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Christopher R. Marlein
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Journal Articles

Myeloma Derived Extracellular Vesicles Containing Endoplasmic Reticulum Remodel the Bone Marrow Microenvironment Towards a Pro-Tumoral Senescent Phenotype

Yu Sun, BSc, MSc, PhD, Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Charlotte Hellmich, MBBChir, Christopher R Marlein, PhD, Anna Haestier, Cesar A. Gomez, MD PhD FRCPath, Christopher J Morris, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 689.
https://doi.org/10.1182/blood-2019-128268
Published: 2019
Journal Articles

Daratumumab Inhibits AML Metabolic Capacity and Tumor Growth through Inhibition of CD38 Mediated Mitochondrial Transfer from Bone Marrow Stromal Cells to Blasts in the Leukemic Microenvironment

Jayna J Mistry, BSc, Charlotte Hellmich, MBBChir, Jamie A Moore, BSc, MSc, Christopher R Marlein, PhD, Genevra Pillinger, MB BS, Angela Collins, MBBS, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1385.
https://doi.org/10.1182/blood-2019-128592
Published: 2019
Journal Articles

Superoxide Drives PI3 Kinase Mediated Mitochondria Transfer from the Bone Marrow Microenvironment to Hematopoietic Stem Cells in Response to Salmonella Typhimurium

Jayna J Mistry, BSc, Christopher R Marlein, PhD, Jamie A Moore, BSc, MSc, Charlotte Hellmich, MBBChir, Iain Macauley, PhD BSc, Naiara Beraza, PhD, Yu Sun, BSc, MSc, PhD, Adam Morfakis, BSc, Angela Patterson, PhD, Rebecca H Horton, Devina Divekar, Christopher J Morris, PhD, Anna Haestier, Bsc, PgD MBBS, MRCOG, Federica Di Palma, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2490.
https://doi.org/10.1182/blood-2019-128241
Published: 2019
Journal Articles

Free Fatty Acid Uptake By Hematopoietic Stem and Progenitor Cells Drives Immune Cell Expansion in Response to Salmonella Typhimurium infection

Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Charlotte Hellmich, MBBChir, Christopher R Marlein, PhD, Naiara Beraza, PhD, Federica Di Palma, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1197.
https://doi.org/10.1182/blood-2019-128237
Published: 2019
Journal Articles

Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment

Amina M. Abdul-Aziz, Yu Sun, Charlotte Hellmich, Christopher R. Marlein, Jayna Mistry, Eoghan Forde, Rachel E. Piddock, Manar S. Shafat, Adam Morfakis, Tarang Mehta, Federica Di Palma, Iain Macaulay, Christopher J. Ingham, Anna Haestier, Angela Collins, Judith Campisi, Kristian M. Bowles, Stuart A. Rushworth
Journal: Blood
Blood (2019) 133 (5): 446–456.
https://doi.org/10.1182/blood-2018-04-845420
Published: 2019
Includes: Supplemental data
Journal Articles

NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts

Christopher R. Marlein, Lyubov Zaitseva, Rachel E. Piddock, Stephen D. Robinson, Dylan R. Edwards, Manar S. Shafat, Zhigang Zhou, Matthew Lawes, Kristian M. Bowles, Stuart A. Rushworth
Journal: Blood
Blood (2017) 130 (14): 1649–1660.
https://doi.org/10.1182/blood-2017-03-772939
Published: 2017
Includes: Supplemental data
Journal Articles

Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment

Manar S. Shafat, Thomas Oellerich, Sebastian Mohr, Stephen D. Robinson, Dylan R. Edwards, Christopher R. Marlein, Rachel E. Piddock, Matthew Fenech, Lyubov Zaitseva, Amina Abdul-Aziz, Jeremy Turner, Johnathan A. Watkins, Matthew Lawes, Kristian M. Bowles, Stuart A. Rushworth
Journal: Blood
Blood (2017) 129 (10): 1320–1332.
https://doi.org/10.1182/blood-2016-08-734798
Published: 2017
Includes: Supplemental data