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Heikki Kuusanmäki
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Journal Articles

Predictors of Response and Rational Combinations for the Novel MCL-1 Inhibitor MIK665 in Acute Myeloid Leukemia

Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh B. Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman
Journal: Blood
Blood (2024) 144 (Supplement 1): 1560.
https://doi.org/10.1182/blood-2024-207199
Published: 2024
Journal Articles

Genomic Subtypes of AML Define Sensitivity to NK Cell Cytotoxicity

Hanna Duàn, Emmi Jokinen, Hanna Lähteenmäki, Jay Klievink, Jonas Bouhlal, Essi Laajala, Jason Theodoropoulos, Heikki Kuusanmäki, Tanja Ruokoranta, Pauliina Rumm, Dean Anthony Lee, Esa Pitkänen, Tomi P Mäkelä, Kimmo Porkka, Oscar E. Brück, Olli Dufva, Satu Mustjoki
Journal: Blood
Blood (2024) 144 (Supplement 1): 329.
https://doi.org/10.1182/blood-2024-199448
Published: 2024
Journal Articles

Integrating Computational Cytomorphological Analysis of Bone Marrow Smears and Clinical Data for Predicting Response to Venetoclax and Hypomethylating Agents in AML

Henri Sundquist, Mikael Tatun, Mikko Purhonen, Laura Toivanen, Johanna Rimpiläinen, Samuli Rounioja, Timo Siitonen, Marja Pyörälä, Pentti Mäntymaa, Sari Kytölä, Kimmo Porkka, Sanna Siitonen, Heikki Kuusanmäki, Mika Kontro, Oscar E. Brück
Journal: Blood
Blood (2024) 144 (Supplement 1): 4320.
https://doi.org/10.1182/blood-2024-206949
Published: 2024
Journal Articles

Integrative Analysis of Transcriptomic and Proteomic Data Identifies Patterns of Primary Resistance to Venetoclax-Azacitidine and Reveals Targetable Vulnerabilities in Acute Myeloid Leukemia (AML)

Ida Vänttinen, Joseph Saad, Tanja Ruokoranta, Sari Kytölä, Pia-Sofia Ettala, Marja Pyörälä, Johanna Rimpiläinen, Timo Siitonen, Caroline A. Heckman, Heikki Kuusanmäki, Mika Kontro
Journal: Blood
Blood (2024) 144 (Supplement 1): 2757.
https://doi.org/10.1182/blood-2024-209429
Published: 2024
Journal Articles

Optimizing drug combinations for T-PLL: restoring DNA damage and P53-mediated apoptotic responses

Jana von Jan, Sanna Timonen, Till Braun, Qu Jiang, Aleksandr Ianevski, Yayi Peng, Kathleen McConnell, Paola Sindaco, Tony Andreas Müller, Sabine Pützer, Hanna Klepzig, Dennis Jungherz, Annika Dechow, Linus Wahnschaffe, Anil K. Giri, Matti Kankainen, Heikki Kuusanmäki, Heidi A. Neubauer, Richard Moriggl, Paolo Mazzeo, Nicole Schmidt, Raphael Koch, Michael Hallek, Amel Chebel, David Armisen, Laurent Genestier, Emmanuel Bachy, Anjali Mishra, Alexandra Schrader, Tero Aittokallio, Satu Mustjoki, Marco Herling
Journal: Blood
Blood (2024) 144 (15): 1595–1610.
https://doi.org/10.1182/blood.2023022884
Published: 2024
Includes: Supplemental data
Journal Articles

Ex Vivo Venetoclax Sensitivity Predicts Clinical Response in Acute Myeloid Leukemia in the Prospective VenEx Trial

Clinical Trials & Observations
Sari Kytölä, Ida Maria Vänttinen, Tanja Ruokoranta, Anu Partanen, Annasofia Holopainen, Joseph Saad, Milla E.L. Kuusisto, Sirpa Koskela, Riikka Katariina Räty, Maija Itälä-Remes, Imre Västrik, Minna Suvela, Alun Owen Parsons, Kimmo Porkka, Krister Wennerberg, Caroline A. Heckman, Tero Jalkanen, Teppo Huttunen, Pia Ettala, MD, Johanna Rimpiläinen, Timo Siitonen, Marja Pyörälä, Heikki Kuusanmäki, Mika Kontro
Journal: Blood
Blood blood.2024024968.
https://doi.org/10.1182/blood.2024024968
Published: 2024
Includes: Supplemental data
Journal Articles

Targeting Venetoclax Resistance in TP53 -Mutated Acute Myeloid Leukemia

Ida Vänttinen, Tanja Ruokoranta, Joseph J Saad, Sari Kytölä, Monica Hellesøy, Stein-Erik Gullaksen, Pia-Sofia Ettala, Marja Pyörälä, Johanna Rimpiläinen, Timo Siitonen, Krister Wennerberg, Bjorn T. Gjertsen, Caroline A. Heckman, Mika Kontro, Heikki Kuusanmäki
Journal: Blood
Blood (2023) 142 (Supplement 1): 2927.
https://doi.org/10.1182/blood-2023-189340
Published: 2023
Journal Articles

Primary Acute Myeloid Leukemia Cells Trigger Distinct Activation Patterns in Expanded NK Cells

Hanna Duàn, Olli Dufva, Emmi Jokinen, Hanna Lähteenmäki, Jay Klievink, Jonas Bouhlal, Jason Theodoropoulos, Heikki Kuusanmäki, Tanja Ruokoranta, Pauliina Rumm, Dean Anthony Lee, Esa Pitkänen, Tomi P Mäkelä, Kimmo Porkka, Oscar Brück, Satu Mustjoki
Journal: Blood
Blood (2023) 142 (Supplement 1): 66.
https://doi.org/10.1182/blood-2023-174037
Published: 2023
Journal Articles

Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia

Heikki Kuusanmäki, Olli Dufva, Markus Vähä-Koskela, Aino-Maija Leppä, Jani Huuhtanen, Ida Vänttinen, Petra Nygren, Jay Klievink, Jonas Bouhlal, Petri Pölönen, Qi Zhang, Shady Adnan-Awad, Cristina Mancebo-Pérez, Joseph Saad, Juho Miettinen, Komal K. Javarappa, Sofia Aakko, Tanja Ruokoranta, Samuli Eldfors, Merja Heinäniemi, Kim Theilgaard-Mönch, Ulla Wartiovaara-Kautto, Mikko Keränen, Kimmo Porkka, Marina Konopleva, Krister Wennerberg, Mika Kontro, Caroline A. Heckman, Satu Mustjoki
Journal: Blood
Blood (2023) 141 (13): 1610–1625.
https://doi.org/10.1182/blood.2021011094
Published: 2023
Includes: Supplemental data
Journal Articles

Erythroid/Megakaryocytic Differentiation Confers BCL-XL Dependency and Venetoclax Resistance in Acute Myeloid Leukemia

Olli Dufva, Heikki Kuusanmäki, Markus Vaha-Koskela, Aino-Maija Leppä, Jani Huuhtanen, Ida Vänttinen, Petra Johanna Nygren, Jay Klievink, Jonas Bouhlal, Petri Pölönen, Qi Zhang, Shady Adnan Awad, Cristina Mancebo, Joseph Saad, Juho J. Miettinen, Komal Kumar Javarappa, Sofia Aakko, Tanja Ruokoranta, Samuli Eldfors, Merja Heinäniemi, Ulla Wartiovaara-Kautto, Marina Konopleva, Mikko A Keränen, Kimmo Porkka, Krister Wennerberg, Mika Kontro, Caroline A. Heckman, Satu Mustjoki
Journal: Blood
Blood (2022) 140 (Supplement 1): 101–103.
https://doi.org/10.1182/blood-2022-158694
Published: 2022
Journal Articles

Ex Vivo Venetoclax Sensitivity Testing Predicts Response and Overall Survival in De Novo and s/R/R AML Patients Treated with Azacitidine and Venetoclax

Sari Kytölä, Ida Vänttinen, Tanja Ruokoranta, Annasofia Holopainen, Anu Partanen, Milla E.L. Kuusisto, Sirpa Koskela, Riikka Räty, Maija Itälä-Remes, Amanda Ranta, Minna Suvela, Alun Parsons, Imre Västrik, Sanna M. Siitonen, Kimmo Porkka, Krister Wennerberg, Caroline A. Heckman, Pia Ettala, Johanna Rimpiläinen, Timo Siitonen, Marja Pyörälä, Heikki Kuusanmäki, Mika Kontro
Journal: Blood
Blood (2022) 140 (Supplement 1): 2020–2022.
https://doi.org/10.1182/blood-2022-159391
Published: 2022
Journal Articles

Ex Vivo Drug Sensitivity Testing to Predict Response to Venetoclax + Azacitidine in Acute Myeloid Leukemia: Interim Results of the Prospective Multicenter Phase II Venex Trial

Heikki Kuusanmäki, Sari Kytölä, Ida Vänttinen, Amanda Ranta, Tanja Ruokoranta, Annasofia Holopainen, Sirpa Koskela, Milla E.L. Kuusisto, Kimmo Porkka, Riikka Räty, Imre Västrik, Krister Wennerberg, Caroline A. Heckman, Pia Ettala, Marja Pyörälä, Johanna Rimpiläinen, Timo Siitonen, Mika Kontro
Journal: Blood
Blood (2021) 138 (Supplement 1): 228.
https://doi.org/10.1182/blood-2021-147691
Published: 2021
Journal Articles

Single-Cell Drug Profiling Reveals Maturation Stage-Dependent Drug Responses in AML

Heikki Kuusanmäki, MSc, Maija Leppä, BSc, Mika Kontro, MD, Olli Dufva, BSc, Debashish Deb, MSc, Bhagwan Yadav, PhD, Satu Mustjoki, MDPhD, Kimmo Porkka, MD PhD, Caroline A Heckman, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3821.
https://doi.org/10.1182/blood.V130.Suppl_1.3821.3821
Published: 2017
Journal Articles

In Silico and Ex Vivo Drug Screening Identifies Dasatinib as a Potential Targeted Therapy for T-ALL

Saara Laukkanen, Petri Pölönen, Toni Grönroos, Heikki Kuusanmäki, MSc, Caroline A Heckman, PhD, Mika Kontro, Merja Heinäniemi, Olli Lohi
Journal: Blood
Blood (2016) 128 (22): 4029.
https://doi.org/10.1182/blood.V128.22.4029.4029
Published: 2016
Journal Articles

A High-Throughput Biology Approach to Identify Novel Therapies Specifically Targeting AML Blasts and Leukemic Stem Cells

Heikki Kuusanmäki, MSc, Aino Maija Leppä, BSc, Debashish Deb, BSc, Caroline A Heckman, PhD
Journal: Blood
Blood (2016) 128 (22): 2755.
https://doi.org/10.1182/blood.V128.22.2755.2755
Published: 2016
Journal Articles

Mutational Landscape of Aggressive Natural Killer Cell Leukemia and Drug Sensitivity Profiling Reveal Therapeutic Options in Natural Killer Cell Malignancies

Olli Dufva, Matti Kankainen, PhD, Tiina Kelkka, PhD, Shady Adnan Awad, MD, Nodoka Sekiguchi, MD, Bhagwan Yadav, MSc, Samuli Eldfors, MSc, Heikki Kuusanmäki, MSc, Emma I Andersson, MSc, Disha Malani, MSc, Paavo Pietarinen, MSc, Leena Saikko, Panu E Kovanen, MD PhD, Junji Suzumiya, MD PhD, Ritsuro Suzuki, MD PhD, Young Hyeh Ko, MD, Won Seog Kim, MD PhD, Shih-Sung Chuang, MD, Thomas P. Loughran, Jr., MD, Wing Chung Chan, MD, Koichi Ohshima, MD PhD, Tero Aittokallio, Fumihiro Ishida, MD PhD, Satu Mustjoki, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2921.
https://doi.org/10.1182/blood.V128.22.2921.2921
Published: 2016
Journal Articles

Identification of Optimized Compound Combinations for the Treatment of NUP98-NSD1+ AML

Jarno Kivioja, MSc, Angeliki Thanasopoulou, PhD, Mika Kontro, MD, Bhagwan Yadav, MSc, Muntasir Mamun Majumder, MSc, Heikki Kuusanmäki, MSc, Alun Parsons, MSc, Kimmo Porkka, MD PhD, Juerg Schwaller, MD, Caroline A Heckman, PhD
Journal: Blood
Blood (2016) 128 (22): 4711.
https://doi.org/10.1182/blood.V128.22.4711.4711
Published: 2016
Journal Articles

Stratification of Multiple Myeloma Patients Based on Ex Vivo Drug Sensitivity and Identification of New Treatments for Patients with High-Risk Relapsed/Refractory Disease

Muntasir Mamun Majumder, MSc,MPharm, Raija Silvennoinen, MD, Pekka Anttila, MD, David Tamborero, PhD, Samuli Eldfors, MSc, Juha Lievonen, MD, Riikka J Karjalainen, Heikki Kuusanmäki, MSc, Alun Parsons, Minna Suvela, Kimmo Porkka, MD PhD, Caroline Heckman
Journal: Blood
Blood (2015) 126 (23): 3006.
https://doi.org/10.1182/blood.V126.23.3006.3006
Published: 2015
Journal Articles

Exome Sequencing of Aggressive Natural Killer Cell Leukemia and Drug Profiling Highlight Candidate Driver Pathways in Malignant Natural Killer Cells

Olli Dufva, BMed, Tiina Kelkka, PhD, Shady Awad, MD, Nodoka Sekiguchi, MD, Heikki Kuusanmäki, MSc, Emma I Andersson, MSc, Samuli Eldfors, MSc, Disha Malani, MSc, Paavo Pietarinen, MSc, Leena Saikko, Panu E Kovanen, MD PhD, Junji Suzumiya, MD PhD, Koichi Ohshima, MD PhD, Young Hyeh Ko, MD, Won Seog Kim, MD PhD, Shih-Sung Chuang, MD, Thomas P. Loughran, Jr., MD, Wing C Chan, MD, Fumihiro Ishida, MD PhD, Satu Mustjoki, MD PhD
Journal: Blood
Blood (2015) 126 (23): 700.
https://doi.org/10.1182/blood.V126.23.700.700
Published: 2015
Journal Articles

Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3

Clinical Trials & Observations
Emma M. Haapaniemi, Meri Kaustio, Hanna L. M. Rajala, Arjan J. van Adrichem, Leena Kainulainen, Virpi Glumoff, Rainer Doffinger, Heikki Kuusanmäki, Tarja Heiskanen-Kosma, Luca Trotta, Samuel Chiang, Petri Kulmala, Samuli Eldfors, Riku Katainen, Sanna Siitonen, Marja-Liisa Karjalainen-Lindsberg, Panu E. Kovanen, Timo Otonkoski, Kimmo Porkka, Kaarina Heiskanen, Arno Hänninen, Yenan T. Bryceson, Raija Uusitalo-Seppälä, Janna Saarela, Mikko Seppänen, Satu Mustjoki, Juha Kere
Journal: Blood
Blood (2015) 125 (4): 639–648.
https://doi.org/10.1182/blood-2014-04-570101
Published: 2015
Includes: Supplemental data