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Journal Articles

Pharmacokinetic analysis identifies a factor VIII immunogenicity threshold after AAV gene therapy in hemophilia A mice

Taran S. Lundgren, Gabriela Denning, Sean R. Stowell, H. Trent Spencer, Christopher B. Doering
Journal: Blood Advances
Blood Adv (2022) 6 (8): 2628–2645.
https://doi.org/10.1182/bloodadvances.2021006359
Published: 2022
Includes: Supplemental data
Journal Articles

Identification of coagulation factor IX variants with enhanced activity through ancestral sequence reconstruction

Kristopher A. Knight, Christopher W. Coyle, Caelan E. Radford, Ernest T. Parker, Andrew Fedanov, Jordan M. Shields, Fania Szlam, Anatolii Purchel, Michelle Chen, Gabriela Denning, Roman M. Sniecinski, Pete Lollar, H. Trent Spencer, Eric A. Gaucher, Christopher B. Doering
Journal: Blood Advances
Blood Adv (2021) 5 (17): 3333–3343.
https://doi.org/10.1182/bloodadvances.2021004742
Published: 2021
Includes: Supplemental data
Journal Articles

Molecular coevolution of coagulation factor VIII and von Willebrand factor

Philip M. Zakas, Christopher W. Coyle, Anja Brehm, Marion Bayer, Barbara Solecka-Witulska, Caelan E. Radford, Christine Brown, Kate Nesbitt, Courtney Dwyer, Christoph Kannicht, H. Trent Spencer, Eric A. Gaucher, Christopher B. Doering, David Lillicrap
Journal: Blood Advances
Blood Adv (2021) 5 (3): 812–822.
https://doi.org/10.1182/bloodadvances.2020002971
Published: 2021
Includes: Supplemental data