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Thomas Büchner
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Journal Articles

Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

Clinical Trials & Observations
Hartmut Döhner, Elihu Estey, David Grimwade, Sergio Amadori, Frederick R. Appelbaum, Thomas Büchner, Hervé Dombret, Benjamin L. Ebert, Pierre Fenaux, Richard A. Larson, Ross L. Levine, Francesco Lo-Coco, Tomoki Naoe, Dietger Niederwieser, Gert J. Ossenkoppele, Miguel Sanz, Jorge Sierra, Martin S. Tallman, Hwei-Fang Tien, Andrew H. Wei, Bob Löwenberg, Clara D. Bloomfield
Journal: Blood
Blood (2017) 129 (4): 424–447.
https://doi.org/10.1182/blood-2016-08-733196
Published: 2017
Journal Articles

Comparison of FLT3-ITD Detection By High-Throughput Amplicon Sequencing to Routine Diagnostics - a Retrospective Analysis of AMLCG Study Patients

Katrin Reiter, MSc, Max Hubmann, MD, Egor Harin, Sebastian Vosberg, Kathrin Bräundl, Bianka Ksienzyk, Stephanie Schneider, PhD, Annika Maria Dufour, PhD, Evelyn Zellmeier, Stefan K. Bohlander, MD, Christina Sauerland, Dipl.-Math, Wolfgang E Berdel, MD, Bernhard J Wörmann, MD, Thomas Büchner, MD, Jan Braess, MD, Wolfgang Hiddemann, MD, Karsten Spiekermann, MD, Philipp A. Greif, MD
Journal: Blood
Blood (2016) 128 (22): 1682.
https://doi.org/10.1182/blood.V128.22.1682.1682
Published: 2016
Journal Articles

PS29MRC - a Novel Predictive Score for Response to Therapy in Acute Myeloid Leukemia

Tobias Herold, MD, Vindi Jurinovic, Klaus H. Metzeler, MD, Aarif Batcha, Stefan Bamopoulos, Maja Rothenberg-Thurley, PhD, Bianka Ksienzyk, Luise Hartmann, MSc, Philipp Greif, Julia Phillippou-Massier, Stefan Krebs, Helmut Blum, Susanne Amler, Stephanie Schneider, PhD, Christina Sauerland, Dipl.-Math, Dennis Görlich, Thomas Büchner, Wolfgang E Berdel, MD, Bernhard J Wörmann, MD, Marion Subklewe, MD, Michael Fiegl, MD, Stefan K. Bohlander, MD, Jan Braess, Wolfgang Hiddemann, MD, PhD, Ulrich Mansmann, PhD, Karsten Spiekermann, MD
Journal: Blood
Blood (2016) 128 (22): 1209.
https://doi.org/10.1182/blood.V128.22.1209.1209
Published: 2016
Journal Articles

Comparison of Treatment Strategies in Patients over 60 Years with AML: Final Analysis of a Prospective Randomized German AML Intergroup Study

Dietger Niederwieser, MD, Verena Sophia Hoffmann, Dr., Markus Pfirrmann, PhD, Haifa Kathrin Al-Ali, MD, Sebastian Schwind, MD, Vladan Vucinic, MD, Rainer Krahl, PhD, Christoph Kahl, Hans-Heinrich Wolf, MD, Ute Kreibich, Prof., Detlef Hähling, Ute Hegenbart, MD, Carsten Hirt, Norma Peter, MD, Axel Florschuetz, Kolja Reifenrath, Antje Schulze, Niklas Zojer, MD, Sebastian Scholl, Christian Junghanss, MD, Wolfram Pönisch, Simone Heyn, MD, Herbert G. Sayer, Andreas Hochhaus, MD, Thomas Heinicke, MD, Thomas Fischer, MD, Alwin Krämer, MD, Peter Dreger, MD, Georg Maschmeyer, MD, Utz Krug, Maria Christina Sauerland, MSc, Achim Heinecke, Rüdiger Hehlmann, MD, Eva Lengfelder, MD, Wolfgang Hiddemann, MD, Hubert Serve, MD, Carsten Müller-Tidow, Wolfgang E Berdel, MD, Thomas Büchner
Journal: Blood
Blood (2016) 128 (22): 1066.
https://doi.org/10.1182/blood.V128.22.1066.1066
Published: 2016
Journal Articles

High Expression of ARMCX1 Predicts Poor Survival in Intensively Treated Older Acute Myeloid Leukemia Patients (≥ 60 years)

Jan-Henrik Mikesch, MD, Christina Sauerland, Dipl.-Math, Tobias Herold, MD, Dennis Görlich, Eike Bormann, Wolfgang Hartmann, MD, Christoph Schliemann, MD, Bernhard J Wörmann, MD, Wolfgang Hiddemann, Karsten Spiekermann, MD, Matthias Stelljes, Utz Krug, MD, Carsten Muller-Tidow, MD, Thomas Büchner, MD, Wolfgang E Berdel, MD, Maria Francisca Arteaga, PhD
Journal: Blood
Blood (2016) 128 (22): 2840.
https://doi.org/10.1182/blood.V128.22.2840.2840
Published: 2016
Journal Articles

Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia

Klaus H. Metzeler, Tobias Herold, Maja Rothenberg-Thurley, Susanne Amler, Maria C. Sauerland, Dennis Görlich, Stephanie Schneider, Nikola P. Konstandin, Annika Dufour, Kathrin Bräundl, Bianka Ksienzyk, Evelyn Zellmeier, Luise Hartmann, Philipp A. Greif, Michael Fiegl, Marion Subklewe, Stefan K. Bohlander, Utz Krug, Andreas Faldum, Wolfgang E. Berdel, Bernhard Wörmann, Thomas Büchner, Wolfgang Hiddemann, Jan Braess, Karsten Spiekermann
Journal: Blood
Blood (2016) 128 (5): 686–698.
https://doi.org/10.1182/blood-2016-01-693879
Published: 2016
Includes: Supplemental data
Journal Articles

Allogeneic Stem Cell Transplantation (SCT) for Acute Myeloid Leukemia (AML) and High-Risk Myelodysplastic Syndrome (MDS) in Elderly Patients (Older than 60 Years)

Michele Pohlen, MD, Christoph Groth, MD, Tim Sauer, MD, Dennis Görlich, Rolf Mesters, MD, Christoph Schliemann, MD, Georg Lenz, MD, Carsten Müller-Tidow, MD, Thomas Büchner, MD, Wolfgang E Berdel, MD, Matthias Stelljes, MD
Journal: Blood
Blood (2015) 126 (23): 2025.
https://doi.org/10.1182/blood.V126.23.2025.2025
Published: 2015
Journal Articles

DNMT3A Mutations Associate with Shorter Survival and Modulate the Prognostic Impact of Mutated NPM1: an Analysis Based on Comprehensive Mutational Screening of 660 AML Patients Treated on German AML Cooperative Group (AMLCG) Trials

Klaus H. Metzeler, MD, Tobias Herold, MD, Maja Rothenberg-Thurley, PhD, Susanne Amler, Cristina Sauerland, Stephanie Schneider, PhD, Nikola P Konstandin, PhD, Annika Maria Dufour, PhD, Kathrin Bräundl, Bianka Ksienzyk, Evelyn Zellmeier, Luise Hartmann, MSc, Philipp A. Greif, MD, Michael Fiegl, MD, Marion S. Subklewe, MD, Stefan K. Bohlander, MD, Utz Krug, MD, Wolfgang E Berdel, MD, Bernhard Wörmann, MD, Thomas Büchner, MD, Andreas Faldum, PhD, Wolfgang Hiddemann, MD, Jan Braess, MD, Karsten Spiekermann, MD
Journal: Blood
Blood (2015) 126 (23): 3815.
https://doi.org/10.1182/blood.V126.23.3815.3815
Published: 2015
Journal Articles

Up-Front Randomization 10 Years Later: The AML Cooperative Group Strategy

Thomas Buchner, MD, Wolfgang E. Berdel, MD, Bernhard J. Woermann, MD, Maria Cristina Sauerland, MSc, Achim Heinecke, PhD, Utz Krug, MD, Wolfgang Hiddemann, MD
Journal: Blood
Blood (2014) 124 (21): 2267.
https://doi.org/10.1182/blood.V124.21.2267.2267
Published: 2014
Journal Articles

Genetic Characterization of Patients with Monoallelic and Biallelic CEBPA Mutations Using a Targeted Sequencing Approach Reveals Differences in the Spectrum of Cooperating Mutations

Nikola P Konstandin, Klaus H. Metzeler, MD, Annika Dufour, PhD, Philipp A Greif, MD, Tobias Herold, MD, Bianka Ksienzyk, Stephanie Schneider, Dr. rer. nat., Wolfgang E Berdel, MD, Thomas Büchner, MD, Bernhard J. Woermann, MD, Cristina Sauerland, MSc, Jan Braess, MD, Wolfgang Hiddemann, MD, Stefan K Bohlander, MD, Karsten Spiekermann, MD
Journal: Blood
Blood (2014) 124 (21): 2385.
https://doi.org/10.1182/blood.V124.21.2385.2385
Published: 2014
Journal Articles

An Optimized Risk Stratification Model in Acute Promyelocytic Leukemia Identifies Patients with an Exceptionally Good Prognosis Regarding the Incidence of Relapse

Anna Hecht, MD, Daniel Nowak, Verena Nowak, Benjamin Hanfstein, MD, Thomas Büchner, MD, Karsten Spiekermann, MD, Christel Weiss, Wolf-Karsten Hofmann, Eva Lengfelder, MD, Florian Nolte
Journal: Blood
Blood (2014) 124 (21): 72.
https://doi.org/10.1182/blood.V124.21.72.72
Published: 2014
Journal Articles

A 16-Gene Signature Associated with High Levels of Wilms Tumor-1 ( WT1 ) Expression Is an Adverse Prognostic Factor in Acute Myeloid Leukemia

Ahmadreza Niavarani, MD PhD, Tobias Herold, MD, Yasmin Reyal, MD PhD, Erin Currie, MSc, Stuart Horswell, PhD, Arash Jalali, PhD, Maria Cristina Sauerland, MSc, Thomas Buchner, MD, Wolfgang Hiddemann, MD, Stefan K Bohlander, PhD, Reza Malekzadeh, MD AGAF, Peter J.M. Valk, PhD, Dominique Bonnet, PhD
Journal: Blood
Blood (2014) 124 (21): 1021.
https://doi.org/10.1182/blood.V124.21.1021.1021
Published: 2014
Journal Articles

Isolated trisomy 13 defines a homogeneous AML subgroup with high frequency of mutations in spliceosome genes and poor prognosis

Tobias Herold, Klaus H. Metzeler, Sebastian Vosberg, Luise Hartmann, Christoph Röllig, Friedrich Stölzel, Stephanie Schneider, Max Hubmann, Evelyn Zellmeier, Bianka Ksienzyk, Vindi Jurinovic, Zlatana Pasalic, Purvi M. Kakadia, Annika Dufour, Alexander Graf, Stefan Krebs, Helmut Blum, Maria Cristina Sauerland, Thomas Büchner, Wolfgang E. Berdel, Bernhard J. Woermann, Martin Bornhäuser, Gerhard Ehninger, Ulrich Mansmann, Wolfgang Hiddemann, Stefan K. Bohlander, Karsten Spiekermann, Philipp A. Greif
Journal: Blood
Blood (2014) 124 (8): 1304–1311.
https://doi.org/10.1182/blood-2013-12-540716
Published: 2014
Includes: Supplemental data
Journal Articles

A Combined Molecular and Clinical Prognostic Index For Relapse and Survival In Cytogenetically Normal AML (PINA)

Friederike Pastore, MD, Annika Dufour, PhD, Tobias Benthaus, MD, Klaus H. Metzeler, MD, Kati Maharry, MAS, Stephanie Schneider, PhD, Bianka Ksienzyk, Gudrun Mellert, Evelyn Zellmeier, Purvi M. Kakadia, PhD, Michael Unterhalt, M.D. Ph.D., Michaela Feuring-Buske, MD, Christian Buske, MD, Jan Braess, MD, Cristina Sauerland, MSc, Achim Heinecke, PhD, Utz Krug, MD, Wolfgang E. Berdel, MD, Thomas Büchner, MD, Bernhard J. Woermann, MD, Wolfgang Hiddemann, MD, Stefan K. Bohlander, MD, Guido Marcucci, MD, Karsten Spiekermann, MD, Clara D. Bloomfield, MD, Eva Hoster, PhD
Journal: Blood
Blood (2013) 122 (21): 1303.
https://doi.org/10.1182/blood.V122.21.1303.1303
Published: 2013
Journal Articles

Activating FLT3 Mutations Display a Wide Range Of Transforming Potential and a Characteristic Pathway Profile Associated With Prognosis In Acute Myeloid Leukemia

Hanna Janke, Friederike Schneider, MD, Daniela Schumacher, Tobias Herold, MD, Hopfner Karl-Peter, PhD, Stephanie Schneider, PhD, Wolfgang E. Berdel, MD, Thomas Büchner, MD, Bernhard J. Woermann, MD, Marion Subklewe, MD, Stefan K. Bohlander, MD, Wolfgang Hiddemann, MD, Harald Polzer, PhD, Karsten Spiekermann, MD
Journal: Blood
Blood (2013) 122 (21): 1312.
https://doi.org/10.1182/blood.V122.21.1312.1312
Published: 2013
Journal Articles

Acute Myeloid Leukemia: The Outcome Is Determined By Age, Genetic Group, White Blood Cell Count, Lactate Dehydrogenase, Rather Than By Chemotherapy Intensity

Thomas Buchner, MD, Wolfgang E. Berdel, MD, Utz Krug, MD, Claudia Haferlach, MD, Susanne Schnittger, PhD, Torsten Haferlach, MD, Carsten Mueller-Tidow, MD, Matthias Stelljes, MD, Rolf M. Mesters, MD, Hubert Serve, MD, Jan Braess, MD, Karsten Spiekermann, MD, Peter Staib, MD, Andreas Grueneisen, MD, Albrecht Reichle, MD, Leopold Balleisen, MD, Hartmut Eimermacher, MD, Aristoteles Giagounidis, MD, PhD, Herbert Rasche, MD, Eva Lengfelder, M.D. Ph.D., Andreas Faldum, MD, Maria Cristina Sauerland, MSc, Achim Heinecke, PhD, Rüdiger Hehlmann, MD, Bernhard J. Woermann, MD, Wolfgang Hiddemann, MD
Journal: Blood
Blood (2013) 122 (21): 1447.
https://doi.org/10.1182/blood.V122.21.1447.1447
Published: 2013
Journal Articles

A Risk Score Integrating BAALC, ERG and WT1 Expression Can Be Used To Improve Risk Stratification In Acute Promyelocytic Leukemia

Anna Hecht, Florian Nolte, MD, Daniel Nowak, MD, Verena Nowak, Benjamin Hanfstein, MD, Thomas Büchner, MD, Karsten Spiekermann, MD, Wolf-Karsten Hofmann, MD, Eva Lengfelder, MD
Journal: Blood
Blood (2013) 122 (21): 1323.
https://doi.org/10.1182/blood.V122.21.1323.1323
Published: 2013
Journal Articles

Acute Myeloid Leukemia With Isolated Trisomy 13 Is a Genetically Homogenous Entity With a High Frequency Of Mutations In Genes Encoding Components Of The Splicing Machinery and Extremely Poor Prognosis

Tobias Herold, MD, Klaus H. Metzeler, MD, Sebastian Vosberg, Stephanie Schneider, PhD, Max Hubmann, MD, Evelyn Zellmeier, Bianka Ksienzyk, Vindi Jurinovic, Zlatana Pasalic, Purvi M. Kakadia, PhD, Annika Dufour, PhD, Alexander Graf, Stefan Krebs, PhD, Helmut Blum, PhD, Cristina Sauerland, MSc, Thomas Büchner, MD, Wolfgang E. Berdel, MD, Bernhard J. Woermann, MD, Ulrich Mansmann, Wolfgang Hiddemann, MD, Stefan K. Bohlander, MD, Karsten Spiekermann, MD, Philipp A Greif, MD
Journal: Blood
Blood (2013) 122 (21): 608.
https://doi.org/10.1182/blood.V122.21.608.608
Published: 2013
Journal Articles

Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia

Sabrina Opatz, Harald Polzer, Tobias Herold, Nikola P. Konstandin, Bianka Ksienzyk, Evelyn Zellmeier, Sebastian Vosberg, Alexander Graf, Stefan Krebs, Helmut Blum, Karl-Peter Hopfner, Purvi M. Kakadia, Stephanie Schneider, Annika Dufour, Jan Braess, Maria Cristina Sauerland, Wolfgang E. Berdel, Thomas Büchner, Bernhard J. Woermann, Wolfgang Hiddemann, Karsten Spiekermann, Stefan K. Bohlander, Philipp A. Greif
Journal: Blood
Blood (2013) 122 (10): 1761–1769.
https://doi.org/10.1182/blood-2013-01-476473
Published: 2013
Includes: Supplemental data
Journal Articles

DNA methylation changes are a late event in acute promyelocytic leukemia and coincide with loss of transcription factor binding

Till Schoofs, Christian Rohde, Katja Hebestreit, Hans-Ulrich Klein, Stefanie Göllner, Isabell Schulze, Mads Lerdrup, Nikolaj Dietrich, Shuchi Agrawal-Singh, Anika Witten, Monika Stoll, Eva Lengfelder, Wolf-Karsten Hofmann, Peter Schlenke, Thomas Büchner, Klaus Hansen, Wolfgang E. Berdel, Frank Rosenbauer, Martin Dugas, Carsten Müller-Tidow
Journal: Blood
Blood (2013) 121 (1): 178–187.
https://doi.org/10.1182/blood-2012-08-448860
Published: 2013
Includes: Supplemental data