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Issue Archive

Volume 7, Issue 12
June 27 2023
Issue Cover

Table of Contents

INSIDE BLOOD ADVANCES

Autologous transplant and second malignancies in MM
Oren Pasvolsky,Qaiser Bashir
View Articletitled, Autologous transplant and second malignancies in MM
A wholesale approach to disarm multiple myeloma
Simone Cenci
View Articletitled, A wholesale approach to disarm multiple myeloma

CLINICAL TRIALS AND OBSERVATIONS

Peri–CAR-T practice patterns and survival predictors for all CAR-T patients and post–CAR-T failure in aggressive B-NHL
Clinical Trials & Observations
Joanna Zurko,Imran Nizamuddin,Narendranath Epperla,Kevin David,Jonathon B. Cohen,Tamara K. Moyo,Thomas Ollila,Brian Hess,Ishan Roy,Robert Ferdman,Jieqi Liu,Sayan Mullick Chowdhury,Jason Romancik,Rahul S. Bhansali,Elyse I. Harris,Mckenzie Sorrell,Rebecca Masel,Adam S. Kittai,Nathan Denlinger,Audrey M. Sigmund,Lindsey Fitzgerald,Carlos Galvez,Shuo Ma,Jane Winter,Barbara Pro,Leo I. Gordon,Alexey Danilov,Deborah Stephens,Nirav N. Shah,Vaishalee Kenkre,Stefan K. Barta,Pallawi Torka,Geoffrey Shouse,Reem Karmali
View Articletitled, Peri–CAR-T practice patterns and survival predictors for all CAR-T patients and post–CAR-T failure in aggressive B-NHL
Supplemental data
Sequential pembrolizumab and AVD are highly effective at any PD-L1 expression level in untreated Hodgkin lymphoma
Clinical Trials & Observations
Pamela B. Allen,Xinyan Lu,Qing Chen,Kaitlyn O’Shea,Joan S. Chmiel,Liron Barnea Slonim,Madina Sukhanova,Hatice Savas,Andrew M. Evens,Ranjana Advani,Barbara Pro,Reem Karmali,Brett Palmer,Robert A. Bayer,Robert M. Eisner,Eric Mou,Gary Dillehay,Leo I. Gordon,Jane N. Winter
View Articletitled, Sequential pembrolizumab and AVD are highly effective at any PD-L1 expression level in untreated Hodgkin lymphoma
Venetoclax treatment in patients with cancer has limited impact on circulating T and NK cells
Clinical Trials & Observations
Charis E. Teh,Hongke Peng,Meng-Xiao Luo,Tania Tan,Marie Trussart,Lauren J. Howson,Chong Chyn Chua,Christine Muttiah,Fiona Brown,Matthew E. Ritchie,Andrew H. Wei,Andrew W. Roberts,Vanessa L. Bryant,Mary Ann Anderson,Geoffrey J. Lindeman,David C. S. Huang,Rachel Thijssen,Daniel H. D. Gray
View Articletitled, Venetoclax treatment in patients with cancer has limited impact on circulating T and NK cells
Supplemental data
Unraveling the pathophysiology of lower-limb postthrombotic syndrome in adolescents: a proof-of-concept study
Clinical Trials & Observations
M. Laura Avila,Robert F. Bentley,Denise Bastas,Leonardo R. Brandão,Jane E. Schneiderman,Leigh Ward,Gina Wong,Samantha Stephens,Kuan Liu,Scott Thomas
View Articletitled, Unraveling the pathophysiology of lower-limb postthrombotic syndrome in adolescents: a proof-of-concept study
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Reduced proliferation of bone marrow MSC after allogeneic stem cell transplantation is associated with clinical outcome
Christiane Katzerke,Judith Schaffrath,Jana Lützkendorf,Maike Janssen,Anne-Kathrin Merbach,Katrin Nerger,Mascha Binder,Cornelia Baum,Kirstin Lauer,Christian Rohde,Edith Willscher,Carsten Müller-Tidow,Lutz P. Müller
View Articletitled, Reduced proliferation of bone marrow MSC after allogeneic stem cell transplantation is associated with clinical outcome
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Compromised antigen binding and signaling interfere with bispecific CD19 and CD79a chimeric antigen receptor function
Isabel Leung,Megan L. Templeton,Yun Lo,Anusha Rajan,Sylvia M. Stull,Sarah M. Garrison,Alexander I. Salter,Kimberly S. Smythe,Colin E. Correnti,Shivani Srivastava,Cecilia C. S. Yeung,Stanley R. Riddell
View Articletitled, Compromised antigen binding and signaling interfere with bispecific CD19 and CD79a chimeric antigen receptor function
Supplemental data
HLH-like toxicities predict poor survival after the use of tisagenlecleucel in children and young adults with B-ALL
Clinical Trials & Observations
Kevin O. McNerney,Stephanie J. Si Lim,Kyle Ishikawa,Alexandra Dreyzin,Anant Vatsayan,John J. Chen,Christina Baggott,Snehit Prabhu,Holly L. Pacenta,Christine Philips,Jenna Rossoff,Heather E. Stefanski,Julie-An Talano,Amy Moskop,Michael Verneris,Doug Myers,Nicole A. Karras,Patrick Brown,Challice L. Bonifant,Muna Qayed,Michelle Hermiston,Prakash Satwani,Christa Krupski,Amy K. Keating,Susanne H. C. Baumeister,Vanessa A. Fabrizio,Vasant Chinnabhandar,Emily Egeler,Sharon Mavroukakis,Kevin J. Curran,Crystal L. Mackall,Theodore W. Laetsch,Liora M. Schultz
View Articletitled, HLH-like toxicities predict poor survival after the use of tisagenlecleucel in children and young adults with B-ALL
Supplemental data
IL-3-zetakine combined with a CD33 costimulatory receptor as a dual CAR approach for safer and selective targeting of AML
Vincenzo Maria Perriello,Maria Caterina Rotiroti,Ilaria Pisani,Stefania Galimberti,Gaia Alberti,Giulia Pianigiani,Valerio Ciaurro,Andrea Marra,Marcella Sabino,Valentina Tini,Giulio Spinozzi,Federica Mezzasoma,Francesco Morena,Sabata Martino,Domenico Salerno,Julian François Ashby,Brittany Wingham,Marta Serafini,Maria Paola Martelli,Brunangelo Falini,Andrea Biondi,Sarah Tettamanti
View Articletitled, IL-3-zetakine combined with a CD33 costimulatory receptor as a dual CAR approach for safer and selective targeting of AML
Supplemental data

Summary of BT modality, BT response and PFS post-CAR-T in all apheresed LBCL patients.

Effective bridging therapy can improve CD19 CAR-T outcomes while maintaining safety in patients with large B-cell lymphoma
Claire Roddie,Lorna Neill,Wendy Osborne,Sunil Iyengar,Eleni Tholouli,David Irvine,Sridhar Chaganti,Caroline Besley,Adrian Bloor,Ceri Jones,Ben Uttenthal,Rod Johnson,Robin Sanderson,Kathleen Cheok,Maria Marzolini,William Townsend,Maeve O'Reilly,Amy A. Kirkwood,Andrea Kuhnl
View Articletitled, Effective bridging therapy can improve CD19 CAR-T outcomes while maintaining safety in patients with large B-cell lymphoma
Supplemental data
Dual targeting of protein translation and nuclear protein export results in enhanced antimyeloma effects
Shirong Li,Jing Fu,Christopher J. Walker,Jun Yang,Divaya Bhutani,Rajshekhar Chakraborty,Niha Mamillapalli,Markus Y. Mapara,Yosef Landesman,Suzanne Lentzsch
View Articletitled, Dual targeting of protein translation and nuclear protein export results in enhanced antimyeloma effects
A wholesale approach to disarm multiple myeloma
Simone Cenci
View Articletitled, A wholesale approach to disarm multiple myeloma

LYMPHOID NEOPLASIA

BTK and PLCG2 remain unmutated in one-third of patients with CLL relapsing on ibrutinib
Silvia Bonfiglio,Lesley-Ann Sutton,Viktor Ljungström,Antonella Capasso,Tatjana Pandzic,Simone Weström,Hassan Foroughi-Asl,Aron Skaftason,Anna Gellerbring,Anna Lyander,Francesca Gandini,Gianluca Gaidano,Livio Trentin,Lisa Bonello,Gianluigi Reda,Csaba Bödör,Niki Stavroyianni,Constantine S. Tam,Roberto Marasca,Francesco Forconi,Panayiotis Panayiotidis,Ingo Ringshausen,Ozren Jaksic,Anna Maria Frustaci,Sunil Iyengar,Marta Coscia,Stephen P. Mulligan,Loïc Ysebaert,Vladimir Strugov,Carolina Pavlovsky,Renata Walewska,Anders Österborg,Diego Cortese,Pamela Ranghetti,Panagiotis Baliakas,Kostas Stamatopoulos,Lydia Scarfò,Richard Rosenquist,Paolo Ghia
View Articletitled, <em>BTK</em> and <em>PLCG2</em> remain unmutated in one-third of patients with CLL relapsing on ibrutinib
Supplemental data
HDAC1 regulates the chromatin landscape to control transcriptional dependencies in chronic lymphocytic leukemia
Tzung-Huei Lai,Hatice Gulcin Ozer,Pierluigi Gasparini,Giovanni Nigita,Rosario Distefano,Lianbo Yu,Janani Ravikrishnan,Selen Yilmaz,Juan Gallegos,Sachet Shukla,Vinay Puduvalli,Jennifer Woyach,Rosa Lapalombella,James Blachly,John C. Byrd,Deepa Sampath
View Articletitled, HDAC1 regulates the chromatin landscape to control transcriptional dependencies in chronic lymphocytic leukemia
Supplemental data

MYELOID NEOPLASIA

Determinants of low health-related quality of life in patients with myelodysplastic syndromes: EUMDS Registry study
Igor Stojkov,Annette Conrads-Frank,Ursula Rochau,Marjan Arvandi,Karin A. Koinig,Michael Schomaker,Moshe Mittelman,Pierre Fenaux,David Bowen,Guillermo F. Sanz,Luca Malcovati,Saskia Langemeijer,Ulrich Germing,Krzysztof Madry,Agnès Guerci-Bresler,Dominic J. Culligan,Ioannis Kotsianidis,Laurence Sanhes,Juliet Mills,Sibylle Puntscher,Daniela Schmid,Corine van Marrewijk,Alexandra Smith,Fabio Efficace,Theo de Witte,Reinhard Stauder,Uwe Siebert
View Articletitled, Determinants of low health-related quality of life in patients with myelodysplastic syndromes: EUMDS Registry study
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Proteome alterations in erythrocytes with PIEZO1 gain-of-function mutations
Clinical Trials & Observations
Immacolata Andolfo,Vittoria Monaco,Flora Cozzolino,Barbara Eleni Rosato,Roberta Marra,Vincenza Cerbone,Valeria Maria Pinto,Gian Luca Forni,Sule Unal,Achille Iolascon,Maria Monti,Roberta Russo
View Articletitled, Proteome alterations in erythrocytes with PIEZO1 gain-of-function mutations
Supplemental data

THROMBOSIS AND HEMOSTASIS

Impaired factor V–related anticoagulant mechanisms and deep vein thrombosis associated with A2086D and W1920R mutations
Naruto Shimonishi,Kenichi Ogiwara,Junko Yoshida,Kyoji Horie,Yuto Nakajima,Shoko Furukawa,Masahiro Takeyama,Keiji Nogami
View Articletitled, Impaired factor V–related anticoagulant mechanisms and deep vein thrombosis associated with A2086D and W1920R mutations
Supplemental data

TRANSPLANTATION

CMV reactivation after allogeneic HCT is associated with a reduced risk of relapse in acute lymphoblastic leukemia
Clinical Trials & Observations
Yu Akahoshi,Hideki Nakasone,Katsuto Takenaka,Satoshi Yamasaki,Momoko Nakamura,Noriko Doki,Masatsugu Tanaka,Yukiyasu Ozawa,Naoyuki Uchida,Takahide Ara,Hirohisa Nakamae,Shuichi Ota,Makoto Onizuka,Shingo Yano,Junji Tanaka,Takahiro Fukuda,Yoshinobu Kanda,Yoshiko Atsuta,Shinichi Kako,Masamitsu Yanada,Yasuyuki Arai
View Articletitled, CMV reactivation after allogeneic HCT is associated with a reduced risk of relapse in acute lymphoblastic leukemia
Supplemental data
Impact of second primary malignancy post–autologous transplantation on outcomes of multiple myeloma: a CIBMTR analysis
Brittany Knick Ragon,Mithun Vinod Shah,Anita D’Souza,Noel Estrada-Merly,Lohith Gowda,Gemlyn George,Marcos de Lima,Shahrukh Hashmi,Mohamed A. Kharfan-Dabaja,Navneet S. Majhail,Rahul Banerjee,Ayman Saad,Gerhard C. Hildebrandt,Hira Mian,Muhammad Bilal Abid,Minoo Battiwalla,Lazaros J. Lekakis,Sagar S. Patel,Hemant S. Murthy,Yago Nieto,Christopher Strouse,Sherif M. Badawy,Samer Al Hadidi,Bhagirathbhai Dholaria,Mahmoud Aljurf,David H. Vesole,Cindy H. Lee,Attaphol Pawarode,Usama Gergis,Kevin C. Miller,Leona A. Holmberg,Aimaz Afrough,Melhem Solh,Pashna N. Munshi,Taiga Nishihori,Larry D. Anderson, Jr.,Baldeep Wirk,Gurbakhash Kaur,Muzaffar H. Qazilbash,Nina Shah,Shaji K. Kumar,Saad Z. Usmani
View Articletitled, Impact of second primary malignancy post–autologous transplantation on outcomes of multiple myeloma: a CIBMTR analysis
Supplemental data
Autologous transplant and second malignancies in MM
Oren Pasvolsky,Qaiser Bashir
View Articletitled, Autologous transplant and second malignancies in MM
Risk of COVID-19 infection in long-term survivors of blood or marrow transplantation: a BMTSS report
Emily E. Johnston,Qingrui Meng,Lindsey Hageman,Jessica Wu,Elizabeth Ross,Shawn Lim,Nora Balas,Alysia Bosworth,Hok Sreng Te,Liton Francisco,Ravi Bhatia,Stephen J. Forman,F. Lennie Wong,Saro H. Armenian,Daniel J. Weisdorf,Wendy Landier,Smita Bhatia
View Articletitled, Risk of COVID-19 infection in long-term survivors of blood or marrow transplantation: a BMTSS report
Supplemental data
Role of NKG2D ligands and receptor in haploidentical related donor hematopoietic cell transplantation
Effie W. Petersdorf,Caroline McKallor,Mari Malkki,Meilun He,Stephen R. Spellman,Katharine C. Hsu,Roland K. Strong,Ted Gooley,Phil Stevenson
View Articletitled, Role of NKG2D ligands and receptor in haploidentical related donor hematopoietic cell transplantation
Supplemental data

RESEARCH LETTERS

Black African-American patients with primary myelofibrosis: a comparative analysis of phenotype and survival
Naseema Gangat,Andrew Kuykendall,Najla Al Ali,Swati Goel,Maymona Abdelmagid,Aref Al-Kali,Hassan B. Alkhateeb,Kebede H. Begna,Abhishek Mangaonkar,Mark R. Litzow,William Hogan,Mithun Shah,Mrinal M. Patnaik,Animesh Pardanani,Rami Komrokji,Ayalew Tefferi
View Articletitled, Black African-American patients with primary myelofibrosis: a comparative analysis of phenotype and survival
Further analysis of incidence of multiple myeloma among atomic-bomb survivors, 1950 to 1994
Noriaki Yoshida,Megumu Fujihara,Dale L. Preston,Kotaro Ozasa,Ayumi Hida,Waka Ohishi,Ritsu Sakata,Kiyohiko Mabuchi
View Articletitled, Further analysis of incidence of multiple myeloma among atomic-bomb survivors, 1950 to 1994
Supplemental data
Plasticity of lineage switch in B-ALL allows for successful rechallenge with CD19-directed immunotherapy
Brittany M. Lee,Corinne Summers,Karen M. Chisholm,Sandra D. Bohling,Kasey J. Leger,Rebecca Gardner,Colleen Annesley,Adam J. Lamble
View Articletitled, Plasticity of lineage switch in B-ALL allows for successful rechallenge with CD19-directed immunotherapy
Supplemental data
Zanubrutinib for the treatment of relapsed/refractory hairy cell leukemia
Clinical Trials & Observations
Constantine S. Tam,Judith Trotman,Stephen Opat,Jennifer C. Stern,Heather Allewelt,Kunthel By,William Novotny,Jane Huang,Alessandra Tedeschi
View Articletitled, Zanubrutinib for the treatment of relapsed/refractory hairy cell leukemia
Supplemental data
Durable responses with ALK inhibitors for primary refractory anaplastic lymphoma Kinase-positive large B-cell lymphoma
Radhika Takiar,Tycel J. Phillips
View Articletitled, Durable responses with ALK inhibitors for primary refractory anaplastic lymphoma Kinase-positive large B-cell lymphoma
BH3 profiling identifies BCL-2 dependence in adult patients with early T-cell progenitor acute lymphoblastic leukemia
Elyse A. Olesinski,Karanpreet S. Bhatia,Aarthi N. Mahesh,Shazwina Rosli,Jameelah S. Mohamed,Wei Y. Jen,Nitin Jain,Jacqueline S. Garcia,Gee C. Wong,Melissa Ooi,Anthony Letai,Marina Konopleva,Shruti Bhatt
View Articletitled, BH3 profiling identifies BCL-2 dependence in adult patients with early T-cell progenitor acute lymphoblastic leukemia
Supplemental data

COMMENTARIES

More on the use of frontline caplacizumab in immune-mediated thrombotic thrombocytopenic purpura
Adrien Picod,Ygal Benhamou,Raïda Bouzid,Agnès Veyradier,Paul Coppo
View Articletitled, More on the use of frontline caplacizumab in immune-mediated thrombotic thrombocytopenic purpura
An agenda to advance research in myelodysplastic syndromes: a TOP 10 priority list from the first international workshop in MDS
Clinical Trials & Observations
Maximilian Stahl,Omar Abdel-Wahab,Andrew H. Wei,Michael R. Savona,Mina L. Xu,Zhuoer Xie,Justin Taylor,Daniel Starczynowski,Guillermo F. Sanz,David A. Sallman,Valeria Santini,Gail J. Roboz,Mrinal M. Patnaik,Eric Padron,Olatoyosi Odenike,Aziz Nazha,Stephen D. Nimer,Ravindra Majeti,Richard F. Little,Steven Gore,Alan F. List,Vijay Kutchroo,Rami S. Komrokji,Tae Kon Kim,Nina Kim,Christopher S. Hourigan,Robert P. Hasserjian,Stephanie Halene,Elizabeth A. Griffiths,Peter L. Greenberg,Maria Figueroa,Pierre Fenaux,Fabio Efficace,Amy E. DeZern,Matteo G. Della Porta,Naval G. Daver,Jane E. Churpek,Hetty E. Carraway,Andrew M. Brunner,Uma Borate,John M. Bennett,Rafael Bejar,Jacqueline Boultwood,Sanam Loghavi,Jan Philipp Bewersdorf,Uwe Platzbecker,David P. Steensma,Mikkael A. Sekeres,Rena J. Buckstein,Amer M. Zeidan
View Articletitled, An agenda to advance research in myelodysplastic syndromes: a TOP 10 priority list from the first international workshop in MDS

ERRATA

Ilett EE, Jørgensen M, Noguera-Julian M, et al. Associations of the gut microbiome and clinical factors with acute GVHD in allogeneic HSCT recipients. Blood Adv. 2020;4(22):5797-5809.
View Articletitled, Ilett EE, Jørgensen M, Noguera-Julian M, et al. Associations of the gut microbiome and clinical factors with acute GVHD in allogeneic HSCT recipients. <em>Blood Adv</em>. 2020;4(22):5797-5809.
Uy GL, Newell LF, Lin TL, et al. Transplant outcomes after CPX-351 vs 7 + 3 in older adults with newly diagnosed high-risk and/or secondary AML. Blood Adv. 2022;6(17):4989-4993.
View Articletitled, Uy GL, Newell LF, Lin TL, et al. Transplant outcomes after CPX-351 vs 7 + 3 in older adults with newly diagnosed high-risk and/or secondary AML. <em>Blood Adv.</em> 2022;6(17):4989-4993.
Fabrizio VA, Boelens JJ, Mauguen A, et al. Optimal fludarabine lymphodepletion is associated with improved outcomes after CAR T-cell therapy. Blood Adv. 2022;6(7):1961-1968.
View Articletitled, Fabrizio VA, Boelens JJ, Mauguen A, et al. Optimal fludarabine lymphodepletion is associated with improved outcomes after CAR T-cell therapy. <em>Blood Adv</em>. 2022;6(7):1961-1968.
Kwiatkowski JL, Hamdy M, El-Beshlawy A, et al. Deferiprone vs deferoxamine for transfusional iron overload in SCD and other anemias: a randomized, open-label noninferiority study. Blood Adv. 2022;6(4):1243-1254.
View Articletitled, Kwiatkowski JL, Hamdy M, El-Beshlawy A, et al. Deferiprone vs deferoxamine for transfusional iron overload in SCD and other anemias: a randomized, open-label noninferiority study. <em>Blood Adv.</em> 2022;6(4):1243-1254.
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