobias Strid,Malin Larsson,Robert Månsson,Ayla De Paepe,Henrik Lilljebjörn,Thoas Fioretos,James Hagman,Mikael Sigvardsson
MYELOID NEOPLASIA
Arginine deprivation using pegylated arginine deiminase has activity against primary acute myeloid leukemia cells in vivo
Farideh Miraki-Moud,Essam Ghazaly,Linda Ariza-McNaughton,Katharine A. Hodby,Andrew Clear,Fernando Anjos-Afonso,Konstantinos Liapis,Marianne Grantham,Fareeda Sohrabi,Jamie Cavenagh,John S. Bomalaski,John G. Gribben,Peter W. Szlosarek,Dominique Bonnet,David C. Taussig
THROMBOSIS AND HEMOSTASIS
TRANSPLANTATION
Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease
Ryan Flynn,Jessica L. Allen,Leo Luznik,Kelli P. MacDonald,Katelyn Paz,Kylie A. Alexander,Ante Vulic,Jing Du,Angela Panoskaltsis-Mortari,Patricia A. Taylor,Jonathan C. Poe,Jonathan S. Serody,William J. Murphy,Geoffrey R. Hill,Ivan Maillard,John Koreth,Corey S. Cutler,Robert J. Soiffer,Joseph H. Antin,Jerome Ritz,Nelson J. Chao,Raphael A. Clynes,Stefanie Sarantopoulos,Bruce R. Blazar
Allogeneic cell transplant expands bone marrow distribution by colonizing previously abandoned areas: an FDG PET/CT analysis
Francesco Fiz,Cecilia Marini,Cristina Campi,Anna Maria Massone,Marina Podestà,Gianluca Bottoni,Roberta Piva,Francesca Bongioanni,Andrea Bacigalupo,Michele Piana,Gianmario Sambuceti,Francesco Frassoni
Inducible caspase-9 suicide gene controls adverse effects from alloreplete T cells after haploidentical stem cell transplantation
Clinical Trials & Observations
Xiaoou Zhou,Gianpietro Dotti,Robert A. Krance,Caridad A. Martinez,Swati Naik,Rammurti T. Kamble,April G. Durett,Olga Dakhova,Barbara Savoldo,Antonio Di Stasi,David M. Spencer,Yu-Feng Lin,Hao Liu,Bambi J. Grilley,Adrian P. Gee,Cliona M. Rooney,Helen E. Heslop,Malcolm K. Brenner
BLOOD WORK
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Cover Image
Cover Image
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The anti–CLEC-2 antibody INU1 rapidly induces internalization of the CLEC-2 receptor in fetal liver cell-derived megakaryocytes (MKs). MKs were permeabilized, and internalized INU1-F488 (green) was counterstained with anti-rat IgG-Cy3 antibodies (cyan). Cell nuclei were stained with 4′,6-diamidino-2-phenylindole (blue), and actin was stained with phalloidin-F647 (red). See the article by Lorenz et al on page 4069.
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