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Issue Archive

Volume 6, Issue 18
September 27 2022
Issue Cover

Table of Contents

STIMULUS REPORT

A gain-of-function variant in the Wiskott-Aldrich syndrome gene is associated with a MYH9-related disease-like syndrome
David Marx,Arnaud Dupuis,Anita Eckly,Anne Molitor,Jérôme Olagne,Guy Touchard,Sihem Kaaki,Cécile Ory,Anne-Laure Faller,Bénédicte Gérard,Melanie Cotter,Lisa Westerberg,Marton Keszei,Bruno Moulin,Christian Gachet,Sophie Caillard,Seiamak Bahram,Raphaël Carapito
View Articletitled, A gain-of-function variant in the Wiskott-Aldrich syndrome gene is associated with a MYH9-related disease-like syndrome
Supplemental data

REVIEW ARTICLES

The potential role of protease systems in hemophilic arthropathy
Wayne W. S. Hauw,Joanne S. J. Chia,Harshal H. Nandurkar,Maithili Sashindranath
View Articletitled, The potential role of protease systems in hemophilic arthropathy
International consensus statement on the management of cardiovascular risk of Bruton’s tyrosine kinase inhibitors in CLL
Farrukh T. Awan,Daniel Addison,Feras Alfraih,Sergio J. Baratta,Rodrigo Noronha Campos,María Silvana Cugliari,Yeow Tee Goh,Valery Alexandrovich Ionin,Stefanie Mundnich,Aaron L. Sverdlov,Constantine Tam,Loïc Ysebaert
View Articletitled, International consensus statement on the management of cardiovascular risk of Bruton’s tyrosine kinase inhibitors in CLL
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Midostaurin plus intensive chemotherapy for younger and older patients with AML and FLT3 internal tandem duplications
Clinical Trials & Observations
Hartmut Döhner,Daniela Weber,Julia Krzykalla,Walter Fiedler,Gerald Wulf,Helmut Salih,Michael Lübbert,Michael W. M. Kühn,Thomas Schroeder,Hans Salwender,Katharina Götze,Jörg Westermann,Lars Fransecky,Karin Mayer,Bernd Hertenstein,Mark Ringhoffer,Hans-Joachim Tischler,Sigrid Machherndl-Spandl,Anika Schrade,Peter Paschka,Verena I. Gaidzik,Frauke Theis,Felicitas Thol,Michael Heuser,Richard F. Schlenk,Lars Bullinger,Maral Saadati,Axel Benner,Richard Larson,Richard Stone,Konstanze Döhner,Arnold Ganser,on behalf of the German-Austrian AML Study Group
View Articletitled, Midostaurin plus intensive chemotherapy for younger and older patients with AML and <em>FLT3</em> internal tandem duplications
Supplemental data
Phase 2 trial of ixazomib, cyclophosphamide, and dexamethasone for previously untreated light chain amyloidosis
Clinical Trials & Observations
Eli Muchtar,Morie A. Gertz,Betsy R. LaPlant,Francis K. Buadi,Nelson Leung,Patrick O’Brien,P. Leif Bergsagel,Amie Fonder,Yi Lisa Hwa,Miriam Hobbs,Dania K. Helgeson,Erin E. Bradt,Wilson Gonsalves,Martha Q. Lacy,Prashant Kapoor,Mustaqueem Siddiqui,Jeremy T. Larsen,Rahma Warsame,Suzanne R. Hayman,Ronald S. Go,David Dingli,Taxiarchis V. Kourelis,Angela Dispenzieri,S. Vincent Rajkumar,Shaji K. Kumar
View Articletitled, Phase 2 trial of ixazomib, cyclophosphamide, and dexamethasone for previously untreated light chain amyloidosis
Supplemental data
The VWF binding aptamer rondoraptivon pegol increases platelet counts and VWF/FVIII in type 2B von Willebrand disease
Clinical Trials & Observations
Cihan Ay,Ingrid Pabinger,Katarina D. Kovacevic,Georg Gelbenegger,Christian Schörgenhofer,Peter Quehenberger,Petra Jilma-Stohlawetz,Raute Sunder-Plassman,James C. Gilbert,Shuhao Zhu,Bernd Jilma,Ulla Derhaschnig
View Articletitled, The VWF binding aptamer rondoraptivon pegol increases platelet counts and VWF/FVIII in type 2B von Willebrand disease
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Assessment of safety and immunogenicity of MHC homozygous iPSC-derived CD34+ hematopoietic progenitors in an NHP model
Saritha S. D’Souza,Akhilesh Kumar,John Maufort,Jason T. Weinfurter,Matthew Raymond,Nick S. Strelchenko,Elizabeth Perrin,Jennifer Coonen,Andres Mejia,Heather A. Simmons,Bruce E. Torbett,Matthew Reynolds,James A. Thomson,Igor I. Slukvin
View Articletitled, Assessment of safety and immunogenicity of MHC homozygous iPSC-derived CD34<sup>+</sup> hematopoietic progenitors in an NHP model
Supplemental data

LYMPHOID NEOPLASIA

Bendamustine or high-dose cytarabine-based induction with rituximab in transplant-eligible mantle cell lymphoma
Clinical Trials & Observations
Diego Villa,Eva Hoster,Olivier Hermine,Wolfram Klapper,Michal Szymczyk,André Bosly,Michael Unterhalt,Lisa M. Rimsza,Colleen A. Ramsower,Ciara L. Freeman,David W. Scott,Alina S. Gerrie,Kerry J. Savage,Laurie H. Sehn,Martin Dreyling
View Articletitled, Bendamustine or high-dose cytarabine-based induction with rituximab in transplant-eligible mantle cell lymphoma
Ponatinib, chemotherapy, and transplant in adults with Philadelphia chromosome–positive acute lymphoblastic leukemia
Clinical Trials & Observations
Josep-Maria Ribera,Olga García-Calduch,Jordi Ribera,Pau Montesinos,Isabel Cano-Ferri,Pilar Martínez,Jordi Esteve,Daniel Esteban,María García-Fortes,Natalia Alonso,José González-Campos,Arancha Bermúdez,Anna Torrent,Eulàlia Genescà,Santiago Mercadal,Joaquín Martínez-Lopez,Ramón García-Sanz
View Articletitled, Ponatinib, chemotherapy, and transplant in adults with Philadelphia chromosome–positive acute lymphoblastic leukemia
Genomic characterization of lymphomas in patients with inborn errors of immunity
Xiaofei Ye,Paul J. Maglione,Claudia Wehr,Xiaobo Li,Yating Wang,Hassan Abolhassani,Elena Deripapa,Dongbing Liu,Stephan Borte,Likun Du,Hui Wan,Andreas Plötner,Yvonne Giannoula,Huai-Bin Ko,Yong Hou,Shida Zhu,Jennifer K. Grossman,Birgitta Sander,Bodo Grimbacher,Lennart Hammarström,Alina Fedorova,Sergio D. Rosenzweig,Anna Shcherbina,Kui Wu,Klaus Warnatz,Charlotte Cunningham-Rundles,Qiang Pan-Hammarström
View Articletitled, Genomic characterization of lymphomas in patients with inborn errors of immunity
Supplemental data
Differential regulation of CTLA4 expression through BTK-dependent and independent mechanisms in CLL
Max Yano,Jessica Nunes,Xiaokui Mo,Kerry A. Rogers,Jennifer A. Woyach,John C. Byrd,Natarajan Muthusamy
View Articletitled, Differential regulation of CTLA4 expression through BTK-dependent and independent mechanisms in CLL
Genomic and microenvironmental landscape of stage I follicular lymphoma, compared with stage III/IV
G. Tjitske Los-de Vries,Wendy B. C. Stevens,Erik van Dijk,Carole Langois-Jacques,Andrew J. Clear,Phylicia Stathi,Margaretha G. M. Roemer,Matias Mendeville,Nathalie J. Hijmering,Birgitta Sander,Andreas Rosenwald,Maria Calaminici,Eva Hoster,Wolfgang Hiddemann,Philippe Gaulard,Gilles Salles,Heike Horn,Wolfram Klapper,Luc Xerri,Catherine Burton,Reuben M. Tooze,Alexandra G. Smith,Christian Buske,David W. Scott,Yasodha Natkunam,Ranjana Advani,Laurie H. Sehn,John Raemaekers,John Gribben,Eva Kimby,Marie José Kersten,Delphine Maucort-Boulch,Bauke Ylstra,Daphne de Jong
View Articletitled, Genomic and microenvironmental landscape of stage I follicular lymphoma, compared with stage III/IV
Supplemental data
High surface IgM levels associate with shorter response to ibrutinib and BTK bypass in patients with CLL
Giorgia Chiodin,Samantha Drennan,Enrica A. Martino,Laura Ondrisova,Isla Henderson,Luis del Rio,Ian Tracy,Annalisa D’Avola,Helen Parker,Silvia Bonfiglio,Lydia Scarfò,Lesley-Ann Sutton,Jonathan C. Strefford,Jade Forster,Oliver Brake,Kathleen N. Potter,Benjamin Sale,Stuart Lanham,Marek Mraz,Paolo Ghia,Freda K. Stevenson,Francesco Forconi
View Articletitled, High surface IgM levels associate with shorter response to ibrutinib and BTK bypass in patients with CLL
Supplemental data

MYELOID NEOPLASIA

Loss of METTL3 attenuates blastic plasmacytoid dendritic cell neoplasm response to PRMT5 inhibition via IFN signaling
Malini Rethnam,Darren Qiancheng Tan,Shi Hao Tan,Jia Li,Rui Yokomori,Ying Li,Henry Yang,Takaomi Sanda,Toshio Suda
View Articletitled, Loss of METTL3 attenuates blastic plasmacytoid dendritic cell neoplasm response to PRMT5 inhibition via IFN signaling
Supplemental data
Upregulated SPAG6 promotes acute myeloid leukemia progression through MYO1D that regulates the EGFR family expression
Jiao Mu,Peng Yuan,Jie Luo,Yafan Chen,Yiyuan Tian,Li Ding,Beibei Zhao,Xiaocheng Wang,Bao Wang,Lin Liu
View Articletitled, Upregulated SPAG6 promotes acute myeloid leukemia progression through MYO1D that regulates the EGFR family expression
Supplemental data

THROMBOSIS AND HEMOSTASIS

Desmopressin response depends on the presence and type of genetic variants in patients with type 1 and type 2 von Willebrand disease
Ferdows Atiq,Jessica Heijdra,Fleur Snijders,Johan Boender,Eva Kempers,Waander L. van Heerde,Dominique P. M. S. M. Maas,Sandy Krouwel,Selene C. Schoormans,Joke de Meris,Saskia E. M. Schols,Karin P. M. van Galen,Johanna G. van der Bom,Marjon H. Cnossen,Karina Meijer,Karin Fijnvandraat,Jeroen Eikenboom,Frank W. G. Leebeek,for the WiN study group
View Articletitled, Desmopressin response depends on the presence and type of genetic variants in patients with type 1 and type 2 von Willebrand disease
Supplemental data
Synonymous ADAMTS13 variants impact molecular characteristics and contribute to variability in active protein abundance
Katarzyna I. Jankowska,Douglas Meyer,David D. Holcomb,Jacob Kames,Nobuko Hamasaki-Katagiri,Upendra K. Katneni,Ryan C. Hunt,Juan C. Ibla,Chava Kimchi-Sarfaty
View Articletitled, Synonymous <em>ADAMTS13</em> variants impact molecular characteristics and contribute to variability in active protein abundance
Supplemental data
Development of a carotid artery thrombolysis stroke model in mice
Jessica A. A. Maclean,Amelia J. Tomkins,Sharelle A. Sturgeon,Benjamin R. Hofma,Imala Alwis,Andre L. Samson,Simone M. Schoenwaelder,Shaun P. Jackson
View Articletitled, Development of a carotid artery thrombolysis stroke model in mice
Supplemental data

TRANSFUSION MEDICINE

Metabolic reprogramming under hypoxic storage preserves faster oxygen unloading from stored red blood cells
Julija Rabcuka,Slawomir Blonski,Athinoula Meli,Samuel Sowemimo-Coker,Damian Zaremba,Daniel Stephenson,Monika Dzieciatkowska,David Nerguizian,Rebecca Cardigan,Piotr M. Korczyk,Peter A. Smethurst,Angelo D’Alessandro,Pawel Swietach
View Articletitled, Metabolic reprogramming under hypoxic storage preserves faster oxygen unloading from stored red blood cells
Supplemental data

TRANSPLANTATION

MicroRNA serum profiles and chronic graft-versus-host disease
Håkon Reikvam,Anh Khoi Vo,Silje Johansen,Anette Lodvir Hemsing,Magne Haugland Solheim,Knut Anders Mosevoll,Tor Henrik Anderson Tvedt,Kimberley Joanne Hatfield
View Articletitled, MicroRNA serum profiles and chronic graft-versus-host disease
Supplemental data
Respiratory viruses in hematopoietic cell transplant candidates: impact of preexisting lower tract disease on outcomes
Yae-Jean Kim,Alpana Waghmare,Hu Xie,Leona Holmberg,Steven A. Pergam,Keith R. Jerome,Wendy M. Leisenring,Chikara Ogimi,Angela P. Campbell,Janet A. Englund,Michael Boeckh
View Articletitled, Respiratory viruses in hematopoietic cell transplant candidates: impact of preexisting lower tract disease on outcomes
Supplemental data

RESEARCH LETTERS

Phenotypic heterogeneity in individuals with MECOM variants in 2 families
Clinical Trials & Observations
Tetsuya Niihori,Reo Tanoshima,Yoji Sasahara,Atsushi Sato,Masahiro Irie,Yuka Saito-Nanjo,Ryo Funayama,Matsuyuki Shirota,Taiki Abe,Yuko Okuyama,Naoto Ishii,Keiko Nakayama,Shigeo Kure,Masue Imaizumi,Yoko Aoki
View Articletitled, Phenotypic heterogeneity in individuals with <em>MECOM</em> variants in 2 families
Supplemental data
A phase 1 trial of copanlisib plus ibrutinib in relapsed/refractory mantle cell lymphoma
Clinical Trials & Observations
David Qualls,Hiu Ying Lam,Karissa Whiting,Anita Kumar,Matthew Matasar,Colette Owens,Chelsea Nichols,James A Espeleta,Annie Qiu,Sarima Subzwari,Erin Biggar,Venkatraman Seshan,Gilles Salles,Anas Younes,Connie Batlevi
View Articletitled, A phase 1 trial of copanlisib plus ibrutinib in relapsed/refractory mantle cell lymphoma
Supplemental data
Safety of BNT162b2 mRNA vaccine booster in the setting of Ad26.COV2.S-associated VITT
Mouhamed Yazan Abou-Ismail,Adam J. Kanack,Noah P. Splinter,Kristi J. Smock,Karen A. Moser,Anand Padmanabhan
View Articletitled, Safety of BNT162b2 mRNA vaccine booster in the setting of Ad26.COV2.S-associated VITT
Anti-CD20 rechallenge with ofatumumab in relapsed/refractory splenic marginal zone lymphoma: the MORE trial
Lydia Scarfò,Silvia Ferrari,Anna Maria Frustaci,Monica Tani,Alessia Bari,Eloise Scarano,Maria Colia,Pamela Ranghetti,Piera Angelillo,Paola Ronchi,Maurilio Ponzoni,Andrés J. M. Ferreri,Paolo Ghia
View Articletitled, Anti-CD20 rechallenge with ofatumumab in relapsed/refractory splenic marginal zone lymphoma: the MORE trial
Supplemental data
Virtual frailty assessment for older adults with hematologic malignancies
Clark DuMontier,Tim Jaung,Nupur E. Bahl,Brad Manor,Marcia Testa,Christina M. Dieli-Conwright,Dae Kim,Tammy Hshieh,Jane A. Driver,Gregory A. Abel
View Articletitled, Virtual frailty assessment for older adults with hematologic malignancies
Supplemental data
Phase 1/2 study of ixazomib with cyclophosphamide and dexamethasone in newly diagnosed AL amyloidosis
Clinical Trials & Observations
Cara A. Rosenbaum,Umut Özbek,Larysa Sanchez,Jonathan Lagdameo,Alex Abrahams,Hani Hassoun,Oscar Lahoud,Ruben Niesvizky,Heather J. Landau,Keren Osman
View Articletitled, Phase 1/2 study of ixazomib with cyclophosphamide and dexamethasone in newly diagnosed AL amyloidosis
Efficacy and safety of azathioprine during remission of immune-mediated thrombotic thrombocytopenic purpura
Christian Bichard,Ilaria Mancini,Pasquale Agosti,Marco Capecchi,Pasqualina De Leo,Sara Arcudi,Barbara Ferrari,Silvia Maria Trisolini,Francesco Longu,Claudio Fozza,Andrea Artoni,Flora Peyvandi
View Articletitled, Efficacy and safety of azathioprine during remission of immune-mediated thrombotic thrombocytopenic purpura
Supplemental data
Hematopoietic fitness of JAK2V617F myeloproliferative neoplasms is linked to clinical outcome
Ghaith Abu-Zeinah,Silvana Di Giandomenico,Daniel Choi,Tatiana Cruz,Katie Erdos,Elwood Taylor, III,Ellen K. Ritchie,Richard T. Silver,Joseph M. Scandura
View Articletitled, Hematopoietic fitness of <em>JAK2<sup>V617F</sup></em> myeloproliferative neoplasms is linked to clinical outcome
Supplemental data
All Issues

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