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Issue Archive

Volume 4, Issue 21
November 10 2020
Issue Cover

Table of Contents

EXCEPTIONAL CASE REPORT

B-lymphoblastic leukemia arising in a patient with chronic neutrophilic leukemia
Clinical Trials & Observations
Craig S. Boddy,Brent T. Tan,Joseph Aoki
View Articletitled, B-lymphoblastic leukemia arising in a patient with chronic neutrophilic leukemia

STIMULUS REPORTS

Outcome of patients with IDH1/2-mutated post–myeloproliferative neoplasm AML in the era of IDH inhibitors
Clinical Trials & Observations
Helen T. Chifotides,Lucia Masarova,Mansour Alfayez,Naval Daver,Yesid Alvarado,Elias Jabbour,Marina Konopleva,Hagop M. Kantarjian,Keyur P. Patel,Courtney D. DiNardo,Srdan Verstovsek
View Articletitled, Outcome of patients with <em>IDH1/2-</em>mutated post–myeloproliferative neoplasm AML in the era of IDH inhibitors
CD34 expression does not correlate with immunophenotypic stem cell or progenitor content in human cord blood products
Sruthi Mantri,Andreas Reinisch,Beruh T. Dejene,Deirdre J. Lyell,David L. DiGiusto,Rajni Agarwal-Hashmi,Ravindra Majeti,Kenneth I. Weinberg,Matthew H. Porteus
View Articletitled, CD34 expression does not correlate with immunophenotypic stem cell or progenitor content in human cord blood products
Supplemental data
Bone marrow dendritic cell aggregates associate with systemic immune dysregulation in chronic myelomonocytic leukemia
Abhishek A. Mangaonkar,Kaaren K. Reichard,Moritz Binder,Giacomo Coltro,Terra L. Lasho,Ryan M. Carr,April Chiu,Vivian Negron,Mehrdad Hefazi,Theodora Anagnostou,Michael M. Timm,James W. Hiebert,Jose C. Villasboas,Wilson I. Gonsalves,Naseema Gangat,Mithun Shah,Hassan B. Alkhateeb,Aref Al-Kali,Michelle A. Elliott,Kebede H. Begna,Alexandra P. Wolanskyj-Spinner,Mark R. Litzow,William J. Hogan,Stephen M. Ansell,Animesh Pardanani,Ayalew Tefferi,Mrinal M. Patnaik
View Articletitled, Bone marrow dendritic cell aggregates associate with systemic immune dysregulation in chronic myelomonocytic leukemia
Supplemental data
Epigenetic silencing of HTLV-1 expression by the HBZ RNA through interference with the basal transcription machinery
Hélène Gazon,Pradeep Singh Chauhan,Florent Porquet,Gabriela Brunsting Hoffmann,Roberto Accolla,Luc Willems
View Articletitled, Epigenetic silencing of HTLV-1 expression by the HBZ RNA through interference with the basal transcription machinery
Supplemental data

REVIEW ARTICLES

Handling challenging questions in the management of chronic myeloid leukemia: when is it safe to stop tyrosine kinase inhibitors?
Clinical Trials & Observations
Delphine Rea
View Articletitled, Handling challenging questions in the management of chronic myeloid leukemia: when is it safe to stop tyrosine kinase inhibitors?
Which patients are at high risk of recurrent venous thromboembolism (deep vein thrombosis and pulmonary embolism)?
Clinical Trials & Observations
Fionnuala Ní Áinle,Barry Kevane
View Articletitled, Which patients are at high risk of recurrent venous thromboembolism (deep vein thrombosis and pulmonary embolism)?

CLINICAL TRIALS AND OBSERVATIONS

The design of a Bayesian platform trial to prevent and eradicate inhibitors in patients with hemophilia
Clinical Trials & Observations
Marnie Bertolet,Maria M. Brooks,Margaret V. Ragni
View Articletitled, The design of a Bayesian platform trial to prevent and eradicate inhibitors in patients with hemophilia
Supplemental data
Efficacy and safety of carfilzomib-based regimens in frail patients with relapsed and/or refractory multiple myeloma
Clinical Trials & Observations
Thierry Facon,Ruben Niesvizky,Maria-Victoria Mateos,David Siegel,Cara Rosenbaum,Sara Bringhen,Katja Weisel,P. Joy Ho,Heinz Ludwig,Shaji Kumar,Kenneth Wang,Mihaela Obreja,Zhao Yang,Zandra Klippel,Khalid Mezzi,Amanda Goldrick,Christina Tekle,Meletios A. Dimopoulos
View Articletitled, Efficacy and safety of carfilzomib-based regimens in frail patients with relapsed and/or refractory multiple myeloma
Supplemental data
Secondary CNL after SAA reveals insights in leukemic transformation of bone marrow failure syndromes
Clinical Trials & Observations
Laurent Schmied,Patricia A. Olofsen,Pontus Lundberg,Alexandar Tzankov,Martina Kleber,Jörg Halter,Mario Uhr,Peter J. M. Valk,Ivo P. Touw,Jakob Passweg,Beatrice Drexler
View Articletitled, Secondary CNL after SAA reveals insights in leukemic transformation of bone marrow failure syndromes
Supplemental data
A phase 3 randomized study of 5-azacitidine maintenance vs observation after transplant in high-risk AML and MDS patients
Clinical Trials & Observations
Betül Oran,Marcos de Lima,Guillermo Garcia-Manero,Peter F. Thall,Ruitao Lin,Uday Popat,Amin M. Alousi,Chitra Hosing,Sergio Giralt,Gabriela Rondon,Glenda Woodworth,Richard E. Champlin
View Articletitled, A phase 3 randomized study of 5-azacitidine maintenance vs observation after transplant in high-risk AML and MDS patients

HEALTH SERVICES AND OUTCOMES

Gender differences in question-asking at the 2019 American Society of Hematology Annual Meeting
Saira Moazzam,Lynn Onstad,Heather O’Leary,Ariela Marshall,Ifeyinwa Osunkwo,Emily Du,Tamara Dunn,Julianne Dunlap,Bill Reed,Selina Luger,Stephanie J. Lee
View Articletitled, Gender differences in question-asking at the 2019 American Society of Hematology Annual Meeting
Decisional involvement and information preferences of patients with hematologic malignancies
Kah Poh Loh,Mazie Tsang,Thomas W. LeBlanc,Anthony Back,Paul R. Duberstein,Supriya Gupta Mohile,Ronald M. Epstein,Heidi D. Klepin,Michael W. Becker,Areej El-Jawahri,Stephanie J. Lee
View Articletitled, Decisional involvement and information preferences of patients with hematologic malignancies

HEMATOPOIESIS AND STEM CELLS

Abortive γδTCR rearrangements suggest ILC2s are derived from T-cell precursors
Samuel B. Shin,Bernard C. Lo,Maryam Ghaedi,R. Wilder Scott,Yicong Li,Melina Messing,Diana Canals Hernaez,Jessica Cait,Taka Murakami,Michael R. Hughes,Kevin B. Leslie,T. Michael Underhill,Fumio Takei,Kelly M. McNagny
View Articletitled, Abortive γδTCR rearrangements suggest ILC2s are derived from T-cell precursors
Supplemental data
FOXO activity adaptation safeguards the hematopoietic stem cell compartment in hyperglycemia
Vinothini Govindarajah,Jung-Mi Lee,Michael Solomon,Bryan Goddard,Ramesh Nayak,Kalpana Nattamai,Hartmut Geiger,Nathan Salomonis,Jose A. Cancelas,Damien Reynaud
View Articletitled, FOXO activity adaptation safeguards the hematopoietic stem cell compartment in hyperglycemia
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Public and private human T-cell clones respond differentially to HCMV antigen when boosted by CD3 copotentiation
Laura R. E. Becher,Wendy K. Nevala,Shari Lee Sutor,Megan Abergel,Michele M. Hoffmann,Christopher A. Parks,Larry R. Pease,Adam G. Schrum,Svetomir N. Markovic,Diana Gil
View Articletitled, Public and private human T-cell clones respond differentially to HCMV antigen when boosted by CD3 copotentiation
Supplemental data
Real-world evidence of tisagenlecleucel for pediatric acute lymphoblastic leukemia and non-Hodgkin lymphoma
Clinical Trials & Observations
Marcelo C. Pasquini,Zhen-Huan Hu,Kevin Curran,Theodore Laetsch,Frederick Locke,Rayne Rouce,Michael A. Pulsipher,Christine L. Phillips,Amy Keating,Matthew J. Frigault,Dana Salzberg,Samantha Jaglowski,Joshua P. Sasine,Joseph Rosenthal,Monalisa Ghosh,Daniel Landsburg,Steven Margossian,Paul L. Martin,Manali K. Kamdar,Peiman Hematti,Sarah Nikiforow,Cameron Turtle,Miguel-Angel Perales,Patricia Steinert,Mary M. Horowitz,Amy Moskop,Lida Pacaud,Lan Yi,Raghav Chawla,Eric Bleickardt,Stephan Grupp
View Articletitled, Real-world evidence of tisagenlecleucel for pediatric acute lymphoblastic leukemia and non-Hodgkin lymphoma
Supplemental data

MYELOID NEOPLASIA

Whole transcriptome sequencing detects a large number of novel fusion transcripts in patients with AML and MDS
Anna Stengel,Rabia Shahswar,Torsten Haferlach,Wencke Walter,Stephan Hutter,Manja Meggendorfer,Wolfgang Kern,Claudia Haferlach
View Articletitled, Whole transcriptome sequencing detects a large number of novel fusion transcripts in patients with AML and MDS
Supplemental data
CD200 expression marks leukemia stem cells in human AML
Jenny M. Ho,Stephanie M. Dobson,Veronique Voisin,Jessica McLeod,James A. Kennedy,Amanda Mitchell,Liqing Jin,Kolja Eppert,Gary Bader,Mark D. Minden,John E. Dick,Jean C. Y. Wang
View Articletitled, CD200 expression marks leukemia stem cells in human AML
Supplemental data
Genetic factors rather than blast reduction determine outcomes of allogeneic HCT in BCR-ABL–negative MPN in blast phase
Clinical Trials & Observations
Vikas Gupta,James A. Kennedy,Jose-Mario Capo-Chichi,Soyoung Kim,Zhen-Huan Hu,Edwin P. Alyea,Uday R. Popat,Ronald M. Sobecks,Bart L. Scott,Aaron T. Gerds,Rachel B. Salit,H. Joachim Deeg,Ryotara Nakamura,Wael Saber
View Articletitled, Genetic factors rather than blast reduction determine outcomes of allogeneic HCT in <em>BCR-ABL</em>–negative MPN in blast phase
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

The transition of M-CSF–derived human macrophages to a growth-promoting phenotype
Kajal Hamidzadeh,Ashton T. Belew,Najib M. El-Sayed,David M. Mosser
View Articletitled, The transition of M-CSF–derived human macrophages to a growth-promoting phenotype
Supplemental data

THROMBOSIS AND HEMOSTASIS

Frequency of venous thromboembolism in 6513 patients with COVID-19: a retrospective study
Clinical Trials & Observations
Jason B. Hill,David Garcia,Mark Crowther,Bryan Savage,Shira Peress,Kevin Chang,Steven Deitelzweig
View Articletitled, Frequency of venous thromboembolism in 6513 patients with COVID-19: a retrospective study
Incidence of VTE in asymptomatic children with deficiencies of antithrombin, protein C, and protein S: a prospective cohort study
Clinical Trials & Observations
Daniela Tormene,Elena Campello,Chiara Simion,Giacomo Turatti,Michelangelo Marobin,Claudia Maria Radu,Anna Pontarin,Paolo Prandoni,Paolo Simioni
View Articletitled, Incidence of VTE in asymptomatic children with deficiencies of antithrombin, protein C, and protein S: a prospective cohort study

Created using Biorender

A genetic modifier of venous thrombosis in zebrafish reveals a functional role for fibrinogen AαE in early hemostasis
Cristina Freire,Richard J. Fish,Rui Vilar,Corinne Di Sanza,Steven J. Grzegorski,Catherine E. Richter,Jordan A. Shavit,Marguerite Neerman-Arbez
View Articletitled, A genetic modifier of venous thrombosis in zebrafish reveals a functional role for fibrinogen AαE in early hemostasis
Supplemental data
Activated platelet-based inhibition of fibrinolysis via thrombin-activatable fibrinolysis inhibitor activation system
Yuko Suzuki,Hideto Sano,Liina Mochizuki,Naoki Honkura,Tetsumei Urano
View Articletitled, Activated platelet-based inhibition of fibrinolysis via thrombin-activatable fibrinolysis inhibitor activation system
Supplemental data

TRANSFUSION MEDICINE

Elevated plasma levels of syndecan-1 and soluble thrombomodulin predict adverse outcomes in thrombotic thrombocytopenic purpura
Ruinan Lu,Jingrui Sui,X. Long Zheng
View Articletitled, Elevated plasma levels of syndecan-1 and soluble thrombomodulin predict adverse outcomes in thrombotic thrombocytopenic purpura
Supplemental data
Processing methods and storage duration impact extracellular vesicle counts in red blood cell units
Clementine Gamonet,Maxime Desmarets,Guillaume Mourey,Sabeha Biichle,Sophie Aupet,Caroline Laheurte,Anne François,Eric Resch,Frédéric Bigey,Delphine Binda,Laurent Bardiaux,Christian Naegelen,Nadine Marpaux,Fanny Angelot Delettre,Philippe Saas,Pascal Morel,Pierre Tiberghien,Jacques Lacroix,Gilles Capellier,Chrystelle Vidal,Francine Garnache-Ottou
View Articletitled, Processing methods and storage duration impact extracellular vesicle counts in red blood cell units
Supplemental data
Pathogen-reduced PRP blocks T-cell activation, induces Treg cells, and promotes TGF-β expression by cDCs and monocytes in mice
Johnson Q. Tran,Marcus O. Muench,Rachael P. Jackman
View Articletitled, Pathogen-reduced PRP blocks T-cell activation, induces T<sub>reg</sub> cells, and promotes TGF-β expression by cDCs and monocytes in mice
Supplemental data

COMMENTARY

In response to “American Society of Hematology 2020 guidelines for treating newly diagnosed acute myeloid leukemia in older adults”
Pavan Reddy,on behalf of the Board of Directors of the American Society for Transplantation and Cellular Therapy,Stella Davies,on behalf of the Board of Directors of the American Society for Transplantation and Cellular Therapy,Navneet Majhail,on behalf of the Board of Directors of the American Society for Transplantation and Cellular Therapy,Brenda Sandmaier,on behalf of the Board of Directors of the American Society for Transplantation and Cellular Therapy,Parameswaran Hari,on behalf of the Board of Directors of the American Society for Transplantation and Cellular Therapy,Corey Cutler,on behalf of the Board of Directors of the American Society for Transplantation and Cellular Therapy
View Articletitled, In response to “American Society of Hematology 2020 guidelines for treating newly diagnosed acute myeloid leukemia in older adults”
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