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Issue Archive

Volume 127, Issue 1
January 7 2016
Issue Cover

Table of Contents

EDITORIAL

Introduction to the review series on advances in acute myeloid leukemia (AML)
Clinical Trials & Observations
Bob Löwenberg,Jacob M. Rowe
View Articletitled, Introduction to the review series on advances in acute myeloid leukemia (AML)

BLOOD FLASHBACK

Dameshek W, Miller EB. The megakaryocytes in idiopathic thrombocytopenic purpura, a form of hypersplenism. Blood. 1946;1(1):27-50.
View Articletitled, Dameshek W, Miller EB. The megakaryocytes in idiopathic thrombocytopenic purpura, a form of hypersplenism. <em>Blood</em>. 1946;1(1):<span class="related-article">27-50</span>.

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Serendipity in splendid isolation: rapamycin
Clinical Trials & Observations
V. Koneti Rao
View Articletitled, Serendipity in splendid isolation: rapamycin
INSIDE BLOOD COMMENTARY
Obinutuzumab: the more the merrier?
Clinical Trials & Observations
Jan A. Burger
View Articletitled, Obinutuzumab: the more the merrier?
INSIDE BLOOD COMMENTARY
Rebooting autoimmunity with autologous HSCT
John A. Snowden
View Articletitled, Rebooting autoimmunity with autologous HSCT
INSIDE BLOOD COMMENTARY
Identifying risk factors for B-cell lymphoma
Christopher R. Flowers,Christine F. Skibola
View Articletitled, Identifying risk factors for B-cell lymphoma
INSIDE BLOOD COMMENTARY
FcγRIII in ITP: it ain’t over 'til it’s over
Keith R. McCrae
View Articletitled, FcγRIII in ITP: it ain’t over 'til it’s over
INSIDE BLOOD COMMENTARY
Unconventional cell death in erythroid cells
Lesley J. Bruce,David J. Anstee
View Articletitled, Unconventional cell death in erythroid cells
INSIDE BLOOD COMMENTARY
Predicting chronic GVHD outcomes: are we there yet?
David A. Jacobsohn
View Articletitled, Predicting chronic GVHD outcomes: are we there yet?

PLENARY PAPER

CLINICAL TRIALS AND OBSERVATIONS
Sirolimus is effective in relapsed/refractory autoimmune cytopenias: results of a prospective multi-institutional trial
Clinical Trials & Observations
Karen L. Bride,Tiffaney Vincent,Kim Smith-Whitley,Michele P. Lambert,Jack J. Bleesing,Alix E. Seif,Catherine S. Manno,James Casper,Stephan A. Grupp,David T. Teachey
View Articletitled, Sirolimus is effective in relapsed/refractory autoimmune cytopenias: results of a prospective multi-institutional trial
Supplemental data

REVIEW SERIES

Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance
Clinical Trials & Observations
David Grimwade,Adam Ivey,Brian J. P. Huntly
View Articletitled, Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance

REVIEW SERIES

Epigenetics and approaches to targeted epigenetic therapy in acute myeloid leukemia
Clinical Trials & Observations
Bas J. Wouters,Ruud Delwel
View Articletitled, Epigenetics and approaches to targeted epigenetic therapy in acute myeloid leukemia

REVIEW SERIES

An update of current treatments for adult acute myeloid leukemia
Clinical Trials & Observations
Hervé Dombret,Claude Gardin
View Articletitled, An update of current treatments for adult acute myeloid leukemia

REVIEW SERIES

Hematopoietic stem cell transplantation for patients with AML in first complete remission
Clinical Trials & Observations
Jan J. Cornelissen,Didier Blaise
View Articletitled, Hematopoietic stem cell transplantation for patients with AML in first complete remission

REVIEW SERIES

Emerging therapeutic drugs for AML
Clinical Trials & Observations
Eytan M. Stein,Martin S. Tallman
View Articletitled, Emerging therapeutic drugs for AML

CLINICAL TRIALS AND OBSERVATIONS

Randomized phase 2 study of obinutuzumab monotherapy in symptomatic, previously untreated chronic lymphocytic leukemia
Clinical Trials & Observations
John C. Byrd,Joseph M. Flynn,Thomas J. Kipps,Michael Boxer,Kathryn S. Kolibaba,David J. Carlile,Guenter Fingerle-Rowson,Nicola Tyson,Jamie Hirata,Jeff P. Sharman
View Articletitled, Randomized phase 2 study of obinutuzumab monotherapy in symptomatic, previously untreated chronic lymphocytic leukemia

HEMATOPOIESIS AND STEM CELLS

Hoxa cluster genes determine the proliferative activity of adult mouse hematopoietic stem and progenitor cells
Brief Report
Charles-Étienne Lebert-Ghali,Marilaine Fournier,Laura Kettyle,Alexander Thompson,Guy Sauvageau,Janet J. Bijl
View Articletitled, <em>Hoxa</em> cluster genes determine the proliferative activity of adult mouse hematopoietic stem and progenitor cells
Supplemental data

IMMUNOBIOLOGY

Autologous stem cell transplantation aids autoimmune patients by functional renewal and TCR diversification of regulatory T cells
Eveline M. Delemarre,Theo van den Broek,Gerdien Mijnheer,Jenny Meerding,Ellen J. Wehrens,Sven Olek,Marianne Boes,Martijn J. C. van Herwijnen,Femke Broere,Annet van Royen,Nico M. Wulffraat,Berent J. Prakken,Eric Spierings,Femke van Wijk
View Articletitled, Autologous stem cell transplantation aids autoimmune patients by functional renewal and TCR diversification of regulatory T cells
Supplemental data

LYMPHOID NEOPLASIA

AID-associated DNA repair pathways regulate malignant transformation in a murine model of BCL6-driven diffuse large B-cell lymphoma
Xiwen Gu,Carmen J. Booth,Zongzhi Liu,Matthew P. Strout
View Articletitled, AID-associated DNA repair pathways regulate malignant transformation in a murine model of BCL6-driven diffuse large B-cell lymphoma
Supplemental data
B-cell non-Hodgkin lymphoma linked to Coxiella burnetii
Clinical Trials & Observations
Cléa Melenotte,Matthieu Million,Gilles Audoly,Audrey Gorse,Hervé Dutronc,Gauthier Roland,Michal Dekel,Asuncion Moreno,Serge Cammilleri,Maria Patrizia Carrieri,Camelia Protopopescu,Philippe Ruminy,Hubert Lepidi,Bertrand Nadel,Jean-Louis Mege,Luc Xerri,Didier Raoult
View Articletitled, B-cell non-Hodgkin lymphoma linked to <em>Coxiella burnetii</em>
Supplemental data

MYELOID NEOPLASIA

Targeting CD123 in acute myeloid leukemia using a T-cell–directed dual-affinity retargeting platform
Muneera Al-Hussaini,Michael P. Rettig,Julie K. Ritchey,Darja Karpova,Geoffrey L. Uy,Linda G. Eissenberg,Feng Gao,William C. Eades,Ezio Bonvini,Gurunadh R. Chichili,Paul A. Moore,Syd Johnson,Lynne Collins,John F. DiPersio
View Articletitled, Targeting CD123 in acute myeloid leukemia using a T-cell–directed dual-affinity retargeting platform
Supplemental data

PLATELETS AND THROMBOPOIESIS

Monovalent Fc receptor blockade by an anti–Fcγ receptor/albumin fusion protein ameliorates murine ITP with abrogated toxicity
Xiaojie Yu,Melissa Menard,József Prechl,Varsha Bhakta,William P. Sheffield,Alan H. Lazarus
View Articletitled, Monovalent Fc receptor blockade by an anti–Fcγ receptor/albumin fusion protein ameliorates murine ITP with abrogated toxicity

RED CELLS, IRON, AND ERYTHROPOIESIS

Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors
Özge Canli,Yasemin B. Alankuş,Sasker Grootjans,Naidu Vegi,Lothar Hültner,Philipp S. Hoppe,Timm Schroeder,Peter Vandenabeele,Georg W. Bornkamm,Florian R. Greten
View Articletitled, Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors
Supplemental data

THROMBOSIS AND HEMOSTASIS

Kinetics and mechanics of clot contraction are governed by the molecular and cellular composition of the blood
Valerie Tutwiler,Rustem I. Litvinov,Andrey P. Lozhkin,Alina D. Peshkova,Tatiana Lebedeva,Fazoil I. Ataullakhanov,Kara L. Spiller,Douglas B. Cines,John W. Weisel
View Articletitled, Kinetics and mechanics of clot contraction are governed by the molecular and cellular composition of the blood
Supplemental data

TRANSPLANTATION

Predictors of survival, nonrelapse mortality, and failure-free survival in patients treated for chronic graft-versus-host disease
Jeanne Palmer,Xiaoyu Chai,Joseph Pidala,Yoshihiro Inamoto,Paul J. Martin,Barry Storer,Iskra Pusic,Mary E. D. Flowers,Mukta Arora,Steven Z. Pavletic,Stephanie J. Lee
View Articletitled, Predictors of survival, nonrelapse mortality, and failure-free survival in patients treated for chronic graft-versus-host disease
Supplemental data

BLOOD WORK

Human African trypanosomiasis diagnosis by peripheral blood smear review in a Spanish traveler
Clinical Trials & Observations
Gabriela Bastidas,Anna Merino
View Articletitled, Human African trypanosomiasis diagnosis by peripheral blood smear review in a Spanish traveler
Systemic AL amyloidosis associated with Waldenström macroglobulinemia: an unusual presenting complication
Beenu Thakral,Rashmi Kanagal-Shamanna
View Articletitled, Systemic AL amyloidosis associated with Waldenström macroglobulinemia: an unusual presenting complication
  • Cover Image

    Cover Image

    issue cover

    Absence of DNA base excision and mismatch repair pathways promotes the early development of BCL6-driven diffuse large B-cell lymphoma in a murine model. A representative hematoxylin and eosin-stained section of tumor-infiltrated spleen shows large and pleomorphic lymphocytes that stain positive for peanut agglutinin (brown), consistent with their germinal center B-cell origin. See the article by Gu et al on page 102.

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