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Issue Archive

Volume 7, Issue 19
October 10 2023
Issue Cover

Table of Contents

INSIDE BLOOD ADVANCES

Further evidence supporting the global use of hydroxyurea
Natasha M. Archer
View Articletitled, Further evidence supporting the global use of hydroxyurea
Blood stem cell grafts: frozen is fine, but fresh is best
Mitchell E. Horwitz
View Articletitled, Blood stem cell grafts: frozen is fine, but fresh is best
The sweet taste of liberalizing dietary restrictions in HCT
Clinical Trials & Observations
Jonathan U. Peled,Kate A. Markey
View Articletitled, The sweet taste of liberalizing dietary restrictions in HCT

REVIEW ARTICLE

Enriching single-arm clinical trials with external controls: possibilities and pitfalls
Clinical Trials & Observations
Jérôme Lambert,Etienne Lengliné,Raphaël Porcher,Rodolphe Thiébaut,Sarah Zohar,Sylvie Chevret
View Articletitled, Enriching single-arm clinical trials with external controls: possibilities and pitfalls

SYSTEMATIC REVIEWS

Infections following bispecific antibodies in myeloma: a systematic review and meta-analysis
Clinical Trials & Observations
Gemma Reynolds,Edward R. Scheffer Cliff,Ghulam Rehman Mohyuddin,Rakesh Popat,Shonali Midha,Melissa Ng Liet Hing,Simon J. Harrison,Aaron S. Kesselheim,Benjamin W. Teh
View Articletitled, Infections following bispecific antibodies in myeloma: a systematic review and meta-analysis
Supplemental data
Hemostatic biomarkers associated with postpartum hemorrhage: a systematic review and meta-analysis
Clinical Trials & Observations
Claire de Moreuil,Dino Mehic,Stephan Nopp,Daniel Kraemmer,Johanna Gebhart,Theresa Schramm,Francis Couturaud,Cihan Ay,Ingrid Pabinger
View Articletitled, Hemostatic biomarkers associated with postpartum hemorrhage: a systematic review and meta-analysis
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Phase 1/2 study of carfilzomib, pomalidomide, and dexamethasone with and without daratumumab in relapsed multiple myeloma
Clinical Trials & Observations
Benjamin A. Derman,Jeffrey Zonder,Donna Reece,Craig Cole,Jesus Berdeja,Andrew T. Stefka,Ajay Major,Andrew Kin,Kent Griffith,Jagoda Jasielec,Andrzej J. Jakubowiak
View Articletitled, Phase 1/2 study of carfilzomib, pomalidomide, and dexamethasone with and without daratumumab in relapsed multiple myeloma
Supplemental data
Improved outcomes of UM171–expanded cord blood transplantation compared with other graft sources: real-world evidence
Clinical Trials & Observations
Sandra Cohen,Nadia Bambace,Imran Ahmad,Jean Roy,Xiaoying Tang,Mei-Jie Zhang,Linda Burns,Frédéric Barabé,Léa Bernard,Jean-Sébastien Delisle,Thomas Kiss,Silvy Lachance,Denis-Claude Roy,Olivier Veilleux,Guy Sauvageau
View Articletitled, Improved outcomes of UM171–expanded cord blood transplantation compared with other graft sources: real-world evidence
Supplemental data
Multicenter phase 2 study of romidepsin plus lenalidomide for previously untreated peripheral T-cell lymphoma
Clinical Trials & Observations
Jia Ruan,Jasmine Zain,Brett Palmer,Borko Jovanovic,Xinlei Mi,Alok Swaroop,Jane N. Winter,Leo I. Gordon,Reem Karmali,Jonathan Moreira,Adam M. Petrich,Barbara Pro
View Articletitled, Multicenter phase 2 study of romidepsin plus lenalidomide for previously untreated peripheral T-cell lymphoma
Supplemental data
Residual burden of liver disease after HCV clearance in hemophilia: a word of caution in the era of gene therapy
Clinical Trials & Observations
Vincenzo La Mura,Niccolò Bitto,Cecilia Capelli,Camilla Caputo,Simona Siboni,Sara Arcudi,Alessandro Ciavarella,Roberta Gualtierotti,Anna Ludovica Fracanzani,Angelo Sangiovanni,Flora Peyvandi
View Articletitled, Residual burden of liver disease after HCV clearance in hemophilia: a word of caution in the era of gene therapy
Supplemental data
Pacritinib is a potent ACVR1 inhibitor with significant anemia benefit in patients with myelofibrosis
Clinical Trials & Observations
Stephen T. Oh,Ruben A. Mesa,Claire N. Harrison,Prithviraj Bose,Aaron T. Gerds,Vikas Gupta,Bart L. Scott,Jean-Jacques Kiladjian,Alessandro Lucchesi,Tim Kong,Sarah A. Buckley,Shanthakumar Tyavanagimatt,Bryan G. Harder,Karisse Roman-Torres,Jennifer Smith,Adam R. Craig,John Mascarenhas,Srdan Verstovsek
View Articletitled, Pacritinib is a potent ACVR1 inhibitor with significant anemia benefit in patients with myelofibrosis
Supplemental data
Early diagnosis of sickle cell disease at birth hospitals and vaccination centers in Angola using point-of-care tests
Clinical Trials & Observations Global Advances
Halimat S. Olaniyan,Christine Briscoe,Margarida Muhongo,Rui Pascoal,António Armando,Brigida Santos,Patrick T. McGann
View Articletitled, Early diagnosis of sickle cell disease at birth hospitals and vaccination centers in Angola using point-of-care tests
Long-term sutimlimab improves quality of life for patients with cold agglutinin disease: CARDINAL 2-year follow-up
Clinical Trials & Observations
Alexander Röth,Catherine M. Broome,Wilma Barcellini,Tor Henrik Anderson Tvedt,Yoshitaka Miyakawa,Shirley D’Sa,David Cella,Sylvie Bozzi,Deepthi Jayawardene,Ronnie Yoo,Frank Shafer,Marek Wardęcki,Ilene C. Weitz
View Articletitled, Long-term sutimlimab improves quality of life for patients with cold agglutinin disease: CARDINAL 2-year follow-up
Supplemental data
Nonrestrictive diet does not increase infections during post-HSCT neutropenia: data from a multicenter randomized trial
Clinical Trials & Observations
Federico Stella,Vincenzo Marasco,Giorgia Virginia Levati,Anna Guidetti,Annamaria De Filippo,Martina Pennisi,Cecilia Vismara,Rosalba Miceli,Silva Ljevar,Cristina Tecchio,Nicola Mordini,Giorgia Gobbi,Lucia Saracino,Paolo Corradini
View Articletitled, Nonrestrictive diet does not increase infections during post-HSCT neutropenia: data from a multicenter randomized trial
Supplemental data
The sweet taste of liberalizing dietary restrictions in HCT
Clinical Trials & Observations
Jonathan U. Peled,Kate A. Markey
View Articletitled, The sweet taste of liberalizing dietary restrictions in HCT

GENE THERAPY

Stable and durable factor IX levels in patients with hemophilia B over 3 years after etranacogene dezaparvovec gene therapy
Clinical Trials & Observations
Annette von Drygalski,Esteban Gomez,Adam Giermasz,Giancarlo Castaman,Nigel S. Key,Susan U. Lattimore,Frank W. G. Leebeek,Wolfgang A. Miesbach,Michael Recht,Robert Gut,Ricardo Dolmetsch,Paul E. Monahan,Sandra Le Quellec,Steven W. Pipe
View Articletitled, Stable and durable factor IX levels in patients with hemophilia B over 3 years after etranacogene dezaparvovec gene therapy
Supplemental data

HEALTH SERVICES AND OUTCOMES

Outcomes of breakthrough COVID-19 infections in patients with hematologic malignancies
Kelly S. Chien,Christine B. Peterson,Elliana Young,Dai Chihara,Elizabet E. Manasanch,Jeremy L. Ramdial,Philip A. Thompson
View Articletitled, Outcomes of breakthrough COVID-19 infections in patients with hematologic malignancies

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Management and outcome of COVID-19 in CTLA-4 insufficiency
Clinical Trials & Observations
Sebastian Ochoa,Michael S. Abers,Lindsey B. Rosen,Amy Rump,Katherine Howe,Jay A. Lieberman,Benjamin L. Wright,Daniel Suez,Máté Krausz,Bodo Grimbacher,Michail S. Lionakis,Gulbu Uzel
View Articletitled, Management and outcome of COVID-19 in CTLA-4 insufficiency

LYMPHOID NEOPLASIA

Salvage therapy with brentuximab-vedotin and bendamustine for patients with R/R PTCL: a retrospective study from the LYSA group
Clinical Trials & Observations
Raphaelle Aubrais,Krimo Bouabdallah,Loic Chartier,Charles Herbaux,Anne Banos,Pauline Brice,David Sibon,Jean Marc Schiano,Thomas Cluzeau,Kamel Laribi,Ronan Le Calloch,Mathieu Bellal,Baptiste Delapierre,Nicolas Daguindau,Sandy Amorim,Kossi Agbetiafa,Adrien Chauchet,Caroline Besson,Eric Durot,Christophe Bonnet,Ludovic Fouillet,Fontanet Bijou,Olivier Tournilhac,Philippe Gaulard,Marie-Cécile Parrens,Gandhi Damaj,on behalf of the Lymphoma Study Association
View Articletitled, Salvage therapy with brentuximab-vedotin and bendamustine for patients with R/R PTCL: a retrospective study from the LYSA group
Supplemental data
TRIM21 enhances bortezomib sensitivity in multiple myeloma by halting prosurvival autophagy
Clinical Trials & Observations
Jing Chen,Wen Cao,Xi Huang,Qingxiao Chen,Shuting Ye,Jianwei Qu,Yang Liu,Xing Guo,Shunnan Yao,Enfan Zhang,Jingsong He,Anqi Li,Li Yang,Zhen Cai
View Articletitled, TRIM21 enhances bortezomib sensitivity in multiple myeloma by halting prosurvival autophagy
Supplemental data
Targeting conditioned media dependencies and FLT-3 in chronic lymphocytic leukemia
Salma Parvin,Aditi Aryal,Shanye Yin,Geoffrey G. Fell,Matthew S. Davids,Catherine J. Wu,Anthony Letai
View Articletitled, Targeting conditioned media dependencies and FLT-3 in chronic lymphocytic leukemia
Supplemental data
A significant proportion of classic Hodgkin lymphoma recurrences represents clonally unrelated second primary lymphoma
Diede A. G. van Bladel,Wendy B. C. Stevens,Leonie I. Kroeze,Ruben A. L. de Groen,Fleur A. de Groot,Jessica L. M. van der Last-Kempkes,Madeleine R. Berendsen,Jos Rijntjes,Jeroen A. C. W. Luijks,Irina Bonzheim,Ellen van der Spek,Wouter J. Plattel,Johannes F. M. Pruijt,Susan D. P. W. M. de Jonge-Peeters,Gerjo A. Velders,Chantal Lensen,Esther R. van Bladel,Birgit Federmann,Brigiet M. Hoevenaars,Agata Pastorczak,Jutte van der Werff ten Bosch,Joost S. P. Vermaat,Peet T. G. A. Nooijen,Konnie M. Hebeda,Falko Fend,Arjan Diepstra,J Han J. M. van Krieken,Patricia J. T. A. Groenen,Michiel van den Brand,Blanca Scheijen
View Articletitled, A significant proportion of classic Hodgkin lymphoma recurrences represents clonally unrelated second primary lymphoma
Supplemental data
Comparing the value of mono- vs coculture for high-throughput compound screening in hematological malignancies
Sophie A. Herbst,Vladislav Kim,Tobias Roider,Eva C. Schitter,Peter-Martin Bruch,Nora Liebers,Carolin Kolb,Mareike Knoll,Junyan Lu,Peter Dreger,Carsten Müller-Tidow,Thorsten Zenz,Wolfgang Huber,Sascha Dietrich
View Articletitled, Comparing the value of mono- vs coculture for high-throughput compound screening in hematological malignancies
Supplemental data

MYELOID NEOPLASIA

Germ line variants in patients with acute myeloid leukemia without a suspicion of hereditary hematologic malignancy syndrome
Francesca Guijarro,Monica López-Guerra,Jordi Morata,Alex Bataller,Sara Paz,Josep Maria Cornet-Masana,Antònia Banús-Mulet,Laia Cuesta-Casanovas,Josep Maria Carbó,Sandra Castaño-Díez,Carlos Jiménez-Vicente,Albert Cortés-Bullich,Ana Triguero,Alexandra Martínez-Roca,Daniel Esteban,Marta Gómez-Hernando,José Ramón Álamo Moreno,Irene López-Oreja,Marta Garrote,Ruth M. Risueño,Raúl Tonda,Ivo Gut,Dolors Colomer,Marina Díaz-Beya,Jordi Esteve
View Articletitled, Germ line variants in patients with acute myeloid leukemia without a suspicion of hereditary hematologic malignancy syndrome
Supplemental data
Characteristics and prognostic impact of IDH mutations in AML: a COG, SWOG, and ECOG analysis
Clinical Trials & Observations
Sara Zarnegar-Lumley,Todd A. Alonzo,Robert B. Gerbing,Megan Othus,Zhuoxin Sun,Rhonda E. Ries,Jim Wang,Amanda Leonti,Matthew A. Kutny,Fabiana Ostronoff,Jerald P. Radich,Frederick R. Appelbaum,Era L. Pogosova-Agadjanyan,Kristen O’Dwyer,Martin S. Tallman,Mark Litzow,Ehab Atallah,Todd M. Cooper,Richard A. Aplenc,Omar Abdel-Wahab,Alan S. Gamis,Selina Luger,Harry Erba,Ross Levine,E. Anders Kolb,Derek L. Stirewalt,Soheil Meshinchi,Katherine Tarlock
View Articletitled, Characteristics and prognostic impact of <em>IDH</em> mutations in AML: a COG, SWOG, and ECOG analysis
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Lack of eosinophil extracellular trap formation due to failure of plasma membrane breakdown in the absence of elastase
Evelien G. G. Sprenkeler,Ines Goetschalckx,Sara Fernández Hermira,Anton T. J. Tool,Mark Hoogenboezem,Robin van Bruggen,Taco W. Kuijpers
View Articletitled, Lack of eosinophil extracellular trap formation due to failure of plasma membrane breakdown in the absence of elastase
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Murine erythroid differentiation kinetics in vivo under normal and anemic stress conditions
Greggory Myers,Yu Wang,Qing Wang,Ann Friedman,Alejandra Sanchez-Martinez,Xiaofang Liu,Singh A. Sharon,Kim-Chew Lim,Rami Khoriaty,James Douglas Engel,Lei Yu
View Articletitled, Murine erythroid differentiation kinetics in vivo under normal and anemic stress conditions
Supplemental data
Simultaneous adjunctive treatment of malaria and its coevolved genetic disorder sickle cell anemia
Innocent Safeukui,Russell E. Ware,Narla Mohandas,Kasturi Haldar
View Articletitled, Simultaneous adjunctive treatment of malaria and its coevolved genetic disorder sickle cell anemia
Supplemental data
Further evidence supporting the global use of hydroxyurea
Natasha M. Archer
View Articletitled, Further evidence supporting the global use of hydroxyurea

THROMBOSIS AND HEMOSTASIS

JAK2V617F mutation is highly prevalent in patients with ischemic stroke: a case-control study
Marie Hvelplund Kristiansen,Lasse Kjær,Vibe Skov,Morten Kranker Larsen,Christina Ellervik,Hans Carl Hasselbalch,Troels Wienecke
View Articletitled, <em>JAK2V617F</em> mutation is highly prevalent in patients with ischemic stroke: a case-control study
Supplemental data
Prevalence and risk factors for bleeding in hereditary hemorrhagic telangiectasia: a National Inpatient Sample study
Jabra Zarka,Kwonho Jeong,Jonathan G. Yabes,Margaret V. Ragni
View Articletitled, Prevalence and risk factors for bleeding in hereditary hemorrhagic telangiectasia: a National Inpatient Sample study

TRANSPLANTATION

Emergence of human CMV-induced NKG2C+ NK cells is associated with CD8+ T-cell recovery after allogeneic HCT
Kattria van der Ploeg,Rosa Sottile,Theodota Kontopoulos,Brian C. Shaffer,Genovefa A. Papanicolaou,Molly A. Maloy,Christina Cho,Kevin S. Robinson,Miguel-Angel Perales,Jean-Benoît Le Luduec,Katharine C. Hsu
View Articletitled, Emergence of human CMV-induced NKG2C<sup>+</sup> NK cells is associated with CD8<sup>+</sup> T-cell recovery after allogeneic HCT
Supplemental data

Donor cells engraft into the brain as Iba1+ bone marrow derived macrophages

Donor bone marrow–derived macrophage engraftment into the central nervous system of patients following allogeneic transplantation
Anisha M. Loeb,Siobhan S. Pattwell,Soheil Meshinchi,Antonio Bedalov,Keith R. Loeb
View Articletitled, Donor bone marrow–derived macrophage engraftment into the central nervous system of patients following allogeneic transplantation
Supplemental data
Clinical impact of cryopreservation of allogeneic hematopoietic cell grafts during the onset of the COVID-19 pandemic
Steven M. Devine,Stephanie Bo-Subait,Michelle Kuxhausen,Stephen R. Spellman,Caitrin Bupp,Kwang Woo Ahn,Heather E. Stefanski,Jeffery J. Auletta,Brent R. Logan,Bronwen E. Shaw
View Articletitled, Clinical impact of cryopreservation of allogeneic hematopoietic cell grafts during the onset of the COVID-19 pandemic
Blood stem cell grafts: frozen is fine, but fresh is best
Mitchell E. Horwitz
View Articletitled, Blood stem cell grafts: frozen is fine, but fresh is best

RESEARCH LETTERS

Acquired BTK mutations associated with resistance to noncovalent BTK inhibitors
Jialei Qi,Sascha Endres,Deyan Yordanov Yosifov,Eugen Tausch,Rashmi Priyadharshini Dheenadayalan,Xiang Gao,Annika Müller,Christof Schneider,Daniel Mertens,Peter Gierschik,Martin Wist,Billy Michael Chelliah Jebaraj,Stephan Stilgenbauer
View Articletitled, Acquired <em>BTK</em> mutations associated with resistance to noncovalent BTK inhibitors
Supplemental data
Vitamin C deficiency in patients with acute myeloid leukemia: a case series and review of the literature
Heather C. Milbar,Avrom Caplan,Robert D. Schwab,Alexandra J. Coromilas,Emily Baumrin,Amy Forrestel,Katharine T. Steele,Robert G. Micheletti,Alexander Perl,Misha Rosenbach
View Articletitled, Vitamin C deficiency in patients with acute myeloid leukemia: a case series and review of the literature
Acquisition of a glycosylated B-cell receptor drives follicular lymphoma toward a dark zone phenotype
Cornelis A. M. van Bergen,Susan L. Kloet,Edwin Quinten,Julieta H. Sepúlveda Yáñez,Roberta Menafra,Marieke Griffioen,Patty M. Jansen,Marvyn T. Koning,Jeroen Knijnenburg,Marcelo A. Navarrete,Szymon M. Kiełbasa,Hendrik Veelken
View Articletitled, Acquisition of a glycosylated B-cell receptor drives follicular lymphoma toward a dark zone phenotype
Supplemental data
Dyadic communication in rare cancer: a registry-based study of patients with Erdheim-Chester disease and their caregivers
Anne S. Reiner,Allison J. Applebaum,Dana Bossert,Justin J. Buthorn,Allison M. Sigler,Deanna Fournier,Kathleen Brewer,Thomas M. Atkinson,Kathleen A. Lynch,Jaime Gilliland,Jun J. Mao,Katherine S. Panageas,Eli L. Diamond
View Articletitled, Dyadic communication in rare cancer: a registry-based study of patients with Erdheim-Chester disease and their caregivers
CAR T-cell therapy has comparable efficacy with autologous transplantation in older adults with DLBCL in partial response
Othman S. Akhtar,Biwei Cao,Xuefeng Wang,Pallawi Torka,Mohammed Al-Jumayli,Frederick L. Locke,Ciara L. Freeman
View Articletitled, CAR T-cell therapy has comparable efficacy with autologous transplantation in older adults with DLBCL in partial response
Supplemental data

COMMENTARY

The race is on: bispecifics vs CAR T cells in B-cell lymphoma
Ashwath Gurumurthi,Jason Westin,Marion Subklewe
View Articletitled, The race is on: bispecifics vs CAR T cells in B-cell lymphoma
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Time to revisit reduced-dose radiotherapy for PCNSL?
Lin A, Brown S, Chinapen S, et al. Patterns of CMV infection after letermovir withdrawal in recipients of posttransplant cyclophosphamide–based transplant. Blood Adv. 2023;7(23):7153-7160.
Jalink M, Jacobs CF, Khwaja J, et al. Daratumumab monotherapy in refractory warm autoimmune hemolytic anemia and cold agglutinin disease. Blood Adv. 2024;8(11):2622-2634.
Epigenetic features support the diagnosis of B-cell prolymphocytic leukemia and identify 2 clinicobiological subtypes
Retreatment of multiple myeloma with previously refractory drugs

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