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Issue Archive

Volume 125, Issue 25
June 18 2015
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
CMV after transplant: T-cell repertoire crooks
Everett Meyer
View Articletitled, CMV after transplant: T-cell repertoire crooks
INSIDE BLOOD COMMENTARY
Beyond the first glance: anthracyclines in AML
Clinical Trials & Observations
Hugo F. Fernandez
View Articletitled, Beyond the first glance: anthracyclines in AML
INSIDE BLOOD COMMENTARY
Daring to learn from humanized mice
Silke Paust,Matthew Bettini
View Articletitled, Daring to learn from humanized mice
INSIDE BLOOD COMMENTARY
Mechanism of enhanced eosinophil survival in inflammation
Nives Zimmermann,Marc E. Rothenberg
View Articletitled, Mechanism of enhanced eosinophil survival in inflammation
INSIDE BLOOD COMMENTARY
GWA study for ADAMTS13 activity
Toshiyuki Miyata
View Articletitled, GWA study for ADAMTS13 activity

PLENARY PAPER

TRANSPLANTATION
CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCRβ repertoire
Yvonne Suessmuth,Rithun Mukherjee,Benjamin Watkins,Divya T. Koura,Knut Finstermeier,Cindy Desmarais,Linda Stempora,John T. Horan,Amelia Langston,Muna Qayed,Hanna J. Khoury,Audrey Grizzle,Jennifer A. Cheeseman,Jason A. Conger,Jennifer Robertson,Aneesah Garrett,Allan D. Kirk,Edmund K. Waller,Bruce R. Blazar,Aneesh K. Mehta,Harlan S. Robins,Leslie S. Kean
View Articletitled, CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCRβ repertoire
Supplemental data

REVIEW ARTICLE

Regulation of thrombosis and vascular function by protein methionine oxidation
Sean X. Gu,Jeff W. Stevens,Steven R. Lentz
View Articletitled, Regulation of thrombosis and vascular function by protein methionine oxidation

HOW I TREAT

How I treat refractory thrombotic thrombocytopenic purpura
Farzana A. Sayani,Charles S. Abrams
View Articletitled, How I treat refractory thrombotic thrombocytopenic purpura

CLINICAL TRIALS AND OBSERVATIONS

Effects of deferasirox-deferoxamine on myocardial and liver iron in patients with severe transfusional iron overload
Clinical Trials & Observations
Yesim Aydinok,Antonis Kattamis,M. Domenica Cappellini,Amal El-Beshlawy,Raffaella Origa,Mohsen Elalfy,Yurdanur Kilinç,Silverio Perrotta,Zeynep Karakas,Vip Viprakasit,Dany Habr,Niculae Constantinovici,Junwu Shen,John B. Porter,on behalf of the HYPERION Investigators
View Articletitled, Effects of deferasirox-deferoxamine on myocardial and liver iron in patients with severe transfusional iron overload
Supplemental data
A randomized comparison of daunorubicin 90 mg/m2 vs 60 mg/m2 in AML induction: results from the UK NCRI AML17 trial in 1206 patients
CME Clinical Trials & Observations
Alan K. Burnett,Nigel H. Russell,Robert K. Hills,Jonathan Kell,Jamie Cavenagh,Lars Kjeldsen,Mary-Frances McMullin,Paul Cahalin,Mike Dennis,Lone Friis,Ian F. Thomas,Don Milligan,Richard E. Clark,on behalf of the UK NCRI AML Study Group
View Articletitled, A randomized comparison of daunorubicin 90 mg/m<sup>2</sup> vs 60 mg/m<sup>2</sup> in AML induction: results from the UK NCRI AML17 trial in 1206 patients
Supplemental data

IMMUNOBIOLOGY

Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3
Jeremy A. Goettel,Subhabrata Biswas,Willem S. Lexmond,Ada Yeste,Laura Passerini,Bonny Patel,Siyoung Yang,Jiusong Sun,Jodie Ouahed,Dror S. Shouval,Katelyn J. McCann,Bruce H. Horwitz,Diane Mathis,Edgar L. Milford,Luigi D. Notarangelo,Maria-Grazia Roncarolo,Edda Fiebiger,Wayne A. Marasco,Rosa Bacchetta,Francisco J. Quintana,Sung-Yun Pai,Christoph Klein,Aleixo M. Muise,Scott B. Snapper
View Articletitled, Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3
Supplemental data
Eosinophil-specific deletion of IκBα in mice reveals a critical role of NF-κB–induced Bcl-xL for inhibition of apoptosis
Christian Schwartz,Ralf Willebrand,Silke Huber,Rudolf A. Rupec,Davina Wu,Richard Locksley,David Voehringer
View Articletitled, Eosinophil-specific deletion of IκBα in mice reveals a critical role of NF-κB–induced Bcl-x<sub>L</sub> for inhibition of apoptosis
Supplemental data
Tumor indoleamine 2,3-dioxygenase (IDO) inhibits CD19-CAR T cells and is downregulated by lymphodepleting drugs
Soranobu Ninomiya,Neeharika Narala,Leslie Huye,Shigeki Yagyu,Barbara Savoldo,Gianpietro Dotti,Helen E. Heslop,Malcolm K. Brenner,Cliona M. Rooney,Carlos A. Ramos
View Articletitled, Tumor indoleamine 2,3-dioxygenase (IDO) inhibits CD19-CAR T cells and is downregulated by lymphodepleting drugs
Supplemental data

LYMPHOID NEOPLASIA

Leukemia stem cells in T-ALL require active Hif1α and Wnt signaling
Vincenzo Giambra,Catherine E. Jenkins,Sonya H. Lam,Catherine Hoofd,Miriam Belmonte,Xuehai Wang,Sam Gusscott,Deanne Gracias,Andrew P. Weng
View Articletitled, Leukemia stem cells in T-ALL require active Hif1α and Wnt signaling
Supplemental data

MYELOID NEOPLASIA

Suppression of SOX7 by DNA methylation and its tumor suppressor function in acute myeloid leukemia
Cheuk Him Man,Tsz Kan Fung,Haixia Wan,Chae Yin Cher,August Fan,Nelson Ng,Christa Ho,Thomas S. K. Wan,Toshiyuki Tanaka,Chi Wai Eric So,Yok Lam Kwong,Anskar Y. H. Leung
View Articletitled, Suppression of <em>SOX7</em> by DNA methylation and its tumor suppressor function in acute myeloid leukemia
Supplemental data
ICL-induced miR139-3p and miR199a-3p have opposite roles in hematopoietic cell expansion and leukemic transformation
Mir Farshid Alemdehy,Jurgen R. Haanstra,Hans W. J. de Looper,Paulina M. H. van Strien,Judith Verhagen-Oldenampsen,Yvette Caljouw,Mathijs A. Sanders,Remco Hoogenboezem,Arnoud H. de Ru,George M. C. Janssen,Stephanie E. Smetsers,Marc B. Bierings,Peter A. van Veelen,Marieke von Lindern,Ivo P. Touw,Stefan J. Erkeland
View Articletitled, ICL-induced <em>miR139-3p</em> and <em>miR199a-3p</em> have opposite roles in hematopoietic cell expansion and leukemic transformation
Supplemental data

THROMBOSIS AND HEMOSTASIS

Genetic variants in the ADAMTS13 and SUPT3H genes are associated with ADAMTS13 activity
Paul S. de Vries,Johan Boender,Michelle A. H. Sonneveld,Fernando Rivadeneira,M. Arfan Ikram,Hanspeter Rottensteiner,Albert Hofman,André G. Uitterlinden,Frank W. G. Leebeek,Oscar H. Franco,Abbas Dehghan,Moniek P. M. de Maat
View Articletitled, Genetic variants in the <em>ADAMTS13</em> and <em>SUPT3H</em> genes are associated with ADAMTS13 activity
Supplemental data

TRANSPLANTATION

Haploidentical vs identical-sibling transplant for AML in remission: a multicenter, prospective study
Yu Wang,Qi-Fa Liu,Lan-Ping Xu,Kai-Yan Liu,Xiao-Hui Zhang,Xiao Ma,Zhi-Ping Fan,De-Pei Wu,Xiao-Jun Huang
View Articletitled, Haploidentical vs identical-sibling transplant for AML in remission: a multicenter, prospective study

BLOOD WORK

Simultaneous PRES and TMA secondary to tacrolimus after allogeneic bone marrow transplant
Daniel B. Aruch,Anne Renteria
View Articletitled, Simultaneous PRES and TMA secondary to tacrolimus after allogeneic bone marrow transplant

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

Daunorubicin dose in AML induction
CME
View Articletitled, Daunorubicin dose in AML induction
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