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Journal Articles

Disease risk but not remission status determines transplant outcomes in AML: long-term outcomes of the ASAP trial

Open Access
Clinical Trials & Observations
Matthias Stelljes, Jan Moritz Middeke, Gesine Bug, Eva-Maria Wagner-Drouet, Lutz P. Müller, Christoph Schmid, Stefan W. Krause, Wolfgang Bethge, Edgar Jost, Uwe Platzbecker, Stefan A. Klein, Judith Niederland, Martin Kaufmann, Kerstin Schäfer-Eckart, Henning Baldauf, Friedrich Stölzel, Sarah Trost, Christoph Röllig, Malte von Bonin, Katharina Egger-Heidrich, Desiree Kunadt, Björn Steffen, Beate Hauptrock, Christoph Schliemann, Katja Sockel, Fabian Lang, Oliver Kriege, Judith Schaffrath, Christian Reicherts, Wolfgang E. Berdel, Hubert Serve, Gerhard Ehninger, Alexander H. Schmidt, Jan-Henrik Mikesch, Martin Bornhäuser, Johannes Schetelig
Journal: Blood
Blood (2025) 146 (19): 2293–2305.
https://doi.org/10.1182/blood.2025028730
Published: 2025
Includes: Supplemental data
Journal Articles

Menin inhibition enhances graft-versus-leukemia effects by T-cell activation and endogenous retrovirus induction in AML

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Viktor Fetsch, Lennard Frederik Schwöbel, Ezgi Ozyerli-Goknar, PhD, Anna-Verena Stell, Marco Punta, Thomas Plenge, Tabea Klaus, Manoj K. Gupta, Geoffroy Andrieux, Khalid Shoumariyeh, Sophie Pfeiffer, Eyleen Corrales, Lina Schlenke, Hosna Baniadam, Simon M. Brandl, Massimo Andreis, Michal Remen, Alina Hartmann, Kathleen Grueter, Melissa Zwick, Natalie Köhler, Monika Kuban, Eric Metzger, Christoph Rummelt, Justus Duyster, Melanie Börries, Maike Hofmann, Julian Färber, Lukas M Braun, Alexander Zähringer, Michael Lübbert, Cristina Toffalori, Luca Vago, Florian H Heidel, Susana Minguet, Petya Apostolova, Tobias Feuchtinger, Kristina Maas-Bauer, Franziska Blaeschke, Michael W.M. Kühn, Marc Timmers, Tobias Wertheimer, Florian Perner, Robert Zeiser
Journal: Blood
Blood blood.2025029712.
https://doi.org/10.1182/blood.2025029712
Published: 2025
Includes: Supplemental data
Journal Articles

RGI-2001 for the prophylaxis of acute graft-versus-host disease after allogeneic HCT

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Clinical Trials & Observations
Zachariah DeFilipp, Hannah Choe, Yvonne A. Efebera, Ayman Saad, Shatha Farhan, Lazaros Lekakis, Jean A. Yared, Gary Schiller, Markus Y. Mapara, Amer Assal, Ted Gooley, Jack D. Bui, Dana Lee, Hayley Lane, Yi-Bin Chen
Journal: Blood
Blood (2025) 146 (17): 2037–2046.
https://doi.org/10.1182/blood.2025029584
Published: 2025
Includes: Supplemental data
Journal Articles

Inflammasome-resistant IPSC-derived myeloid-derived suppressor cells ameliorate xenogeneic graft-versus-host disease

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Lie Ma, Brent Koehn, Michael Zaiken, Keli L. Hippen, Kyle Smith, Jeremy Allred, Robin Williams, Ke Yao, Jordan Fink, Asim Saha, Benjamin Koop, Nathaniel Payne, Renata Widelak, Angela Panoskaltsis-Mortari, Megan J. Riddle, Jakub Tolar, Cindy Eide, Lily Xia, Alec D. Witty, Amit K. Mehta, Matthew Denholtz, Mehrdad Hefazi, Sophia Hani, Saad S. Kenderian, Jeffrey S. Miller, Jeffrey J. Molldrem, Leslie S. Kean, Bahram Valamehr, Bruce R. Blazar
Journal: Blood
Blood (2025) 146 (17): 2047–2062.
https://doi.org/10.1182/blood.2025028562
Published: 2025
Includes: Supplemental data
Journal Articles

Remestemcel-L-rknd (Ryoncil): the first approved cellular therapy for steroid-refractory acute GVHD

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Aaron Etra, James L. M. Ferrara, John E. Levine
Journal: Blood
Blood (2025) 146 (16): 1897–1901.
https://doi.org/10.1182/blood.2025028553
Published: 2025
Journal Articles

Mucosal calprotectin is associated with severity of aGI-GVHD and poor outcomes after allogeneic stem cell transplantation

Open Access
Ekin Ece Gurer Kluge, Elisabeth Meedt, Julia Feicht, Kedi Cao, Andreas Hiergeist, Andreas Mamilos, Daniela Hirsch, Matthias Hoepting, Dr. med, Anna-Sophia Kattner, Dr. med, Carina Matos, Sigrid Bülow, Erik Thiele Orberg, Philipp Beckhove, Arne Kandulski, Matthias Evert, Kai Hildner, Marina Kreutz, Matthias Edinger, Daniel Wolff, Wolfgang Herr, Hendrik Poeck, André Gessner, Daniela Andrea Weber, Birte Kehr, Ernst Holler, Prof. Dr. med, Sakhila Ghimire
Journal: Blood
Blood blood.2025029402.
https://doi.org/10.1182/blood.2025029402
Published: 2025
Includes: Supplemental data
Journal Articles

Augmented CD47 expression impairs alloreactive T-cell clearance after allo-HCT

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Cindy Flamann, Haroon Shaikh, Carina Matos, Marina Kreutz, Hla Ali, Michael A. G. Kern, Maike Büttner-Herold, Benedikt Jacobs, Simon Völkl, Christopher Lischer, Christian Kellner, Johannes Berges, Katrin Bitterer, Domenica Saul, Manisha Goel, Cornelia S. Link-Rachner, Alma Zernecke, Daniela Weber, Dimitrios Mougiakakos, Andreas Mackensen, Andreas Beilhack, Heiko Bruns
Journal: Blood
Blood (2025) 146 (11): 1359–1373.
https://doi.org/10.1182/blood.2023023056
Published: 2025
Includes: Supplemental data
Journal Articles

Inflammatory memory of stem cells: implications for hematologic diseases

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Dongchang Zhao, Pavan Reddy
Journal: Blood
Blood (2025) 146 (11): 1265–1275.
https://doi.org/10.1182/blood.2024028197
Published: 2025
Journal Articles

A single dose of a CD137 antibody–drug conjugate protects rhesus macaque allogeneic HCT recipients against acute GVHD

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Ulrike Gerdemann, Kyle Kimler, Matthew R. Warren, Connor McGuckin, Ryan A. Fleming, Matthew R. D’Ambra, Alal Eran, Alexandre Albanese, Edward Chen, Marlana Winschel, Lorenzo Cagnin, Jennifer Lane, Lev Gorfinkel, Bartley Adams, Jean Kwun, Leanne Lanieri, Megan Hoban, Tahirih L. Lamothe, Sharon Hyzy, Lisa M. Olson, Angela Panoskaltsis-Mortari, Susan E. Prockop, Bruce R. Blazar, Leslie S. Kean, Victor Tkachev
Journal: Blood
Blood (2025) 146 (9): 1127–1141.
https://doi.org/10.1182/blood.2024027239
Published: 2025
Includes: Supplemental data
Journal Articles

Challenges in GVHD and GVL after hematopoietic stem cell transplantation for myeloid malignancies

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Gerard Socie
Journal: Blood
Blood (2025) 146 (8): 926–937.
https://doi.org/10.1182/blood.2025028617
Published: 2025
Includes: Supplemental data
Journal Articles

Phase 1/2 study of high-dose palifermin for GVHD prophylaxis in patients undergoing HLA-matched unrelated donor HCT

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Clinical Trials & Observations Brief Report
Eduard Schulz, Lauren M. Curtis, Noa G. Holtzman, Seth M. Steinberg, Kaska Wloka, Alen Ostojic, Alain Mina, Najla El Jurdi, Filip Pirsl, Ashley Carpenter, Mahshid Golagha, Arlene Sirajuddin, Theo Heller, Brian C. Shaffer, Frances T. Hakim, Jeffrey S. Rubin, Ronald E. Gress, Steven Z. Pavletic
Journal: Blood
Blood (2025) 146 (8): 944–950.
https://doi.org/10.1182/blood.2024028303
Published: 2025
Includes: Supplemental data
Journal Articles

Outcomes of allogeneic HCT in Hodgkin lymphoma in the era of checkpoint inhibitors: a joint CIBMTR and EBMT analysis

Free
CME Clinical Trials & Observations
Miguel-Angel Perales, Farrukh T. Awan, Ariane Boumendil, Jinalben Patel, Luca Castagna, Emanuele Angelucci, Herve Finel, Alexander Kulagin, Bertram Glass, Paolo Corradini, Alex F. Herrera, Didier Blaise, Mohamed A. Kharfan-Dabaja, Khalid Halahleh, Sairah Ahmed, Carmen Martínez, Sebastian Giebel, Silvia Montoto, Richard J. Jones, Nausheen Ahmed, Ryan C. Lynch, Marcos J. De Lima, Mazyar Shadman, Craig S. Sauter, Kwang W. Ahn, Mehdi Hamadani, Ali Bazarbachi, Anna Sureda
Journal: Blood
Blood (2025) 146 (8): 1011–1029.
https://doi.org/10.1182/blood.2024027197
Published: 2025
Includes: Supplemental data
Journal Articles

How I treat acute lymphoblastic leukemia in the era of immunotherapy while revisiting the myth of second remission

Available to Purchase
Ibrahim Aldoss, Mary C. Clark, Stephen J. Forman
Journal: Blood
Blood (2025) 146 (6): 667–678.
https://doi.org/10.1182/blood.2024027267
Published: 2025
Journal Articles

Pretransplant targeting of TNFRSF25 and CD25 stimulates recipient Tregs in target tissues, ameliorating GVHD post-HSCT

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Duneia McManus, Sabrina N Copsel, Brent J Pfeiffer, Dietlinde Wolf, Henry Barreras, Symon Ma, Ali Khodor, Seitaro Komai, Marina Burgos da Silva, Hajar Hazime, Miguel Gallardo, Sarah Grace R Lime, Marcel R.M. van den Brink, Jung-Hyun Park, Maria T Abreu, Geoffrey R Hill, Victor L Perez, Robert B Levy
Journal: Blood
Blood blood.2025028418.
https://doi.org/10.1182/blood.2025028418
Published: 2025
Includes: Supplemental data
Journal Articles

Heterogeneity of high-potency multilineage hematopoietic stem cells and identification of “Super” transplantability

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Fang Dong, Sen Zhang, Caiying Zhu, Zining Yang, Lisha Wang, Yao Ma, Jiayi Lu, Xialin Li, Xiaofang Wang, Nini Wang, Shanshan Zhang, Miner Xie, Jinhong Wang, Xiaobing Zhang, Yawei Zheng, Shihui Ma, Hideo Ema, Hui Cheng, Sha Hao, Toshio Suda, Yu Lan, Bing Liu, Ping Zhu, Junren Chen, Tao Cheng
Journal: Blood
Blood (2025) 146 (5): 546–557.
https://doi.org/10.1182/blood.2024027872
Published: 2025
Includes: Supplemental data
Journal Articles

High incidence of severe TA-TMA increases mortality in adult allogeneic transplant recipients: a prospective MIDAS Consortium study

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Clinical Trials & Observations
Sumithira Vasu, Qiuhong Zhao, Elizabeth Greer Miller, Patrick Elder, Lucille Langenberg, Spero Cataland, Stella M. Davies, Nelli Bejanyan, Theresa Hahn
Journal: Blood
Blood (2025) 146 (5): 638–646.
https://doi.org/10.1182/blood.2025028390
Published: 2025
Includes: Supplemental data
Journal Articles

How I treat Wiskott-Aldrich syndrome

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Tanja C. Vallée, Michael H. Albert, Sung-Yun Pai
Journal: Blood
Blood (2025) 146 (1): 41–51.
https://doi.org/10.1182/blood.2024026288
Published: 2025
Includes: Supplemental data
Journal Articles

Isatuximab, carfilzomib, lenalidomide, and dexamethasone induction in newly diagnosed myeloma: analysis of the MIDAS trial

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Clinical Trials & Observations
Aurore Perrot, Cyrille Touzeau, Jerome Lambert, Cyrille Hulin, Denis Caillot, Lionel Karlin, Bertrand Arnulf, Philippe Rey, Laurent Garderet, Margaret Macro, Martine Escoffre Barbe, Julie Gay, Thomas Chalopin, Romain Gounot, Jean-Marc Schiano, Mourad Tiab, Mohamad Mohty, Frederique Kuhnowski, Jean Fontan, Salomon Manier, Frederique Orsini-Piocelle, Laure Vincent, Sophie Rigaudeau, Xavier Leleu, Benjamin Hebraud, Laurent Flet, Jean-Valere Malfuson, Caroline Jacquet, Driss Chaoui, Nathalie Meuleman, Wajed Abarah, Lydia Montes, Riad Benramdane, Cecile Sonntag, Hacene Zerazhi, Alina Danu, Olivier Allangba, Mamoun Dib, Murielle Roussel, Sophie Cereja, Julien Depaus, Nicolas Branche, Helene Demarquette, Valentine Richez, Brieuc Cherel, Laurent Frenzel, Marie-Christiane Vekemans, Noemie Bigot, Herve Avet-Loiseau, Jill Corre, Philippe Moreau
Journal: Blood
Blood (2025) 146 (1): 52–61.
https://doi.org/10.1182/blood.2024026230
Published: 2025
Journal Articles

Use of machine learning techniques to predict poor survival after hematopoietic cell transplantation for myelofibrosis

Open Access
Juan Carlos Hernández-Boluda, Adrián Mosquera-Orgueira, Luuk Gras, Linda Koster, Joe Tuffnell, Nicolaus Kröger, Massimiliano Gambella, Thomas Schroeder, Marie Robin, Katja Sockel, Jakob Passweg, Igor Wolfgang Blau, Ibrahim Yakoub-Agha, Ruben Van Dijck, Mattias Stelljes, Henrik Sengeloev, Jan Vydra, Uwe Platzbecker, Moniek de Witte, Frédéric Baron, Kristina Carlson, Javier Rojas, Carlos Pérez Míguez, Davide Crucitti, Kavita Raj, Joanna Drozd-Sokolowska, Giorgia Battipaglia, Nicola Polverelli, Tomasz Czerw, Donal P. McLornan
Journal: Blood
Blood (2025) 145 (26): 3139–3152.
https://doi.org/10.1182/blood.2024027287
Published: 2025
Includes: Supplemental data
Journal Articles

Expansions of circulating plasmablasts producing commensal-reactive IgA antibodies are predictors for chronic GVHD

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Katharina M. Habenicht, Jana Wanzek, Anna Bootz, Simon Schäfer, Lara Vollmer, Andreas Hiergeist, Matthias Fante, Jakob Hasenbank, Andrea Schneider, Ingrid Vasova, Silvia Spoerl, Anna Brandt, Michael Rehli, Petra Hoffmann, Stefan Wirtz, Jesika Kotorri, Roman G. Gerlach, André Gessner, Andreas Mackensen, Julia Winkler, Daniel Wolff, Thomas H. Winkler
Journal: Blood
Blood (2025) 145 (26): 3178–3188.
https://doi.org/10.1182/blood.2024027301
Published: 2025
Includes: Supplemental data