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Volume 114, Issue 6

August 6 2009

In this Issue

INSIDE BLOOD
BLOOD WORK
PLENARY PAPERS
REVIEW ARTICLES
HOW I TREAT
CLINICAL TRIALS AND OBSERVATIONS
GENE THERAPY
HEMATOPOIESIS AND STEM CELLS
IMMUNOBIOLOGY
LYMPHOID NEOPLASIA
PLATELETS AND THROMBOPOIESIS
RED CELLS, IRON, AND ERYTHROPOIESIS
TRANSPLANTATION
VASCULAR BIOLOGY
CORRESPONDENCE
ERRATUM

Table of Contents

INSIDE BLOOD

INSIDE BLOOD

STAT6 in PMBL: pathogenic or passenger?

David A. Frank

View Articletitled, STAT6 in PMBL: pathogenic or passenger?

IMMUNOBIOLOGY

Th17 cells in ovarian cancer

David H. Munn

View Articletitled, Th17 cells in ovarian cancer

PLATELETS & THROMBOPOIESIS

Double jeopardy

Richard H. Aster

View Articletitled, Double jeopardy

TRANSPLANTATION

Waking up regulatory T cells

Kjetil Taskén

View Articletitled, Waking up regulatory T cells

TRANSPLANTATION

SOS: too many irons in the fire!

Marcos de Lima

View Articletitled, SOS: too many irons in the fire!

VASCULAR BIOLOGY

Is Virchow's triad complete?

Paul A. Kyrle,Sabine Eichinger

View Articletitled, Is Virchow's triad complete?

BLOOD WORK

Intravascular lymphoma

View Articletitled, Intravascular lymphoma

PLENARY PAPERS

Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments

Ilona Kryczek,Mousumi Banerjee,Pui Cheng,Linhua Vatan,Wojciech Szeliga,Shuang Wei,Emina Huang,Emily Finlayson,Diane Simeone,Theodore H. Welling,Alfred Chang,George Coukos,Rebecca Liu,Weiping Zou

View Articletitled, Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments

Supplemental data

REVIEW ARTICLES

The leukemic stem cell niche: current concepts and therapeutic opportunities

Steven W. Lane,David T. Scadden,D. Gary Gilliland

View Articletitled, The leukemic stem cell niche: current concepts and therapeutic opportunities

HOW I TREAT

How I treat von Willebrand disease

Francesco Rodeghiero,Giancarlo Castaman,Alberto Tosetto

View Articletitled, How I treat von Willebrand disease

CLINICAL TRIALS AND OBSERVATIONS

A randomized phase 3 study of tipifarnib compared with best supportive care, including hydroxyurea, in the treatment of newly diagnosed acute myeloid leukemia in patients 70 years or older
Clinical Trials & Observations

Jean-Luc Harousseau,Giovanni Martinelli,Wieslaw W. Jedrzejczak,Joseph M. Brandwein,Dominique Bordessoule,Tamas Masszi,Gert J. Ossenkoppele,Julia A. Alexeeva,Gernot Beutel,Johan Maertens,Maria-Belen Vidriales,Hervé Dombret,Xavier Thomas,Alan K. Burnett,Tadeusz Robak,Nuriet K. Khuageva,Anatoly K. Golenkov,Elena Tothova,Lars Mollgard,Youn C. Park,Annick Bessems,Peter De Porre,Angela J. Howes,for the FIGHT-AML-301 Investigators

View Articletitled, A randomized phase 3 study of tipifarnib compared with best supportive care, including hydroxyurea, in the treatment of newly diagnosed acute myeloid leukemia in patients 70 years or older

GENE THERAPY

A novel human gamma-globin gene vector for genetic correction of sickle cell anemia in a humanized sickle mouse model: critical determinants for successful correction

Ajay Perumbeti,Tomoyasu Higashimoto,Fabrizia Urbinati,Robert Franco,Herbert J. Meiselman,David Witte,Punam Malik

View Articletitled, A novel human gamma-globin gene vector for genetic correction of sickle cell anemia in a humanized sickle mouse model: critical determinants for successful correction

Supplemental data

HEMATOPOIESIS AND STEM CELLS

Cell-nonautonomous function of Id1 in the hematopoietic progenitor cell niche

Hyung Chan Suh,Ming Ji,John Gooya,Michael Lee,Kimberly D. Klarmann,Jonathan R. Keller

View Articletitled, Cell-nonautonomous function of Id1 in the hematopoietic progenitor cell niche

Supplemental data

IMMUNOBIOLOGY

Treatment with anti-FasL antibody preserves memory lymphocytes and virus-specific cellular immunity in macaques challenged with simian immunodeficiency virus

Bhawna Poonia,Maria S. Salvato,Hideo Yagita,Toshihiro Maeda,Ko Okumura,C. David Pauza

View Articletitled, Treatment with anti-FasL antibody preserves memory lymphocytes and virus-specific cellular immunity in macaques challenged with simian immunodeficiency virus

The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5′-diphosphate-ribose) polymerase-1

Pengcheng Zhu,Denis Martinvalet,Dipanjan Chowdhury,Dong Zhang,Ann Schlesinger,Judy Lieberman

View Articletitled, The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5′-diphosphate-ribose) polymerase-1

Supplemental data

LYMPHOID NEOPLASIA

2-phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells

Andrew J. Steele,Archibald G. Prentice,A. Victor Hoffbrand,Birunthini C. Yogashangary,Stephen M. Hart,Mark W. Lowdell,Edward R. Samuel,Janet M. North,Elisabeth P. Nacheva,Anastasios Chanalaris,Panagiotis Kottaridis,Kate Cwynarski,R. Gitendra Wickremasinghe

View Articletitled, 2-phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells

Supplemental data

Pretargeting CD45 enhances the selective delivery of radiation to hematolymphoid tissues in nonhuman primates

Damian J. Green,John M. Pagel,Eneida R. Nemecek,Yukang Lin,Aimee Kenoyer,Anastasia Pantelias,Donald K. Hamlin,D. Scott Wilbur,Darrell R. Fisher,Joseph G. Rajendran,Ajay K. Gopal,Steven I. Park,Oliver W. Press

View Articletitled, Pretargeting CD45 enhances the selective delivery of radiation to hematolymphoid tissues in nonhuman primates

Recurrent mutations of the STAT6 DNA binding domain in primary mediastinal B-cell lymphoma

Olga Ritz,Chrystelle Guiter,Flavia Castellano,Karola Dorsch,Julia Melzner,Jean-Philippe Jais,Gwendoline Dubois,Philippe Gaulard,Peter Möller,Karen Leroy

View Articletitled, Recurrent mutations of the STAT6 DNA binding domain in primary mediastinal B-cell lymphoma

Supplemental data

PLATELETS AND THROMBOPOIESIS

Differential expression of NADPH oxidases in megakaryocytes and their role in polyploidy

Donald J. McCrann,Alexia Eliades,Maria Makitalo,Kuniharu Matsuno,Katya Ravid

View Articletitled, Differential expression of NADPH oxidases in megakaryocytes and their role in polyploidy

Supplemental data

Megakaryocyte impairment by eptifibatide-induced antibodies causes prolonged thrombocytopenia
Brief Report

Andreas Greinacher,Birgitt Fuerll,Heike Zinke,Bernd Müllejans,William Krüger,Noemi Michetti,Wolfgang Motz,Hansjörg Schwertz

View Articletitled, Megakaryocyte impairment by eptifibatide-induced antibodies causes prolonged thrombocytopenia

RED CELLS, IRON, AND ERYTHROPOIESIS

The HBS1L-MYB intergenic interval associated with elevated HbF levels shows characteristics of a distal regulatory region in erythroid cells

Karin Wahlberg,Jie Jiang,Helen Rooks,Kiran Jawaid,Fumihiko Matsuda,Masao Yamaguchi,Mark Lathrop,Swee Lay Thein,Steve Best

View Articletitled, The <em>HBS1L-MYB</em> intergenic interval associated with elevated HbF levels shows characteristics of a distal regulatory region in erythroid cells

Supplemental data

TRANSPLANTATION

Protection from graft-versus-host disease by HIV-1 envelope protein gp120-mediated activation of human CD4⁺CD25⁺ regulatory T cells

Christian Becker,Christian Taube,Tobias Bopp,Christoph Becker,Kai Michel,Jan Kubach,Sebastian Reuter,Nina Dehzad,Markus F. Neurath,Kurt Reifenberg,Franz-Joseph Schneider,Edgar Schmitt,Helmut Jonuleit

View Articletitled, Protection from graft-versus-host disease by HIV-1 envelope protein gp120-mediated activation of human CD4<sup>+</sup>CD25<sup>+</sup> regulatory T cells

Supplemental data

Serum ferritin as risk factor for sinusoidal obstruction syndrome of the liver in patients undergoing hematopoietic stem cell transplantation

Simone Cunha Maradei,Angelo Maiolino,Alexandre Mello de Azevedo,Marta Colares,Luis Fernando Bouzas,Marcio Nucci

View Articletitled, Serum ferritin as risk factor for sinusoidal obstruction syndrome of the liver in patients undergoing hematopoietic stem cell transplantation

VASCULAR BIOLOGY

Valves of the deep venous system: an overlooked risk factor
Brief Report

Erin G. Brooks,Winifred Trotman,Marilyn P. Wadsworth,Douglas J. Taatjes,Mark F. Evans,Frank P. Ittleman,Peter W. Callas,Charles T. Esmon,Edwin G. Bovill

View Articletitled, Valves of the deep venous system: an overlooked risk factor

Supplemental data

CORRESPONDENCE

Response: Recipient plasmacytoid dendritic cells and graft-versus-host disease

Takanori Teshima,Masanori Kadowaki,Motoko Koyama

View Articletitled, Response: Recipient plasmacytoid dendritic cells and graft-versus-host disease

ERRATUM

Verhaar et al. UV-C irradiation disrupts platelet surface disulfide bonds and activates the platelet integrin αIIbβ3. Blood. 2008;112(13):4935-4939.

View Articletitled, Verhaar et al. UV-C irradiation disrupts platelet surface disulfide bonds and activates the platelet integrin αIIbβ3. <em>Blood</em>. 2008;112(13):4935-4939.

Cover Image

Cover Image

Greinacher and colleagues demonstrate that eptifibatide induces antibodies in patients that can reduce the expression of GPIIbIIIa and the viability of megakaryocytes. This effect only occurs in the presence of eptifibatide and the GPIIbIIIa-directed antibody (compare red staining pattern in top and bottom panels). Cover art prepared by Diana Lim. See the article by Greinacher et al on page 1250.
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