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Issue Archive

Volume 114, Issue 24
December 3 2009
Issue Cover

Table of Contents

INSIDE BLOOD

HEMATOPOIESIS & STEM CELLS
Why some cells are “more equal” than others?
Mariusz Z. Ratajczak,Dong-Myung Shin
View Articletitled, Why some cells are “more equal” than others?
CLINICAL TRIALS
Fine-tuning targeted therapy of CML
Neil P. Shah
View Articletitled, Fine-tuning targeted therapy of CML
PLATELETS & THROMBOPOIESIS
Ready to analyze genetically modified human platelets
Meinrad Gawaz
View Articletitled, Ready to analyze genetically modified human platelets

BLOOD WORK

Blast crisis
View Articletitled, Blast crisis

REVIEW ARTICLES

The role of B cells in the pathogenesis of graft-versus-host disease
Alexander Shimabukuro-Vornhagen,Michael J. Hallek,Rainer F. Storb,Michael S. von Bergwelt-Baildon
View Articletitled, The role of B cells in the pathogenesis of graft-versus-host disease

CLINICAL TRIALS AND OBSERVATIONS

Evidence of serum immunoglobulin abnormalities up to 9.8 years before diagnosis of chronic lymphocytic leukemia: a prospective study
Clinical Trials & Observations
Huei-Ting Tsai,Neil E. Caporaso,Robert A. Kyle,Jerry A. Katzmann,Angela Dispenzieri,Richard B. Hayes,Gerald E. Marti,Maher Albitar,Paolo Ghia,S. Vincent Rajkumar,Ola Landgren
View Articletitled, Evidence of serum immunoglobulin abnormalities up to 9.8 years before diagnosis of chronic lymphocytic leukemia: a prospective study
Nilotinib for the frontline treatment of Ph+ chronic myeloid leukemia
Clinical Trials & Observations
Gianantonio Rosti,Francesca Palandri,Fausto Castagnetti,Massimo Breccia,Luciano Levato,Gabriele Gugliotta,Adele Capucci,Michele Cedrone,Carmen Fava,Tamara Intermesoli,Giovanna Rege Cambrin,Fabio Stagno,Mario Tiribelli,Marilina Amabile,Simona Luatti,Angela Poerio,Simona Soverini,Nicoletta Testoni,Giovanni Martinelli,Giuliana Alimena,Fabrizio Pane,Giuseppe Saglio,Michele Baccarani,for the GIMEMA CML Working Party
View Articletitled, Nilotinib for the frontline treatment of Ph<sup>+</sup> chronic myeloid leukemia
Chronic myeloid leukemia: a prospective comparison of interphase fluorescence in situ hybridization and chromosome banding analysis for the definition of complete cytogenetic response: a study of the GIMEMA CML WP
Clinical Trials & Observations
Nicoletta Testoni,Giulia Marzocchi,Simona Luatti,Marilina Amabile,Carmen Baldazzi,Monica Stacchini,Mauro Nanni,Giovanna Rege-Cambrin,Emilia Giugliano,Ursula Giussani,Elisabetta Abruzzese,Simonetta Kerim,Maria Grazia Grimoldi,Alessandro Gozzetti,Barbara Crescenzi,Carlo Carcassi,Paolo Bernasconi,Antonio Cuneo,Francesco Albano,Giuseppina Fugazza,Alfonso Zaccaria,Giovanni Martinelli,Fabrizio Pane,Gianantonio Rosti,Michele Baccarani
View Articletitled, Chronic myeloid leukemia: a prospective comparison of interphase fluorescence in situ hybridization and chromosome banding analysis for the definition of complete cytogenetic response: a study of the GIMEMA CML WP
Supplemental data
Dasatinib treatment of chronic-phase chronic myeloid leukemia: analysis of responses according to preexisting BCR-ABL mutations
Clinical Trials & Observations
Martin C. Müller,Jorge E. Cortes,Dong-Wook Kim,Brian J. Druker,Philipp Erben,Ricardo Pasquini,Susan Branford,Timothy P. Hughes,Jerald P. Radich,Lynn Ploughman,Jaydip Mukhopadhyay,Andreas Hochhaus
View Articletitled, Dasatinib treatment of chronic-phase chronic myeloid leukemia: analysis of responses according to preexisting <em>BCR-ABL</em> mutations
Supplemental data
Abnormal serum free light chain ratio in patients with multiple myeloma in complete remission has strong association with the presence of oligoclonal bands: implications for stringent complete remission definition
Brief Report
Carlos Fernández de Larrea,María Teresa Cibeira,Montserrat Elena,Juan Ignacio Arostegui,Laura Rosiñol,Montserrat Rovira,Xavier Filella,Jordi Yagüe,Joan Bladé
View Articletitled, Abnormal serum free light chain ratio in patients with multiple myeloma in complete remission has strong association with the presence of oligoclonal bands: implications for stringent complete remission definition
Classification of amyloidosis by laser microdissection and mass spectrometry–based proteomic analysis in clinical biopsy specimens
Brief Report
Julie A. Vrana,Jeffrey D. Gamez,Benjamin J. Madden,Jason D. Theis,H. Robert Bergen, III,Ahmet Dogan
View Articletitled, Classification of amyloidosis by laser microdissection and mass spectrometry–based proteomic analysis in clinical biopsy specimens
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells
Sandra Düber,Martin Hafner,Martina Krey,Stefan Lienenklaus,Bishnudeo Roy,Elias Hobeika,Michael Reth,Thorsten Buch,Ari Waisman,Karsten Kretschmer,Siegfried Weiss
View Articletitled, Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells
Supplemental data
Undifferentiated hematopoietic cells are characterized by a genome-wide undermethylation dip around the transcription start site and a hierarchical epigenetic plasticity
Yun Shin Chung,Hye Joung Kim,Tae-Min Kim,Sung-Hyun Hong,Kyung-Rim Kwon,Sungwhan An,Jung-Hoon Park,Suman Lee,Il-Hoan Oh
View Articletitled, Undifferentiated hematopoietic cells are characterized by a genome-wide undermethylation dip around the transcription start site and a hierarchical epigenetic plasticity
Supplemental data

IMMUNOBIOLOGY

Cell-cell cooperation at the T helper cell/mast cell immunological synapse
Nicolas Gaudenzio,Nicolas Espagnolle,Lennart T. Mars,Roland Liblau,Salvatore Valitutti,Eric Espinosa
View Articletitled, Cell-cell cooperation at the T helper cell/mast cell immunological synapse
Supplemental data
B-cell follicle development remodels the conduit system and allows soluble antigen delivery to follicular dendritic cells
Marc Bajénoff,Ronald N. Germain
View Articletitled, B-cell follicle development remodels the conduit system and allows soluble antigen delivery to follicular dendritic cells
Supplemental data
Appearance of peripheral blood plasma cells and memory B cells in a primary and secondary immune response in humans
Brief Report
Geraldine Blanchard-Rohner,Anoop S. Pulickal,Cornelia M. Jol-van der Zijde,Matthew D. Snape,Andrew J. Pollard
View Articletitled, Appearance of peripheral blood plasma cells and memory B cells in a primary and secondary immune response in humans
ATG-induced expression of FOXP3 in human CD4+ T cells in vitro is associated with T-cell activation and not the induction of FOXP3+ T regulatory cells
Brief Report
Raewyn Broady,Jie Yu,Megan K. Levings
View Articletitled, ATG-induced expression of FOXP3 in human CD4<sup>+</sup> T cells in vitro is associated with T-cell activation and not the induction of FOXP3<sup>+</sup> T regulatory cells
Supplemental data

LYMPHOID NEOPLASIA

Characterization of a rituximab variant with potent antitumor activity against rituximab-resistant B-cell lymphoma
Bohua Li,Lei Zhao,Huaizu Guo,Chong Wang,Xunming Zhang,Lan Wu,Lin Chen,Qing Tong,Weizhu Qian,Hao Wang,Yajun Guo
View Articletitled, Characterization of a rituximab variant with potent antitumor activity against rituximab-resistant B-cell lymphoma
Supplemental data
TC-PTP is required for the maintenance of MYC-driven B-cell lymphomas
Ryan M. Young,Avital Polsky,Yosef Refaeli
View Articletitled, TC-PTP is required for the maintenance of <em>MYC</em>-driven B-cell lymphomas
Supplemental data

MYELOID NEOPLASIA

Cotreatment with panobinostat and JAK2 inhibitor TG101209 attenuates JAK2V617F levels and signaling and exerts synergistic cytotoxic effects against human myeloproliferative neoplastic cells
Yongchao Wang,Warren Fiskus,Daniel G. Chong,Kathleen M. Buckley,Kavita Natarajan,Rekha Rao,Atul Joshi,Ramesh Balusu,Sanjay Koul,Jianguang Chen,Andrew Savoie,Celalettin Ustun,Anand P. Jillella,Peter Atadja,Ross L. Levine,Kapil N. Bhalla
View Articletitled, Cotreatment with panobinostat and JAK2 inhibitor TG101209 attenuates JAK2V617F levels and signaling and exerts synergistic cytotoxic effects against human myeloproliferative neoplastic cells
Supplemental data
FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD–specific STAT5 activation
Goichi Yoshimoto,Toshihiro Miyamoto,Siamak Jabbarzadeh-Tabrizi,Tadafumi Iino,Jennifer L. Rocnik,Yoshikane Kikushige,Yasuo Mori,Takahiro Shima,Hiromi Iwasaki,Katsuto Takenaka,Koji Nagafuji,Shin-ichi Mizuno,Hiroaki Niiro,Gary D. Gilliland,Koichi Akashi
View Articletitled, FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD–specific STAT5 activation
Supplemental data

PLATELETS AND THROMBOPOIESIS

Human platelets produced in nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice upon transplantation of human cord blood CD34+ cells are functionally active in an ex vivo flow model of thrombosis
Isabelle I. Salles,Tim Thijs,Christine Brunaud,Simon F. De Meyer,Johan Thys,Karen Vanhoorelbeke,Hans Deckmyn
View Articletitled, Human platelets produced in nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice upon transplantation of human cord blood CD34<sup>+</sup> cells are functionally active in an ex vivo flow model of thrombosis
Supplemental data

THROMBOSIS AND HEMOSTASIS

Urokinase-type plasminogen activator increases hepatocyte growth factor activity required for skeletal muscle regeneration
Thomas H. Sisson,Mai-Huong Nguyen,Bi Yu,Margaret L. Novak,Richard H. Simon,Timothy J. Koh
View Articletitled, Urokinase-type plasminogen activator increases hepatocyte growth factor activity required for skeletal muscle regeneration
Supplemental data

TRANSPLANTATION

Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethality
Lisa K. Jasperson,Christoph Bucher,Angela Panoskaltsis-Mortari,Andrew L. Mellor,David H. Munn,Bruce R. Blazar
View Articletitled, Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethality
Supplemental data
The transfer of adaptive immunity to CMV during hematopoietic stem cell transplantation is dependent on the specificity and phenotype of CMV-specific T cells in the donor
Phillip Scheinberg,Jan J. Melenhorst,Jason M. Brenchley,Brenna J. Hill,Nancy F. Hensel,Pratip K. Chattopadhyay,Mario Roederer,Louis J. Picker,David A. Price,A. John Barrett,Daniel C. Douek
View Articletitled, The transfer of adaptive immunity to CMV during hematopoietic stem cell transplantation is dependent on the specificity and phenotype of CMV-specific T cells in the donor
Supplemental data

VASCULAR BIOLOGY

An impaired transendothelial migration potential of chronic lymphocytic leukemia (CLL) cells can be linked to ephrin-A4 expression
Eva M. Trinidad,Mónica Ballesteros,Jaime Zuloaga,Agustín Zapata,Luis M. Alonso-Colmenar
View Articletitled, An impaired transendothelial migration potential of chronic lymphocytic leukemia (CLL) cells can be linked to ephrin-A4 expression
Supplemental data
Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation
Amber N. Stratman,Kristine M. Malotte,Rachel D. Mahan,Michael J. Davis,George E. Davis
View Articletitled, Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation
Supplemental data
Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage
Nancy A. Turner,Leticia Nolasco,Zaverio M. Ruggeri,Joel L. Moake
View Articletitled, Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage
  • Cover Image

    Cover Image

    issue cover

    B cells are central players of humoral immune responses. After binding to their antigens, humoral antibodies can lead to complement activation, antibody-mediated cellular cytotoxicity, and Fc-mediated endocytosis. Besides producing antibodies, B cells exert several other important antibody-independent functions such as antigen presentation, cytokine production, and immunoregulation. Professional illustration by A. Y. Chen. See the article by Shimabukuro-Vornhagen et al on page 4919.

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