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Issue Archive

Volume 115, Issue 4
January 28 2010
Issue Cover

Table of Contents

INSIDE BLOOD

HEMATOPOIESIS & STEM CELLS
Scl and stem cell quiescence
Brian P. Sorrentino
View Articletitled, Scl and stem cell quiescence
CLINICAL TRIALS
PET positive, PET negative, or PET peeve?
Jonathan W. Friedberg
View Articletitled, PET positive, PET negative, or PET peeve?
THROMBOSIS & HEMOSTASIS
Platelet factor V to the rescue
Rodney M. Camire
View Articletitled, Platelet factor V to the rescue
TRANSPLANTATION
UCB and atmospheric noise
Michael R. Verneris,John E. Wagner
View Articletitled, UCB and atmospheric noise

EDITORIALS

Keeping up with Blood: introducing our CME program
Georgia B. Vogelsang,Cynthia E. Dunbar, MD
View Articletitled, Keeping up with <em>Blood</em>: introducing our CME program

PLENARY PAPERS

Single-unit dominance after double-unit umbilical cord blood transplantation coincides with a specific CD8+ T-cell response against the nonengrafted unit
Jonathan A. Gutman,Cameron J. Turtle,Thomas J. Manley,Shelly Heimfeld,Irwin D. Bernstein,Stanley R. Riddell,Colleen Delaney
View Articletitled, Single-unit dominance after double-unit umbilical cord blood transplantation coincides with a specific CD8<sup>+</sup> T-cell response against the nonengrafted unit

REVIEW ARTICLES

Dysregulation of bone remodeling by imatinib mesylate
Kate Vandyke,Stephen Fitter,Andrea L. Dewar,Timothy P. Hughes,Andrew C. W. Zannettino
View Articletitled, Dysregulation of bone remodeling by imatinib mesylate

CLINICAL TRIALS AND OBSERVATIONS

Interim positron emission tomography scans in diffuse large B-cell lymphoma: an independent expert nuclear medicine evaluation of the Eastern Cooperative Oncology Group E3404 study
CME
Sandra J. Horning,Malik E. Juweid,Heiko Schöder,Gregory Wiseman,Alex McMillan,Lode J. Swinnen,Ranjana Advani,Randy Gascoyne,Andrew Quon
View Articletitled, Interim positron emission tomography scans in diffuse large B-cell lymphoma: an independent expert nuclear medicine evaluation of the Eastern Cooperative Oncology Group E3404 study
Thrombosis in primary myelofibrosis: incidence and risk factors
Clinical Trials & Observations
Tiziano Barbui,Alessandra Carobbio,Francisco Cervantes,Alessandro M. Vannucchi,Paola Guglielmelli,Elisabetta Antonioli,Alberto Alvarez-Larrán,Alessandro Rambaldi,Guido Finazzi,Giovanni Barosi
View Articletitled, Thrombosis in primary myelofibrosis: incidence and risk factors

GENE THERAPY

Retrovirus gene therapy for X-linked chronic granulomatous disease can achieve stable long-term correction of oxidase activity in peripheral blood neutrophils
Elizabeth M. Kang,Uimook Choi,Narda Theobald,Gilda Linton,Debra A. Long Priel,Doug Kuhns,Harry L. Malech
View Articletitled, Retrovirus gene therapy for X-linked chronic granulomatous disease can achieve stable long-term correction of oxidase activity in peripheral blood neutrophils
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Scl regulates the quiescence and the long-term competence of hematopoietic stem cells
Julie Lacombe,Sabine Herblot,Shanti Rojas-Sutterlin,André Haman,Stéphane Barakat,Norman N. Iscove,Guy Sauvageau,Trang Hoang
View Articletitled, <em>Scl</em> regulates the quiescence and the long-term competence of hematopoietic stem cells
Supplemental data

IMMUNOBIOLOGY

Rap1 controls lymphocyte adhesion cascade and interstitial migration within lymph nodes in RAPL-dependent and -independent manners
Yukihiko Ebisuno,Koko Katagiri,Tomoya Katakai,Yoshihiro Ueda,Tomomi Nemoto,Hiroyuki Inada,Junichi Nabekura,Takaharu Okada,Reiji Kannagi,Toshiyuki Tanaka,Masayuki Miyasaka,Nancy Hogg,Tatsuo Kinashi
View Articletitled, Rap1 controls lymphocyte adhesion cascade and interstitial migration within lymph nodes in RAPL-dependent and -independent manners
Supplemental data

LYMPHOID NEOPLASIA

Cyclosporine-induced immune suppression alters establishment of HTLV-1 infection in a rabbit model
Rashade A. H. Haynes, II,Evan Ware,Christopher Premanandan,Bevin Zimmerman,Lianbo Yu,Andrew J. Phipps,Michael D. Lairmore
View Articletitled, Cyclosporine-induced immune suppression alters establishment of HTLV-1 infection in a rabbit model
A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma
Ying-Wei Lin,Zanna M. Beharry,Elizabeth G. Hill,Jin H. Song,Wenxue Wang,Zuping Xia,Zhenhua Zhang,Peter D. Aplan,Jon C. Aster,Charles D. Smith,Andrew S. Kraft
View Articletitled, A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma
Supplemental data
Combination of novel proteasome inhibitor NPI-0052 and lenalidomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma
Dharminder Chauhan,Ajita V. Singh,Bryan Ciccarelli,Paul G. Richardson,Michael A. Palladino,Kenneth C. Anderson
View Articletitled, Combination of novel proteasome inhibitor NPI-0052 and lenalidomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma
Supplemental data
VEGF/VEGFR2 interaction down-regulates matrix metalloproteinase–9 via STAT1 activation and inhibits B chronic lymphocytic leukemia cell migration
Brief Report
Estefanía Ugarte-Berzal,Javier Redondo-Muñoz,Pilar Eroles,Mercedes Hernández del Cerro,José A. García-Marco,María José Terol,Angeles García-Pardo
View Articletitled, VEGF/VEGFR2 interaction down-regulates matrix metalloproteinase–9 via STAT1 activation and inhibits B chronic lymphocytic leukemia cell migration
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Tumor necrosis factor–related apoptosis-inducing ligand 1 (TRAIL1) enhances the transition of red blood cells from the larval to adult type during metamorphosis in Xenopus
Kei Tamura,Shuuji Mawaribuchi,Shin Yoshimoto,Tadayoshi Shiba,Nobuhiko Takamatsu,Michihiko Ito
View Articletitled, Tumor necrosis factor–related apoptosis-inducing ligand 1 (TRAIL1) enhances the transition of red blood cells from the larval to adult type during metamorphosis in <em>Xenopus</em>
Supplemental data
Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery
Daniel R. Crooks,Manik C. Ghosh,Ronald G. Haller,Wing-Hang Tong,Tracey A. Rouault
View Articletitled, Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery

THROMBOSIS AND HEMOSTASIS

Thrombotic risk assessment in the antiphospholipid syndrome requires more than the quantification of lupus anticoagulants
Katrien Devreese,Kathelijne Peerlinck,Marc F. Hoylaerts
View Articletitled, Thrombotic risk assessment in the antiphospholipid syndrome requires more than the quantification of lupus anticoagulants
Supplemental data
Residual platelet factor V ensures thrombin generation in patients with severe congenital factor V deficiency and mild bleeding symptoms
Connie Duckers,Paolo Simioni,Luca Spiezia,Claudia Radu,Paolo Dabrilli,Sabrina Gavasso,Jan Rosing,Elisabetta Castoldi
View Articletitled, Residual platelet factor V ensures thrombin generation in patients with severe congenital factor V deficiency and mild bleeding symptoms

VASCULAR BIOLOGY

KSHV-induced notch components render endothelial and mural cell characteristics and cell survival
Ren Liu,Xiuqing Li,Anil Tulpule,Yue Zhou,Jeffrey S. Scehnet,Shaobing Zhang,Jong-Soo Lee,Preet M. Chaudhary,Jae Jung,Parkash S. Gill
View Articletitled, KSHV-induced notch components render endothelial and mural cell characteristics and cell survival
Supplemental data
Induction of nitric oxide by erythropoietin is mediated by the β common receptor and requires interaction with VEGF receptor 2
Larysa Sautina,Yuri Sautin,Elaine Beem,Zhuo Zhou,Anna Schuler,Jennafer Brennan,Sergey I. Zharikov,YanPeng Diao,Jorg Bungert,Mark S. Segal
View Articletitled, Induction of nitric oxide by erythropoietin is mediated by the β common receptor and requires interaction with VEGF receptor 2
Liprin β1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity
Brief Report
Camilla Norrmén,Wouter Vandevelde,Annelii Ny,Pipsa Saharinen,Massimiliano Gentile,Guttorm Haraldsen,Pauli Puolakkainen,Eugene Lukanidin,Mieke Dewerchin,Kari Alitalo,Tatiana V. Petrova
View Articletitled, Liprin β1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity
Supplemental data

CORRESPONDENCE

G-CSF–induced aneuploidy does not affect CD34+ cells and does not require cell division
Caroline Marmier-Savet,Fabrice Larosa,Faezeh Legrand,Brigitte Witz,Mauricette Michallet,Dana Ranta,Pascale Louvat,Marc Puyraveau,Nicole Raus,Maribel Tavernier,Suzanne Mathieu-Nafissi,Olivier Hequet,Jean-René Pallandre,Franck Vitte,Marie-Agnès Collonge-Rame,Fabienne Pouthier,Jean-Luc Bresson,Eric Deconinck,Pierre Tiberghien,Eric Robinet
View Articletitled, G-CSF–induced aneuploidy does not affect CD34<sup>+</sup> cells and does not require cell division
Friday leukemia: myth or reality?
Stefan Wilop,Oliver Galm,Laura Thompson,Rainhardt Osieka,Tim H. Brummendorf,Edgar Jost
View Articletitled, Friday leukemia: myth or reality?
Mutational analysis of SHOC2, a novel gene for Noonan-like syndrome, in JMML
Christian Flotho,Christiane Batz,Henrik Hasle,Eva Bergsträsser,Marry M. van den Heuvel-Eibrink,Marco Zecca,Charlotte M. Niemeyer,Martin Zenker
View Articletitled, Mutational analysis of <em>SHOC2</em>, a novel gene for Noonan-like syndrome, in JMML
A hypothesis that explains the heterogeneity of drug-induced immune thrombocytopenia
Renhao Li
View Articletitled, A hypothesis that explains the heterogeneity of drug-induced immune thrombocytopenia
Successful treatment of IgM-mediated autoimmune hemolytic anemia with bortezomib
Kenneth R. Carson,Lee G. Beckwith,Jayesh Mehta
View Articletitled, Successful treatment of IgM-mediated autoimmune hemolytic anemia with bortezomib
Plerixafor-moblized stem cells alone are capable of inducing early engraftment across the MHC-haploidentical canine barrier
Monica S. Thakar,Erlinda B. Santos,Simon Fricker,Gary Bridger,Rainer Storb,Brenda M. Sandmaier
View Articletitled, Plerixafor-moblized stem cells alone are capable of inducing early engraftment across the MHC-haploidentical canine barrier

OTHER DEPARTMENTS

Continuing Medical Education (CME) questions: PET scans in B-cell lymphoma
CME
View Articletitled, Continuing Medical Education (CME) questions: PET scans in B-cell lymphoma
  • Cover Image

    Cover Image

    issue cover

    Hypothetical schema for the effects of the tyrosine kinase inhibitor imatinib on bone metabolism. Imatinib causes increased bone volume by inhibiting osteoclast (OC) formation and activity and increasing osteoblast (OB) activity. The inhibitory effects of imatinib on signaling through c-fms and, potentially, c-kit, CAII, and PDGFR decreases the formation and activity of bone-resorbing OC. Additionally, inhibition of PDGFR by imatinib inhibits OB proliferation but also relieves the inhibitory effects of PDGF on OB bone formation. See the article by Vandyke et al on page 766.

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