Elena Santagostino,for the PROLONG-9FP Investigators Study Group,Uri Martinowitz,for the PROLONG-9FP Investigators Study Group,Toshko Lissitchkov,for the PROLONG-9FP Investigators Study Group,Brigitte Pan-Petesch,for the PROLONG-9FP Investigators Study Group,Hideji Hanabusa,for the PROLONG-9FP Investigators Study Group,Johannes Oldenburg,for the PROLONG-9FP Investigators Study Group,Lisa Boggio,for the PROLONG-9FP Investigators Study Group,Claude Negrier,for the PROLONG-9FP Investigators Study Group,Ingrid Pabinger,for the PROLONG-9FP Investigators Study Group,Mario von Depka Prondzinski,for the PROLONG-9FP Investigators Study Group,Carmen Altisent,for the PROLONG-9FP Investigators Study Group,Giancarlo Castaman,for the PROLONG-9FP Investigators Study Group,Koji Yamamoto,for the PROLONG-9FP Investigators Study Group,Maria-Teresa Álvarez-Roman,for the PROLONG-9FP Investigators Study Group,Christine Voigt,for the PROLONG-9FP Investigators Study Group,Nicole Blackman,for the PROLONG-9FP Investigators Study Group,Iris Jacobs,for the PROLONG-9FP Investigators Study Group

View Articletitled, Long-acting recombinant coagulation factor IX albumin fusion protein (rIX-FP) in hemophilia B: results of a phase 3 trial

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GENE THERAPY

Telomerase gene therapy rescues telomere length, bone marrow aplasia, and survival in mice with aplastic anemia

Christian Bär,Juan Manuel Povedano,Rosa Serrano,Carlos Benitez-Buelga,Miriam Popkes,Ivan Formentini,Maria Bobadilla,Fatima Bosch,Maria A. Blasco

View Articletitled, Telomerase gene therapy rescues telomere length, bone marrow aplasia, and survival in mice with aplastic anemia

Supplemental data

LYMPHOID NEOPLASIA

CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas

Mélanie Juilland,Montserrat Gonzalez,Tabea Erdmann,Yara Banz,Zala Jevnikar,Stephan Hailfinger,Alexandar Tzankov,Michael Grau,Georg Lenz,Urban Novak,Margot Thome

View Articletitled, CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas

Supplemental data

Polycomb-dependent epigenetic landscape in adult T-cell leukemia

Dai Fujikawa,Shota Nakagawa,Makoto Hori,Naoya Kurokawa,Ai Soejima,Kazumi Nakano,Tadanori Yamochi,Makoto Nakashima,Seiichiro Kobayashi,Yuetsu Tanaka,Masako Iwanaga,Atae Utsunomiya,Kaoru Uchimaru,Makoto Yamagishi,Toshiki Watanabe

View Articletitled, Polycomb-dependent epigenetic landscape in adult T-cell leukemia

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MYELOID NEOPLASIA

Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1

Shengqing Gu,Wayne W. Chan,Golam Mohi,Joel Rosenbaum,Azin Sayad,Zhibin Lu,Carl Virtanen,Shaoguang Li,Benjamin G. Neel,Richard A. Van Etten

View Articletitled, Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1

Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Long-term treatment follow-up of children with sickle cell disease monitored with abnormal transcranial Doppler velocities
Clinical Trials & Observations

Françoise Bernaudin,Suzanne Verlhac,Cécile Arnaud,Annie Kamdem,Isabelle Hau,Emmanuella Leveillé,Manuela Vasile,Florence Kasbi,Fouad Madhi,Christine Fourmaux,Sandra Biscardi,Eliane Gluckman,Gérard Socié,Jean-Hugues Dalle,Ralph Epaud,Corinne Pondarré

View Articletitled, Long-term treatment follow-up of children with sickle cell disease monitored with abnormal transcranial Doppler velocities

TRANSFUSION MEDICINE

CD8⁺ T cells mediate antibody-independent platelet clearance in mice
Brief Report

Connie M. Arthur,Seema R. Patel,H. Cliff Sullivan,Annie M. Winkler,Chris A. Tormey,Jeanne E. Hendrickson,Sean R. Stowell

View Articletitled, CD8+ T cells mediate antibody-independent platelet clearance in mice

Supplemental data

TRANSPLANTATION

Larger number of invariant natural killer T cells in PBSC allografts correlates with improved GVHD-free and progression-free survival
Clinical Trials & Observations

Florent Malard,Myriam Labopin,Patrice Chevallier,Thierry Guillaume,Alix Duquesne,Fanny Rialland,Sophie Derenne,Pierre Peterlin,Anne-Gaelle Leauté,Eolia Brissot,Marc Gregoire,Philippe Moreau,Philippe Saas,Béatrice Gaugler,Mohamad Mohty

View Articletitled, Larger number of invariant natural killer T cells in PBSC allografts correlates with improved GVHD-free and progression-free survival

Supplemental data

BLOOD WORK

Resolution of osteosclerosis after alloHCT in systemic mastocytosis

Celalettin Ustun,Elizabeth L. Courville

View Articletitled, Resolution of osteosclerosis after alloHCT in systemic mastocytosis

ERRATA

Parry EM, Alder JK, Qi X, Chen JJ-L, Armanios M. Syndrome complex of bone marrow failure and pulmonary fibrosis predicts germline defects in telomerase. Blood. 2011;117(21):5607-5611.

View Articletitled, Parry EM, Alder JK, Qi X, Chen JJ-L, Armanios M. Syndrome complex of bone marrow failure and pulmonary fibrosis predicts germline defects in telomerase. Blood. 2011;117(21):5607-5611.

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An immunofluorescence staining of the activating transcription factor 3 in the human activated B-cell type–diffuse large B-cell lymphoma cell line TMD8. See the article by Juilland et al on page 1780.
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Table of Contents

ANNIVERSARY EDITORIAL

Blood’s 70th anniversary: arsenic—from poison pill to magic bullet

BLOOD FLASHBACK

Hermansky F, Pudlak P. Albinism associated with hemorrhagic diathesis and unusual pigmented reticular cells in the bone marrow: report of two cases with histochemical studies. Blood. 1959;14(2):162-169.

BLOOD COMMENTARIES

(Dicer)phering roles of microRNA in platelets

A new era for hemophilia B treatment
Clinical Trials & Observations

ATF3, a new player in DLBCL cell survival

Tax fingerprint in adult T-cell leukemia

Hydroxyurea for abnormal TCDs: safe to switch?

Platelet refractoriness: it’s not the B-all and end-all

PLENARY PAPER

Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets

EVIDENCE-BASED FOCUSED REVIEW

Should IGHV status and FISH testing be performed in all CLL patients at diagnosis? A systematic review and meta-analysis
Clinical Trials & Observations

CLINICAL TRIALS AND OBSERVATIONS

Long-acting recombinant coagulation factor IX albumin fusion protein (rIX-FP) in hemophilia B: results of a phase 3 trial
Clinical Trials & Observations

GENE THERAPY

Telomerase gene therapy rescues telomere length, bone marrow aplasia, and survival in mice with aplastic anemia

LYMPHOID NEOPLASIA

CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas

Polycomb-dependent epigenetic landscape in adult T-cell leukemia

MYELOID NEOPLASIA

Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1

RED CELLS, IRON, AND ERYTHROPOIESIS

Long-term treatment follow-up of children with sickle cell disease monitored with abnormal transcranial Doppler velocities
Clinical Trials & Observations

TRANSFUSION MEDICINE

CD8⁺ T cells mediate antibody-independent platelet clearance in mice
Brief Report

TRANSPLANTATION

Larger number of invariant natural killer T cells in PBSC allografts correlates with improved GVHD-free and progression-free survival
Clinical Trials & Observations

BLOOD WORK

Resolution of osteosclerosis after alloHCT in systemic mastocytosis

ERRATA

Parry EM, Alder JK, Qi X, Chen JJ-L, Armanios M. Syndrome complex of bone marrow failure and pulmonary fibrosis predicts germline defects in telomerase. Blood. 2011;117(21):5607-5611.

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Table of Contents

ANNIVERSARY EDITORIAL

BLOOD FLASHBACK

BLOOD COMMENTARIES

A new era for hemophilia B treatment Clinical Trials & Observations

PLENARY PAPER

EVIDENCE-BASED FOCUSED REVIEW

Should IGHV status and FISH testing be performed in all CLL patients at diagnosis? A systematic review and meta-analysis Clinical Trials & Observations

CLINICAL TRIALS AND OBSERVATIONS

Long-acting recombinant coagulation factor IX albumin fusion protein (rIX-FP) in hemophilia B: results of a phase 3 trial Clinical Trials & Observations

GENE THERAPY

LYMPHOID NEOPLASIA

MYELOID NEOPLASIA

RED CELLS, IRON, AND ERYTHROPOIESIS

Long-term treatment follow-up of children with sickle cell disease monitored with abnormal transcranial Doppler velocities Clinical Trials & Observations

TRANSFUSION MEDICINE

CD8+ T cells mediate antibody-independent platelet clearance in mice Brief Report

TRANSPLANTATION

Larger number of invariant natural killer T cells in PBSC allografts correlates with improved GVHD-free and progression-free survival Clinical Trials & Observations

BLOOD WORK

ERRATA

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A new era for hemophilia B treatment
Clinical Trials & Observations

Should IGHV status and FISH testing be performed in all CLL patients at diagnosis? A systematic review and meta-analysis
Clinical Trials & Observations

Long-acting recombinant coagulation factor IX albumin fusion protein (rIX-FP) in hemophilia B: results of a phase 3 trial
Clinical Trials & Observations

Long-term treatment follow-up of children with sickle cell disease monitored with abnormal transcranial Doppler velocities
Clinical Trials & Observations

CD8⁺ T cells mediate antibody-independent platelet clearance in mice
Brief Report

Larger number of invariant natural killer T cells in PBSC allografts correlates with improved GVHD-free and progression-free survival
Clinical Trials & Observations