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Issue Archive

Volume 8, Issue 10
May 28 2024
Issue Cover

Table of Contents

INSIDE BLOOD ADVANCES

Mesenchymal stem cells: paving the way for myeloma onset?
Annamaria Gulla,Mariateresa Fulciniti
View Articletitled, Mesenchymal stem cells: paving the way for myeloma onset?
Race and insurance: real-world insights on CAR-T outcomes
Nausheen Ahmed,Natalie S. Grover
View Articletitled, Race and insurance: real-world insights on CAR-T outcomes

REVIEW ARTICLE

Immune status and selection of patients for immunotherapy in myeloma: a proposal
Madhav V. Dhodapkar
View Articletitled, Immune status and selection of patients for immunotherapy in myeloma: a proposal

SYSTEMATIC REVIEW

Cytoreductive therapy in younger adults with polycythemia vera: a meta-analysis of safety and outcomes
Clinical Trials & Observations
Reem S. Chamseddine,Oleksandr Savenkov,Shehroz Rana,Mohammed Khalid,Richard T. Silver,Nicole Kucine,Joseph M. Scandura,Ghaith Abu-Zeinah
View Articletitled, Cytoreductive therapy in younger adults with polycythemia vera: a meta-analysis of safety and outcomes
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Haploidentical stem cell donor choice for patients with acute myeloid leukemia: a study from the ALWP of the EBMT
Clinical Trials & Observations
Jaime Sanz,Myriam Labopin,Didier Blaise,Anna Maria Raiola,Alessandro Busca,Jan Vydra,Johanna Tischer,Patrice Chevallier,Stefania Bramanti,Renato Fanin,Gérard Socié,Edouard Forcade,Nicolaus Kröger,Yener Koc,Maija Itäla-Remes,Marco Zecca,Arnon Nagler,Eolia Brissot,Alexandros Spyridonidis,Ali Bazarbachi,Sebastian Giebel,Simona Piemontese,Mohamad Mohty,Fabio Ciceri
View Articletitled, Haploidentical stem cell donor choice for patients with acute myeloid leukemia: a study from the ALWP of the EBMT
Adoptive transfer of donor B lymphocytes: a phase 1/2a study for patients after allogeneic stem cell transplantation
Clinical Trials & Observations
Julia Winkler,Hannes Tittlbach,Andrea Schneider,Ingrid Vasova,Julian Strobel,Susanne Herold,Stefanie Maas,Bernd M. Spriewald,Roland Repp,Lambros Kordelas,Michael Mach,Daniel Wolff,Matthias Edinger,Andreas Mackensen,Thomas H. Winkler
View Articletitled, Adoptive transfer of donor B lymphocytes: a phase 1/2a study for patients after allogeneic stem cell transplantation
Supplemental data
Cardiovascular events reported in patients with B-cell malignancies treated with zanubrutinib
Clinical Trials & Observations
Javid J. Moslehi,Richard R. Furman,Constantine S. Tam,Joe-Elie Salem,Christopher R. Flowers,Aileen Cohen,Meng Zhang,Jun Zhang,Lipeng Chen,Han Ma,Jennifer R. Brown
View Articletitled, Cardiovascular events reported in patients with B-cell malignancies treated with zanubrutinib
Supplemental data
Microclots, as defined by amyloid-fibrinogen aggregates, predict risks of disseminated intravascular coagulation and mortality
Clinical Trials & Observations
Jeremy Schofield,Simon T. Abrams,Rosalind Jenkins,Steven Lane,Guozheng Wang,Cheng-Hock Toh
View Articletitled, Microclots, as defined by amyloid-fibrinogen aggregates, predict risks of disseminated intravascular coagulation and mortality
Supplemental data
Differentiation syndrome associated with treatment with IDH2 inhibitor enasidenib: pooled analysis from clinical trials
Clinical Trials & Observations
Pau Montesinos,Amir T. Fathi,Stéphane de Botton,Eytan M. Stein,Amer M. Zeidan,Yue Zhu,Thomas Prebet,Carlos E. Vigil,Iryna Bluemmert,Xin Yu,Courtney D. DiNardo
View Articletitled, Differentiation syndrome associated with treatment with <em>IDH2</em> inhibitor enasidenib: pooled analysis from clinical trials
Supplemental data
A phase 1 study of the irreversible FLT3 inhibitor FF-10101 in relapsed or refractory acute myeloid leukemia
Clinical Trials & Observations
Mark Levis,Alexander Perl,Gary Schiller,Amir T. Fathi,Gail Roboz,Eunice S. Wang,Jessica Altman,Trivikram Rajkhowa,Makoto Ando,Takeaki Suzuki,Ruth Ann Subach,Gary Maier,Timothy Madden,Mary Johansen,Kin Cheung,Michael Kurman,Catherine Smith
View Articletitled, A phase 1 study of the irreversible FLT3 inhibitor FF-10101 in relapsed or refractory acute myeloid leukemia
Supplemental data

HEALTH SERVICES AND OUTCOMES

Impact of race and social determinants of health on outcomes in patients with aggressive B-cell NHL treated with CAR-T therapy
Clinical Trials & Observations
Reem Karmali,Rushad Machhi,Narendranath Epperla,Geoffrey Shouse,Jason Romancik,Tamara K. Moyo,Vaishalee Kenkre,Thomas A. Ollila,Lindsey Fitzgerald,Brian Hess,Kevin David,Ishan Roy,Joanna Zurko,Sayan Mullick Chowdhury,Kaitlin Annunzio,Robert Ferdman,Rahul S. Bhansali,Elyse I. Harris,Jieqi Liu,Imran Nizamuddin,Shuo Ma,Jonathan Moreira,Jane Winter,Barbara Pro,Deborah M. Stephens,Alexey Danilov,Nirav N. Shah,Jonathon B. Cohen,Stefan K. Barta,Pallawi Torka,Leo I. Gordon
View Articletitled, Impact of race and social determinants of health on outcomes in patients with aggressive B-cell NHL treated with CAR-T therapy

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Unleashed monocytic engagement in Sézary syndrome during the combination of anti-CCR4 antibody with type I interferon
Tony T. Jiang,Oleg Kruglov,Oleg E. Akilov
View Articletitled, Unleashed monocytic engagement in Sézary syndrome during the combination of anti-CCR4 antibody with type I interferon
Supplemental data
Impact of diagnostic investigations in the management of CAR T-cell–associated neurotoxicity
Clinical Trials & Observations
Matteo Mauget,Sophie Lemercier,Quentin Quelven,Adel Maamar,Faustine Lhomme,Sophie De Guibert,Roch Houot,Guillaume Manson
View Articletitled, Impact of diagnostic investigations in the management of CAR T-cell–associated neurotoxicity
Supplemental data

LYMPHOID NEOPLASIA

A multicenter study of venetoclax-based treatment for patients with Richter transformation of chronic lymphocytic leukemia
Clinical Trials & Observations
Paul J. Hampel,Mahesh Swaminathan,Kerry A. Rogers,Erin M. Parry,Jan A. Burger,Matthew S. Davids,Wei Ding,Alessandra Ferrajoli,Jonathan M. Hyak,Nitin Jain,Saad S. Kenderian,Yucai Wang,William G. Wierda,Jennifer A. Woyach,Sameer A. Parikh,Philip A. Thompson
View Articletitled, A multicenter study of venetoclax-based treatment for patients with Richter transformation of chronic lymphocytic leukemia
Supplemental data
Stromal alterations in patients with monoclonal gammopathy of undetermined significance, smoldering myeloma, and multiple myeloma
Lucienne Bogun,Annemarie Koch,Bo Scherer,Roland Fenk,Uwe Maus,Felix Bormann,Karl Köhrer,Patrick Petzsch,Thorsten Wachtmeister,Romans Zukovs,Sascha Dietrich,Rainer Haas,Thomas Schroeder,Paul Jäger,Stefanie Geyh
View Articletitled, Stromal alterations in patients with monoclonal gammopathy of undetermined significance, smoldering myeloma, and multiple myeloma
Supplemental data

MYELOID NEOPLASIA

Mutations in myeloid transcription factors and activated signaling genes predict chronic myeloid leukemia outcomes
Maria Agustina Perusini,Daniela Žáčková,Taehyung Kim,Katia Pagnano,Carolina Pavlovsky,Ivana Ježíšková,Anežka Kvetková,Tomáš Jurček,Jaeyoon Kim,Youngseok Yoo,Seongyoon Yi,Hyewon Lee,Kyoung Ha Kim,Myunghee Chang,Jose-Mario Capo-Chichi,Jessie J. F. Medeiros,Andrea Arruda,Mark Minden,Zhaolei Zhang,Sagi Abelson,Jiri Mayer,Dennis Dong Hwan Kim
View Articletitled, Mutations in myeloid transcription factors and activated signaling genes predict chronic myeloid leukemia outcomes
Supplemental data
RUNX1 C-terminal mutations impair blood cell differentiation by perturbing specific enhancer-promoter networks
Nathan D. Jayne,Zhengyu Liang,Do-Hwan Lim,Poshen B. Chen,Cristina Diaz,Kei-Ichiro Arimoto,Lingbo Xia,Mengdan Liu,Bing Ren,Xiang-Dong Fu,Dong-Er Zhang
View Articletitled, RUNX1 C-terminal mutations impair blood cell differentiation by perturbing specific enhancer-promoter networks
Supplemental data
Kinome expression profiling improves risk stratification and therapeutic targeting in myelodysplastic syndromes
Chi-Yuan Yao,Chien-Chin Lin,Yu-Hung Wang,Chein-Jun Kao,Cheng-Hong Tsai,Hsin-An Hou,Hwei-Fang Tien,Chia-Lang Hsu,Wen-Chien Chou
View Articletitled, Kinome expression profiling improves risk stratification and therapeutic targeting in myelodysplastic syndromes
Supplemental data

PLATELETS AND THROMBOPOIESIS

Platelet proteomic profiling in sitosterolemia suggests thrombocytopenia is driven by lipid disorder and not platelet aberrations
Jessica Del Castillo,Anton T. J. Tool,Karin van Leeuwen,Floris P. J. van Alphen,Marion M. Brands,Monique H. Suijker,Alexander B. Meijer,Arie J. Hoogendijk,Taco W. Kuijpers
View Articletitled, Platelet proteomic profiling in sitosterolemia suggests thrombocytopenia is driven by lipid disorder and not platelet aberrations
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Mitapivat improves ineffective erythropoiesis and iron overload in adult patients with pyruvate kinase deficiency
Eduard J. van Beers,Hanny Al-Samkari,Rachael F. Grace,Wilma Barcellini,Andreas Glenthøj,Melissa DiBacco,Megan Wind-Rotolo,Rengyi Xu,Vanessa Beynon,Parija Patel,John B. Porter,Kevin H. M. Kuo
View Articletitled, Mitapivat improves ineffective erythropoiesis and iron overload in adult patients with pyruvate kinase deficiency
Successes and pitfalls in orphan drug development for sickle cell disease
Enrico Costa,Antonella Isgrò,Mariane de Montalembert,Hubert G. M. Leufkens,Russell E. Ware,Lucia De Franceschi
View Articletitled, Successes and pitfalls in orphan drug development for sickle cell disease
Supplemental data
Amino acid supplementation confers protection to red blood cells before Plasmodium falciparum bystander stress
Heather Colvin Binns,Elmira Alipour,Cameron E. Sherlock,Dinah S. Nahid,John F. Whitesides,Anderson O’Brien Cox,Cristina M. Furdui,Glen S. Marrs,Daniel B. Kim-Shapiro,Regina Joice Cordy
View Articletitled, Amino acid supplementation confers protection to red blood cells before <em>Plasmodium falciparum</em> bystander stress
Supplemental data

THROMBOSIS AND HEMOSTASIS

Race and ethnicity reporting and representation in hemophilia clinical trials
Clinical Trials & Observations
Stacey A. Fedewa,Leonard A. Valentino,Andee Koo,Lorraine Cafuir,Duc Q. Tran,Ana Antun,Christine L. Kempton
View Articletitled, Race and ethnicity reporting and representation in hemophilia clinical trials
Targeting neutrophil extracellular trap accumulation under flow in patients with immune-mediated thrombotic thrombocytopenic purpura
Noritaka Yada,Quan Zhang,Antonia Bignotti,Sarah H. Gralnek,Dennis Sosnovske,Keenan Hogan,Zhan Ye,Liang Zheng,X. Long Zheng
View Articletitled, Targeting neutrophil extracellular trap accumulation under flow in patients with immune-mediated thrombotic thrombocytopenic purpura
Supplemental data

RESEARCH LETTERS

Subsequent malignant neoplasms in patients previously treated with anti-CD19 CAR T-cell therapy
Megan Melody,Narendranath Epperla,Geoffrey Shouse,Jason Romancik,Pamela Allen,Tamara K. Moyo,Vaishalee Kenkre,Thomas Ollila,Lindsey Fitzgerald,Brian Hess,Kevin David,Megan M. Herr,Oluwatobi Odetola,Adam Lin,Jonathan Moreira,Shuo Ma,Jane N. Winter,Ishan Roy,Deborah Stephens,Alexey Danilov,Nirav N. Shah,Stefan K. Barta,Matthew Cortese,Jonathon B. Cohen,Leo I. Gordon,Reem Karmali
View Articletitled, Subsequent malignant neoplasms in patients previously treated with anti-CD19 CAR T-cell therapy
Nivolumab plus brentuximab vedotin for relapsed/refractory peripheral T-cell lymphoma and cutaneous T-cell lymphoma
Clinical Trials & Observations
Pier Luigi Zinzani,Gilles Salles,Alison J. Moskowitz,Armando Santoro,Amitkumar Mehta,Paul M. Barr,Neha Mehta-Shah,Graham P. Collins,Stephen M. Ansell,Joshua D. Brody,Eva Domingo-Domenech,Nathalie A. Johnson,David Cunningham,Silvia Ferrari,Julie Lisano,Jennifer Krajewski,Rachael Wen,Alev Akyol,Russell Crowe,Kerry J. Savage
View Articletitled, Nivolumab plus brentuximab vedotin for relapsed/refractory peripheral T-cell lymphoma and cutaneous T-cell lymphoma
Supplemental data
Blinatumomab consolidation for adult B-cell acute lymphoblastic leukemia in first and second complete remission
Clinical Trials & Observations
Irene Urbino,Etienne Lengliné,Florence Rabian,Marco Cerrano,Rathana Kim,Florian Chevillon,Dario Ferrero,Marie Sébert,Nathalie Dhédin,Raphaël Itzykson,Lionel Adès,Emmanuel Raffoux,Hervé Dombret,Ernesta Audisio,Emmanuelle Clappier,Nicolas Boissel
View Articletitled, Blinatumomab consolidation for adult B-cell acute lymphoblastic leukemia in first and second complete remission
Supplemental data
Depletion of miR-144/451 alleviates anemia in β-thalassemic mice
Ling Ling,Fangfang Wang,Yaoyao Li,Sheng He,Fan Wu,Lei Yang,Lei Xu,Ting Wang,Shuting Zhou,Fan Yang,Zichen Wei,Lan Yang,Zhe Yang,Xiao Fang,Yali Zhou,Jun Xue,Xiaolin Yin,Hongwei Wei,Duonan Yu
View Articletitled, Depletion of miR-144/451 alleviates anemia in β-thalassemic mice
Supplemental data

RESPONSE

Selection of statistical tests considering competing risks: the importance of understanding the assumptions in each test
Yu Akahoshi
View Articletitled, Selection of statistical tests considering competing risks: the importance of understanding the assumptions in each test

ERRATUM

Phillips NS, Mulrooney DA, Williams AM, et al. Neurocognitive impairment associated with chronic morbidity in long-term survivors of Hodgkin Lymphoma. Blood Adv. 2023;7(23):7270-7278.
View Articletitled, Phillips NS, Mulrooney DA, Williams AM, et al. Neurocognitive impairment associated with chronic morbidity in long-term survivors of Hodgkin Lymphoma. <em>Blood Adv.</em> 2023;7(23):7270-7278.
  • Cover Image

    Cover Image

    issue cover

    May-Grünwald-Giemsa–stained and partially differentiated K562 leukemia cells treated with 12-O-tetradecanoylphorbol-13-acetate. See the article by Jayne et al.

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