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Issue Archive

Volume 6, Issue 8
April 26 2022
Issue Cover

Table of Contents

STIMULUS REPORT

The CLL comorbidity index in a population-based cohort: a tool for clinical care and research
Emelie C. Rotbain,Max J. Gordon,Noomi Vainer,Henrik Frederiksen,Henrik Hjalgrim,Alexey V. Danilov,Carsten U. Niemann
View Articletitled, The CLL comorbidity index in a population-based cohort: a tool for clinical care and research
Supplemental data

REVIEW ARTICLE

Post–hematopoietic stem cell transplantation immune-mediated anemia: a literature review and novel therapeutics
Yazan Migdady,Yifan Pang,Shelley S. Kalsi,Richard Childs,Sally Arai
View Articletitled, Post–hematopoietic stem cell transplantation immune-mediated anemia: a literature review and novel therapeutics

CLINICAL TRIALS AND OBSERVATIONS

Outcome of donor-derived TAA-T cell therapy in patients with high-risk or relapsed acute leukemia post allogeneic BMT
Clinical Trials & Observations
Hannah Kinoshita,Kenneth R. Cooke,Melanie Grant,Maja Stanojevic,C. Russell Cruz,Michael Keller,Maria Fernanda Fortiz,Fahmida Hoq,Haili Lang,A. John Barrett,Hua Liang,Jay Tanna,Nan Zhang,Abeer Shibli,Anushree Datar,Kenneth Fulton,Divyesh Kukadiya,Anqing Zhang,Kirsten M. Williams,Hema Dave,Jeffrey S. Dome,David Jacobsohn,Patrick J. Hanley,Richard J. Jones,Catherine M. Bollard
View Articletitled, Outcome of donor-derived TAA-T cell therapy in patients with high-risk or relapsed acute leukemia post allogeneic BMT
Supplemental data

GENE THERAPY

Pharmacokinetic analysis identifies a factor VIII immunogenicity threshold after AAV gene therapy in hemophilia A mice
Taran S. Lundgren,Gabriela Denning,Sean R. Stowell,H. Trent Spencer,Christopher B. Doering
View Articletitled, Pharmacokinetic analysis identifies a factor VIII immunogenicity threshold after AAV gene therapy in hemophilia A mice
Supplemental data

LYMPHOID NEOPLASIA

Genome-wide CRISPR/Cas9 screening identifies determinant of panobinostat sensitivity in acute lymphoblastic leukemia
Clinical Trials & Observations
Chuang Jiang,Maoxiang Qian,Yoshihiro Gocho,Wentao Yang,Guoqing Du,Shuhong Shen,Jun J. Yang,Hui Zhang
View Articletitled, Genome-wide CRISPR/Cas9 screening identifies determinant of panobinostat sensitivity in acute lymphoblastic leukemia
Supplemental data
Indirect comparison of tisagenlecleucel and historical treatments for relapsed/refractory diffuse large B-cell lymphoma
Clinical Trials & Observations
Richard T. Maziarz,Jie Zhang,Hongbo Yang,Xinglei Chai,Chengbo Yuan,Elisabeth Schwarz,Mihael Jakovac,Marcela Martinez-Prieto,Abhijit Agarwal,Evgeny Degtyarev,Constantine Tam,Gilles Salles
View Articletitled, Indirect comparison of tisagenlecleucel and historical treatments for relapsed/refractory diffuse large B-cell lymphoma
Supplemental data
A randomized trial of alendronate as prophylaxis against loss in bone mineral density following lymphoma treatment
Clinical Trials & Observations
Paw Jensen,Lasse Hjort Jakobsen,Martin Bøgsted,Joachim Baech,Simon Lykkeboe,Marianne Tang Severinsen,Peter Vestergaard,Tarec Christoffer El-Galaly
View Articletitled, A randomized trial of alendronate as prophylaxis against loss in bone mineral density following lymphoma treatment
Supplemental data
The TΑp63/BCL2 axis represents a novel mechanism of clinical aggressiveness in chronic lymphocytic leukemia
Stamatia Laidou,Dionysios Grigoriadis,Sofia Papanikolaou,Spyros Foutadakis,Stavroula Ntoufa,Maria Tsagiopoulou,Giannis Vatsellas,Achilles Anagnostopoulos,Anastasia Kouvatsi,Niki Stavroyianni,Fotis Psomopoulos,Antonios M. Makris,Marios Agelopoulos,Dimitris Thanos,Anastasia Chatzidimitriou,Nikos Papakonstantinou,Kostas Stamatopoulos
View Articletitled, The TΑp63/BCL2 axis represents a novel mechanism of clinical aggressiveness in chronic lymphocytic leukemia
Supplemental data
Incidence and time trends of second primary malignancies after non-Hodgkin lymphoma: a Swedish population-based study
Joel Joelsson,Tove Wästerlid,Richard Rosenquist,Lasse Hjort Jakobsen,Tarec C. El-Galaly,Karin E. Smedby,Sandra Eloranta
View Articletitled, Incidence and time trends of second primary malignancies after non-Hodgkin lymphoma: a Swedish population-based study
Supplemental data
Circulating tumor DNA predicts therapeutic outcome in mantle cell lymphoma
Clinical Trials & Observations
Rahul Lakhotia,Christopher Melani,Kieron Dunleavy,Stefania Pittaluga,Nakhle Saba,Liza Lindenberg,Esther Mena,Ethan Bergvall,Andrea Nicole Lucas,Allison Jacob,Erik Yusko,Seth M. Steinberg,Elaine S. Jaffe,Adrian Wiestner,Wyndham H. Wilson,Mark Roschewski
View Articletitled, Circulating tumor DNA predicts therapeutic outcome in mantle cell lymphoma
Supplemental data

MYELOID NEOPLASIA

SORT1/LAMP2-mediated extracellular vesicle secretion and cell adhesion are linked to lenalidomide resistance in multiple myeloma
Clinical Trials & Observations
Tomofumi Yamamoto,Jun Nakayama,Yusuke Yamamoto,Masahiko Kuroda,Yutaka Hattori,Takahiro Ochiya
View Articletitled, SORT1/LAMP2-mediated extracellular vesicle secretion and cell adhesion are linked to lenalidomide resistance in multiple myeloma
Supplemental data
ELN2017 risk stratification improves outcome prediction when applied to the prospective GIMEMA AML1310 protocol
Clinical Trials & Observations
Francesco Buccisano,Raffaele Palmieri,Alfonso Piciocchi,Valentina Arena,Anna Candoni,Lorella Melillo,Valeria Calafiore,Roberto Cairoli,Paolo de Fabritiis,Gabriella Storti,Prassede Salutari,Francesco Lanza,Giovanni Martinelli,Mario Luppi,Saveria Capria,Luca Maurillo,Maria Ilaria Del Principe,Giovangiacinto Paterno,Maria Antonietta Irno Consalvo,Tiziana Ottone,Serena Lavorgna,Maria Teresa Voso,Paola Fazi,Marco Vignetti,William Arcese,Adriano Venditti
View Articletitled, ELN2017 risk stratification improves outcome prediction when applied to the prospective GIMEMA AML1310 protocol
Supplemental data
Clofarabine with topotecan, vinorelbine, and thiotepa reinduction regimen for children and young adults with relapsed AML
Kavitha Ramaswamy,Peter G. Steinherz,Anurag K. Agrawal,Christopher J. Forlenza,Audrey Mauguen,Mikhail Roshal,Tanya Trippett,Nancy A. Kernan,Maria Luisa Sulis,Neerav Shukla
View Articletitled, Clofarabine with topotecan, vinorelbine, and thiotepa reinduction regimen for children and young adults with relapsed AML
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

A new murine model of Barth syndrome neutropenia links TAFAZZIN deficiency to increased ER stress-induced apoptosis
Jihee Sohn,Jelena Milosevic,Thomas Brouse,Najihah Aziz,Jenna Elkhoury,Suya Wang,Alexander Hauschild,Nick van Gastel,Murat Cetinbas,Sara F. Tufa,Douglas R. Keene,Ruslan I. Sadreyev,William T. Pu,David B. Sykes
View Articletitled, A new murine model of Barth syndrome neutropenia links TAFAZZIN deficiency to increased ER stress-induced apoptosis
Supplemental data
Lymphocyte cytosolic protein 1 (L-plastin) I232F mutation impairs granulocytic proliferation and causes neutropenia
Clinical Trials & Observations
Upendra Mahat,Bhavuk Garg,Chao-Yie Yang,Hrishikesh Mehta,Rabi Hanna,Heesun J. Rogers,Aron Flagg,Andrei I. Ivanov,Seth J. Corey
View Articletitled, Lymphocyte cytosolic protein 1 (L-plastin) I232F mutation impairs granulocytic proliferation and causes neutropenia
Supplemental data

PLATELETS AND THROMBOPOIESIS

Platelet SHARPIN regulates platelet adhesion and inflammatory responses through associations with αIIbβ3 and LUBAC
Clinical Trials & Observations
Ana Kasirer-Friede,Emilia Peuhu,Johanna Ivaska,Sanford J. Shattil
View Articletitled, Platelet SHARPIN regulates platelet adhesion and inflammatory responses through associations with αIIbβ3 and LUBAC
Supplemental data

THROMBOSIS AND HEMOSTASIS

SIPA in 10 milliseconds: VWF tentacles agglomerate and capture platelets under high shear
Zixiang Leonardo Liu,Christopher Bresette,Cyrus K. Aidun,David N. Ku
View Articletitled, SIPA in 10 milliseconds: VWF tentacles agglomerate and capture platelets under high shear
Supplemental data

TRANSPLANTATION

Conditioning intensity and probability of live birth after blood or marrow transplantation, a BMTSS report
Nora Balas,Lindsey Hageman,Jessica Wu,Liton Francisco,Elizabeth Schlichting,Alysia Bosworth,Hok Sreng Te,F. Lennie Wong,Wendy Landier,Donna Salzman,Daniel J. Weisdorf,Stephen J. Forman,Mukta Arora,Saro H. Armenian,Smita Bhatia
View Articletitled, Conditioning intensity and probability of live birth after blood or marrow transplantation, a BMTSS report
Supplemental data
Genetic associations with immune-mediated outcomes after allogeneic hematopoietic cell transplantation
Paul J. Martin,David M. Levine,Barry E. Storer,Cassandra L. Sather,Stephen R. Spellman,John A. Hansen
View Articletitled, Genetic associations with immune-mediated outcomes after allogeneic hematopoietic cell transplantation
Supplemental data
Establishment of a predictive model for GVHD-free, relapse-free survival after allogeneic HSCT using ensemble learning
Makoto Iwasaki,Junya Kanda,Yasuyuki Arai,Tadakazu Kondo,Takayuki Ishikawa,Yasunori Ueda,Kazunori Imada,Takashi Akasaka,Akihito Yonezawa,Kazuhiro Yago,Masaharu Nohgawa,Naoyuki Anzai,Toshinori Moriguchi,Toshiyuki Kitano,Mitsuru Itoh,Nobuyoshi Arima,Tomoharu Takeoka,Mitsumasa Watanabe,Hirokazu Hirata,Kosuke Asagoe,Isao Miyatsuka,Le My An,Masanori Miyanishi,Akifumi Takaori-Kondo,,on behalf of the Kyoto Stem Cell Transplantation Group (KSCTG)
View Articletitled, Establishment of a predictive model for GVHD-free, relapse-free survival after allogeneic HSCT using ensemble learning
Supplemental data

RESEARCH LETTER

Risk of infections with B-cell maturation antigen-directed immunotherapy in multiple myeloma
Clinical Trials & Observations
Meera Mohan,Sneha Nagavally,Binod Dhakal,Sabarinath Venniyil Radhakrishnan,Saurabh Chhabra,Anita D’Souza,Parameswaran Hari
View Articletitled, Risk of infections with B-cell maturation antigen-directed immunotherapy in multiple myeloma
Supplemental data
Development of BRAFV600E-positive acute myeloid leukemia in a patient on long-term dabrafenib for multisystem LCH
Marta Salek,Ninad Oak,Melissa Hines,Jamie L. Maciaszek,Ruth Tatevossian,Akshay Sharma,Kim E. Nichols,Patrick Campbell
View Articletitled, Development of <em>BRAF<sup>V600E</sup></em>-positive acute myeloid leukemia in a patient on long-term dabrafenib for multisystem LCH
Cyclophosphamide induces durable molecular and clinical responses in patients with relapsed T-LGL leukemia
Zachary Braunstein,Eric McLaughlin,Anjali Mishra,Jonathan E. Brammer
View Articletitled, Cyclophosphamide induces durable molecular and clinical responses in patients with relapsed T-LGL leukemia
Supplemental data
CRISPR/Cas9 genome-edited universal CAR T cells in patients with relapsed/refractory lymphoma
Yelei Guo,Chuan Tong,Liping Su,Wenying Zhang,Hejin Jia,Yang Liu,Qingming Yang,Zhiqiang Wu,Yao Wang,Weidong Han
View Articletitled, CRISPR/Cas9 genome-edited universal CAR T cells in patients with relapsed/refractory lymphoma
Supplemental data

COMMENTARY

Minor PNH clones do not distinguish inherited bone marrow failure syndromes from immune-mediated aplastic anemia
Atsushi Narita,Shunsuke Miwata,Masayuki Imaya,Yusuke Tsumura,Ayako Yamamori,Manabu Wakamatsu,Motoharu Hamada,Rieko Taniguchi,Yusuke Okuno,Hideki Muramatsu,Yoshiyuki Takahashi
View Articletitled, Minor PNH clones do not distinguish inherited bone marrow failure syndromes from immune-mediated aplastic anemia
Supplemental data

ERRATA

Singh A, Brandow AM, Panepinto JA. COVID-19 in individuals with sickle cell disease/trait compared with other Black individuals. Blood Adv. 2021;5(7):1915-1921.
View Articletitled, Singh A, Brandow AM, Panepinto JA. COVID-19 in individuals with sickle cell disease/trait compared with other Black individuals. <em>Blood Adv.</em> 2021;5(7):1915-1921.
Ferrari N, Ward G, Gewinner C, et al. Antagonism of inhibitors of apoptosis proteins reveals a novel, immune response-based therapeutic approach for T-cell lymphoma. Blood Adv. 2021;5(20):4003-4016.
View Articletitled, Ferrari N, Ward G, Gewinner C, et al. Antagonism of inhibitors of apoptosis proteins reveals a novel, immune response-based therapeutic approach for T-cell lymphoma. <em>Blood Adv.</em> 2021;5(20):4003-4016.
Eshel A, Sharon I, Nagler A, et al. Origins of bloodstream infections following fecal microbiota transplantation: a strain-level analysis. Blood Adv. 2022;6(2):568-573.
View Articletitled, Eshel A, Sharon I, Nagler A, et al. Origins of bloodstream infections following fecal microbiota transplantation: a strain-level analysis. <em>Blood Adv.</em> 2022;6(2):568-573.
Bornhauser B, Cario G, Rinaldi A, et al. The hematopoietic stem cell marker VNN2 is associated with chemoresistance in pediatric B-cell precursor ALL. Blood Adv. 2020;4(17):4052-4064.
View Articletitled, Bornhauser B, Cario G, Rinaldi A, et al. The hematopoietic stem cell marker VNN2 is associated with chemoresistance in pediatric B-cell precursor ALL. <em>Blood Adv.</em> 2020;4(17):4052-4064.
All Issues

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Nuclear Receptor Rev-erbα Role in Fine-Tuning Erythropoietin Gene Expression
Active infection at the time of CD34+ selected stem cell boost is associated with treatment failure and poor survival
Biological and Clinical Determinants Shaping Heterogeneity in Mantle Cell Lymphoma
Targeting metabolic dependencies in JAK2-V617F–driven MPNs
Predictive model for the risk of cytokine release syndrome with glofitamab treatment for diffuse large B-cell lymphoma

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