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Volume 130, Issue 14

October 5 2017

In this Issue

INSIDE BLOOD COMMENTARIES
REVIEW ARTICLE
CLINICAL TRIALS AND OBSERVATIONS
IMMUNOBIOLOGY AND IMMUNOTHERAPY
LYMPHOID NEOPLASIA
MYELOID NEOPLASIA
THROMBOSIS AND HEMOSTASIS
LETTERS TO BLOOD
BLOOD WORK
ERRATA

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY

Mitochondria on the move: BMSCs fuel AML energy

Rosa Lapalombella

In this issue of Blood, Marlein et al¹ identify a tumor-specific NOX2-dependent transfer of mitochondria from bone marrow stromal cells (BMSCs) to acute myeloid leukemia (AML) cells via AML-derived tunneling nanotubes (see figure), supporting inhibition of NOX2 as a novel therapeutic strategy in AML.

View Articletitled, Mitochondria on the move: BMSCs fuel AML energy

INSIDE BLOOD COMMENTARY

Maestro tissue factor reaches new hEIGHT

Edward L. G. Pryzdial

In this issue of Blood, Kamikubo et al broaden the already diverse tissue factor (TF) repertoire to include activation of anti–hemophilia A clotting factor VIII (FVIII), which amplifies coagulation initiation.¹

View Articletitled, Maestro tissue factor reaches new hEIGHT

REVIEW ARTICLE

Integrin α_IIbβ₃ outside-in signaling

Tom N. Durrant,Marion T. van den Bosch,Ingeborg Hers

View Articletitled, Integrin αIIbβ3 outside-in signaling

Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Phase 1 study of the anti-CD22 immunotoxin moxetumomab pasudotox for childhood acute lymphoblastic leukemia
Clinical Trials & Observations

Alan S. Wayne,Nirali N. Shah,Deepa Bhojwani,Lewis B. Silverman,James A. Whitlock,Maryalice Stetler-Stevenson,Weili Sun,Meina Liang,Jie Yang,Robert J. Kreitman,Mark C. Lanasa,Ira Pastan

View Articletitled, Phase 1 study of the anti-CD22 immunotoxin moxetumomab pasudotox for childhood acute lymphoblastic leukemia

Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

HDAC6 inhibition upregulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies

Malgorzata Bobrowicz,Michal Dwojak,Beata Pyrzynska,Joanna Stachura,Angelika Muchowicz,Elise Berthel,Nicole Dalla-Venezia,Mieszko Kozikowski,Marta Siernicka,Nina Miazek,Piotr Zapala,Antoni Domagala,Kamil Bojarczuk,Agata Malenda,Joanna Barankiewicz,Agnieszka Graczyk-Jarzynka,Agnieszka Zagozdzon,Magdalena Gabrysiak,Jean-Jacques Diaz,Marta Karp,Ewa Lech-Maranda,Malgorzata Firczuk,Krzysztof Giannopoulos,Dimitar G. Efremov,Luca Laurenti,Dunja Baatout,Lukas Frenzel,Agata Malinowska,Mikolaj Slabicki,Thorsten Zenz,Abdessamad Zerrouqi,Jakub Golab,Magdalena Winiarska

View Articletitled, HDAC6 inhibition upregulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies

Supplemental data

LYMPHOID NEOPLASIA

Neutral tumor evolution in myeloma is associated with poor prognosis
Brief Report

David C. Johnson,Oleg Lenive,Jonathan Mitchell,Graham Jackson,Roger Owen,Mark Drayson,Gordon Cook,John R. Jones,Charlotte Pawlyn,Faith E. Davies,Brian A. Walker,Christopher Wardell,Walter M. Gregory,David Cairns,Gareth J. Morgan,Richard S. Houlston,Martin F. Kaiser

View Articletitled, Neutral tumor evolution in myeloma is associated with poor prognosis

Supplemental data

Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations
Brief Report

Benjamin H. Durham,Bartlomiej Getta,Sascha Dietrich,Justin Taylor,Helen Won,James M. Bogenberger,Sasinya Scott,Eunhee Kim,Young Rock Chung,Stephen S. Chung,Jennifer Hüllein,Tatjana Walther,Lu Wang,Sydney X. Lu,Christopher C. Oakes,Raoul Tibes,Torsten Haferlach,Barry S. Taylor,Martin S. Tallman,Michael F. Berger,Jae H. Park,Thorsten Zenz,Omar Abdel-Wahab

View Articletitled, Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations

Supplemental data

MYELOID NEOPLASIA

NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts

Christopher R. Marlein,Lyubov Zaitseva,Rachel E. Piddock,Stephen D. Robinson,Dylan R. Edwards,Manar S. Shafat,Zhigang Zhou,Matthew Lawes,Kristian M. Bowles,Stuart A. Rushworth

View Articletitled, NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts

Supplemental data

THROMBOSIS AND HEMOSTASIS

Selective factor VIII activation by the tissue factor–factor VIIa–factor Xa complex

Yuichi Kamikubo,G. Loredana Mendolicchio,Antonella Zampolli,Patrizia Marchese,Andrea S. Rothmeier,Jennifer Nagrampa Orje,Andrew J. Gale,Sriram Krishnaswamy,András Gruber,Henrik Østergaard,Lars C. Petersen,Wolfram Ruf,Zaverio M. Ruggeri

Publisher's Note: There is an Inside Blood Commentary on this article in this issue.

View Articletitled, Selective factor VIII activation by the tissue factor–factor VIIa–factor Xa complex

Supplemental data

LETTERS TO BLOOD

Pregnancy outcomes in inherited bone marrow failure syndromes

John M. Gansner,Maureen M. Achebe,Kathryn J. Gray,Revital Yefidoff-Freedman,Elena Labovitis,Aric Parnes,Jean M. Connors,Nathan T. Connell,Marie N. Discenza,Robert I. Handin,Nancy Berliner,Akiko Shimamura,Elizabeth S. Ginsburg,Nicole A. Smith

View Articletitled, Pregnancy outcomes in inherited bone marrow failure syndromes

Pregnancies in patients with inherited bone marrow failure syndromes in the NCI cohort
Clinical Trials & Observations

Neelam Giri,Pamela Stratton,Sharon A. Savage,Blanche P. Alter

View Articletitled, Pregnancies in patients with inherited bone marrow failure syndromes in the NCI cohort

A multi-institutional outcomes analysis of patients with relapsed or refractory DLBCL treated with ibrutinib

Allison M. Winter,Daniel J. Landsburg,Anthony R. Mato,Krista Isaac,Francisco J. Hernandez-Ilizaliturri,Nishitha Reddy,Stephen Smith,Mazyar Shadman,Mitchell R. Smith,Paolo Caimi,Deepa Jagadeesh,Brian T. Hill

View Articletitled, A multi-institutional outcomes analysis of patients with relapsed or refractory DLBCL treated with ibrutinib

Autoimmune HIT due to apheresis catheter heparin flushes for stem cell harvesting before autotransplantation for myeloma

Hira Mian,Theodore E. Warkentin,Jo-Ann I. Sheppard,Anna MacDonald,Lori-Ann Linkins,Ann Benger,Ronan Foley

View Articletitled, Autoimmune HIT due to apheresis catheter heparin flushes for stem cell harvesting before autotransplantation for myeloma

BLOOD WORK

Crystal-storing histiocytosis associated with thymic extranodal marginal zone lymphoma

Jayalakshmi P. Balakrishna,Elaine S. Jaffe

View Articletitled, Crystal-storing histiocytosis associated with thymic extranodal marginal zone lymphoma

ERRATA

Ekert PG, Jabbour AM, Manoharan A, et al. Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma. Blood. 2006;108(5):1461-1468.

View Articletitled, Ekert PG, Jabbour AM, Manoharan A, et al. Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma. Blood. 2006;108(5):1461-1468.

Sayani FA, Abrams CS. How I treat refractory thrombotic thrombocytopenic purpura. Blood. 2015;125(25):3860-3867.

View Articletitled, Sayani FA, Abrams CS. How I treat refractory thrombotic thrombocytopenic purpura. Blood. 2015;125(25):3860-3867.

Cover Image

Cover Image

Mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemia (AML) blasts is driven by NOX2-derived superoxide. The cover image shows a tunneling nanotube formed by the AML blast (orange) and mitochondria (green) from bone marrow stromal cells in the tunneling nanotube. See the article by Marlein et al on page 1649.
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Table of Contents

INSIDE BLOOD COMMENTARIES

Mitochondria on the move: BMSCs fuel AML energy

Maestro tissue factor reaches new hEIGHT

REVIEW ARTICLE

Integrin α_IIbβ₃ outside-in signaling

CLINICAL TRIALS AND OBSERVATIONS

Phase 1 study of the anti-CD22 immunotoxin moxetumomab pasudotox for childhood acute lymphoblastic leukemia
Clinical Trials & Observations

IMMUNOBIOLOGY AND IMMUNOTHERAPY

HDAC6 inhibition upregulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies

LYMPHOID NEOPLASIA

Neutral tumor evolution in myeloma is associated with poor prognosis
Brief Report

Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations
Brief Report

MYELOID NEOPLASIA

NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts

THROMBOSIS AND HEMOSTASIS

Selective factor VIII activation by the tissue factor–factor VIIa–factor Xa complex

LETTERS TO BLOOD

Pregnancy outcomes in inherited bone marrow failure syndromes

Pregnancies in patients with inherited bone marrow failure syndromes in the NCI cohort
Clinical Trials & Observations

A multi-institutional outcomes analysis of patients with relapsed or refractory DLBCL treated with ibrutinib

Autoimmune HIT due to apheresis catheter heparin flushes for stem cell harvesting before autotransplantation for myeloma

BLOOD WORK

Crystal-storing histiocytosis associated with thymic extranodal marginal zone lymphoma

ERRATA

Ekert PG, Jabbour AM, Manoharan A, et al. Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma. Blood. 2006;108(5):1461-1468.

Sayani FA, Abrams CS. How I treat refractory thrombotic thrombocytopenic purpura. Blood. 2015;125(25):3860-3867.

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ASH Publications

American Society of Hematology

Issue Archive

Table of Contents

INSIDE BLOOD COMMENTARIES

REVIEW ARTICLE

CLINICAL TRIALS AND OBSERVATIONS

Phase 1 study of the anti-CD22 immunotoxin moxetumomab pasudotox for childhood acute lymphoblastic leukemia Clinical Trials & Observations

IMMUNOBIOLOGY AND IMMUNOTHERAPY

LYMPHOID NEOPLASIA

Neutral tumor evolution in myeloma is associated with poor prognosis Brief Report

Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations Brief Report

MYELOID NEOPLASIA

THROMBOSIS AND HEMOSTASIS

LETTERS TO BLOOD

Pregnancies in patients with inherited bone marrow failure syndromes in the NCI cohort Clinical Trials & Observations

BLOOD WORK

ERRATA

Cover Image

Email alerts

ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only

Phase 1 study of the anti-CD22 immunotoxin moxetumomab pasudotox for childhood acute lymphoblastic leukemia
Clinical Trials & Observations

Neutral tumor evolution in myeloma is associated with poor prognosis
Brief Report

Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations
Brief Report

Pregnancies in patients with inherited bone marrow failure syndromes in the NCI cohort
Clinical Trials & Observations