Cover Image

Cover Image

Astrocytes (stained with anti-GFAP; green) grow radially outward from the optic nerve head in the developing retina. Blood vessels (stained with isolectin; red) follow, guided by tip cells. Astrocytes provide a permissive substrate and secrete factors such as SDF-1 that mediate the morphology and behavior of tip cells, which express the cognate receptor CXCR4. See the article by Strasser et al on page 5102.
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Refined ELN 2024 risk stratification improves survival prognostication following venetoclax-based therapy in AML

Safety and efficacy of pegcetacoplan treatment for cold agglutinin disease and warm antibody autoimmune hemolytic anemia

Childhood Langerhans cell histiocytosis hematological involvement: severity associated with BRAFV600E loads

Long-term Outcomes of tyrosine kinase inhibitors in chronic myeloid leukemia

Leukemic myeloblasts with erythrophagocytosis

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Table of Contents

INSIDE BLOOD

Threatening clots in MGUS and myeloma

The anergic B cell

First do no harm

Factor XII bridges coagulation and fibrinolysis again

REVIEW ARTICLES

Mast cell proteases: multifaceted regulators of inflammatory disease

CLINICAL TRIALS AND OBSERVATIONS

Arterial and venous thrombosis in monoclonal gammopathy of undetermined significance and multiple myeloma: a population-based study
Clinical Trials & Observations

Validation of a predictive model for identifying an increased risk for thromboembolism in children with acute lymphoblastic leukemia: results of a multicenter cohort study
Clinical Trials & Observations

Neurolymphomatosis: an International Primary CNS Lymphoma Collaborative Group report
Clinical Trials & Observations

HEMATOPOIESIS AND STEM CELLS

Hematopoietic stem cell function requires 12/15-lipoxygenase–dependent fatty acid metabolism

Hematopoietic activity of human short-term repopulating cells in mobilized peripheral blood cell transplants is restricted to the first 5 months after transplantation
Brief Report

IMMUNOBIOLOGY

Complement receptor 2/CD21⁻ human naive B cells contain mostly autoreactive unresponsive clones

Systematic cytokine receptor profiling reveals GM-CSF as a novel TLR-independent activator of human plasmacytoid predendritic cells
Brief Report

LYMPHOID NEOPLASIA

Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells

Increased angiogenic sprouting in poor prognosis FL is associated with elevated numbers of CD163⁺ macrophages within the immediate sprouting microenvironment
Brief Report

MYELOID NEOPLASIA

Senescence induction in human fibroblasts and hematopoietic progenitors by leukemogenic fusion proteins
Brief Report

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development

PLATELETS AND THROMBOPOIESIS

Synergism between platelet collagen receptors defined using receptor-specific collagen-mimetic peptide substrata in flowing blood

RED CELLS, IRON, AND ERYTHROPOIESIS

The IgG-specific endoglycosidase EndoS inhibits both cellular and complement-mediated autoimmune hemolysis

THROMBOSIS AND HEMOSTASIS

Sensitive and selective detection of free FXIII activation peptide: a potential marker of acute thrombotic events

TRANSPLANTATION

Practice patterns for evaluation, consent, and care of related donors and recipients at hematopoietic cell transplantation centers in the United States

VASCULAR BIOLOGY

Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching

Factor XII stimulates ERK1/2 and Akt through uPAR, integrins, and the EGFR to initiate angiogenesis

Chronic coumarin treatment is associated with increased extracoronary arterial calcification in humans
Brief Report

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Table of Contents

INSIDE BLOOD

REVIEW ARTICLES

CLINICAL TRIALS AND OBSERVATIONS

Arterial and venous thrombosis in monoclonal gammopathy of undetermined significance and multiple myeloma: a population-based study Clinical Trials & Observations

Validation of a predictive model for identifying an increased risk for thromboembolism in children with acute lymphoblastic leukemia: results of a multicenter cohort study Clinical Trials & Observations

Neurolymphomatosis: an International Primary CNS Lymphoma Collaborative Group report Clinical Trials & Observations

HEMATOPOIESIS AND STEM CELLS

Hematopoietic activity of human short-term repopulating cells in mobilized peripheral blood cell transplants is restricted to the first 5 months after transplantation Brief Report

IMMUNOBIOLOGY

Systematic cytokine receptor profiling reveals GM-CSF as a novel TLR-independent activator of human plasmacytoid predendritic cells Brief Report

LYMPHOID NEOPLASIA

Increased angiogenic sprouting in poor prognosis FL is associated with elevated numbers of CD163+ macrophages within the immediate sprouting microenvironment Brief Report

MYELOID NEOPLASIA

Senescence induction in human fibroblasts and hematopoietic progenitors by leukemogenic fusion proteins Brief Report

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

PLATELETS AND THROMBOPOIESIS

RED CELLS, IRON, AND ERYTHROPOIESIS

THROMBOSIS AND HEMOSTASIS

TRANSPLANTATION

VASCULAR BIOLOGY

Chronic coumarin treatment is associated with increased extracoronary arterial calcification in humans Brief Report

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Arterial and venous thrombosis in monoclonal gammopathy of undetermined significance and multiple myeloma: a population-based study
Clinical Trials & Observations

Validation of a predictive model for identifying an increased risk for thromboembolism in children with acute lymphoblastic leukemia: results of a multicenter cohort study
Clinical Trials & Observations

Neurolymphomatosis: an International Primary CNS Lymphoma Collaborative Group report
Clinical Trials & Observations

Hematopoietic activity of human short-term repopulating cells in mobilized peripheral blood cell transplants is restricted to the first 5 months after transplantation
Brief Report

Systematic cytokine receptor profiling reveals GM-CSF as a novel TLR-independent activator of human plasmacytoid predendritic cells
Brief Report

Increased angiogenic sprouting in poor prognosis FL is associated with elevated numbers of CD163⁺ macrophages within the immediate sprouting microenvironment
Brief Report

Senescence induction in human fibroblasts and hematopoietic progenitors by leukemogenic fusion proteins
Brief Report

Chronic coumarin treatment is associated with increased extracoronary arterial calcification in humans
Brief Report