Gualtiero Palareti,on behalf of the DULCIS (D-dimer and ULtrasonography in Combination Italian Study) Investigators,Benilde Cosmi,on behalf of the DULCIS (D-dimer and ULtrasonography in Combination Italian Study) Investigators,Cristina Legnani,on behalf of the DULCIS (D-dimer and ULtrasonography in Combination Italian Study) Investigators,Emilia Antonucci,on behalf of the DULCIS (D-dimer and ULtrasonography in Combination Italian Study) Investigators,Valeria De Micheli,on behalf of the DULCIS (D-dimer and ULtrasonography in Combination Italian Study) Investigators,Angelo Ghirarduzzi,on behalf of the DULCIS (D-dimer and ULtrasonography in Combination Italian Study) Investigators,Daniela Poli,on behalf of the DULCIS (D-dimer and ULtrasonography in Combination Italian Study) Investigators,Sophie Testa,on behalf of the DULCIS (D-dimer and ULtrasonography in Combination Italian Study) Investigators,Alberto Tosetto,on behalf of the DULCIS (D-dimer and ULtrasonography in Combination Italian Study) Investigators,Vittorio Pengo,on behalf of the DULCIS (D-dimer and ULtrasonography in Combination Italian Study) Investigators,Paolo Prandoni,on behalf of the DULCIS (D-dimer and ULtrasonography in Combination Italian Study) Investigators

View Articletitled, D-dimer to guide the duration of anticoagulation in patients with venous thromboembolism: a management study

Preemptive rituximab infusions after remission efficiently prevent relapses in acquired thrombotic thrombocytopenic purpura
Clinical Trials & Observations

Miguel Hie,Julie Gay,Lionel Galicier,François Provôt,Claire Presne,Pascale Poullin,Guy Bonmarchand,Alain Wynckel,Ygal Benhamou,Philippe Vanhille,Aude Servais,Dominique Bordessoule,Jean-Philippe Coindre,Mohamed Hamidou,Jean-Paul Vernant,Agnès Veyradier,Paul Coppo,the French Thrombotic Microangiopathies Reference Centre

View Articletitled, Preemptive rituximab infusions after remission efficiently prevent relapses in acquired thrombotic thrombocytopenic purpura

Supplemental data

Thrombotic thrombocytopenic purpura and pregnancy: presentation, management, and subsequent pregnancy outcomes
Clinical Trials & Observations

Marie Scully,Mari Thomas,Mary Underwood,Henry Watson,Katherine Langley,Raymond S. Camilleri,Amanda Clark,Desmond Creagh,Rachel Rayment,Vickie Mcdonald,Ashok Roy,Gillian Evans,Siobhan McGuckin,Fionnuala Ni Ainle,Rhona Maclean,William Lester,Michael Nash,Rosemary Scott,Patrick O Brien,collaborators of the UK TTP Registry

View Articletitled, Thrombotic thrombocytopenic purpura and pregnancy: presentation, management, and subsequent pregnancy outcomes

Supplemental data

HEMATOPOIESIS AND STEM CELLS

Dissection of vertebrate hematopoiesis using zebrafish thrombopoietin

Ondřej Svoboda,David L. Stachura,Olga Machoňová,Petr Pajer,Jiří Brynda,Leonard I. Zon,David Traver,Petr Bartůněk

View Articletitled, Dissection of vertebrate hematopoiesis using zebrafish thrombopoietin

Supplemental data

IMMUNOBIOLOGY

miR-217 is an oncogene that enhances the germinal center reaction

Virginia G. de Yébenes,Nahikari Bartolomé-Izquierdo,Rubén Nogales-Cadenas,Pablo Pérez-Durán,Sonia M. Mur,Nerea Martínez,Lorena Di Lisio,Davide F. Robbiani,Alberto Pascual-Montano,Marta Cañamero,Miguel A. Piris,Almudena R. Ramiro

View Articletitled, miR-217 is an oncogene that enhances the germinal center reaction

Supplemental data

LYMPHOID NEOPLASIA

Smac mimetic and glucocorticoids synergize to induce apoptosis in childhood ALL by promoting ripoptosome assembly

Katharina Belz,Hannah Schoeneberger,Sibylle Wehner,Andreas Weigert,Halvard Bönig,Thomas Klingebiel,Iduna Fichtner,Simone Fulda

View Articletitled, Smac mimetic and glucocorticoids synergize to induce apoptosis in childhood ALL by promoting ripoptosome assembly

Supplemental data

TP53 mutations occur in 15.7% of ALL and are associated with MYC-rearrangement, low hypodiploidy, and a poor prognosis

Anna Stengel,Susanne Schnittger,Sandra Weissmann,Sabrina Kuznia,Wolfgang Kern,Alexander Kohlmann,Torsten Haferlach,Claudia Haferlach

View Articletitled, TP53 mutations occur in 15.7% of ALL and are associated with MYC-rearrangement, low hypodiploidy, and a poor prognosis

Supplemental data

Translocation t(2;11) in CLL cells results in CXCR4/MAML2 fusion oncogene
Brief Report

Mario Acunzo,Giulia Romano,Dorothee Wernicke,Veronica Balatti,Laura Z. Rassenti,Marie dell’Aquila,Thomas J. Kipps,Yuri Pekarsky,Carlo M. Croce

View Articletitled, Translocation t(2;11) in CLL cells results in CXCR4/MAML2 fusion oncogene

Supplemental data

MYELOID NEOPLASIA

MLL-AF6 fusion oncogene sequesters AF6 into the nucleus to trigger RAS activation in myeloid leukemia

Elena Manara,Emma Baron,Claudia Tregnago,Sanja Aveic,Valeria Bisio,Silvia Bresolin,Riccardo Masetti,Franco Locatelli,Giuseppe Basso,Martina Pigazzi

View Articletitled, MLL-AF6 fusion oncogene sequesters AF6 into the nucleus to trigger RAS activation in myeloid leukemia

Supplemental data

Impact of FLT3^ITD mutant allele level on relapse risk in intermediate-risk acute myeloid leukemia
Brief Report

David C. Linch,Robert K. Hills,Alan K. Burnett,Asim Khwaja,Rosemary E. Gale

View Articletitled, Impact of FLT3ITD mutant allele level on relapse risk in intermediate-risk acute myeloid leukemia

Supplemental data

PLATELETS AND THROMBOPOIESIS

SDF-1 dynamically mediates megakaryocyte niche occupancy and thrombopoiesis at steady state and following radiation injury

Lisa M. Niswander,Katherine H. Fegan,Paul D. Kingsley,Kathleen E. McGrath,James Palis

View Articletitled, SDF-1 dynamically mediates megakaryocyte niche occupancy and thrombopoiesis at steady state and following radiation injury

Supplemental data

TRANSPLANTATION

Pretransplant comorbidities predict severity of acute graft-versus-host disease and subsequent mortality
Clinical Trials & Observations

Mohamed L. Sorror,Paul J. Martin,Rainer F. Storb,Smita Bhatia,Richard T. Maziarz,Michael A. Pulsipher,Michael B. Maris,Christopher Davis,H. Joachim Deeg,Stephanie J. Lee,David G. Maloney,Brenda M. Sandmaier,Frederick R. Appelbaum,Theodore A. Gooley

View Articletitled, Pretransplant comorbidities predict severity of acute graft-versus-host disease and subsequent mortality

Chemokine treatment rescues profound T-lineage progenitor homing defect after bone marrow transplant conditioning in mice

Shirley L. Zhang,Xinxin Wang,Sugata Manna,Daniel A. Zlotoff,Jerrod L. Bryson,Bruce R. Blazar,Avinash Bhandoola

View Articletitled, Chemokine treatment rescues profound T-lineage progenitor homing defect after bone marrow transplant conditioning in mice

Supplemental data

RETRACTIONS

Banerjee P, Tripp A, Lairmore MD, Crawford L, Sieburg M, Ramos JC, Harrington W Jr, Beilke MA, Feuer G. Adult T-cell leukemia/lymphoma development in HTLV-1-infected humanized SCID mice. Blood. 2010;115(13):2640-2648.

View Articletitled, Banerjee P, Tripp A, Lairmore MD, Crawford L, Sieburg M, Ramos JC, Harrington W Jr, Beilke MA, Feuer G. Adult T-cell leukemia/lymphoma development in HTLV-1-infected humanized SCID mice. Blood. 2010;115(13):2640-2648.

Cover Image

Cover Image

AF6 is a cytoplasmic protein with two distinctive features: one single PDZ and two RAS-interacting (RA) domains. These characteristics enable AF6, either alone or when fused to MLL, to modulate multiple signal transduction pathways in vivo, especially those involving RAS. The authors demonstrate that MLL-AF6 affects AF6 localization in t(6;11) myeloid leukemia cells in order to aberrantly activate RAS (green) and its downstream signaling to empower the tumorigenic potential. The silencing of MLL-AF6 relocalizes the AF6 protein back into the cytoplasm, leading to reduction of both RAS levels and activity. These results imply that RAS may play a crucial oncogenic role in this subtype of AML. See the article by Manara et al on page 263.
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INSIDE BLOOD COMMENTARIES

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PLENARY PAPER

PERSPECTIVES

BLOOD SPOTLIGHT

Paraneoplastic thrombocytosis: the secrets of tumor self-promotion Clinical Trials & Observations

HOW I TREAT

Current concepts in the diagnosis and management of cytokine release syndrome Clinical Trials & Observations

CLINICAL TRIALS AND OBSERVATIONS

D-dimer to guide the duration of anticoagulation in patients with venous thromboembolism: a management study Clinical Trials & Observations

Preemptive rituximab infusions after remission efficiently prevent relapses in acquired thrombotic thrombocytopenic purpura Clinical Trials & Observations

Thrombotic thrombocytopenic purpura and pregnancy: presentation, management, and subsequent pregnancy outcomes Clinical Trials & Observations

HEMATOPOIESIS AND STEM CELLS

IMMUNOBIOLOGY

LYMPHOID NEOPLASIA

Translocation t(2;11) in CLL cells results in CXCR4/MAML2 fusion oncogene Brief Report

MYELOID NEOPLASIA

Impact of FLT3ITD mutant allele level on relapse risk in intermediate-risk acute myeloid leukemia Brief Report

PLATELETS AND THROMBOPOIESIS

TRANSPLANTATION

Pretransplant comorbidities predict severity of acute graft-versus-host disease and subsequent mortality Clinical Trials & Observations

RETRACTIONS

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ASH Publications

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This Feature Is Available To Subscribers Only

Paraneoplastic thrombocytosis: the secrets of tumor self-promotion
Clinical Trials & Observations

Current concepts in the diagnosis and management of cytokine release syndrome
Clinical Trials & Observations

D-dimer to guide the duration of anticoagulation in patients with venous thromboembolism: a management study
Clinical Trials & Observations

Preemptive rituximab infusions after remission efficiently prevent relapses in acquired thrombotic thrombocytopenic purpura
Clinical Trials & Observations

Thrombotic thrombocytopenic purpura and pregnancy: presentation, management, and subsequent pregnancy outcomes
Clinical Trials & Observations

Translocation t(2;11) in CLL cells results in CXCR4/MAML2 fusion oncogene
Brief Report

Impact of FLT3^ITD mutant allele level on relapse risk in intermediate-risk acute myeloid leukemia
Brief Report

Pretransplant comorbidities predict severity of acute graft-versus-host disease and subsequent mortality
Clinical Trials & Observations